Hormonal and genotoxic activity of resveratrol

Toxicology Letters

Volumn 136, Issue 2, 2002, Pages 133-142

  Schmitt, E ^a   Lehmann, L ^b   Metzler, M ^b   Stopper, H ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

Breast cancer cells; Cell cycle; Estrogen receptor; Genotoxicity; Micronuclei; Phytoestrogens; Resveratrol

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA; RESVERATROL; TUBULIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; ASSAY; CELL CYCLE; CELL PROLIFERATION; CELL STIMULATION; CELL STRAIN MCF 7; CELL STRAIN V 79; CENTROMERE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG EXPOSURE; ESTROGEN ACTIVITY; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA L 5178 Y; METAPHASE CHROMOSOME; MICRONUCLEUS; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ANIMALS; BREAST NEOPLASMS; CELL CYCLE; CELL DIVISION; CELL SURVIVAL; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGEN RECEPTOR ALPHA; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; KINETOCHORES; LYMPHOMA; METAPHASE; MICE; MICRONUCLEUS TESTS; MOLECULAR STRUCTURE; PROTEIN BINDING; RECEPTORS, ESTROGEN; STILBENES; TIME FACTORS; TUBULIN; TUMOR CELLS, CULTURED;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; MINK CELL FOCUS-FORMING VIRUS;

EID: 0037114449     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00290-4     Document Type: Article

References (32)

1. Ashby J., Tinwell H., Pennie W., Brooks A.N., Lefevre P.A., Beresford N., Sumpter J.P. Partial and weak oestrogenicity of the red wine constituent resveratrol: consideration of its superagonist activity in MCF-7 cells and its suggested cardiovascular protective effects. J. Appl. Toxicol. 19:1999;39-45.
2. Bertelli A., Giovannini L., Stradi R., Tillement J.P. Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4′,5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats. Int. J. Tissue React. 18:1996;67-71.
3. Bertelli A.A., Giovannini L., Stradi R., Tillement J.P., Bertelli A. Kinetics of trans- and cis-resveratrol (3,4′,5-trihydroxystilbene) after red wine oral administration in rats. Int. J. Clin. Pharmacol. Res. 16:1996;77-81.
4. Bhat K.P., Pezzuto J.M. Cancer chemopreventive activity of resveratrol. Ann. N.Y. Acad. Sci. 957:2002;210-229.
5. Blache D., Rustan I., Durand P., Lesgards G., Loreau N. Gas chromatographic analysis of resveratrol in plasma, lipoproteins and cells after in vitro incubations. J. Chromat. B Biomed. Sci. Appl. 702:1997;103-110.
6. Bowers J.L., Tyulmenkov V.V., Jernigan S.C., Klinge C.M. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β Endocrinology. 141:2000;3657-3667.
7. 3. Free Radical Biol. Med. 26:1999;1531-1537.
8. Chun Y.J., Kim M.Y., Guengerich F.P. Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Biochem. Biophys. Res. Commun. 262:1999;20-24.
9. Ciolino H.P., Yeh G.C. Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity. Mol. Pharmacol. 56:1999;784-790. überprüfen, habe ich nicht gefunden.
10. El Attar T., Virji A. The effects of red wine and its components on growth and proliferation of human oral squamous carcinoma cells. Anticancer Res. 19:1999;5407-5414.
11. Freyberger A., Hartmann E., Hildebrand H., Krotlinger F. Differential response of immature rat uterine tissue to ethinylestradiol and the red wine constituent resveratrol. Arch. Toxicol. 74:(11):2001;709-715.
12. Gehm B.D., McAndrews J.M., Chien P.Y., Jameson Y.L. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc. Natl. Acad. Sci. USA. 94:1997;14138-14143.
13. Gusman J., Malonne H., Atassi G. A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol. Carcinogenesis. 22:(8):2001;1111-1117.
14. Hsieh T.C., Burfeind P., Laud K., Backer J.M., Traganos F., Darzynkiewicz Z., Wu J.M. Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials. Int. J. Oncol. 15:1999;245-252.
15. Jang M., Cai L., Udeani G.O., Slowing K.V., Thomas C.F., Beecher C.W., Fong H.H., Farnsworth N.R., Kinghorn A.D., Mehta R.G., Moon R.C., Pezzuto J.M. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 275:1997;218-220.
16. Kuwajerwala N., Cifuentes E., Gautam S., Menon M., Barrack E.R., Reddy G.P. Resveratrol induces prostate cancer cell entry into s phase and inhibits DNA synthesis. Cancer Res. 62:(9):2002;2488-2492.
17. Lin J.K., Tsai S.H. Chemoprevention of cancer and cardiovascular disease by resveratrol. Proc. Natl. Sci. Counc. Repub. China B. 23:1999;99-106.
18. Lu R., Serrero G. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J. Cell Physiol. 179:1999;297-304.
19. Lu J., Ho C.H., Ghai G., Chen K.Y. Resveratrol analog, 3,4,5,4′-tetrahydroxystilbene, differentially induces pro-apoptotic p53/Bax gene expression and inhibits the growth of transformed cells but not their normal counterparts. Carcinogenesis. 22:(2):2001;321-328.
20. Matsuoka A., Furuta A., Ozaki M., Fukuhara K., Miyata N. Resveratrol, a naturally occurring polyphenol, induces sister chromatid exchanges in a Chinese hamster lung (CHL) cell line. Mutat. Res. 494:2001;107-113.
21. Mattivi F. Solid phase extraction of trans-resveratrol from wines for HPLC analysis. Z. Lebensm. Unters. Forsch. 196:1993;522-525.
22. Mgbonyebi O., Russo J., Russo I.H. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. Int. J. Oncol. 12:1998;865-869.
23. Peterson J., Dwyer J. Flavanoids: dietary occurrence and biochemical activity. Nutr. Res. 18:1998;1995-2018.
24. Pfeiffer E., Metzler M. Interaction of p-benzoquinone and p-biphenoquinone with microtubule proteins in vitro. Chem. -Biol. Interact. 102:1996;37-53.
25. Romero-Perez A.I., Lamuela R.M., Waterhouse A., de la Torre-Boronat M. Direct HPLC analysis of cis- and trans-resveratrol and piceid isomers in spanish red vitis vinifera wines. J. Agric. Food Chem. 43:1996;281-283.
26. Savouret J.F., Quesne M. Resveratrol and cancer: a review. Biomed. Pharmacother. 56:(2):2002;84-87.
27. Schneider Y., Duranton B., Gosse F., Schleiffer R., Seiler N., Raul F. Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis. Nutr. Cancer. 39:2001;102-107.
28. Schultz N., Onfelt A. Sensitivity of cytokinesis to hydrophobic interactions. Chemical induction of bi- and multinucleated cells. Chem. -Biol. Interact. 126:2000;97-123.
29. Shelanski M.L., Gaskin F., Cantor C.R. Microtubule assembly in the absence of added nucleotides. Proc. Natl. Acad. Sci. USA. 70:1973;765-768.
30. Stopper H., Kirchner S., Schiffmann D., Poot M. Cell cycle disturbance in relation to micronucleus formation induced by the carcinogenic estrogen diethylstilbestrol. Pathobiology. 62:1994;180-185.
31. Wamhoff H., Richardt G., Schneider V., Tulke A. Wein und Gesundheit. Chemie in unserer Zeit. 32:(Suppl.):1998;87-93.
32. Wu J.M., Wang Z.R., Hsieh T.C., Bruder J.L., Zou J.G., Huang Y.Z. Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine. Review Int. J. Mol. Med. 8:(1):2001;3-17.