Volatile anesthetic actions on the GABAA receptors: Contrasting effects of α1(S270) and β2(N265) point mutations

Neuropharmacology

Volumn 42, Issue 3, 2002, Pages 337-345

  Nishikawa, K ^a,b   Jenkins, A ^a   Paraskevakis, I ^a   Harrison, N L ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Subunit; GABAA receptor; Human embryonic kidney (HEK) cells; Isoflurane; Patch clamp; Site directed mutagenesis

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; HALOTHANE; ISOFLURANE; RECEPTOR SUBUNIT; SERINE;

ALPHA CHAIN; AMINO ACID SUBSTITUTION; ARTICLE; BETA CHAIN; CELL LINE; CHANNEL GATING; CONTROLLED STUDY; CORRELATION FUNCTION; DOSE RESPONSE; DRUG BINDING; DRUG EFFECT; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE GENETICS; RECEPTOR AFFINITY; VOLTAGE CLAMP;

AMINO ACID SEQUENCE; ANESTHETICS, INHALATION; ASPARAGINE; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GAMMA-AMINOBUTYRIC ACID; HALOTHANE; HUMANS; ISOFLURANE; POINT MUTATION; RECEPTORS, GABA-A; SERINE;

EID: 0036118231     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00189-7     Document Type: Article

References (32)

1. A receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital
2. International union of pharmacology. XV. Subtypes of gamma-aminobutyric acid A receptors: Classification on the basis of subunit structure and receptor function
3. The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid
4. High-efficiency transformation of mammalian cells by plasmid DNA
5. Site-directed mutagenesis of virtually any plasmid by eliminating a unique site
6. A receptor
7. Volume changes on protein folding
8. Positive modulation of human gamma-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane
9. Prediction of protein antigenic determinants from amino acid sequences
10. A receptor
11. Enhancement of gamma-aminobutyric acid-activated Cl- currents in cultured rat hippocampal neurones by three volatile anaesthetics
12. Agonist gating and isoflurane potentiation in the human gamma-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue
13. A/glycine receptors: Expression and barbiturate pharmacology
14. Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane
15. A and glycine receptors and the effects of TM2 and TM3 mutations
16. A simple method for displaying the hydropathic character of a protein
17. A receptor channels
18. Which GABAA-receptor subtypes really occur in the brain?
19. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors
20. Distinct loci mediate the direct and indirect actions of the anesthetic etomidate at GABA (A) receptors
21. General anesthetics modulate GABA receptor channel complex in rat dorsal root ganglion neurons
22. Membrane and synaptic actions of halothane on rat hippocampal pyramidal neurons and inhibitory interneurons
23. Complementary regulation of anaesthetic activation of human (alpha6beta3gamma2L) and Drosophila (RDL) GABA receptors by a single amino acid residue
24. Transient expression shows ligand gating and allosteric potentiation of GABAA receptor subunits
25. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes
26. Structure and pharmacology of gamma-aminobutyric acid A receptor subtypes
27. A novel allosteric modulatory site on the GABAA receptor beta subunit
28. Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation
29. Effects of two volatile anesthetics and a volatile convulsant on the excitatory and inhibitory amino acid responses in dissociated CNS neurons of the rat
30. A receptor gene family
31. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit
32. The characterization of amino acid sequences in proteins by statistical methods