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Volumn 81, Issue 4, 1996, Pages 1501-1509

Wortmannin inhibits both insulin- and contraction-stimulated glucose uptake and transport in rat skeletal muscle

Author keywords

hindlimb; phosphatidylinositol 3 kinase; signaling

Indexed keywords

3 METHYLGLUCOSE; GLUCOSE; HUMAN INSULIN; INSULIN RECEPTOR KINASE; INSULIN RECEPTOR SUBSTRATE 1; NEUTRAL INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

EID: 0029800475     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.81.4.1501     Document Type: Article
Times cited : (87)

References (34)
  • 2
    • 0026695636 scopus 로고
    • Elevated muscle glycogen and anaerobic energy production during exhaustive exercise in man
    • Bangsbo, J., T. E. Graham, B. Kiens, and B. Saltin. Elevated muscle glycogen and anaerobic energy production during exhaustive exercise in man. J. Physiol. Lond. 451: 205-227, 1992.
    • (1992) J. Physiol. Lond. , vol.451 , pp. 205-227
    • Bangsbo, J.1    Graham, T.E.2    Kiens, B.3    Saltin, B.4
  • 3
    • 0028029445 scopus 로고
    • PI 3-kinase activation is required for insulin stimulation of glucose transport into L6 myotubes
    • Berger, J., N. Hayes, D. M. Szalkowski, and B. Zhang. PI 3-kinase activation is required for insulin stimulation of glucose transport into L6 myotubes. Biochem. Biophys. Res. Commun. 205: 570-576, 1994.
    • (1994) Biochem. Biophys. Res. Commun. , vol.205 , pp. 570-576
    • Berger, J.1    Hayes, N.2    Szalkowski, D.M.3    Zhang, B.4
  • 4
    • 0028013299 scopus 로고
    • Experimental approaches in muscle metabolism: Hindlimb perfusion and isolated muscle incubations
    • Endocrinol-Metab. 29
    • Bonen, A., M. G. Clark, and E. J. Henriksen. Experimental approaches in muscle metabolism: hindlimb perfusion and isolated muscle incubations. Am. J. Physiol. 266 (Endocrinol-Metab. 29): E1-E16, 1994.
    • (1994) Am. J. Physiol. , vol.266
    • Bonen, A.1    Clark, M.G.2    Henriksen, E.J.3
  • 5
    • 0024333633 scopus 로고
    • Adenine nucleotide degradation in human skeletal muscle during prolong exercise
    • Broberg, S. and K. Sahlin. Adenine nucleotide degradation in human skeletal muscle during prolong exercise. J. Appl. Physiol. 67:116-122, 1989.
    • (1989) J. Appl. Physiol. , vol.67 , pp. 116-122
    • Broberg, S.1    Sahlin, K.2
  • 6
    • 0028260280 scopus 로고
    • Inhibition of the translocation of GLUT-1 and GLUT-4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, Wortmannin
    • Clarke, J. E., P. W. Young, K. Yonezawa, M. Kasuga, and G. D. Holman. Inhibition of the translocation of GLUT-1 and GLUT-4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, Wortmannin. Biochem. J. 300: 631-635, 1994.
    • (1994) Biochem. J. , vol.300 , pp. 631-635
    • Clarke, J.E.1    Young, P.W.2    Yonezawa, K.3    Kasuga, M.4    Holman, G.D.5
  • 7
    • 0025309699 scopus 로고
    • Long-term treatment of isolated rat soleus muscle with phorbol ester leads to loss of contraction-induced glucose transport
    • Cleland, P. J., K. Abel, S. Rattigan, and M. Clark. Long-term treatment of isolated rat soleus muscle with phorbol ester leads to loss of contraction-induced glucose transport. Biochem. J. 267: 659-663, 1990.
    • (1990) Biochem. J. , vol.267 , pp. 659-663
    • Cleland, P.J.1    Abel, K.2    Rattigan, S.3    Clark, M.4
  • 8
    • 0028850452 scopus 로고
    • Wortmannin and its structural analogue demethoxyviridin inhibits stimulated phospholipase A2 activity in Swiss 3T3 cells
    • Cross, M. J., A, Stewart, M. N. Hodgkin, D. J. Kerr, and M. J. O. Wakeham. Wortmannin and its structural analogue demethoxyviridin inhibits stimulated phospholipase A2 activity in Swiss 3T3 cells. J. Biol. Chem. 270: 25352-25355, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25352-25355
    • Cross, M.J.1    Stewart, A.2    Hodgkin, M.N.3    Kerr, D.J.4    Wakeham, M.J.O.5
  • 9
    • 0029024435 scopus 로고
    • The effects of wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, on insulin-stimulated glucose transport, GLUT-4 translocation, antilipolysis and DNA synthesis
    • Evans, J. L., C. M. Honer, B. E. Womelsdorf, E. L. Kaplan, and P. A. Bell. The effects of wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, on insulin-stimulated glucose transport, GLUT-4 translocation, antilipolysis and DNA synthesis. Cell. Signalling 7: 365-376, 1995.
    • (1995) Cell. Signalling , vol.7 , pp. 365-376
    • Evans, J.L.1    Honer, C.M.2    Womelsdorf, B.E.3    Kaplan, E.L.4    Bell, P.A.5
  • 10
    • 0026539998 scopus 로고
    • Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat
    • Folli, F., M. J. Saad, J. M. Backer, and C. R. Kahn. Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat. J. Biol. Chem. 267: 22171-22177, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 22171-22177
    • Folli, F.1    Saad, M.J.2    Backer, J.M.3    Kahn, C.R.4
  • 11
    • 0024605473 scopus 로고
    • Polymyxin B inhibits stimulation of glucose transport in muscle by hypoxia or contractions
    • Endocrinol. Metab. 19
    • Henriksen, E., M. Sleeper, J. Zierath, and J. Holloszy. Polymyxin B inhibits stimulation of glucose transport in muscle by hypoxia or contractions. Am. J. Physiol. 256 (Endocrinol. Metab. 19): E662-E667, 1989.
    • (1989) Am. J. Physiol. , vol.256
    • Henriksen, E.1    Sleeper, M.2    Zierath, J.3    Holloszy, J.4
  • 12
    • 0000473845 scopus 로고
    • Studies of tissue permeability
    • Holloszy, J. O., and H. T. Narahara. Studies of tissue permeability. J. Biol. Chem. 240: 3493-3500, 1965.
    • (1965) J. Biol. Chem. , vol.240 , pp. 3493-3500
    • Holloszy, J.O.1    Narahara, H.T.2
  • 13
    • 0022497099 scopus 로고
    • Oxygen cost of twitch and tetanic isometric contractions of rat skeletal muscle
    • Endocrinol. Metab. 13
    • Hood, D., J. Gorski, and R. Terjung. Oxygen cost of twitch and tetanic isometric contractions of rat skeletal muscle. Am. J. Physiol. 250 (Endocrinol. Metab. 13): E449-E456, 1986.
    • (1986) Am. J. Physiol. , vol.250
    • Hood, D.1    Gorski, J.2    Terjung, R.3
  • 14
    • 0028865424 scopus 로고
    • The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake
    • Isakoff, S. J., C. Taha, E. Rose, J. Marcusohn, A. Klip, and E. Y. Skolnik. The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake. Proc. Natl. Acad. Sci. USA 92: 10247-10251, 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 10247-10251
    • Isakoff, S.J.1    Taha, C.2    Rose, E.3    Marcusohn, J.4    Klip, A.5    Skolnik, E.Y.6
  • 15
    • 0027233477 scopus 로고
    • A microtiter well assay system to measure insulin activation of insulin receptor kinase in intact human mononuclear cells
    • Klein, H. H., B. Kowalewski, M. Drenckhan, S. Neugebauer, S. Matthaei, and G. Kotzke. A microtiter well assay system to measure insulin activation of insulin receptor kinase in intact human mononuclear cells. Diabetes 42: 883-890, 1993.
    • (1993) Diabetes , vol.42 , pp. 883-890
    • Klein, H.H.1    Kowalewski, B.2    Drenckhan, M.3    Neugebauer, S.4    Matthaei, S.5    Kotzke, G.6
  • 16
    • 0028914037 scopus 로고
    • Wortmannin inhibits insulin-stimulated but not contraction-stimulated glucose transport activity in skeletal muscle
    • Lee, A. D., P. A. Hansen, and J. O. Holloszy. Wortmannin inhibits insulin-stimulated but not contraction-stimulated glucose transport activity in skeletal muscle. FEBS Lett. 361: 51-54, 1995.
    • (1995) FEBS Lett. , vol.361 , pp. 51-54
    • Lee, A.D.1    Hansen, P.A.2    Holloszy, J.O.3
  • 19
    • 0029064123 scopus 로고
    • Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin
    • Lund, S., G. D. Holman, O. Schmitz, and O. Pedersen. Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin. Proc. Natl. Acad. Sci. USA 92: 5817-5821, 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5817-5821
    • Lund, S.1    Holman, G.D.2    Schmitz, O.3    Pedersen, O.4
  • 20
    • 0029015694 scopus 로고
    • A wortmanninsensitive phosphatidylinositol 4-kinase that regulates hormonesensitive pools of inositolphospholipids
    • Nakanishi, S., K. J. Catt, and T. Balla. A wortmanninsensitive phosphatidylinositol 4-kinase that regulates hormonesensitive pools of inositolphospholipids. Proc. Natl. Acad. Sci. USA 92: 5317-5321, 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5317-5321
    • Nakanishi, S.1    Catt, K.J.2    Balla, T.3
  • 22
    • 0028124189 scopus 로고
    • Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes-studies with a selective inhibitor wortmannin
    • Okada, T., Y. Kawano, T. Sakakibara, O. Hazeki, and M. Ui. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes-studies with a selective inhibitor wortmannin. J. Biol. Chem. 269: 3568-3573, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3568-3573
    • Okada, T.1    Kawano, Y.2    Sakakibara, T.3    Hazeki, O.4    Ui, M.5
  • 23
    • 0023239905 scopus 로고
    • Kinetics of glucose transport in rat muscle: Effects of insulin and contractions
    • Endocrinol. Metab. 16
    • Ploug, T., H. Galbo, J. Vinten, M. Jørgensen, and E. A. Richter. Kinetics of glucose transport in rat muscle: effects of insulin and contractions. Am. J. Physiol. 253 (Endocrinol. Metab. 16): E12-E20, 1987.
    • (1987) Am. J. Physiol. , vol.253
    • Ploug, T.1    Galbo, H.2    Vinten, J.3    Jørgensen, M.4    Richter, E.A.5
  • 24
    • 0029013767 scopus 로고
    • Effect of immobilization on glucose transport and glucose transporter expression in rat skeletal muscle
    • Endocrinol. Metab. 31
    • Ploug, T., T. Ohkuwa, A. Handberg, J. Vissing, and H. Galbo. Effect of immobilization on glucose transport and glucose transporter expression in rat skeletal muscle. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E980-E986, 1995.
    • (1995) Am. J. Physiol. , vol.268
    • Ploug, T.1    Ohkuwa, T.2    Handberg, A.3    Vissing, J.4    Galbo, H.5
  • 25
    • 0021447734 scopus 로고
    • Enhanced muscle glucose metabolism after exercise: Modulation by local factors
    • Endocrinol. Metab. 9
    • Richter, E. A., L. P. Garetto, M. N. Goodman, and N. B. Ruderman. Enhanced muscle glucose metabolism after exercise: modulation by local factors. Am. J. Physiol. 246 (Endocrinol. Metab. 9): E476-E482, 1984.
    • (1984) Am. J. Physiol. , vol.246
    • Richter, E.A.1    Garetto, L.P.2    Goodman, M.N.3    Ruderman, N.B.4
  • 26
    • 0015117034 scopus 로고
    • Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism
    • Ruderman, N. B., C. R. S. Houghton, and R. Hems. Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism. Biochem. J. 124: 639-651, 1971.
    • (1971) Biochem. J. , vol.124 , pp. 639-651
    • Ruderman, N.B.1    Houghton, C.R.S.2    Hems, R.3
  • 27
    • 0027905021 scopus 로고
    • Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
    • Schu, P. V., K. Takegawa, M. J. Fry, J. H. Stack, M. D. Waterfield, and S. D. Emr. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science Wash. DC 260: 88-91, 1993.
    • (1993) Science Wash. DC , vol.260 , pp. 88-91
    • Schu, P.V.1    Takegawa, K.2    Fry, M.J.3    Stack, J.H.4    Waterfield, M.D.5    Emr, S.D.6
  • 28
    • 0022451151 scopus 로고
    • Characteristics of rat hindlimbs perfused with erythrocyte- and albumin-free medium
    • Cell Physiol. 20
    • Shiota, M., and T. Sugano. Characteristics of rat hindlimbs perfused with erythrocyte- and albumin-free medium. Am. J. Physiol. 251 (Cell Physiol. 20): C78-C84, 1986.
    • (1986) Am. J. Physiol. , vol.251
    • Shiota, M.1    Sugano, T.2
  • 29
    • 0022032944 scopus 로고
    • Effects of acidosis on rat muscle metabolism and performance during heavy exercise
    • Cell Physiol. 17
    • Spriet, L., C. Matsos, S. Peters, G. J. Heigenhauser, and N. Jones. Effects of acidosis on rat muscle metabolism and performance during heavy exercise. Am. J. Physiol. 248 (Cell Physiol. 17): C337-C347, 1985.
    • (1985) Am. J. Physiol. , vol.248
    • Spriet, L.1    Matsos, C.2    Peters, S.3    Heigenhauser, G.J.4    Jones, N.5
  • 30
    • 0028012445 scopus 로고
    • Direct activation of the phosphatidylinositol 3-kinase by the insulin receptor
    • Van Horn, D. J., M. G. Myers, and J. M. Backer. Direct activation of the phosphatidylinositol 3-kinase by the insulin receptor. J. Biol. Chem. 269: 29-32, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 29-32
    • Van Horn, D.J.1    Myers, M.G.2    Backer, J.M.3
  • 31
    • 0028269845 scopus 로고
    • Adenosine receptors mediate synergistic stimulation of muscle glucose uptake and transport by insulin and by contractions in rat skeletal muscle
    • Vergauwen, L., P. Hespel, and E. A. Richter. Adenosine receptors mediate synergistic stimulation of muscle glucose uptake and transport by insulin and by contractions in rat skeletal muscle. J. Clin. Invest. 93: 974-981, 1994.
    • (1994) J. Clin. Invest. , vol.93 , pp. 974-981
    • Vergauwen, L.1    Hespel, P.2    Richter, E.A.3
  • 32
    • 0028947991 scopus 로고
    • The effects of wortmannin on rat skeletal muscle
    • Yeh, J., E. A. Gulve, L. Rameh, and M. J. Birnbaum. The effects of wortmannin on rat skeletal muscle. J. Biol. Chem. 270: 2107-2111, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 2107-2111
    • Yeh, J.1    Gulve, E.A.2    Rameh, L.3    Birnbaum, M.J.4
  • 33
    • 0025825770 scopus 로고
    • Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction
    • Cell Physiol. 29
    • Youn, J. H., E. A, Gulve, and J. O. Holloszy. Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction. Am. J. Physiol. 260 (Cell Physiol. 29): C555-C561, 1991.
    • (1991) Am. J. Physiol. , vol.260
    • Youn, J.H.1    Gulve, E.A.2    Holloszy, J.O.3
  • 34
    • 0025855143 scopus 로고
    • Polymyxin B inhibits contraction-stimulated glucose uptake in rat skeletal muscle
    • Young, J. C., T. G. Kurowski, A. M. Maurice, R. Nesher, and N. B. Ruderman. Polymyxin B inhibits contraction-stimulated glucose uptake in rat skeletal muscle. J. Appl. Physiol. 70: 1650-1654, 1991.
    • (1991) J. Appl. Physiol. , vol.70 , pp. 1650-1654
    • Young, J.C.1    Kurowski, T.G.2    Maurice, A.M.3    Nesher, R.4    Ruderman, N.B.5


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