SH2-B is required for both male and female reproduction

Molecular and Cellular Biology

Volumn 22, Issue 9, 2002, Pages 3066-3077

  Ohtsuka, Satoshi ^a   Takaki, Satoshi ^a   Iseki, Masanori ^a   Miyoshi, Kanta ^a   Nakagata, Naomi ^a   Kataoka, Yuki ^a   Yoshida, Nobuaki ^a   Takatsu, Kiyoshi ^a   Yoshimura, Akihiko ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CYTOKINE; FOLLITROPIN; GROWTH FACTOR; HORMONE; INSULIN; MESSENGER RNA; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FEMALE GENITAL SYSTEM; GENE DISRUPTION; IMMUNOHISTOCHEMISTRY; MALE; MALE GENITAL SYSTEM; MOUSE; NONHUMAN; NORTHERN BLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; B-LYMPHOCYTES; CARRIER PROTEINS; CELL DIVISION; FEMALE; FERTILIZATION IN VITRO; FLOW CYTOMETRY; FOLLICLE STIMULATING HORMONE; GENE DELETION; GENE EXPRESSION REGULATION; INFERTILITY; INSULIN-LIKE GROWTH FACTOR I; MALE; MAST CELLS; MICE; MICE, KNOCKOUT; OOCYTES; REPRODUCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPERMATOZOA; T-LYMPHOCYTES;

ANIMALIA; MAMMALIA;

EID: 0036238898     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.9.3066-3077.2002     Document Type: Article

References (48)

1. The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction
2. Insulin-like growth factor-I (IGF-I) and IGF-II hormonal action in cultured rat granulosa cells: Mediation via type I but not type II IGF receptors
3. Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function
4. Functional effects of APS and SH2-B on insulin receptor signalling
5. APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase
6. Effects of an Igf1 gene null mutation on mouse reproduction
7. IRS-2 pathways integrate female reproduction and energy homeostasis
8. SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone
9. Specific insulin-like growth factor (IGF) I- and II-binding sites on rat granulosa cells: Relation to IGF action
10. SH2-Bβ is a Rac binding protein that regulates cell motility
11. Impairing follicle-stimulating hormone (FSH) signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance
12. Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells
13. Gonadotropin stimulation of the expansion of cumulus oophori isolated from mice: General conditions for expansion in vitro
14. Insulin action in the normal and polycystic ovary
15. Production of insulin-like growth factors by ovarian granulosa cells
16. Expression of the genes encoding the insulin-like growth factors and their receptors in the human ovary
17. Rat ovarian insulin-like growth factor I (IGF-I) gene expression is granulosa cell-selective: 5′-untranslated mRNA variant representation and hormonal regulation
18. SH2-B is required for growth hormone-induced actin reorganization
19. Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase
20. Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins
21. Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality
22. SH2-Bα is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase
23. Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility
24. Phenotype and genotype in polycystic ovary syndrome
25. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (lgf1r)
26. Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain
27. Insulin-like growth factor I gene expression in the rat ovary is confined to the granulosa cells of developing follicles
28. The yeast trihybrid system - Genetic detection of trans-phosphorylated ITAM-SH2-interactions
29. Jak2 is essential for signaling through a variety of cytokine receptors
30. Identification and characterization of novel substrates of Trk receptors in developing neurons
31. PSM, an insulin-dependent, pro-rich, PH, SH2 domain containing partner of the insulin receptor
32. Platelet-derived growth factor (PDGF) stimulates the association of SH2-Bβ with PDGF receptor and phosphorylation of SH2-Bβ
33. Identification of SH2-Bβ as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2
34. Differential binding to and regulation of JAK2 by the SH2 domain and N- terminal region of SH2-Bβ
35. SH2-B, a membrane-associated adapter, is phosphorylated on multiple serines/threonines in response to nerve growth factor by kinases within the MEK/ERK cascade
36. Identification of SH2-Bβ as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling
37. Characterization of Lnk, an adaptor protein expressed in lymphocytes
38. Control of B cell production by the adaptor protein Lnk. Definition of a conserved family of signal-modulating proteins
39. Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein
40. An IFN-gamma-dependent pathway plays a critical role in the pathogenesis of murine immunodeficiency syndrome induced by LP-BM5 murine leukemia virus
41. APS, an adaptor protein containing PH and SH2 domains inhibits the JAK-STAT pathway in collaboration with c-Cbl
42. Insulin-like growth factor-1 receptor and insulin receptor association with a Src homology-2 domain-containing putative adapter
43. Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation
44. APS, an adaptor protein containing PH and SH2 domains is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis
45. Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis
46. Insulin-like growth factor I regulates gonadotropin responsiveness in the murine ovary