Synthesis and biological evaluation of novel naphthocarbazoles as potential anticancer agents

Journal of Medicinal Chemistry

Volumn 48, Issue 5, 2005, Pages 1401-1413

  Routier, Sylvain ^a   Peixoto, Paul ^a   Mérour, Jean Yves ^a   Coudert, Gérard ^a   Dias, Nathalie ^b   Bailly, Christian ^b   Pierré, Alain ^c   Léonce, Stéphane ^c   Caignard, Daniel Henry ^c  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b INSERM   (France)

^c INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 (HYDROXY) 6 [2 (DIMETHYLAMINO)ETHYL]NAPHTHO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,14H) DIONE; 2 (HYDROXY) 6 [2 [(2 HYDROXYETHYL)AMINO]ETHYL]NAPHTHO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,14H) DIONE; 2 (HYDROXY) 6 [3 (DIMETHYLAMINO)PROPYL]NAPHTHO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,14H) DIONE; 2 (HYDROXY) 6 METHYLNAPHTHO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,14H) DIONE; 3 (HYDROXY) 6 [2 (DIMETHYLAMINO)ETHYL]NAPHTHO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,14H) DIONE; 3 (HYDROXY) 6 [2 [(2 HYDROXYETHYL)AMINO]ETHYL]NAPHTHO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,14H) DIONE; 3 (HYDROXY) 6 [3 (DIMETHYLAMINO)PROPYL]NAPHTHO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,14H) DIONE; 3 (HYDROXY) 6 METHYLNAPHTHO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,14H) DIONE; 6 [2 (DIMETHYLAMINO)ETHYL]NAPHTHO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,14H) DIONE; 6 METHYL 14 [2 (DIMETHYLAMINO)ETHYL]NAPHTHO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,14H) DIONE; 6 METHYLNAPHTHO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H,14H) DIONE; ANTINEOPLASTIC AGENT; CARBAZOLE DERIVATIVE; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR; DNA TOPOISOMERASE INHIBITOR; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; INDOLE DERIVATIVE; NAPHTHALENE DERIVATIVE; PLASMID DNA; REBECCAMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE; CONTROLLED STUDY; CYCLIZATION; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA L 1210; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBAZOLES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASES; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MICE; NAPHTHALENES; PHTHALIMIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 14944374500     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049213f     Document Type: Article

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