Cytotoxic activity of 3,3′,4,4′,5,5′-hexahydroxystilbene against breast cancer cells is mediated by induction of p53 and downregulation of mitochondrial superoxide dismutase

Toxicology in Vitro

Volumn 22, Issue 5, 2008, Pages 1361-1370

  Murias, Marek ^a   Luczak, Michal W ^a   Niepsuj, Anna ^a   Krajka Kuzniak, Violetta ^a   Zielinska Przyjemska, Malgorzata ^a   Jagodzinski, Pawel P ^a   Jäger, Walter ^b   Szekeres, Thomas ^c   Jodynis Liebert, Jadwiga ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b UNIVERSITY OF VIENNA   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

3,3 ,4,4 ,5,5 trans tetrahydroxystilbene; Breast cancer cell lines; Caspase 3; Caspase 8; Caspase 9; Catalase; MDA MB 231; Mitochondrial apoptotic pathway; p53; Resveratrol; Superoxide dismutase; T47D; ZR 75 1

Indexed keywords

3,3',4,4',5,5' HEXAHYDROXYSTILBENE; ANTIOXIDANT; BIOLOGICAL MARKER; CASPASE 3; CASPASE 8; CASPASE 9; CATALASE; GLUTATHIONE; MITOCHONDRIAL ENZYME; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STILBENE DERIVATIVE; SUPEROXIDE DISMUTASE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; CLONOGENIC ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; OXIDATIVE STRESS; PROTEIN INDUCTION; RESPIRATORY CHAIN;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CASPASES; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CLONE CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME ACTIVATION; FEMALE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PYROGALLOL; STILBENES; SUPEROXIDE DISMUTASE; TUMOR SUPPRESSOR PROTEIN P53;

VITACEAE;

EID: 44749087180     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.03.002     Document Type: Article

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