Phosphoinositide 3-kinase is required for insulin-induced but not for growth hormone- or hyperosmolarity-lnduced glucose uptake in 3T3-l1 adipocytes

Molecular Endocrinology

Volumn 11, Issue 10, 1997, Pages 1552-1562

  Sakaue, Hiroshi ^a   Ogawa, Wataru ^a   Takata, Masafumi ^a   Kuroda, Shoji ^a   Kotani, Ko ^a   Matsumoto, Michihiro ^a   Sakaue, Motoyoshi ^a   Nishio, Shoko ^b   Ueno, Hikaru ^b   Kasuga, Masato ^a  

^a KOBE UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; GLUCOSE; GLUCOSE TRANSPORTER; GROWTH HORMONE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE THREONINE KINASE; SORBITOL; TYROSINE; UNCLASSIFIED DRUG; WORTMANNIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; GLUCOSE TRANSPORT; HYPEROSMOLARITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOVIRIDAE; ANIMALIA;

EID: 8544234984     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.11.10.9986     Document Type: Article

References (56)

1. Lee J, Pilch PF 1994 The insulin receptor: structure, function, and signaling. Am J Physiol 266:C319-C334
2. Carpenter LC, Cantley LC 1996 Phosphoinositide kinases. Curr Opin Cell Biol 8:153-158
3. Myers Jr MG, White MF 1996 Insulin signal transduction and the IRS proteins. Annu Rev Pharmacol Toxicol 36:615-658
4. Hara K, Yonezawa K, Sakaue H, Ando A, Kotani K, Kitamura T, Kitamura Y, Ueda H, Stephens L, Jackson TR, Hawkins PT, Dhand R, Clark AE, Holman GD, Waterfield MD, Kasuga M 1994 1-Phosphatidylinositol 3-kinase activity is required for insulin stimulated glucose transport but not for RAS activation in CHO cells. Proc Natl Acad Sci USA 91:7415-7419
5. Ui M, Okada T, Hazeki K, Hazeki O 1994 Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem Sci 20:303-307
6. Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD 1995 A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. EMBO J 14:3339-3348
7. Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R 1997 Linkage of G-protein-couple receptors to the MAPK signaling pathway through PI 3-kinase γ. Science 275:394-397
8. Meyers R, Cantley LC 1997 Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase. J Biol Chem 272:4384-4390
9. 2 activity in Swiss 3T3 cells: wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase. J Biol Chem 270:25352-25355
10. Brunn GJ, Williams J, Sabers C, Widerrecht G, Lawrence Jr JC, Abraham RT 1996 Direct inhibition of the signaling function of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J 15:5265-5267
11. Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Khan RC 1994 Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol 14:4902-4911
12. Birnbaum MJ 1992 The insulin-sensitive glucose transporter, Int Rev Cytol 137A:239-297
13. Zorzano A, Wilkinson W, Kotlair N, Toidis G, Wadzinski BE, Ruoho AE, Pilch PF 1989 Insulin-regulated glucose uptake in rat adipocytes is mediated by two transporter isoforms present in at least two vesicle populations. J Biol Chem 264:12358-12363
14. Kotani K, Carozzi AJ, Sakaue H, Hara K, Robinson LJ, Clark SF, Yonezawa K, James DE, Kasuga M 1995 Requirement for phosphoinositide 3-kinase in insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes. Biochem Biophys Res Commun 209:343-348
15. Quon MJ, Chen H, Ing BR, Liu M-L, Zarnowski MJ, Yonezawa K, Kasuga M, Cushman SW, Taylor SI 1995 Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells. Mol Cell Biol 15:5403-5411
16. Kozma L, Baltensperger K, Klarlund J, Porras A, Santos E, Czech MP 1993 The ras signaling pathway mimics insulin action on glucose transporter translocation. Proc Natl Acad Sci USA 90:4460-4464
17. Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J 1994 Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527-532
18. Hausdorff SF, Fragioni JV, Birnbaum MJ 1994 Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes. J Biol Chem 269:21391-21394
19. Dorrestijn J, Ouwens DM, Van den Berghe N, Bos JL, Maassen JA 1996 Expression of dominant negative Ras mutant dose not affect stimulation of glucose uptake and glycogen synthesis by insulin. Diabetologia 39:558-563
20. Welsh GI, Foulstone EJ, Young SW, Tavaré JM, Proud CG 1994 Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase. Biochem J 303:15-20
21. Tanner W, Leingang KA, Mueckler MM, Glenn KC 1992 Cellular mechanism of the insulin-like effect of growth hormone in adipocytes. Rapid translocation of the HepG2-type and adipocyte/muscle glucose transporters. Biochem J 282:99-106
22. Czech MP, Lawrence Jr JC, Lynn WS 1974 Hexose transport in isolated brown fat cells. A model system for investigating insulin action on membrane transport. J Biol Chem 249:5421-5427
23. Shechter Y, Karlish SJ 1980 Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl ions. Nature 284:556-558
24. Haystead TA, Sim AT, Carting D, Honnor RC, Tukitani Y, Cohen P, Hardie DG 1989 Effects of the tumor promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337:78-81
25. Widnell, CC, Baldwin SA, Davies A, Martin S, Pasternak CA 1990 Cellular stress induces a redistribution of the glucose transporter. FASEB J 4:1634-1637
26. Toyoda N, Robinson FW, Smith MM, Flanagan JE, Kono T 1986 Apparent translocation of glucose transport activity in rat epididymal adipocytes by insulin-like effects of high pH or hyperosmolarity. J Biol Chem 261:2117-2122
27. Yeh JI, Gulve EA, Rameh L, Birnbaum MJ 1995 The effects of wortmannin on rat skeletal muscle. J Biol Chem 270:2107-2111
28. Lund S, Holman GD, Schmitz O Pedersen O 1995 Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin. Proc Natl Acad Sci USA 92:5817-5821
29. Miyake S, Makimura M, Kanegae Y, Harada S, Sato Y, Takamori K, Tokuda C, Saito I 1996 Efficient generation of recombinant adenoviruses using adenovirus DNA terminal protein complex and a cosmid bearing the full length virus genome. Proc Natl Acad Sci USA 93:1320-1324
30. Hall A 1994 Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu Rev Cell Biol 10:31-53
31. Sakaue M, Bowtell D, Kasuga M 1995 A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways. Mol Cell Biol 15:379-388
32. Souza SC, Frick GP, Yip R, Lobo RB, Tai LR, Goodman HM 1994 Growth hormone stimulates tyrosine phosphorylation of insulin receptor substrate-1. J Biol Chem 269:30085-30088
33. Argetsinger LS, Hsu GW, Myers Jr MG, Billestrup N, White MF, Carter-Su C 1995 Growth hormone, interferon-γ, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J Biol Chem 270:14685-14692
34. Clark AE, Holman GD, Kozka IJ 1991 Determination of the rates of appearance and loss of glucose transporters at the cell surface of rat adipose cells. Biochem J 278:235-241
35. Kohn AD, Summers SA, Birnbaum MJ, Roth RA 1996 Expression of constitutively active Akt ser/thr kinase in 3T3-I1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271:31372-31378
36. Finger DC, Birnbaum MJ 1994 A role for Raf-1 in the divergent signaling pathways mediating insulin-stimulated glucose transport. J Biol Chem 269:10127-10132
37. Marcusohn J, Isakoff SJ, Rose E, Symon M, Skolnik EY 1995 The GTP-binding protein dose not couple PI 3-kinase to insulin-stimulated glucose transport in adipocytes. Curr Biol 5:1296-1302
38. Sakaue H, Hara K, Noguchi T, Matozaki T, Kotani K, Ogawa W, Yonezawa K, Water-field MD, Kasuga M 1995 Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells. J Biol Chem 270:1304-11309
39. Marcusohn J, Isakoff SJ, Rose E, Symon M, Skolnik EY 1995 The GTP-binding protein dose not couple PI 3-kinase to insulin-stimulated glucose transport in adipocytes. Curr Biol 5:1296-1302
40. Campbell GS, Pang L, Miyasaka T, Saltiel AR, Cater-Su C 1992 Stimulation by growth hormone of MAP kinase activity in 3T3-F442A fibroblasts J Biol Chem 267: 6074-6080
41. Kyriakis JM, Avruch J 1996 Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays 18:567-577
42. Lim L, Manser E, Leung T, Hall C 1996 Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways. Eur J Biochem 242:171-85
43. Coso OA, Chiariello M, Yu JC, Teramoto H, Crespo P, Xu N, Miki T, Gutkind JS 1995 The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137-1146
44. Tsakiridis T, Taha C, Gristein S, Klip A 1996 Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase. J Biol Chem 271:19664-19667
45. Moule SK, Welsh GI, Edgell NJ, Foulstone EJ, Proud CG, Denton RM 1997 Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and β-adrenergic agonists in arat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms. J Biol Chem 272:7713-7719
46. Konishi A, Matsuzaki H, Tanaka M, Ono Y, Tokunaga C, Kuroda S, Kikawa U 1996 Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA 93:7639-7634
47. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME 1997 Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-665
48. Ando A, Momomura K, Tobe K, Yamamoto-Honda R, Sakura H, Tamori Y, Kaburagi Y, Koshio O, Akanuma Y, Yazaki Y, Kasuga M, Kadowaki T 1992 Enhanced insulin-induced mitogenesis and mitogen-activated protein kinase activities in mutant insulin receptors with substitution of two COOH-terminal tyrosine autophophorylation sites by phenylalanine. J Biol Chem 267:12788-12796
49. Ando A, Yonezawa K, Gout I, Nakata T, Ueda H, Hara K, Kitamura Y, Noda Y, Takenawa T, Hirokawa N, Kasuga M 1994 A complex of GRB2-dynamin binds to tyrosine phosphorylated insulin receptor substrate-1 after insulin treatment. EMBO J 13:3033-3038
50. Tanaka T, Salmon DJ, Cline MJ 1985 Efficient generation of antibodies to oncoproteins by using synthetic peptide antigens. Proc Natl Acad Sci USA 82:3400-3404
51. Jung V, Wei W, Ballester R, Camonis J, Mi S, Van-Aelst L, Wigler M, Broek D 1994 Two types of RAS mutants that dominantly interfere with activators of RAS. Mol Cell Biol 14:3707-3718
52. Ueno H, Yamamoto H, Ito S, Li J, Takeshita A 1997 Adenovirus-mediated transfer of a dominant-negative H-ras suppresses neointimal formation in balloon-injured arteries in vivo. Arterioscl Thromb Vasc Biol 17:898-904
53. Kitamura Y, Kitamura T, Sakaue H, Maeda T, Ueno H, Nishio S, Ohno S, Osada S-I, Sakaue M, Ogawa W, Kasuga, M 1997 Interaction of Nck-associated protein 1 with activated GTP-binding protein. Biochem J 322:873-878
54. Kanegae Y, Lee G, Tanaka M, Nakai M, Sakai T, Sugano S, Saito I 1995 Efficient gene activation in mammalian cells by using recombinant adenoviruses expressing site specific CRE recombinase. Nucleic Acids Res 23:3816-3821
55. Niwa H, Yamamura K, Miyazaki J 1991 Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108:193-199
56. Kanegae Y, Makimura M, Saito I 1994 A simple and efficient method for purification of infectious recombinant adenovirus. Jpn J Med Sci Biol 47:157-166