Isoobtusilactone A induces cell cycle arrest and apoptosis through reactive oxygen species/apoptosis signal-regulating kinase 1 signaling pathway in human breast cancer cells

Cancer Research

Volumn 67, Issue 15, 2007, Pages 7406-7420

  Kuo, Po Lin ^a   Chen, Chung Yi ^b   Hsu, Ya Ling ^a  

^a CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^b FOOYIN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE 9; CDC25C PROTEIN; CYCLIN A; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYTOCHROME C; ISOOBTUSILACTONE A; PROTEIN; PROTEIN 14 3 3; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; REACTIVE OXYGEN METABOLITE; SERINE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; THIOREDOXIN; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CANCER MODEL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DEPHOSPHORYLATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; FEMALE; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ALKANES; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BREAST NEOPLASMS; CASPASES; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASE; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN A; CYCLIN B; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOCHROMES C; FEMALE; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LACTONES; MAP KINASE KINASE KINASE 5; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, NUDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 34547641948     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-1089     Document Type: Article

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