Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane

British Journal of Anaesthesia

Volumn 86, Issue 5, 2001, Pages 618-626

  Alkire, M T ^a   Haier, R J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anaesthetics i.v., porpofol; Anaesthetics volatile, isoflurane; Brain, cerebral cortex; Brain, metabolism; Hypnotics benzodiazepine, diazepam; Hypnotics benzodiazepine, flunitrazepam; Measurement techniques, radionuclide imaging; Measurement techniques, tomography; Metabolism, glucose; Neurotransmitter, acetylcholine

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; BENZODIAZEPINE RECEPTOR; BETA ADRENERGIC RECEPTOR; CHOLINERGIC RECEPTOR; DIAZEPAM; DIHYDROALPRENOLOL; FLUNITRAZEPAM; FLUORODEOXYGLUCOSE F 18; GLUCOSE; ISOFLURANE; MUSCARINIC RECEPTOR; NALOXONE; OPIATE RECEPTOR; PROPOFOL; QUINUCLIDINYL BENZILATE; SEROTONIN; TRITIUM;

ANESTHESIA MECHANISM; ARTICLE; BINDING SITE; BRAIN METABOLISM; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG RECEPTOR BINDING; GABAERGIC SYSTEM; GENERAL ANESTHESIA; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR DENSITY; RETROSPECTIVE STUDY; UNCONSCIOUSNESS; VOLUNTEER;

EID: 0035032014     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/86.5.618     Document Type: Article

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