Synthetic Approaches to Indolo[6,7-α]pyrrolo[3,4-c]carbazoles: Potent Cyclin D1/CDK4 Inhibitors

Journal of Organic Chemistry

Volumn 69, Issue 9, 2004, Pages 2967-2975

  Faul, Margaret M ^a,c   Engler, Thomas A ^b   Sullivan, Kevin A ^a   Grutsch, John L ^a   Clayton, Marcella T ^a   Martinelli, Michael J ^a   Pawlak, Joseph M ^a   LeTourneau, Michael ^a   Coffey, D Scott ^a   Pedersen, Steven W ^a   Kolis, Stanley P ^a   Furness, Kelly ^b   Malhotra, Sushant ^b   Al Awar, Rima S ^b   Ray, James E ^b  

^a Global Chem Proc Res and Devmt   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR STRUCTURE; OXIDATION; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

INDOLOCARBAZOLE PLATFORM; STRUCTURE-ACITVITY RELATIONSHIPS (SAR);

AROMATIC COMPOUNDS;

ACETAMIDE DERIVATIVE; CARBAZOLE DERIVATIVE; CARBON; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; GLYOXYLIC ACID DERIVATIVE; INDOLE ACETAMIDE DERIVATIVE; INDOLO[6,7 A]PYRROLO[3,4 C]CARBAZOLE DERIVATIVE; INDOLYLMALEIMIDE DERIVATIVE; MALEIMIDE DERIVATIVE; N METHYL (INDOL 7 YL)OXOACETATE DERIVATIVE; NITROGEN 13; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; DRUG POTENCY; EVALUATION; INHIBITION KINETICS; INTERMETHOD COMPARISON; OXIDATION KINETICS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SYNTHESIS;

ACETAMIDES; ACETATES; ANTINEOPLASTIC AGENTS; CARBAZOLES; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; HUMANS; INDOLES; MALEIMIDES; OXIDANTS; PHOTOCHEMISTRY; PROTO-ONCOGENE PROTEINS; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 11144354452     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo035606v     Document Type: Article

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