Non-volatile general anaesthetics reduce spinal activity by suppressing plateau potentials

Neuroscience

Volumn 88, Issue 2, 1999, Pages 353-358

  Guertin, P A ^a   Hounsgaard, J ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

L type calcium channels; Nociception; Pain; Propofol; Sensorimotor

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CALCIUM CHANNEL; PENTOBARBITAL; PROPOFOL; THIOPENTAL;

ANIMAL TISSUE; ARTICLE; DRUG EFFECT; DRUG RECEPTOR BINDING; GENERAL ANESTHESIA; NONHUMAN; PRIORITY JOURNAL; SENSORIMOTOR CORTEX; SPINAL CORD; TURTLE;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ACTION POTENTIALS; ADJUVANTS, ANESTHESIA; ANESTHETICS, INTRAVENOUS; ANIMALS; BICUCULLINE; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; EXCITATORY POSTSYNAPTIC POTENTIALS; GABA ANTAGONISTS; INTERNEURONS; MOTOR NEURONS; PENTOBARBITAL; PROPOFOL; RECEPTORS, GABA-A; SEROTONIN; SPINAL CORD; TETRODOTOXIN; THIOPENTAL; TURTLES;

EID: 0032889649     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00371-6     Document Type: Article

References (31)

1. Antognini J. F. The relationship among brain, spinal cord and anesthetic requirements. Med. Hypoth. 48:1997;83-87.
2. Antognini J. F., Schwartz K. Exaggerated anesthetic requirements in the preferentially anesthetized brain. Anesthesiology. 79:1993;1244-1249.
3. Appadu B. L., Lambert D. G. Interaction of i.v. anaesthetic agents with 5-HT3 receptors. Br. J. Anaesth. 76:1996;271-273.
4. Besson J. M., Rivot J. P., Abdelmoumene M., Aleonard P. Study of the action of anesthetics on the activity of the dorsal horn cells of the spinal cord. J. Physiol., Paris. 62:1970;350-351.
5. Collins J. G., Kendig J. J., Mason P. Anesthetic actions within the spinal cord: contributions to the state of general anesthesia. Trends Neurosci. 18:1995;549-553.
6. Delgado-Lezama R., Perrier J.-F., Nedergaard S., Svirskis G., Hounsgaard J. Metabotropic synaptic regulation of intrinsic response properties of turtle spinal motoneurones. J. Physiol., Lond. 504:1997;97-102.
7. Eken T., Kiehn O. Bistable firing properties of soleus motor units in unrestrained rats. Acta physiol. scand. 136:1989;383-394.
8. Franks N. P., Lieb W. R. Inhibitory synapses. Anaesthetics set their sites on ion channels. Nature. 389:1997;334-335.
9. Franks N. P., Lieb W. R. Molecular and cellular mechanisms of general anaesthesia. Nature. 367:1994;607-614.
10. Hales T., Lambert J. J. The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones. Br. J. Pharmac. 104:1991;619-628.
11. Hasegawa A. E., Zacny J. P. The influence of three L-type calcium channel blockers on morphine effects in healthy volunteers. Anesth. Analg. 85:1997;633-638.
12. 2+ channels in rat cerebrocortical membranes. Br. J. Anaesth. 77:1996;248-253.
13. Hofbauer R. K., Bonhomme V., Meuret P., Plourde G., Backman S. B., Fiset P., Bushnell M. C. Effect of propofol-induced changes in consciousness on behavioral and physiological responses to pain. Soc. Neurosci. Abstr. 705.5:1997;1811.
14. Hounsgaard J., Hultborn H., Jespersen B., Kiehn O. Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J. Physiol. 405:1988;345-367.
15. Hounsgaard J., Kiehn O. Serotonin-induced bistability of turtle motoneurones caused by a nifedipine-sensitive calcium plateau potential. J. Physiol. 414:1989;265-282.
16. 2+-mediated plateau potentials in a subpopulation of interneurons in the ventral horn of the turtle spinal cord. Eur. J. Neurosci. 4:1992;183-188.
17. Hounsgaard J., Mintz I. Calcium conductance and firing properties of spinal motoneurones in the turtle. J. Physiol. 398:1988;591-603.
18. Jewett B. A., Gibbs L. M., Tarasiuk A., Kendig J. J. Propofol and barbiturate depression of spinal nociceptive neurotransmission. Anesthesiology. 77:1992;1148-1154.
19. Jiang M. C., Cleland C. L., Gebhart G. F. Intrinsic properties of deep dorsal horn neurons in the L6-S1 spinal cord of the intact rat. J. Neurophysiol. 74:1995;1819-1827.
20. King B. S., Rampil I. J. Anesthetic depression of spinal motor neurons may contribute to lack of movement in response to noxious stimuli. Anesthesiology. 81:1994;1484-1492.
21. A receptor channel of mouse spinal neurones in culture. J. Physiol., Lond. 417:1989;483-500.
22. Morisset V., Nagy F. Modulation of regenerative membrane properties by stimulation of metabotropic glutamate receptors in rat deep dorsal horn neurons. J. Neurophysiol. 76:1996;2794-2798.
23. Nicoll R. A., Madison D. V. General anesthetics hyperpolarize neurons in the vertebrate central nervous system. Science. 217:1982;1055-1057.
24. Olcese R., Cesare U., Maestrone E., Nobile M. The general anesthetic propofol inhibits transmembrane calcium current in chick sensory neurons. Anesth. Analg. 78:1994;955-960.
25. Rampil I. J. Anesthetic potency is not altered after hypothermic spinal cord transection in rats. Anesthesiology. 80:1994;606-610.
26. Russo R. E., Hounsgaard J. Plateau-generating neurones in the dorsal horn in an in vitro preparation of the turtle spinal cord. J. Physiol. 493.1:1996;39-54.
27. Russo R. E., Hounsgaard J. Burst-generating neurones in the dorsal horn in an in vitro preparation of the turtle spinal cord. J. Physiol. 493.1:1996;55-66.
28. 2+ channels. Neuroscience. 61:1994;191-197.
29. Schwartz A. E., Maneksha F. R., Backus W. W., Kanchuger M. S., Young W. L. Nimodipine decreases the minimum alveolar concentration of isoflurane in dogs. Can. J. Anaesthesiol. 38:1991;239-242.
30. Svirskis G., Hounsgaard J. Depolarization-induced facilitation of a plateau-generating current in ventral horn neurons in the turtle spinal cord. J. Neurophysiol. 78:1997;1740-1742.
31. Yang C. Y., Wong C. S., Yu C. C., Luk H. N., Lin C. I. Propofol inhibits cardiac L-type calcium current in guinea pig ventricular myocytes. Anesthesiology. 84:1996;626-635.