Caveolins and caveolae: Molecular and functional relationships

Experimental Cell Research

Volumn 271, Issue 1, 2001, Pages 36-44

  Razani, Babak ^a   Lisanti, Michael P ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CAVEOLIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; INSULIN RECEPTOR; INTEGRIN; NITRIC OXIDE SYNTHASE; PHOSPHOLIPASE D1; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE C; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

BIOGENESIS; CARCINOGENESIS; CAVEOLA; CHOLESTEROL TRANSPORT; ENDOCYTOSIS; IN VIVO STUDY; MEMBRANE VESICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSCYTOSIS;

EID: 0035890289     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5372     Document Type: Article

References (79)

1. Fine structure of blood capillaries
2. The fine structure of the gall bladder epithelium of the mouse
3. Lipid rafts and signal transduction
4. Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton
5. Caveolin, a protein component of caveolae membrane coats
6. VIP 21, A 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles
7. The sequence of human caveolin reveals identity with VIP 21, a component of transport vesicles
8. Identification, sequence and expression of caveolin-2 defines a caveolin gene family
9. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle
10. Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles
11. De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin
12. Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth
13. Mutational analysis of caveolin-induced vesicle formation. Expression of caveolin-1 recruits caveolin-2 to caveolae membranes
14. Targeted down-regulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade
15. A photo-reactive derivative of ganglioside GM1 specifically cross-links VIP21-caveolin on the cell surface
16. VIP21/caveolin is a cholesterol-binding protein
17. Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles
18. VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro
19. Oligomeric structure of caveolin: Implications for caveolae membrane organization
20. Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo
21. The membrane spanning domains of caveolins 1 and 2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo
22. Mutational analysis of the properties of caveolin-1. A novel role for the C-terminal domain in mediating homotypic caveolin-caveolin interactions
23. A molecular dissection of caveolin-1 membrane attachment and oligomerization. Two separate regions of the caveolin-1 C-terminal domain mediate membrane binding and oligomer/oligomer interactions in vivo
24. Permeability of muscle capillaries to small heme-peptides: Evidence for the existence of patent transendothelial channels
25. Filipin-sensitive caveolae-mediated transport in endothelium: Reduced transcytosis, scavenger endoctytosis, and capillary permeability of select macromolecules
26. Plasmalemmal vesicles function as transcytotic carriers for small proteins in the continuous endothelium
27. Potocytosis: Sequestration and transport of small molecules by caveolae
28. Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins
29. Regulated internalization of caveolae
30. Bound simian virus 40 translocates to caveolin-enriched membrane domains, and its entry is inhibited by drugs that selectively disrupt caveolae
31. Involvement of cellular caveolae in bacterial entry into mast cells
32. Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER
33. Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases
34. Endothelial transcytotic machinery involves supramolecular protein-lipid complexes
35. Role of GTP hydrolysis in fission of caveolae directly from plasma membranes
36. Dynamin-mediated internalization of caveolae
37. Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium
38. Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate
39. Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation
40. A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane
41. Characterization of a cytosolic heat-shock protein-caveolin chaperone complex: Involvement in cholesterol trafficking
42. Plasma membrane caveolae mediate the efflux of cellular free cholesterol
43. Intracellular cholesterol transport in synchronized human skin fibroblasts
44. Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol
45. Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers
46. Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae
47. The class B, type I scavenger receptor promotes the selective uptake of high density lipoprotein cholesterol ethers into cavoelae
48. Signal transducing molecules and GPI-linked proteins form a caveolin-rich insoluble complex in MDCK cells
49. Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: Implications for human disease
50. Evidence for a regulated interaction of hetero-trimeric G proteins with caveolin
51. Src tyrosine kinases G alpha subunits and H-Ras share a common membrane-anchored scaffolding protein, Caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases
52. i1 alpha) and c-Src tyrosine kinase to caveolae membranes: Clarifying the role of N-myristoylation
53. Copurification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent free purification of caveolae membranes
54. Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells
55. Targeting of nitric oxide synthase to endothelilal cell caveolae via palmitoylation: Implications for caveolae localization
56. Caveolae, caveolin and caveolin-rich membrane domains: A signalling hypothesis
57. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins
58. Caveolin-1 interacts with the insulin receptor and can differentially modulate insulin signaling in transfected Cos-7 cells and rat adipose cells
59. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin: Functional significance of the NOS caveolin binding domain in vivo
60. Regulation of G protein-coupled receptor kinases by caveolin
61. Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae
62. Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: Implications for caveolae localization
63. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1
64. Caveolin versus Calmodulin. Counterbalancing allosteric modulators of endothelial nitric oxide synthase
65. Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity
66. In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation
67. Tyrosine phosphorylation of a 22-kDa protein is correlated with transformation by Rous sarcoma virus
68. Reduction of caveolin and caveolae in oncogenically transformed cells
69. Reciprocal regulation of Neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for mammary tumorigenesis
70. Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation
71. Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells
72. Evidence that Myc isoforms transcriptionally repress caveolin-1 gene expression via an INR-dependent mechanism
73. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain
74. Involvement of caveolin-1 in meiotic cell-cycle progression in Caenorhabditis elegans
75. Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers
76. Invasion activating caveolin-1 mutation in human scirrhous breast cancers
77. Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy
78. Caveolin-1 null mice are viable, but show evidence of hyper-proliferative and vascular abnormalities