Identification of transduction elements for benzodiazepine modulation of the GABA(A) receptor: Three residues are required for allosteric coupling

Journal of Neuroscience

Volumn 19, Issue 23, 1999, Pages 10213-10220

  Boileau, Andrew J ^a   Czajkowski, Cynthia ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Allosteric coupling; Benzodiazepine binding site; Benzodiazepines; Chimeric subunits; GABA; GABA(A) receptor; Inverse agonist; M2 domain; M2 M3 loop; Mutagenesis; Positive modulation; Xenopus oocytes; subunit; subunit

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE; BETA CARBOLINE DERIVATIVE; ION CHANNEL;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; MUTAGENESIS; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING;

EID: 0033492836     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-23-10213.1999     Document Type: Article

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