The L293 residue in transmembrane domain 2 of the 5-HT3A receptor is a molecular determinant of allosteric modulation by 5-hydroxyindole

Neuropharmacology

Volumn 54, Issue 8, 2008, Pages 1153-1165

  Hu, Xiang Qun ^a   Lovinger, David M ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

5 HT3A receptor; Allosteric modulation; Desensitization; Electrophysiology; Gating; Structure function

Indexed keywords

5 HYDROXYINDOLE; CYSTEINE; DOPAMINE; LEUCINE; SERINE; SEROTONIN 3 RECEPTOR;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; DESENSITIZATION; HUMAN; HUMAN CELL; MUTAGENESIS; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; AMINO ACIDS; CELLS, CULTURED; DATA INTERPRETATION, STATISTICAL; HUMANS; INDOLES; ION CHANNEL GATING; KINETICS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; POINT MUTATION; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN; SEROTONIN AGONISTS; SIGNAL TRANSDUCTION;

EID: 43949089810     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.03.009     Document Type: Article

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