The anaesthetic action and modulation of GABA(A) receptor activity by the novel water-soluble aminosteroid Org 20599

Neuropharmacology

Volumn 35, Issue 9-10, 1996, Pages 1209-1222

  Hill Venning, C ^a,c   Peters, J A ^a   Callachan, H ^a   Lambert, J J ^a   Gemmell, D K ^b   Anderson, A ^b   Byford, A ^b   Hamilton, N ^b   Hill, D R ^b   Marshall, R J ^b   Campbell, A C ^b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Chromaffin cells; GABA(A) receptor; Hippocampal neurones; Human GABA(A) receptor subunits; Intravenous anaesthetic agents; Org 20599

Indexed keywords

21 CHLORO 3ALPHA HYDROXY 2BETA MORPHOLINO 5ALPHA PREGNAN 20 ONE METHANESULFONATE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ALFAXALONE; AMINOSTEROID; INTRAVENOUS ANESTHETIC AGENT; PENTOBARBITAL; PROPOFOL; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR; STEROID; SULFUR 35; TERT BUTYLBICYCLOPHOSPHOROTHIOATE; THIOPENTAL; UNCLASSIFIED DRUG; WATER;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BRAIN MEMBRANE; CATTLE; CHROMAFFIN CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; DRUG SOLUBILITY; EMBRYO; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; INTRAVENOUS ANESTHESIA; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEMBRANE CURRENT; MOUSE; NERVE CELL CULTURE; NEUROMODULATION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; REGULATORY MECHANISM; XENOPUS LAEVIS;

ANESTHETICS; ANIMALS; BINDING, COMPETITIVE; CATTLE; CHROMAFFIN CELLS; ELECTROPHYSIOLOGY; GABA MODULATORS; HUMANS; MALE; MEMBRANES; MICE; MICE, INBRED STRAINS; NEURONS; PREGNANEDIONES; PREGNANOLONE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RNA; SOLUBILITY; TRANSCRIPTION, GENETIC; XENOPUS LAEVIS;

EID: 0030470999     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00069-X     Document Type: Article

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