-
1
-
-
0028931509
-
Novel antitumor indolocarbazole compound 6-N-formylamino-12, 13-dihydro-1,11-dihydroxy-13-(β-D-glucopyranosyl)-5H-indolo[2,3-a] pyrrolo[3,4-c]carbazole-5,7(6H)-dione (NB-506): Induction of topoisomerase I-mediated DNA cleavage and mechanisms of cell line-selective cytotoxicity
-
Yoshinari, T., Matsumoto, M., Arakawa, H., Okada, H., Noguchi, K., Suda, H., Okura, A. and Nishimura, S. Novel antitumor indolocarbazole compound 6-N-formylamino-12, 13-dihydro-1,11-dihydroxy-13-(β-D-glucopyranosyl)-5H-indolo[2,3-a] pyrrolo[3,4-c]carbazole-5,7(6H)-dione (NB-506): induction of topoisomerase I-mediated DNA cleavage and mechanisms of cell line-selective cytotoxicity. Cancer Res., 55, 1310-1315 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 1310-1315
-
-
Yoshinari, T.1
Matsumoto, M.2
Arakawa, H.3
Okada, H.4
Noguchi, K.5
Suda, H.6
Okura, A.7
Nishimura, S.8
-
2
-
-
0028905348
-
Novel indolocarbazole compound 6-N-formylamino-2,13-dihydro-1,11-dihydroxy-13-(β-D-glucopyranosyl)-5H- indolo[2,3-a]pyrrolo-[3,4-c]carbazole-5,7(6H)-dione (NB-506): Its potent antitumor activity in mice
-
Arakawa, H., Iguchi, T., Morita, M., Yoshinari, T., Kojiri, K., Suda, H., Okura, A. and Nishimura, S. Novel indolocarbazole compound 6-N-formylamino-2,13-dihydro-1,11-dihydroxy-13-(β-D-glucopyranosyl)-5H- indolo[2,3-a]pyrrolo-[3,4-c]carbazole-5,7(6H)-dione (NB-506): its potent antitumor activity in mice. Cancer Res., 55, 1316-1320 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 1316-1320
-
-
Arakawa, H.1
Iguchi, T.2
Morita, M.3
Yoshinari, T.4
Kojiri, K.5
Suda, H.6
Okura, A.7
Nishimura, S.8
-
3
-
-
0033199091
-
Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I
-
Yoshinari, T., Ohkubo, M., Fukasawa, K., Egashira, S., Hara, Y., Matsumoto, M., Nakai, K., Arakawa, H., Morishima, H. and Nishimura, S. Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I. Cancer Res., 59, 4271-4275 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 4271-4275
-
-
Yoshinari, T.1
Ohkubo, M.2
Fukasawa, K.3
Egashira, S.4
Hara, Y.5
Matsumoto, M.6
Nakai, K.7
Arakawa, H.8
Morishima, H.9
Nishimura, S.10
-
4
-
-
0029956091
-
Antimetastatic effect of a novel indolocarbazole (NB-506) on IMC-HM murine tumor cells metastasized to the liver
-
Arakawa, H., Matsumoto, H., Morita, M., Sasaki, M., Taguchi, K., Okura, A. and Nishimura, S. Antimetastatic effect of a novel indolocarbazole (NB-506) on IMC-HM murine tumor cells metastasized to the liver. Jpn. J. Cancer Res., 87, 518-523 (1996).
-
(1996)
Jpn. J. Cancer Res.
, vol.87
, pp. 518-523
-
-
Arakawa, H.1
Matsumoto, H.2
Morita, M.3
Sasaki, M.4
Taguchi, K.5
Okura, A.6
Nishimura, S.7
-
5
-
-
0029973431
-
Practical synthesis of indolopyrrolocarbazoles
-
Ohkubo, M., Nishimura, T., Jona, H., Honma, T. and Morishima, H. Practical synthesis of indolopyrrolocarbazoles. Tetrahedron, 52, 8099-8112 (1996).
-
(1996)
Tetrahedron
, vol.52
, pp. 8099-8112
-
-
Ohkubo, M.1
Nishimura, T.2
Jona, H.3
Honma, T.4
Morishima, H.5
-
6
-
-
0022378065
-
Activity of a novel 4-quinolinecarboxylic acid, NSC 3688390 [6-fluoro-2-(2′-fluoro-1,1′-biphenyl-4-yl)-3-methyl-4- quinolinecarboxylic acid sodium salt], against experimental tumors
-
Dexter, D. L., Hesson, D. P., Ardecky, R. J., Rao, G. V., Tippett, D. L., Dusak, B. A., Paull, K. D., Plowman, J., DeLarco, B. M., Narayanan, V. L. and Forbes, M. Activity of a novel 4-quinolinecarboxylic acid, NSC 3688390 [6-fluoro-2-(2′-fluoro-1,1′-biphenyl-4-yl)-3-methyl-4- quinolinecarboxylic acid sodium salt], against experimental tumors. Cancer Res., 45, 5563-5568 (1985).
-
(1985)
Cancer Res.
, vol.45
, pp. 5563-5568
-
-
Dexter, D.L.1
Hesson, D.P.2
Ardecky, R.J.3
Rao, G.V.4
Tippett, D.L.5
Dusak, B.A.6
Paull, K.D.7
Plowman, J.8
DeLarco, B.M.9
Narayanan, V.L.10
Forbes, M.11
-
7
-
-
0013909023
-
Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man
-
Freireich, E. J., Gehan, E. A., Rall, D. P., Schmidt, L. H. and Skipper, H. E. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother. Rep., 50, 219-244 (1966).
-
(1966)
Cancer Chemother. Rep.
, vol.50
, pp. 219-244
-
-
Freireich, E.J.1
Gehan, E.A.2
Rall, D.P.3
Schmidt, L.H.4
Skipper, H.E.5
-
8
-
-
0025788486
-
A new antitumor substance, BE-13793c, produced by a streptomycete. Taxonomy, fermentation, isolation, structure determination and biological activity
-
Kojiri, K., Kondo, H., Yoshinari, T., Arakawa, H., Nakajima, S., Satoh, F., Kawamura, K., Okura, A., Suda, H. and Okanishi, M. A new antitumor substance, BE-13793C, produced by a streptomycete. Taxonomy, fermentation, isolation, structure determination and biological activity. J. Antibiot. (Tokyo), 44, 723-728 (1991).
-
(1991)
J. Antibiot. (Tokyo)
, vol.44
, pp. 723-728
-
-
Kojiri, K.1
Kondo, H.2
Yoshinari, T.3
Arakawa, H.4
Nakajima, S.5
Satoh, F.6
Kawamura, K.7
Okura, A.8
Suda, H.9
Okanishi, M.10
-
9
-
-
0027297782
-
ED-110, a novel indolocarbazole, prevents the growth of experimental tumors in mice
-
Arakawa, H., Iguchi, T., Yoshinari, T., Kojiri, K., Suda, H. and Okura, A. ED-110, a novel indolocarbazole, prevents the growth of experimental tumors in mice. Jpn. J. Cancer Res., 84, 574-581 (1993).
-
(1993)
Jpn. J. Cancer Res.
, vol.84
, pp. 574-581
-
-
Arakawa, H.1
Iguchi, T.2
Yoshinari, T.3
Kojiri, K.4
Suda, H.5
Okura, A.6
-
10
-
-
0027461273
-
Induction of topoisomerase I-mediated DNA cleavage by a new indolocarbazole, ED-110
-
Yoshinari, T., Yamada, A., Uemura, D., Nomura, K., Arakawa, H., Kojiri, K., Yoshida, E., Suda, H. and Okura, A. Induction of topoisomerase I-mediated DNA cleavage by a new indolocarbazole, ED-110. Cancer Res., 53, 490-494 (1993).
-
(1993)
Cancer Res.
, vol.53
, pp. 490-494
-
-
Yoshinari, T.1
Yamada, A.2
Uemura, D.3
Nomura, K.4
Arakawa, H.5
Kojiri, K.6
Yoshida, E.7
Suda, H.8
Okura, A.9
-
11
-
-
0033519179
-
Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506
-
Ohkubo, M., Kojiri, K., Kondo, H., Tanaka, S., Kawamoto, H., Nishimura, T., Nishimura, I., Yoshinari, T., Arakawa, H., Suda, H., Morishima, H. and Nishimura, S. Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506. Bioorg. Med. Chem. Lett., 9, 1219-1224 (1999).
-
(1999)
Bioorg. Med. Chem. Lett.
, vol.9
, pp. 1219-1224
-
-
Ohkubo, M.1
Kojiri, K.2
Kondo, H.3
Tanaka, S.4
Kawamoto, H.5
Nishimura, T.6
Nishimura, I.7
Yoshinari, T.8
Arakawa, H.9
Suda, H.10
Morishima, H.11
Nishimura, S.12
-
12
-
-
0033614922
-
Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities
-
Bailly, C., Qu, X., Chaires, J. B., Colson, P., Houssier, C., Ohkubo, M., Nishimura, S. and Yoshinari, T. Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities. J. Med. Chem., 42, 2927-2935 (1999).
-
(1999)
J. Med. Chem.
, vol.42
, pp. 2927-2935
-
-
Bailly, C.1
Qu, X.2
Chaires, J.B.3
Colson, P.4
Houssier, C.5
Ohkubo, M.6
Nishimura, S.7
Yoshinari, T.8
|