메뉴 건너뛰기




Volumn 22, Issue 19, 2002, Pages 8411-8421

Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABAA receptors

Author keywords

Acetylcholine receptor; Desensitization; Electrophysiology; GABA receptor; Gating; Ion channel; Pore

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ISOLEUCINE; LEUCINE; RECEPTOR SUBUNIT; SERINE; THREONINE;

EID: 0036813523     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-19-08411.2002     Document Type: Article
Times cited : (67)

References (59)
  • 1
    • 0031870973 scopus 로고    scopus 로고
    • Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism
    • Auerbach A, Akk G (1998) Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism. J Gen Physiol 112:181-197.
    • (1998) J Gen Physiol , vol.112 , pp. 181-197
    • Auerbach, A.1    Akk, G.2
  • 3
    • 0031799363 scopus 로고    scopus 로고
    • International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: Classification on the basis of subunit structure and receptor function
    • Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ (1998) International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: Classification on the basis of subunit structure and receptor function. Pharmacol Rev 50:291-313.
    • (1998) Pharmacol Rev , vol.50 , pp. 291-313
    • Barnard, E.A.1    Skolnick, P.2    Olsen, R.W.3    Mohler, H.4    Sieghart, W.5    Biggio, G.6    Braestrup, C.7    Bateson, A.N.8    Langer, S.Z.9
  • 4
    • 0034740987 scopus 로고    scopus 로고
    • Mutation of the 9′ leucine in the GABA-A receptor gamma-2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states
    • Bianchi MT, Macdonald RL (2001) Mutation of the 9′ leucine in the GABA-A receptor gamma-2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states. Neuropharmacology 41:737-744.
    • (2001) Neuropharmacology , vol.41 , pp. 737-744
    • Bianchi, M.T.1    Macdonald, R.L.2
  • 6
    • 0033492836 scopus 로고    scopus 로고
    • A receptor: Three residues are required for allosteric coupling
    • A receptor: Three residues are required for allosteric coupling. J Neurosci 19:10213-10220.
    • (1999) J Neurosci , vol.19 , pp. 10213-10220
    • Boileau, A.J.1    Czajkowski, C.2
  • 9
    • 0031967525 scopus 로고    scopus 로고
    • Substitutions of the highly conserved M2 leucine create spontaneously opening rhol gamma-aminobutyric acid receptors
    • Chang Y, Weiss DS (1998) Substitutions of the highly conserved M2 leucine create spontaneously opening rhol gamma-aminobutyric acid receptors. Mol Pharmacol 53:511-523.
    • (1998) Mol Pharmacol , vol.53 , pp. 511-523
    • Chang, Y.1    Weiss, D.S.2
  • 10
    • 0032728861 scopus 로고    scopus 로고
    • Allosteric activation mechanism of the alpha1beta2gamma2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine
    • Chang Y, Weiss DS (1999) Allosteric activation mechanism of the alpha1beta2gamma2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine. Biophys J 77:2542-2551.
    • (1999) Biophys J , vol.77 , pp. 2542-2551
    • Chang, Y.1    Weiss, D.S.2
  • 12
    • 0023392945 scopus 로고
    • High efficiency transformation of mammalian cells by plasmid DNA
    • Chen C, Okayama H (1987) High efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7:2745-2752.
    • (1987) Mol Cell Biol , vol.7 , pp. 2745-2752
    • Chen, C.1    Okayama, H.2
  • 13
    • 0032199006 scopus 로고    scopus 로고
    • Binding, gating, affinity, and efficacy: The interpretation of structure-activity relationships for agonists and of the effects of mutating receptors
    • Colquhoun D (1998) Binding, gating, affinity, and efficacy: The interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. Br J Pharmacol 125:924-947.
    • (1998) Br J Pharmacol , vol.125 , pp. 924-947
    • Colquhoun, D.1
  • 14
    • 0002147782 scopus 로고
    • A Q-matrix cookbook: How to write only one program to calculate the single-channel and macroscopic predictions for any kinetic mechanism
    • Sakmann B, Neher E, eds, New York: Plenum
    • Colquhoun D, Hawkes AG (1995) A Q-matrix cookbook: How to write only one program to calculate the single-channel and macroscopic predictions for any kinetic mechanism. In: Single-channel Recording (Sakmann B, Neher E, eds), pp 589-633, New York: Plenum.
    • (1995) Single-channel Recording , pp. 589-633
    • Colquhoun, D.1    Hawkes, A.G.2
  • 16
    • 0029123899 scopus 로고
    • The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating
    • Filatov GN, White MM (1995) The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating. Mol Pharmacol 48:379-384.
    • (1995) Mol Pharmacol , vol.48 , pp. 379-384
    • Filatov, G.N.1    White, M.M.2
  • 17
    • 0034602567 scopus 로고    scopus 로고
    • Allosteric modulation in spontaneously active mutant gamma-aminobutyric acid(A) receptors in frogs
    • Findlay GS, Ueno S, Harrison NL, Harris RA (2000) Allosteric modulation in spontaneously active mutant gamma-aminobutyric acid(A) receptors in frogs. Neurosci Lett 293:155-158.
    • (2000) Neurosci Lett , vol.293 , pp. 155-158
    • Findlay, G.S.1    Ueno, S.2    Harrison, N.L.3    Harris, R.A.4
  • 18
    • 0033517736 scopus 로고    scopus 로고
    • A hydrophobic photolabel inhibits nicotinic acetylcholine receptors via open-channel block following a slow step
    • Forman SA (1999) A hydrophobic photolabel inhibits nicotinic acetylcholine receptors via open-channel block following a slow step. Biochemistry 38:14559-14564.
    • (1999) Biochemistry , vol.38 , pp. 14559-14564
    • Forman, S.A.1
  • 19
    • 0032923920 scopus 로고    scopus 로고
    • Novel modulation of a nicotinic receptor channel mutant reveals that the open state is stabilized by ethanol
    • Forman SA, Zhou Q (1999) Novel modulation of a nicotinic receptor channel mutant reveals that the open state is stabilized by ethanol. Mol Pharmacol 55:102-108.
    • (1999) Mol Pharmacol , vol.55 , pp. 102-108
    • Forman, S.A.1    Zhou, Q.2
  • 20
    • 0028031541 scopus 로고
    • Neurotransmitter-gated ion channels as unconventional allosteric proteins
    • Galzi JL, Changeux JP (1994) Neurotransmitter-gated ion channels as unconventional allosteric proteins. Curr Opin Struct Biol 4:554-565.
    • (1994) Curr Opin Struct Biol , vol.4 , pp. 554-565
    • Galzi, J.L.1    Changeux, J.P.2
  • 21
    • 0029416984 scopus 로고
    • Dependence of the GABA-A receptor gating kinetics on the alpha-subunit isoform: Implications for structure-function relations and synaptic transmission
    • Gingrich KJ, Roberts WA, Kass RS (1995) Dependence of the GABA-A receptor gating kinetics on the alpha-subunit isoform: Implications for structure-function relations and synaptic transmission. J Physiol (Lond) 489:529-543.
    • (1995) J Physiol (Lond) , vol.489 , pp. 529-543
    • Gingrich, K.J.1    Roberts, W.A.2    Kass, R.S.3
  • 22
    • 0034064135 scopus 로고    scopus 로고
    • Asymmetric and independent contribution of the second transmembrane segment 12′ residues to diliganded gating of acetylcholine receptor channels: A single-channel study with choline as the agonist
    • Grosman C, Auerbach A (2000) Asymmetric and independent contribution of the second transmembrane segment 12′ residues to diliganded gating of acetylcholine receptor channels: A single-channel study with choline as the agonist. J Gen Physiol 115:637-651.
    • (2000) J Gen Physiol , vol.115 , pp. 637-651
    • Grosman, C.1    Auerbach, A.2
  • 23
    • 0034677524 scopus 로고    scopus 로고
    • Mapping the conformational wave of acetylcholine receptor channel gating
    • Grosman C, Zhou M, Auerbach A (2000) Mapping the conformational wave of acetylcholine receptor channel gating. Nature 403:773-776.
    • (2000) Nature , vol.403 , pp. 773-776
    • Grosman, C.1    Zhou, M.2    Auerbach, A.3
  • 24
    • 0029063267 scopus 로고
    • Point mutations in the M2 region of the alpha, beta, or gamma subunit of the GABAA channel that abolish block by picrotoxin
    • Gurley D, Amin J, Ross PC, Weiss DS, White G (1995) Point mutations in the M2 region of the alpha, beta, or gamma subunit of the GABAA channel that abolish block by picrotoxin. Receptors Channels 3:13-20.
    • (1995) Receptors Channels , vol.3 , pp. 13-20
    • Gurley, D.1    Amin, J.2    Ross, P.C.3    Weiss, D.S.4    White, G.5
  • 25
    • 0032945358 scopus 로고    scopus 로고
    • GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts
    • Haas KF, Macdonald RL (1999) GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts. J Physiol (Lond) 514:27-45.
    • (1999) J Physiol (Lond) , vol.514 , pp. 27-45
    • Haas, K.F.1    Macdonald, R.L.2
  • 27
    • 0033669603 scopus 로고    scopus 로고
    • Modeling the functional effects of allosteric modulators at pharmacological receptors: An extension of the two-state model of receptor activation
    • Hall DA (2000) Modeling the functional effects of allosteric modulators at pharmacological receptors: An extension of the two-state model of receptor activation. Mol Pharmacol 58:1412-1423.
    • (2000) Mol Pharmacol , vol.58 , pp. 1412-1423
    • Hall, D.A.1
  • 28
    • 0035042719 scopus 로고    scopus 로고
    • Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment
    • Horenstein J, Wagner DA, Czajkowski C, Akabas MH (2001) Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment. Nat Neurosci 4:477-485.
    • (2001) Nat Neurosci , vol.4 , pp. 477-485
    • Horenstein, J.1    Wagner, D.A.2    Czajkowski, C.3    Akabas, M.H.4
  • 29
    • 0025173684 scopus 로고
    • Spontaneous and agonist-induced openings of an acetylcholine receptor channel composed of bovine muscle alpha-, beta- and deltasubunits
    • Jackson MB, Imoto K, Mishina M, Konno T, Numa S, Sakmann B (1990) Spontaneous and agonist-induced openings of an acetylcholine receptor channel composed of bovine muscle alpha-, beta- and deltasubunits. Pflügers Arch 417:129-135.
    • (1990) Pflügers Arch , vol.417 , pp. 129-135
    • Jackson, M.B.1    Imoto, K.2    Mishina, M.3    Konno, T.4    Numa, S.5    Sakmann, B.6
  • 30
    • 0029112106 scopus 로고
    • Desensitized states prolong GABA-A channel responses to brief agonist pulses
    • Jones MV, Westbrook GL (1995) Desensitized states prolong GABA-A channel responses to brief agonist pulses. Neuron 15:181-191.
    • (1995) Neuron , vol.15 , pp. 181-191
    • Jones, M.V.1    Westbrook, G.L.2
  • 31
    • 0027970398 scopus 로고
    • Visual identification of individual transfected cells for electrophysiology using antibody-coated beads
    • Jurman ME, Boland LM, Liu Y, Yellen G (1994) Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques 17:876-881.
    • (1994) Biotechniques , vol.17 , pp. 876-881
    • Jurman, M.E.1    Boland, L.M.2    Liu, Y.3    Yellen, G.4
  • 32
    • 0029593370 scopus 로고
    • Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins
    • Karlin A, Akabas MH (1995) Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Neuron 15:1231-1244.
    • (1995) Neuron , vol.15 , pp. 1231-1244
    • Karlin, A.1    Akabas, M.H.2
  • 33
    • 0031008576 scopus 로고    scopus 로고
    • Hydrophobicity regained
    • Karplus PA (1997) Hydrophobicity regained. Protein Science 6:1302-1307.
    • (1997) Protein Science , vol.6 , pp. 1302-1307
    • Karplus, P.A.1
  • 34
    • 0032707446 scopus 로고    scopus 로고
    • Agonist gating and isoflurane potentiation in the human gamma-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue
    • Koltchine VV, Finn SE, Jenkins A, Nikolaeva N, Lin A, Harrison NL (1999) Agonist gating and isoflurane potentiation in the human gamma-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue. Mol Pharmacol 56:1087-1093.
    • (1999) Mol Pharmacol , vol.56 , pp. 1087-1093
    • Koltchine, V.V.1    Finn, S.E.2    Jenkins, A.3    Nikolaeva, N.4    Lin, A.5    Harrison, N.L.6
  • 35
    • 0032515083 scopus 로고    scopus 로고
    • Molecular modulation of recombinant rat alpha1beta2gamma2 GABA(A) receptor channels by diazepam
    • Krampfl K, Lepier A, Jahn K, Franke C, Bufler J (1998) Molecular modulation of recombinant rat alpha1beta2gamma2 GABA(A) receptor channels by diazepam. Neurosci Lett 256:143-146.
    • (1998) Neurosci Lett , vol.256 , pp. 143-146
    • Krampfl, K.1    Lepier, A.2    Jahn, K.3    Franke, C.4    Bufler, J.5
  • 36
    • 0029163027 scopus 로고
    • Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors
    • Labarca C, Nowak MW, Zhang H, Tang L, Deshpande P, Lester HA (1995) Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature 376:514-516.
    • (1995) Nature , vol.376 , pp. 514-516
    • Labarca, C.1    Nowak, M.W.2    Zhang, H.3    Tang, L.4    Deshpande, P.5    Lester, H.A.6
  • 37
    • 0034143449 scopus 로고    scopus 로고
    • A receptor kinetics: Evidence for slowed agonist unbinding
    • A receptor kinetics: Evidence for slowed agonist unbinding. J Neurosci 20:899-907.
    • (2000) J Neurosci , vol.20 , pp. 899-907
    • Li, X.1    Pearce, R.A.2
  • 40
    • 0019985295 scopus 로고
    • Conformations of torpedo acetylcholine receptor associated with ion transport and desensitization
    • Neubig RR, Boyd ND, Cohen JB (1982) Conformations of torpedo acetylcholine receptor associated with ion transport and desensitization. Biochemistry 21:3460-3467.
    • (1982) Biochemistry , vol.21 , pp. 3460-3467
    • Neubig, R.R.1    Boyd, N.D.2    Cohen, J.B.3
  • 41
    • 0028796049 scopus 로고
    • Evolutionary history of the ligand-gated ion-channel superfamily of receptors
    • Ortells MO, Lunt GG (1995) Evolutionary history of the ligand-gated ion-channel superfamily of receptors. Trends Neurosci 18:121-127.
    • (1995) Trends Neurosci , vol.18 , pp. 121-127
    • Ortells, M.O.1    Lunt, G.G.2
  • 43
    • 0031781630 scopus 로고    scopus 로고
    • State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit
    • Pascual JM, Karlin A (1998) State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit. J Gen Physiol 111:717-739.
    • (1998) J Gen Physiol , vol.111 , pp. 717-739
    • Pascual, J.M.1    Karlin, A.2
  • 44
    • 4243846708 scopus 로고    scopus 로고
    • The binary elements model: An allosteric model of drug action incorporating multiple binding sites and multiple gates
    • Pearce RA (2001) The binary elements model: An allosteric model of drug action incorporating multiple binding sites and multiple gates. Anesthesiology 95:A120.
    • (2001) Anesthesiology , vol.95
    • Pearce, R.A.1
  • 47
    • 0035910631 scopus 로고    scopus 로고
    • Butanol effects on gamma-aminobutyric acid concentration-responses in human alpha-1beta-2gamma-2L GABA receptors with a mutation at alpha-1 S270
    • Scheller M, Forman SA (2001) Butanol effects on gamma-aminobutyric acid concentration-responses in human alpha-1beta-2gamma-2L GABA receptors with a mutation at alpha-1 S270. Neurosci Lett 297:179-182.
    • (2001) Neurosci Lett , vol.297 , pp. 179-182
    • Scheller, M.1    Forman, S.A.2
  • 48
    • 3142643600 scopus 로고    scopus 로고
    • Distinct deactivation and desensitization kinetics of recombinant GABAA receptors
    • Tia S, Wang JF, Kotchabhakdi N, Vicini S (1996) Distinct deactivation and desensitization kinetics of recombinant GABAA receptors. Neuropharmacology 35:1375-1382.
    • (1996) Neuropharmacology , vol.35 , pp. 1375-1382
    • Tia, S.1    Wang, J.F.2    Kotchabhakdi, N.3    Vicini, S.4
  • 49
    • 0029836596 scopus 로고    scopus 로고
    • Effects of mutating leucine to threonine in the M2 segment of alpha1 and beta1 subunits of GABAA alpha1beta1 receptors
    • Tierney ML, Birnir B, Pillai NP, Clements JD, Howitt SM, Cox GB, Gage PW (1996) Effects of mutating leucine to threonine in the M2 segment of alpha1 and beta1 subunits of GABAA alpha1beta1 receptors. J Membr Biol 154:11-21.
    • (1996) J Membr Biol , vol.154 , pp. 11-21
    • Tierney, M.L.1    Birnir, B.2    Pillai, N.P.3    Clements, J.D.4    Howitt, S.M.5    Cox, G.B.6    Gage, P.W.7
  • 50
    • 0029955444 scopus 로고    scopus 로고
    • Endogenous subunits can cause ambiguities in the pharmacology of exogenous gamma-aminobutyric acidA receptors expressed in human embryonic kidney 293 cells
    • Ueno S, Zorumski C, Bracamontes J, Steinbach JH (1996) Endogenous subunits can cause ambiguities in the pharmacology of exogenous gamma-aminobutyric acidA receptors expressed in human embryonic kidney 293 cells. Mol Pharmacol 50:931-938.
    • (1996) Mol Pharmacol , vol.50 , pp. 931-938
    • Ueno, S.1    Zorumski, C.2    Bracamontes, J.3    Steinbach, J.H.4
  • 51
    • 0033018069 scopus 로고    scopus 로고
    • Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes
    • Ueno S, Wick MJ, Ye Q, Harrison NL, Harris RA (1999) Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes. Br J Pharmacol 127:377-382.
    • (1999) Br J Pharmacol , vol.127 , pp. 377-382
    • Ueno, S.1    Wick, M.J.2    Ye, Q.3    Harrison, N.L.4    Harris, R.A.5
  • 52
    • 0033778416 scopus 로고    scopus 로고
    • Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: Effects on channel gating and regulation by ethanol
    • Ueno S, Lin A, Nikolaeva N, Trudell JR, Mihic SJ, Harris RA, Harrison NL (2000) Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: Effects on channel gating and regulation by ethanol. Br J Pharmacol 131:296-302.
    • (2000) Br J Pharmacol , vol.131 , pp. 296-302
    • Ueno, S.1    Lin, A.2    Nikolaeva, N.3    Trudell, J.R.4    Mihic, S.J.5    Harris, R.A.6    Harrison, N.L.7
  • 53
    • 0028921479 scopus 로고
    • Acetylcholine receptor channel imaged in the open state
    • Unwin N (1995) Acetylcholine receptor channel imaged in the open state. Nature 373:37-43.
    • (1995) Nature , vol.373 , pp. 37-43
    • Unwin, N.1
  • 54
    • 0025310662 scopus 로고
    • Functional properties of recombinant rat GABAA receptors depend upon subunit composition
    • Verdoorn TA, Draguhn A, Ymer S, Seeburg PH, Sakmann B (1990) Functional properties of recombinant rat GABAA receptors depend upon subunit composition. Neuron 4:919-928.
    • (1990) Neuron , vol.4 , pp. 919-928
    • Verdoorn, T.A.1    Draguhn, A.2    Ymer, S.3    Seeburg, P.H.4    Sakmann, B.5
  • 55
    • 0032102496 scopus 로고    scopus 로고
    • The location of the gate in the acetylcholine receptor channel
    • Wilson GG, Karlin A (1998) The location of the gate in the acetylcholine receptor channel. Neuron 20:1269-1281.
    • (1998) Neuron , vol.20 , pp. 1269-1281
    • Wilson, G.G.1    Karlin, A.2
  • 56
    • 0035970016 scopus 로고    scopus 로고
    • Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method
    • Wilson GG, Karlin A (2001) Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method. Proc Natl Acad Sci USA 98:1241-1248.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1241-1248
    • Wilson, G.G.1    Karlin, A.2
  • 57
    • 0029865892 scopus 로고    scopus 로고
    • Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit
    • Xu M, Akabas MH (1996) Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit. J Gen Physiol 107:195-205.
    • (1996) J Gen Physiol , vol.107 , pp. 195-205
    • Xu, M.1    Akabas, M.H.2
  • 58
    • 0027194134 scopus 로고
    • Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes
    • Yakel JL, Lagrutta A, Adelman JP, North RA (1993) Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes. Proc Natl Acad Sci USA 90:5030-5033.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5030-5033
    • Yakel, J.L.1    Lagrutta, A.2    Adelman, J.P.3    North, R.A.4
  • 59
    • 0034610350 scopus 로고    scopus 로고
    • The n-alcohol site in the nicotinic receptor pore is a hydrophobic patch
    • Zhou QL, Zhou Q, Forman SA (2000) The n-alcohol site in the nicotinic receptor pore is a hydrophobic patch. Biochemistry 39:14920-14926.
    • (2000) Biochemistry , vol.39 , pp. 14920-14926
    • Zhou, Q.L.1    Zhou, Q.2    Forman, S.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.