Asymmetric and independent contribution of the second transmembrane segment 12' residues to diliganded gating of acetylcholine receptor channels: A single-channel study with choline as the agonist

Journal of General Physiology

Volumn 115, Issue 5, 2000, Pages 637-651

  Grosman, Claudio ^a   Auerbach, Anthony ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Allosteric proteins; Bronsted plot; Double mutant cycles; Kinetics; Nicotinic receptors

Indexed keywords

CHOLINE; COMPLEMENTARY DNA; NICOTINIC RECEPTOR;

ANIMAL CELL; ARTICLE; CHOLINERGIC SYSTEM; ENERGY; KINETICS; MEMBRANE CHANNEL; MEMBRANE CONDUCTANCE; MOUSE; MUTATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC SITE; ANIMALS; CELL LINE; CHOLINE; ENERGY TRANSFER; HUMANS; ION CHANNEL GATING; KIDNEY; KINETICS; LINEAR MODELS; MEMBRANE POTENTIALS; MICE; MUTAGENESIS, SITE-DIRECTED; NICOTINIC AGONISTS; PATCH-CLAMP TECHNIQUES; RECEPTORS, NICOTINIC;

EID: 0034064135     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.115.5.637     Document Type: Article

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