Consciousness Unbound: Toward a Paradigm of General Anesthesia

Anesthesiology

Volumn 100, Issue 2, 2004, Pages 428-433

  Mashour, George A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; BARBITURIC ACID DERIVATIVE; DESFLURANE; ETOMIDATE; INHALATION ANESTHETIC AGENT; INTRAVENOUS ANESTHETIC AGENT; ISOFLURANE; NITROUS OXIDE; PROPOFOL; SEVOFLURANE;

BRAIN; COGNITION; CONSCIOUSNESS; ELECTROENCEPHALOGRAM; GENERAL ANESTHESIA; HUMAN; INHALATION ANESTHESIA; INTRAVENOUS ANESTHESIA; MAJOR CLINICAL STUDY; NEUROSCIENCE; PRIORITY JOURNAL; REVIEW;

ANESTHETICS, GENERAL; BRAIN; COGNITION; HUMANS;

EID: 1642540155     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200402000-00035     Document Type: Review

References (44)

1. Tang P, Xu Y: Large-scale molecular dynamics simulations of general anesthetic effects on the ion channel in the fully hydrated membrane: The implication of molecular mechanisms of general anesthesia. Proc Natl Acad Sci USA 2002; 99:16035-40
2. A receptors in an endogenous sleep pathway. Nat Neurosci 2002; 5:979-84
3. Kaisti KK, Metsahonkala L, Teras M, Oikonen V, Aalto S, Jaaskelainen S, Hinkka S, Scheinin H: Effects of surgical levels of propofol and sevoflurane anesthesia on cerebral blood flow in healthy subjects studied with positron emission tomography. ANESTHESIOLOGY 2002; 96:1358-70
4. von der Malsburg C: The correlation theory of brain function, MPI Biophysical Chemistry, Internal Report 81-2. Reprinted in Neural Networks II. Edited by Domany E, van Hemmen JL, Schulten K. Berlin, Springer, 1994
5. von der Malsburg C: The correlation theory of brain function, MPI Biophysical Chemistry, Internal Report 81-2. Reprinted in Neural Networks II. Edited by Domany E, van Hemmen JL, Schulten K. Berlin, Springer, 1994
6. Crick F, Koch C: A framework for consciousness. Nature 2003; 6:119-26
7. Roskies AL: The binding problem. Neuron 1999; 24:7-9
8. Wolfe JM, Cave KR: The psychophysical evidence for a binding problem in human vision. Neuron 1999; 24:11-7
9. Damasio AR: Disorders of complex visual processing: agnosia, achromatopsia, Balint's syndrome, and related difficulties of orientation and construction, Principles of Behavioral Neurology. Edited by Mesulam MM. Philadelphia, Davis, 1985
10. Felleman DJ, van Essen DC: Distributed hierarchical processing in the primate cerebral cortex. Cereb Cortex 1991; 1:1-47
11. Fujita I, Tanaka K, Ito M, Cheng K: Columns for visual features of objects in monkey inferotemporal cortex. Nature 1992; 360:343-6
12. Tanaka K: Neuronal mechanisms of object recognition. Science 1993; 262:685-8
13. Singer W: Putative functions of temporal correlations in neocortical processing, Large Scale Neuronal Theories of the Brain. Edited by Koch C, Davis J. Cambridge, Massachusetts Institute of Technology Press, 1994, pp 201-38
14. Singer W: Neuronal synchronization: A solution to the binding problem? The Mind-Brain Continuum. Edited by Llinas R, Churchland PS. Cambridge, Massachusetts Institute of Technology Press, 1996, pp 101-30
15. Gray CM: The temporal correlation hypothesis of visual feature integration: Still alive and well. Neuron 1999; 24:31-47
16. Ballard DH, Hinton GE, Sejnowski TJ: Parallel visual computation. Nature 1983; 306:21-6
17. van Essen DC, Anderson CH, Felleman DJ: Information processing in the primate visual system: An integrated systems perspective. Science 1992; 255:419-23
18. Levitan IB, Kaczmarek LK: The Neuron, 2nd edition. Oxford, Oxford University Press, 1997, pp 425, 499
19. Nicolelis MA, Chapin JK: Spatiotemporal structure of somatosensory responses of many-neuron ensembles in the rat ventral posterior medial nucleus of the thalamus. J Neurosci 1994; 14:3511-32
20. Nicolelis MA, Ghazanfar AA, Stambough CR, Oliveira LM, Laubach M, Chapin JK, Nelson RJ, Kaas JH: Simultaneous encoding of tactile information by three primate cortical areas. Nat Neurosci 1998; 1:621-30
21. Milner P: A model for visual shape recognition. Psychol Rev 1974; 81:521-35
22. Joliot M, Ribary U, Llinas R: Human oscillatory brain activity near 40 Hz coexists with cognitive temporal binding. Proc Natl Acad Sci USA 1994; 91:11748-51
23. Fries P, Roelfsema PR, Engel AK, Koenig P, Singer W: Synchronization of oscillatory responses in visual cortex correlates with perception in interocular rivalry. Proc Natl Acad Sci USA 1997; 94:12699-704
24. Rodriguez E, George N, Lachaux JP, Martinerie J, Renault B, Varela FJ: Perception's shadow: Long-distance gamma band synchronization of human brain activity. Nature 1999; 397:430-3
25. Llinas R, Ribary U: Coherent 40-Hz oscillation characterizes dream state in humans. Proc Natl Acad Sci USA 1993; 90:2078-81
26. Abraham HD, Duffy FH: EEG coherence in post-LSD visual hallucinations. Psychiatry Res 2001; 107:151-63
27. Prichep LS, John ER: QEEG profiles of psychiatric disorders. Brain Topogr 1992; 4:249-57
28. Llinas RR, Ribary U, Jeanmonod D, Kronberg E, Mitra PP: Thalmocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography. Proc Natl Acad Sci USA 1999; 96:15222-7
29. Shadlen MN, Movshon JA: Synchrony unbound: A critical evaluation of the temporal binding hypothesis. Neuron 1999; 24:67-77
30. Thiele A, Stoner G: Neuronal synchrony does not correlate with motion coherence in cortical area MT. Nature 2003; 421:366-70
31. Varela F, Lachaux JP, Rodriguez E, Martinerie J: The brainweb: Phase synchronization and large-scale integration. Natl Rev Neurosci 2001; 2:229-39
32. John ER, Prichep LS, Valdes-Sosa P, Bosch J, Aubert E, Gugino LD, Kox W, Tom M, di Michele F: Invariant reversible QEEG effects of anesthetics. Conscious Cogn 2001; 10:165-83
33. John ER: The neurophysics of consciousness. Brain Res Rev 2002; 39:1-28
34. Gugino LD, Chabot RJ, Prichep S, John ER, Formanek V, Aglio LS: Quantitative EEG changes associated with loss and return of consciousness in healthy adult volunteers anaesthetized with propofol or sevoflurane. Br J Anaesth 2001; 87:421-8
35. Fiset P, Paus T, Daloze T, Plourde G, Meuret P, Bonhomme V, Hajj-Ali N, Backman SB, Evans AC: Brain mechanisms of propofol-induced loss of consciousness in humans: A positron-emission tomographic study. J Neurosci 1999; 19:5506-13
36. Ma J, Shen B, Stewart LS, Herrick IA, Leung LS: The septohippocampal system participates in general anesthesia. J Neurosci 2002; 22(RC200):1-6
37. Uchida S, Nakayama H, Maehara T, Hirai N, Arakaki H, Nakamura M, Nakabayashi T, Shimizu H: Suppression of gamma activity in the human medial temporal lobe by sevoflurane anesthesia. Neuroreport 2000; 11:39-42
38. Simon W, Hapfelmeier G, Kochs E, Zieglgansberger W, Rammes G: Isoflurane blocks synaptic plasticity in the mouse hippocampus. ANESTHESIOLOGY 2001; 94:1058-65
39. Pack CC, Berezovskii VK, Born RT: Dynamic properties of neurons in cortical area MT in alert and anaesthetized macaque monkeys. Nature 2001; 414:905-8
40. Gazzaniga M: The Mind's Past. Berkeley, University of California Press, 1998
41. Urban BW: Current assessment of targets and theories of anaesthesia. Br J Anaesth 2002; 89:167-83
42. Campagna JA, Miller KW, Forman SA: Mechanisms of actions of inhaled anesthetics. N Engl J Med 2003; 2110-24
43. Antognini JF, Schwartz K: Exaggerated anesthetic requirements in the preferentially anesthetized brain. ANESTHESIOLOGY 1993; 79:1244-9
44. Sleigh JW, Steyn-Ross DA, Steyn-Ross ML, Williams ML, Smith P: Comparison of changes in electroencephalographic measures during induction of general anesthesia: Influence of the gamma frequency band and electromyogram signal. Br J Anaesth 2001; 86:50-8