5-Hydroxyindole potentiates human α7 nicotinic receptor-mediated responses and enhances acetylcholine-induced glutamate release in cerebellar slices

Neuropharmacology

Volumn 43, Issue 3, 2002, Pages 374-384

  Zwart, R ^a   De Filippi, G ^a   Broad, L M ^a   McPhie, G I ^a   Pearson, K H ^a   Baldwinson, T ^a   Sher, E ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

7 Nicotinic receptor; 5 Hydroxyindole; Cerebellar slice; Modulation; Potentiation; Xenopus oocyte

Indexed keywords

5 HYDROXYINDOLE; ACETYLCHOLINE; ALPHA BUNGAROTOXIN; BUNGAROTOXIN RECEPTOR; CALCIUM; GLUTAMIC ACID; METHYLLYCACONITINE; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; EVOKED RESPONSE; FEMALE; GRANULE CELL; HUMAN; HUMAN CELL; ION CURRENT; MOSSY FIBER; NEUROBLASTOMA CELL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYNAPSE; SYNAPTIC TRANSMISSION; XENOPUS;

ACETYLCHOLINE; ANIMALS; CALCIUM; CELLS, CULTURED; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; FEMALE; GLUTAMIC ACID; IMAGE PROCESSING, COMPUTER-ASSISTED; INDOLES; MEMBRANE POTENTIALS; MICROELECTRODES; OOCYTES; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, NICOTINIC; SYNAPTIC TRANSMISSION; XENOPUS LAEVIS;

EID: 0036711318     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00094-1     Document Type: Article

References (48)

1. Arneric S.P. Preclinical pharmacology of ABT-418: a prototypical cholinergic channel activator for the potential treatment of Alzheimer's disease. CNS Drug Reviews. 1:1995;1-26.
2. Bertrand D., Devillers-Thiéry A., Revah F., Galzi J.L., Hussy N., Mulle C., Bertrand S., Ballivet M., Changeux J.P. Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain. Proceedings of the National Academy of Sciences (USA). 89:1992;1261-1265.
3. Bina K.G., Guzman P., Broide R.S., Leslie F.M., Smith M.A., O'Dowd D.K. Localization of α7 nicotinic receptor subunit mRNA and α-bungarotoxin binding sites in developing mouse somatosensory thalamocortical system. Journal of Comparative Neurology. 363:1995;321-332.
4. Briggs C.A., McKenna D.G. Activation and inhibition of the human α7 nicotinic acetylcholine receptor by agonists. Neuropharmacology. 37:1998;1095-1102.
5. Cachelin A.B., Rust G. Unusual pharmacology of (+)-tubocurarine with rat neuronal nicotinic acetylcholine receptors containing β4 subunits. Molecular Pharmacology. 46:1994;1168-1174.
6. Chen D., Patrick J.W. The α-bungarotoxin-binding nicotinic acetylcholine receptor from rat brain contains only the α7 subunit. Journal of Biological Chemistry. 272:1997;24024-24029.
7. Clementi F., Cabrini D., Gotti C., Sher E. Pharmacological characterization of cholinergic receptors in a human neuroblastoma cell line. Journal of Neurochemistry. 97:1986;291-297.
8. Couturier S., Bertrand D., Matter J.M., Hernandez M.C., Bertrand S., Millar N., Valera S., Barkas T., Ballivet M. A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-bungarotoxin. Neuron. 5:1990;847-856.
9. De Filippi G., Baldwinson T., Sher E. Evidence for nicotinic acetylcholine receptor activation in rat cerebellar slices. Pharmacology, Biochemistry and Behavior. 70:2001;447-455.
10. Delbono O., Gopalakrishnan M., Renganathan M., Monteggia L.M., Messi M.L., Sullivan J.P. Activation of the recombinant human α7 nicotinic acetylcholine receptor significantly raises intracellular free calcium. Journal of Pharmacology and Experimental Therapeutics. 280:1997;428-438.
11. Dominguez del Toro E., Juiz J.M., Peng X., Lindstrom J., Criado M. Immunocytochemical localization of the α7 subunit of the nicotinic acetylcholine receptor in the rat central nervous system. Journal of Comparative Neurology. 349:1994;325-342.
12. Dominguez del Toro E., Juiz J.M., Smillie F.I., Lindstrom J., Criado M. Epression of α7 neuronal nicotinic receptors during postnatal development of the rat cerebellum. Developmental Brain Research. 98:1997;125-133.
13. Edwards F.A., Konnerth A., Sakmann B., Takahashi T.E. A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system. Pflügers Archives (European Journal of Physiology). 414:1989;600-612.
14. Fujii S., Ji Z., Sumikawa K. Inactivation of α7 ACh receptors and activation of non-α7 ACh receptors both contribute to long-term potentiation induction in the hippocampal CA1 region. Neuroscience Letters. 286:2000;134-138.
15. Gotti C., Briscini L., Verderio C., Oortgiesen M., Balestra B., Clementi F. Native nicotinic acetylcholine receptors in human IMR-32 neuroblastoma cells: functional, immunological and pharmacological properties. European Journal of Neuroscience. 7:1995;2083-2092.
16. Grottick A.J., Trube G., Corrigall W.A., Huwyler J., Malherbe P., Wyler R., Higgins G.A. Evidence that nicotinic α7 receptors are not involved in the hyperlocomotor and rewarding effects of nicotine. Journal of Pharmacology and Experimental Therapeutics. 294:2000;1112-1119.
17. 3 receptors. Journal of Physiology (London). 519:1999;713-722.
18. Gurley D.A., Harris E.W., Li C., Johnson E.C., Lanthorn T.H. 5-Hydroxyindole potentiates the nicotinic acetylcholine receptor α7 subtype. Society for Neuroscience Abstracts. 26:2000;1916.
19. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Archives (European Journal of Physiology). 391:1981;85-100.
20. A channel subtypes. Molecular Neurobiology. 18:1998;35-86.
21. Houlihan L.M., Slater Y., Guerra D.L., Peng J.H., Kuo Y.P., Lukas R.J., Cassels B.K., Bermudez I. Activity of cytisine and its brominated isosteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors. Journal of Neurochemistry. 78:2001;1029-1043.
22. Hunter B.E., De Fiebre C.M., Papke R.L., Kem W.R., Meyer E.M. A novel nicotinic agonist facilitates induction of long-term potentiation in the rat hippocampus. Neuroscience Letters. 168:1994;130-134.
23. 3 receptor-mediated ion current in N1E-115 neuroblastoma cells. British Journal of Pharmacology 108. 1993;287-289.
24. 3 receptors in N1E-115 neuroblastoma cells. British Journal of Pharmacology. 112:1994;541-546.
25. Krause R.M., Buisson B., Bertrand S., Corringer P.J., Galzi J.L., Changeux J.P., Bertrand D. Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor. Molecular Pharmacology. 53:1998;283-294.
26. Levin E.D., Rezvani A.H. Development of nicotinic drug therapy for cognitive disorders. European Journal of Pharmacology. 393:2000;141-146.
27. Lloyd G.K., Williams M. Neuronal nicotinic acetylcholine receptors as novel drug targets. Journal of Pharmacology and Experimental Therapeutics. 292:2000;461-467.
28. Mansvelder H.D., McGehee D.S. Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron. 27:2000;349-357.
29. Menzaghi F., Whelan K.T., Risbrough V.B., Rao T.S., Lloyd G.K. Interaction between a novel cholinergic ion channel agonist, SIB-1765F and L-DOPA in the reserpine model of Parkinson's disease in rats. Journal of Pharmacology and Experimental Therapeutics. 280:1997;393-401.
30. Mullen G., Napier J., Balestra M., DeCory T., Hale G., Macor J., Mack R., Loch J. III, Wu E., Kover A., Verhoest P., Sampognaro A., Phillips E., Zhu Y., Murray R., Griffith R., Blosser J., Gurley D., Machulskis A., Zongrone J., Rosen A., Gordon J. (-)-Spiro[1-azabicyclo[2]octane-3,5′-oxazolidin-2′-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor. Journal of Medical Chemistry. 43:2000;4045-4050.
31. Orr-Urtreger A., Göldner F.M., Saeki M., Lorenzo I., Goldberg L., De Biasi M., Dani J.A., Patrick J.W., Beaudet A.L. Mice deficient in the α7 neuronal nicotinic acetylcholine receptor lack α-bungarotoxin binding sites and hippocampal fast nicotinic currents. Journal of Neuroscience. 17:1997;9165-9171.
32. Palma E., Bertrand S., Binzoni T., Bertrand D. Neuronal nicotinic α7 receptor expressed in Xenopus oocytes presents five putative binding sites for methyllycaconitine. Journal of Physiology (London). 491:1996;151-161.
33. Radcliffe K.A., Fisher J.L., Gray R., Dani J.A. Nicotinic modulation of glutamate and GABA synaptic transmission of hippocampal neurons. Annals of the New York Academy of Sciences. 868:1999;591-610.
34. Rathouz M.M., Berg D.K. Synaptic-type acetylcholine receptors raise intracellular calcium levels in neurons by two mechanisms. Journal of Neuroscience. 14:1994;6935-6945.
35. Role L.W., Berg D.K. Nicotinic receptors in the development and modulation of CNS synapses. Neuron. 16:1996;1077-1085.
36. Sands S.B., Costa A.C.S., Patrick J.W. Barium permeability of neuronal nicotinic receptor α7 expressed in Xenopus oocytes. Biophysical Journal. 65:1993;2614-2621.
37. Schoepfer R., Conroy W.G., Whiting P., Gore M., Lindstrom J. Brain α-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily. Neuron. 5:1990;35-48.
38. Scott L.J., Goa K.L. Galantamine, a review of its use in Alzheimer's disease. Drugs. 60:2000;1095-1122.
39. Séguela P., Wadiche J., Dineley-Miller K., Dani J.A., Patrick J.W. Molecular cloning, functional properties, and distribution of rat brain α7: a nicotinic cation channel highly permeable to calcium. Journal of Neuroscience. 13:1993;596-604.
40. Shan Q., Haddrill J.L., Lynch J.W. Ivermectin: an unconventional agonist of the glycine receptor chloride channel. Journal of Biological Chemistry. 276:2001;12556-12564.
41. Steinbach J.H., Chen Q. Antagonist and partial agonist actions of D-tubocurarine at mammalian muscle acetylcholine receptors. The Journal of Neuroscience. 15:1995;230-240.
42. Stühmer W. Electrophysiologic recordings from Xenopus oocytes. Methods in Enzymology. 293:1998;280-300.
43. 3 receptor-mediated ion current in N1E-115 neuroblastoma cells by 5-hydroxyindole and analogues. Neuropharmacology. 36:1997;649-653.
44. 3 receptor by full and partial agonists. British Journal of Pharmacology. 117:1996;839-846.
45. Wonnacott S. Presynaptic nicotinic ACh receptors. Trends in Neuroscience. 20:1997;92-98.
46. Zwart R., Vijverberg H.P.M. Potentiation and inhibition of neuronal nicotinic receptors by atropine: competitive and noncompetitive effects. Molecular Pharmacology. 52:1997;886-895.
47. Zwart R., Vijverberg H.P.M. Potentiation and inhibition of neuronal α4β4 nicotinic acetylcholine receptors by choline. European Journal of Pharmacology. 393:2000;209-214.
48. Zwart R., Van Kleef R.G.D.M., Gotti C., Smulders C.J.G.M., Vijverberg H.P.M. Competitive potentiation of acetylcholine effects on neuronal nicotinic receptors by acetylcholinesterase-inhibiting drugs. Journal of Neurochemistry. 75:2000;2492-2500.