The transmembrane domain of the 5-HT3 receptor: Its role in selectivity and gating

Biochemical Society Transactions

Volumn 32, Issue 3, 2004, Pages 535-539

  Lummis, S C R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Cys loop receptor; Ion selectivity; Ionotrophic receptor; Ligand gated ion channel; Pore; Serotonin receptor

Indexed keywords

ION CHANNEL; SEROTONIN 3 RECEPTOR;

ALPHA HELIX; CHANNEL GATING; CONFERENCE PAPER; HYDROPHOBICITY; IMAGING SYSTEM; ION MONITORING; LIGAND BINDING; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CYSTEINE; HUMANS; IONS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, SEROTONIN, 5-HT3; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3042607959     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0320535     Document Type: Conference Paper

References (43)

1. North, R.A. (1995) in Handbook of Receptors and Channels Series (Peroutka, S.J., ed.), CRC Press, Boca Raton, FL
2. Reeves, D.C. and Lummis, S.C. (2002) Mol. Membr. Biol. 19, 11-26
3. Le Novere, N., Grutter, T. and Changeux, J.P. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 3210-3215
4. Reeves, D.C., Sayed, M.F.R., Chau, P.-L., Price, K.L. and Lummis, S.C.R. (2003) Biophys. J. 84, 2338-2344
5. Schapira, M., Abagyan, R. and Totrov, M. (2002) BMC Struct. Biol. 2, 1-8
6. Cromer, B.A., Morton, C.J. and Parker, M.W. (2002) Trends Biochem. Sci. 27, 280-287
7. Niesler, B., Frank, B., Kapeller, J. and Rappold, G.A. (2003) Gene 310, 101-111
8. Imoto, K., Busch, C., Sakmann, B., Mishina, M., Konno, T., Nakai, J., Bujo, H., Mori, Y., Fukuda, K. and Numa, S. (1988) Nature (London) 335, 645-648
9. Labarca, C., Nowak, M.W., Zhang, H., Tang, L., Deshpande, P. and Lester, H.A. (1995) Nature (London) 376, 514-516
10. Bertrand, D., Galzi, J.L., Devillers-Thiery, A., Bertrand, S. and Changeux, J.P. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 6971-6975
11. Miyazawa, A., Fujiyoshi, Y. and Unwin, N. (2003) Nature (London) 424, 949-955
12. Revah, F., Galzi, J.L., Giraudat, J., Haumont, P.Y., Lederer, F. and Changeux, J.P. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 4675-4679
13. Unwin, N. (1993) J. Mol. Biol. 229, 1101-1124
14. Reeves, D.C., Goren, E.N., Akabas, M.H. and Lummis, S.C. (2001) J. Biol. Chem. 276, 42035-42042
15. Panicker, S., Cruz, H., Arrabit, C. and Slesinger, P.A. (2002) J. Neurosci. 22, 1629-1639
16. Xu, M. and Akabas, M.H. (1996) J. Gen. Physiol. 107, 195-205
17. Akabas, M.H., Stauffer, D.A., Xu, M. and Karlin, A. (1992) Science 258, 307-310
18. Williams, D.B. and Akabas, M.H. (1999) Biophys. J. 77, 2563-2574
19. Derkach, V., Surprenant, A. and North, R.A. (1989) Nature (London) 339, 706-709
20. Galzi, J.L., Devillers-Thiery, A., Hussy, N., Bertrand, S., Changeux, J.P. and Bertrand, D. (1992) Nature (London) 359, 500-505
21. Corringer, P.J., Bertrand, S., Galzi, J.L., Devillers-Thiery, A., Changeux, J.P. and Bertrand, D. (1999) Neuron 22, 831-843
22. Konno, T., Busch, C., von Kitzing, E., Imoto, K., Wang, F., Nakai, J., Mishina, M., Numa, S. and Sakmann, B. (1991) Proc. R. Soc. London B 244, 69-79
23. Keramidas, A., Moorhouse, A.J., French, C.R., Schofield, P.R. and Barry, P.H. (2000) Biophys. J. 79, 247-259
24. Gunthorpe, M.J. and Lummis, S.C. (2001) J. Biol. Chem. 276, 10977-10983
25. Wotring, V.E., Miller, T.S. and Weiss, D.S. (2003) J. Physiol. (Cambridge, U.K.) 548, 527-540
26. Corringer, P.J., Bertrand, S., Galzi, J.L., Devillers-Thiery, A., Changeux, J.P. and Bertrand, D. (1999) Novartis Found. Symp. 225, 215-224
27. Thompson, A.J. and Lummis, S.C (2003) Br. J. Pharmacol. 140, 359-365
28. Keramidas, A., Moorhouse, A.J., Pierce, K.D., Schofield, P.R. and Barry, P.H. (2002) J. Gen. Physiol. 119, 393-410
29. Jensen, M.L., Timmermann, D., Johansen, T.H., Schousboe, A., Varming, T. and Ahring, P.K. (2002) J. Biol. Chem. 277, 41438-41447
30. Kelley, S.P., Dunlop, J.I., Kirkness, E.F., Lambert, J.J. and Peters, J.A. (2003) Nature (London) 424, 321-324
31. Unwin, N. (2000) Philos. Trans. R. Soc. London B 355, 1813-1829
32. Mott, D., Erreger, K., Banke, T. and Traynelis, S. (2001) J. Physiol. (Cambridge, U.K.) 535, 427-443
33. Kash, T.L., Jenkins, A., Kelley, J.C., Trudell, J.R. and Harrison, N.L. (2003) Nature (London) 421, 272-275
34. Sigel, E., Buhr, A. and Baur, R. (1999) J. Neurochem. 73, 1758-1764
35. Lynch, J.W., Rajendra, S., Pierce, K.D., Handford, C.A., Barry, P.H. and Schofield, P.R. (1997) EMBO J. 16, 110-120
36. Rovira, J.C., Ballesta, J.J., Vicente-Agullo, F., Campos-Caro, A., Criado, M., Sala, F. and Sala, S. (1998) FEBS Lett. 433, 89-92
37. Deane, C.M. and Lummis, S.C. (2001) J. Biol. Chem. 276, 37962-37966
38. Lyford, L.K., Sproul, A.D., Eddins, D., TcLaughlin, J.T. and Rosenberg, R.L. (2003) Mol. Pharmacol. 64, 650-658
39. Kash, T.L., Dizon, M.J., Trudell, J.R. and Harrison, N.L. (2004) J. Biol. Chem. 279, 4887-4893
40. Hu, X.Q., Zhang, L., Stewart, R.R. and Weight, F.F. (2003) J. Biol. Chem. 278, 46583-46589
41. Akabas, M.H. and Karlin, A. (1995) Biochemistry 34, 12496-12500
42. Dang, H., England, P.M., Farivar, S.S., Dougherty, D.A. and Lester, H.A. (2000) Mol. Pharmacol. 57, 1114-1122
43. England, P.M., Zhang, Y., Dougherty, D.A. and Lester, H.A. (1999) Cell (Cambridge, Mass.) 96, 89-98