Transcription factor activation and mitogenic synergism in airway smooth muscle cells

European Respiratory Journal

Volumn 21, Issue 5, 2003, Pages 759-769

  Ediger, T L ^a   Schulte, N A ^a   Murphy, T J ^b   Toews, M L ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Activator protein 1; Asthma; Growth factors; Nuclear factor B; Proliferation; Rho

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EPIDERMAL GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; LUCIFERASE; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; RHO FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT;

AIRWAY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE CONSTRUCT; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INFLAMMATION; MITOGENESIS; PRIORITY JOURNAL; REPORTER GENE; SERUM RESPONSIVE ELEMENT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRANSCRIPTION INITIATION;

ACUTE-PHASE PROTEINS; BOTULINUM TOXINS; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; EPIDERMAL GROWTH FACTOR; HUMANS; LYSOPHOSPHOLIPIDS; MAP KINASE SIGNALING SYSTEM; MITOGENS; MYOCYTES, SMOOTH MUSCLE; TRACHEA; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

EID: 0038056323     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.03.00075702     Document Type: Article

References (33)

1. Hirst SJ. Airway smooth muscle cell culture: application to studies of airway wall remodelling and phenotype plasticity in asthma. Eur Respir J 1996; 9: 808-820.
2. Hershenson MB, Naureckas ET, Li J. Mitogen-activated signaling in cultured airway smooth muscle cells. Can J Physiol Pharmacol 1997; 75: 898-910.
3. Toews ML, Ediger TL, Romberger DJ, Rennard SI. Lysophosphatidic acid in airway function and disease. Biochim Biophys Acta 2002; 1582: 240-250.
4. Ediger TL, Toews ML. Synergistic stimulation of airway smooth muscle cell mitogenesis. J Pharmacol Exp Ther 2000; 294: 1076-1082.
5. Cerutis DR, Nogami M, Anderson JL, et al. Lysophosphatidic acid and EGF stimulate mitogenesis in human airway smooth muscle cells. Am J Physiol 1997; 273: L10-L15.
6. Kranenburg O, Moolenaar WH. Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. Oncogene 2001; 20: 1540-1546.
7. Pierce KL, Luttrell LM, Lefkowitz RJ. New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene 2001; 20: 1532-1539.
8. Barnes PJ, Adcock IM. Transcription factors and asthma. Eur Respir J 1998; 12: 221-234.
9. Abbott KL, Robida AM, Davis ME, et al. Differential regulation of vascular smooth muscle nuclear factor kappa-B by Gαq-coupled and cytokine receptors. J Mol Cell Cardiol 2000; 32: 391-403.
10. Ediger TL, Danforth BL, Toews ML. Lysophosphatidic acid upregulates the epidermal growth factor receptor in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2002; 282: L91-L98.
11. Togashi H, Emala CW, Hall IP, Hirshman CA. Carbachol-induced actin reorganization involves Gi activation of Rho in human airway smooth muscle cells. Am J Physiol 1998; 274: L803-L809.
12. Panettieri RA, Murray RK, DePalo LR, Yadvish PA, Kotlikoff MI. A human airway smooth muscle cell line that retains physiological responsiveness. Am J Physiol 1989; 256: C329-C335.
13. Kotani H, Newton PB 3rd, Zhang S, et al. Improved methods of retroviral vector transduction and production for gene therapy. Hum Gene Ther 1994; 5: 19-28.
14. Krymskaya VP, Orsini MJ, Eszterhas AJ, et al. Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle. Am J Respir Cell Mol Biol 2000; 23: 546-554.
15. Zwick E, Hackel PO, Prenzel N, Ullrich A. The EGF receptor as central transducer of heterologous signalling systems. Trends Pharmacol Sci 1999; 20: 408-412.
16. Angel P, Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1991; 1072: 129-157.
17. Nogami M, Whittle SM, Romberger DJ, Rennard SI, Toews ML. Lysophosphatidic acid regulation of cyclic AMP accumulation in cultured human airway smooth muscle cells. Mol Pharmacol 1995; 48: 766-773.
18. Perona R, Montaner S, Saniger L, Sanchez-Perez I, Bravo R, Lacal JC. Activation of the nuclear factor-κB by Rho, CDC42, and Rac-1 proteins. Genes Dev 1997; 11: 463-475.
19. Siehler S, Wang Y, Fan X, Windh RT, Manning DR. Sphingosine-1-phosphate activates nuclear factor-κB through a unique set of Edg receptors: evidence for convergent pathways involving protein kinase C and Rho. FASEB J 2001; 15: A577.
20. Cook SJ, Aziz N, McMahon M. The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation. Mol Cell Biol 1999; 19: 330-341.
21. Orsini MJ, Krymskaya VP, Eszterhas AJ, Benovic JL, Panettieri RAJ, Penn RB. MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation. Am J Physiol 1999; 277: L479-L488.
22. Ravenhall C, Guida E, Harris T, Koutsoubos V, Stewart A. The importance of ERK activity in the regulation of cyclin D1 levels and DNA synthesis in human cultured airway smooth muscle. Br J Pharmacol 2000; 131: 17-28.
23. De Cesare D, Fimia GM, Sassone-Corsi P. Signaling routes to CREM and CREB: plasticity in transcriptional activation. Trends Biochem Sci 1999; 24: 281-285.
24. Shahrestanifar M, Fan X, Manning DR. Lysophosphatidic acid activates NF-κB in fibroblasts: a requirement for multiple inputs. J Biol Chem 1999; 274: 3828-3833.
25. Palmetshofer A, Robson SC, Nehls V. Lysophosphatidic acid activates nuclear factor kappa B and induces proinflammatory gene expression in endothelial cells. Thromb Haemost 1999; 82: 1532-1537.
26. Hill CS, Treisman R. Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors. EMBO J 1995; 14: 5037-5047.
27. Karin M, Liu Z, Zandi E. AP-1 function and regulation. Curr Opin Cell Biol 1997; 9: 240-246.
28. Roberson MS, Ban M, Zhang T, Mulvaney JM. Role of the cyclic AMP response element binding complex and activation of mitogen-activated protein kinases in synergistic activation of the glycoprotein hormone α subunit gene by epidermal growth factor and forskolin. Mol Cell Biol 2000; 20: 3331-3344.
29. Moores SL, Selfors LM, Fredericks J, et al. Vav family proteins couple to diverse cell surface receptors. Mol Cell Biol 2000; 20: 6364-6373.
30. Sah VP, Seasholtz TM, Sagi SA, Brown JH. The role of Rho in G protein-coupled receptor signal transduction. Annu Rev Pharmacol Toxicol 2000; 40: 459-489.
31. 2 activation of Rho. Am J Physiol 1999; 277: L653-L661.
32. Moolenaar WH. Bioactive lysophospholipids and their G protein-coupled receptors. Exp Cell Res 1999; 253: 230-238.
33. Seasholtz TM, Majumdar M, Kaplan DD, Brown JH. Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration. Circ Res 1999; 84: 1186-1193.