Novel 5-azaindolocarbazoles as cytotoxic agents and Chk1 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 9, 2008, Pages 5303-5321

  Lefoix, Myriam ^a   Coudert, Gérard ^a   Routier, Sylvain ^a   Pfeiffer, Bruno ^b   Caignard, Daniel Henri ^b   Hickman, John ^b   Pierré, Alain ^b   Golsteyn, Roy M ^b   Léonce, Stéphane ^b   Bossard, Céline ^b   Mérour, Jean Yves ^a  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

5 Azaindole; 5 Azaindolocarbazole; Chk1 inhibitors; Cytoxicity

Indexed keywords

1,3 DIOXOLO[4,5 B] 6 (2 DIMETHYLAMINOETHYL) 1H PYRIDO[3',4':4,5]PYRROLO[3,2 I]PYRROLO[3,4 G]CARBAZOLE 5,7(6H,12H) DIONE; 1,3 DIOXOLO[4,5 B] 6 METHYL 1H PYRIDO[3',4':4,5]PYRROLO[3,2 I]PYRROLO[3,4 G]CARBAZOLE 5,7 DIONE; 10 BENZYLOXY 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; 10 BENZYLOXY 6 (2 DIMETHYLAMINOETHYL) 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; 10 BENZYLOXY 6 METHYL 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; 10 HYDROXY 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; 10 HYDROXY 6 METHYL 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; 3 BENZYL 12 (BETA DEXTRO GLUCOPYRANOSYL) 6 METHYL 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE 3 IUM BROMIDE; 3 BENZYL 6 METHYL 12 (2,3,4,6 TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE 3 IUM BROMIDE; 3 BENZYL 6 METHYL 12 (3,4,6 TRI O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE 3 IUM BROMIDE; 6 (2 DIMETHYLAMINOETHYL) 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; 6 (2 DIMETHYLAMINOETHYL) 9 HYDROXY 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; 6 METHYL 12 (2,3,4,6 TETRA O BENZYL BETA DEXTRO GLUCOPYRANOSYL) 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; 6 METHYL 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; 9 BENZYLOXY 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; 9 BENZYLOXY 3 METHYL 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE 3 IUM IODIDE; 9 BENZYLOXY 6 (2 DIMETHYLAMINOETHYL) 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; 9 BENZYLOXY 6 METHYL 1H PYRIDO[3',4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; 9 HYDROXY 1H PYRIDO[3'4':4,5]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; 9 HYDROXY 6 METHYL 1H PYRIDO[3',4':4,5]PYRROLO[3,2 I]PYRROLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,12H) DIONE; ANTINEOPLASTIC AGENT; CARBAZOLE DERIVATIVE; CHECKPOINT KINASE 1; CYTOTOXIC AGENT; GLUCOSE DERIVATIVE; HETEROCYCLIC COMPOUND; INDOLE DERIVATIVE; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CHEMICAL STRUCTURE; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PHOTOCHEMISTRY; STILLE REACTION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; AZA COMPOUNDS; CARBAZOLES; CELL CYCLE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PROTEIN KINASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 43049106472     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.086     Document Type: Article

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