Effects of subanesthetic doses of ketamine on regional cerebral blood flow, oxygen consumption, and blood volume in humans

Anesthesiology

Volumn 99, Issue 3, 2003, Pages 614-623

  Långsjö, Jaakko W ^a   Kaisti, Kaike K ^c   Aalto, Sargo ^a   Hinkka, Susanna ^e   Aantaa, Riku ^c   Oikonen, Vesa ^a   Sipilä, Hannu ^a   Kurki, Timo ^c   Silvanto, Martti ^d   Scheinin, Harry ^a,b  

^a TURKU PET CENTRE   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c TURKU UNIVERSITY HOSPITAL   (Finland)

^d CENTRAL MILITARY HOSPITAL   (Finland)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; KETAMINE; OXYGEN; OXYGEN 15; TRACER; WATER;

ADULT; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN OXYGEN CONSUMPTION; CINGULATE GYRUS; CONCENTRATION RESPONSE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; FRONTAL CORTEX; HUMAN; HUMAN EXPERIMENT; MALE; MEAN ARTERIAL PRESSURE; NEUROSURGERY; NORMAL HUMAN; OCCIPITAL CORTEX; PAIN; PARIETAL LOBE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; THALAMUS;

ADULT; AFFECT; ANESTHETICS, DISSOCIATIVE; BLOOD VOLUME; CEREBROVASCULAR CIRCULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; HEMODYNAMIC PROCESSES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; KETAMINE; MALE; OXYGEN CONSUMPTION; RESPIRATORY MECHANICS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0041324623     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200309000-00016     Document Type: Article

References (54)

1. White PF, Way WL, Trevor AJ: Ketamine: Its pharmacology and therapeutic uses. ANESTHESIOLOGY, 1982; 56:119-36
2. Kohrs R, Durieux ME: Ketamine: Teaching an old drug new tricks. Anesth Analg 1998; 87:1186-93
3. Hoffman WE, Pelligrino D, Werner C, Kochs E, Albrecht RF, Schulte am Esch J: Ketamine decreases plasma catecholamines and improves outcome from incomplete cerebral ischemia in rats. ANESTHESIOLOGY 1992; 76:755-62
4. Shapira Y, Lam AM, Eng CC, Laohaprasit V, Michel M: Therapeutic time window and dose response of the beneficial effects of ketamine in experimental head injury. Stroke 1994; 25:1637-43
5. Dawson B, Michenfelder JD, Theye RA: Effects of ketamine on canine cerebral blood flow and metabolism: Modification by prior administration of thiopental. Anesth Analg 1971; 50:443-7
6. Cavazzuti M, Porro CA, Biral GP, Benassi C, Barbieri GC: Ketamine effects on local cerebral blood flow and metabolism in the rat. J Cereb Blood Flow Metab 1987; 7:806-11
7. Sakabe T, Nakakimura K: Effects of anesthetic agents and other drugs on cerebral blood flow, metabolism, and intracranial pressure, Anesthesia and Neurosurgery, 4th edition. Edited by Cottrell JE, Smith DS. St. Louis, Missouri, Mosby, 2001, p 136
8. Björkman S, Åkeson J, Nilsson F, Messeter K, Roth B: Ketamine and midazolam decrease cerebral blood flow and consequently their own rate of transport to the brain: An application of mass balance pharmacokinetics with a changing regional blood flow. J Pharmacokinet Biopharm 1992; 20:637-52
9. 15O demonstrate ketamine actions in cns dynamically. Neuropsychopharmacology 2001; 25:165-72
10. 18F]fluorodeoxyglucose (FDG). Eur Neuropsychopharmacol 1997; 7:9-24
11. Takeshita H, Okuda Y, Sari A: The effects of ketamine on cerebral circulation and metabolism in man. ANESTHESIOLOGY 1972; 36:69-75
12. Shafer SL, Siegel LC, Cooke JE, Scott JC: Testing computer-controlled infusion pumps by simulation. ANESTHESIOLOGY 1988; 68:261-6
13. Domino EF, Domino SE, Smith RE, Domino LE, Goulet JR, Domino KE, Zsigmond EK: Ketamine kinetics in unmedicated and diazepam-premedicated subjects. Clin Pharmacol Ther 1984; 36:645-53
14. Gross AS, Nicolay A, Eschalier A: Simultaneous analysis of ketamine and bupivacaine in plasma by high-performance liquid chromatography. J Chromatogr B 1999; 728:107-15
15. Kaisti KK, Långsjö JW, Aalto S, Oikonen V, Sipilä H, Teräs M, Hinkka S, Metsähonkala L, Scheinin H: Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in man. ANESTHESIOLOGY 2003; 99:603-13
16. McNair DM, Lorr M, Droppleman LF: Profile of Mood States Manual. San Diego, Education & Industrial Testing Service, 1971
17. Kaisti KK, Metsähonkala L, Teräs M, Oikonen V, Aalto S, Jääskeläinen S, Hinkka S, Scheinin H: Effects of surgical levels of propofol and sevoflurane anesthesia on cerebral blood flow in healthy subjects studied with positron emission tomography. ANESTHESIOLOGY 2002; 96:1358-70
18. Friston KJ, Holmes AP, Worsley KJ, Poline J-P, Frith CD, Frackowiak RS: Statistical parametric maps in functional imaging: A general linear approach. Hum Brain Mapp 1995; 2:189-210
19. Friston KJ, Holmes A, Poline JB, Price CJ, Frith CD: Detecting activations in PET and fMRI: Levels of inference and power. Neuroimage 1996; 4:223-35
20. Talairach J, Tournoux P: Co-planar Stereotaxic Atlas of the Human Brain, 1st edition. Stuttgart. Georg Thieme Verlag, 1988
21. Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, Kochunov PV, Nickerson D, Mikiten SA, Fox PT: Automated Talairach atlas labels for functional brain mapping. Hum Brain Mapp 2000; 10:120-31
22. Oren RE, Rasool NA, Rubinstein EH: Effect of ketamine on cerebral cortical blood flow and metabolism in rabbits. Stroke 1987; 18:441-4
23. Schwedler M, Miletich DJ, Albrecht RF: Cerebral blood flow and metabolism following ketamine administration. Can Anaesth Soc J 1982; 29:222-6
24. Åkeson J, Björkman S, Messeter K, Rosen I, Helfer M: Cerebral pharmacodynamics of anaesthetic and subanaesthetic doses of ketamine in the normoventilated pig. Acta Anaesthesiol Scand 1993; 37:211-8
25. Strebel S, Kaufmann M, Maitre L, Schaefer HG: Effects of ketamine on cerebral blood flow velocity in humans: Influence of pretreatment with midazolam or esmolol. Anaesthesia 1995; 50:223-8
26. Mayberg TS, Lam AM, Matta BF, Domino KB, Winn HR: Ketamine does not increase cerebral blood flow velocity of intracranial pressure during isoflurane/nitrous oxide anesthesia in patients undergoing craniotomy. Anesth Analg 1995; 81:84-9
27. Herrschaft H, Schmidt H, Gleim F, Albus G: The response of human cerebral blood flow to anesthesia with thiopentone, methohexitone, propanidid, ketamine, and etomidate. Adv Neurosurg 1975; 3:120-33
28. 2 response. Anesth Analg 2000; 90:377-82
29. Summors AC, Gupta AK, Matta BF: Dynamic cerebral autoregulation during sevoflurane anesthesia: A comparison with isoflurane. Anesth Analg 1999; 88:341-5
30. Bedforth NM, Girling KJ, Skinner HJ, Mahajan RP: Effects of desflurane on cerebral autoregulation. Br J Anaesth 2001; 87:193-7
31. Engelhard K, Werner C, Mollenberg O, Kochs E: S(+)-ketamine/propofol maintain dynamic cerebrovascular autoregulation in humans. Can J Anaesth 2001; 48:1034-9
32. Fox PT, Raichle ME: Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci U S A 1986; 83:1140-4
33. Fox PT, Raichle ME, Mintun MA, Dence C: Nonoxidative glucose consumption during focal physiologic neural activity. Science 1988; 241:462-4
34. Magistretti PJ, Pellerin L, Rothman DL, Shulman RG: Energy on demand. Science 1999; 283:496-7
35. Shulman RG, Hyder F, Rothman DL: Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging. Proc Natl Acad Sci U S A 2001; 98:6417-22
36. Rothman DL, Behar KL, Hyder F, Shulman RG: In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: Implications for brain function. Annu Rev Physiol 2003; 65:401-27
37. Bergsneider M, Becker DP: Intracranial pressure monitoring, Anesthesia and Neurosurgery, 4th edition. Edited by Cottrell JE, Smith DS. St. Louis, Missouri, Mosby, 2001, pp 104-5
38. Kikuchi T, Wang Y, Shinbori H, Sato K, Okumura F: Effects of ketamine and pentobarbitone on acetylcholine release from the rat frontal cortex in vivo. Br J Anaesth 1997; 79:128-30
39. Wang Y, Kikuchi T, Sakai M, Wu JL, Sato K, Okumura F: Age-related modifications of effects of ketamine and propofol on rat hippocampal acetylcholine release studied by in vivo brain microdialysis. Acta Anaesthesiol Scand 2000; 44:112-7
40. Nelson CL, Burk JA, Bruno JP, Sarter M: Effects of acute and repeated systemic administration of ketamine on prefrontal acetylcholine release and sustained attention performance in rats. Psychopharmacology 2002; 161:168-79
41. Kubota T, Hirota K, Yoshida H, Takahashi S, Anzawa N, Ohkawa H, Kushikata T, Matsuki A: Effects of sedatives on noradrenaline release from the medial prefrontal cortex in rats. Psychopharmacology 1999; 146:335-8
42. Kubota T, Hirota K, Anzawa N, Yoshida H, Kushikata T, Matsuki A: Physostigmine antagonizes ketamine-induced noradrenaline release from the medial prefrontal cortex in rats. Brain Res 1999; 840:175-8
43. Albanese J, Arnaud S, Rey M, Thomachot L, Alliez B, Martin C: Ketamine decreases intracranial pressure and electroencephalographic activity in traumatic brain injury patients during propofol sedation. ANESTHESIOLOGY 1997; 87:1328-34
44. Hougaard K, Hansen A, Brodersen P: The effect of ketamine on regional cerebral blood flow in man. ANESTHESIOLOGY 1974; 41:562-7
45. Petrovic P, Kalso E, Petersson KM, Ingvar M: Placebo and opioid analgesia: Imaging a shared neuronal network. Science 2002; 295:1737-40
46. Gyulai FE, Firestone LL, Mintun MA, Winter PM: In vivo imaging of nitrous oxide-induced changes in cerebral activation during noxious heat stimuli. ANESTHESIOLOGY 1997; 86:538-48
47. Coghill RC, Sang CN, Maisog JM, Iadarola MJ: Pain intensity processing within the human brain: A bilateral, distributed mechanism. J Neurophysiol 1999; 82:1934-43
48. Derbyshire SW, Jones AK, Gyulai F, Clark S, Townsend D, Firestone LL: Pain processing during three levels of noxious stimulation produces differential patterns of central activity. Pain 1997; 73:431-45
49. Wagner KJ, Willoch F, Kochs EF, Siessmeier T, Tolle TR, Schwaiger M, Bartenstein P: Dose-dependent regional cerebral blood flow changes during remifentanil infusion in humans: A positron emission tomography study. ANESTHESIOLOGY 2001; 94:732-9
50. Adler LJ, Gyulai FE, Diehl DJ, Mintun MA, Winter PM, Firestone LL: Regional brain activity changes associated with fentanyl analgesia elucidated by positron emission tomography. Anesth Analg 1997; 84:120-6
51. Jevtovic-Todorovic V, Todorovic SM, Mennerick S, Powell S, Dikranian K, Benshoff N, Zorumski CF, Olney JW: Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nat Med 1998; 4:460-3
52. Gyulai FE, Firestone LL, Mintun MA, Winter PM: In vivo imaging of human limbic responses to nitrous oxide inhalation. Anesth Analg 1996; 83:291-8
53. Devinsky O, Morrell MJ, Vogt BA: Contributions of anterior cingulate cortex to behaviour. Brain 1995; 118:279-306
54. Cheung RT, Hachinski V: The insula and cerebrogenic sudden death. Arch Neurol 2000; 57:1685-8