메뉴 건너뛰기




Volumn 14, Issue 5, 2008, Pages 199-209

Epithelial-mesenchymal transition and the invasive potential of tumors

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CELL ADHESION MOLECULE; FASCIN; IMMUNOGLOBULIN; PODOPLANIN; PROTEIN TYROSINE KINASE; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN;

EID: 42749091317     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2008.03.004     Document Type: Article
Times cited : (304)

References (99)
  • 1
    • 12444323307 scopus 로고    scopus 로고
    • Integrating cells into tissues
    • W.H. Feeman & Company
    • Lodish H., et al. Integrating cells into tissues. Molecular Cell Biology. 6th edn (2008), W.H. Feeman & Company 801-846
    • (2008) Molecular Cell Biology. 6th edn , pp. 801-846
    • Lodish, H.1
  • 2
    • 0008114765 scopus 로고    scopus 로고
    • Small intestine
    • Schwartz S., et al. (Ed), McGraw-Hill
    • Evers B.M., et al. Small intestine. In: Schwartz S., et al. (Ed). Principles of Surgery. 7th edn (1999), McGraw-Hill 1217-1263
    • (1999) Principles of Surgery. 7th edn , pp. 1217-1263
    • Evers, B.M.1
  • 4
    • 20744439516 scopus 로고    scopus 로고
    • The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
    • Hay E.D. The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Dev. Dyn. 233 (2005) 706-720
    • (2005) Dev. Dyn. , vol.233 , pp. 706-720
    • Hay, E.D.1
  • 5
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2 (2002) 442-454
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 6
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J., et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117 (2004) 927-939
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1
  • 7
    • 22244473343 scopus 로고    scopus 로고
    • The fallacy of epithelial mesenchymal transition in neoplasia
    • Tarin D., et al. The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res. 65 (2005) 5996-6000
    • (2005) Cancer Res. , vol.65 , pp. 5996-6000
    • Tarin, D.1
  • 8
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: building a framework
    • Gupta G.P., and Massagué J. Cancer metastasis: building a framework. Cell 127 (2006) 679-695
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massagué, J.2
  • 9
    • 38849093994 scopus 로고    scopus 로고
    • Direct evidence for epithelial-mesenchymal transitions in breast cancer
    • Trimboli A.J., et al. Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res. 68 (2008) 937-945
    • (2008) Cancer Res. , vol.68 , pp. 937-945
    • Trimboli, A.J.1
  • 10
    • 33846457870 scopus 로고    scopus 로고
    • Cancer statistics, 2007
    • Jemal A., et al. Cancer statistics, 2007. CA Cancer J. Clin. 57 (2007) 43-66
    • (2007) CA Cancer J. Clin. , vol.57 , pp. 43-66
    • Jemal, A.1
  • 11
    • 22144497081 scopus 로고    scopus 로고
    • Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and β-catenin
    • Brabletz T., et al. Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and β-catenin. Cells Tissues Organs 179 (2005) 56-65
    • (2005) Cells Tissues Organs , vol.179 , pp. 56-65
    • Brabletz, T.1
  • 12
    • 0036301919 scopus 로고    scopus 로고
    • β-catenin and the morphogenesis of colorectal cancer
    • Brabletz T., et al. β-catenin and the morphogenesis of colorectal cancer. Virchows Arch. 441 (2002) 1-11
    • (2002) Virchows Arch. , vol.441 , pp. 1-11
    • Brabletz, T.1
  • 13
    • 13944268218 scopus 로고    scopus 로고
    • L1, a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers
    • Gavert N., et al. L1, a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J. Cell Biol. 168 (2005) 633-642
    • (2005) J. Cell Biol. , vol.168 , pp. 633-642
    • Gavert, N.1
  • 15
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery J.P., and Sleeman J.P. Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 7 (2006) 131-142
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 16
    • 5444230567 scopus 로고    scopus 로고
    • Transcriptional regulation of cadherins during development and carcinogenesis
    • Peinado H., et al. Transcriptional regulation of cadherins during development and carcinogenesis. Int. J. Dev. Biol. 48 (2004) 365-375
    • (2004) Int. J. Dev. Biol. , vol.48 , pp. 365-375
    • Peinado, H.1
  • 17
    • 23144442645 scopus 로고    scopus 로고
    • Regulation of cadherin-mediated adhesion in morphogenesis
    • Gumbiner B.M. Regulation of cadherin-mediated adhesion in morphogenesis. Nat. Rev. Mol. Cell Biol. 6 (2005) 622-634
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 622-634
    • Gumbiner, B.M.1
  • 18
    • 0031718204 scopus 로고    scopus 로고
    • Differential molecular interactions of β-catenin and plakoglobin in adhesion, signaling and cancer
    • Ben-Ze'ev A., and Geiger B. Differential molecular interactions of β-catenin and plakoglobin in adhesion, signaling and cancer. Curr. Opin. Cell Biol. 10 (1998) 629-639
    • (1998) Curr. Opin. Cell Biol. , vol.10 , pp. 629-639
    • Ben-Ze'ev, A.1    Geiger, B.2
  • 19
    • 28344433073 scopus 로고    scopus 로고
    • Deconstructing the cadherin-catenin-actin complex
    • Yamada S., et al. Deconstructing the cadherin-catenin-actin complex. Cell 123 (2005) 889-901
    • (2005) Cell , vol.123 , pp. 889-901
    • Yamada, S.1
  • 20
    • 0028245813 scopus 로고
    • Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness
    • Birchmeier W., and Behrens J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim. Biophys. Acta 1198 (1994) 11-26
    • (1994) Biochim. Biophys. Acta , vol.1198 , pp. 11-26
    • Birchmeier, W.1    Behrens, J.2
  • 21
    • 0025818032 scopus 로고
    • Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
    • Vleminckx K., et al. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 66 (1991) 107-119
    • (1991) Cell , vol.66 , pp. 107-119
    • Vleminckx, K.1
  • 22
    • 0032510494 scopus 로고    scopus 로고
    • A causal role for E-cadherin in the transition from adenoma to carcinoma
    • Perl A.K., et al. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392 (1998) 190-193
    • (1998) Nature , vol.392 , pp. 190-193
    • Perl, A.K.1
  • 23
    • 33750614651 scopus 로고    scopus 로고
    • Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis
    • Derksen P.W., et al. Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell 10 (2006) 437-449
    • (2006) Cancer Cell , vol.10 , pp. 437-449
    • Derksen, P.W.1
  • 24
    • 34547609385 scopus 로고    scopus 로고
    • Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer
    • Ceteci F., et al. Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer. Cancer Cell 12 (2007) 145-159
    • (2007) Cancer Cell , vol.12 , pp. 145-159
    • Ceteci, F.1
  • 25
    • 33749024777 scopus 로고    scopus 로고
    • Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis
    • Christiansen J.J., and Rajasekaran A.K. Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res. 66 (2006) 8319-8326
    • (2006) Cancer Res. , vol.66 , pp. 8319-8326
    • Christiansen, J.J.1    Rajasekaran, A.K.2
  • 26
    • 37549071388 scopus 로고    scopus 로고
    • Adaptation versus selection: the origins of metastatic behavior
    • Scheel C., et al. Adaptation versus selection: the origins of metastatic behavior. Cancer Res. 67 (2007) 11476-11479
    • (2007) Cancer Res. , vol.67 , pp. 11476-11479
    • Scheel, C.1
  • 27
    • 37549003179 scopus 로고    scopus 로고
    • Clonal selection of metastasis within the life history of a tumor
    • Talmadge J.E. Clonal selection of metastasis within the life history of a tumor. Cancer Res. 67 (2007) 11471-11475
    • (2007) Cancer Res. , vol.67 , pp. 11471-11475
    • Talmadge, J.E.1
  • 28
    • 34249289041 scopus 로고    scopus 로고
    • Snail, ZEB and bHLH factors in tumor progression: an alliance against the epithelial phenotype?
    • Peinado H., et al. Snail, ZEB and bHLH factors in tumor progression: an alliance against the epithelial phenotype?. Nat. Rev. Cancer 7 (2007) 415-428
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 415-428
    • Peinado, H.1
  • 29
    • 1042267263 scopus 로고    scopus 로고
    • Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
    • Cavallaro U., and Christofori G. Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat. Rev. Cancer 4 (2004) 118-132
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 118-132
    • Cavallaro, U.1    Christofori, G.2
  • 30
    • 0036120562 scopus 로고    scopus 로고
    • The cadherin-catenin adhesion system in signaling and cancer
    • Conacci-Sorrell M., et al. The cadherin-catenin adhesion system in signaling and cancer. J. Clin. Invest. 109 (2002) 987-991
    • (2002) J. Clin. Invest. , vol.109 , pp. 987-991
    • Conacci-Sorrell, M.1
  • 31
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling in development and disease
    • Clevers H. Wnt/β-catenin signaling in development and disease. Cell 127 (2006) 469-480
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 32
    • 0345599013 scopus 로고    scopus 로고
    • Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of β-catenin signalling, Slug and MAPK
    • Conacci-Sorrell M., et al. Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of β-catenin signalling, Slug and MAPK. J. Cell Biol. 163 (2003) 847-857
    • (2003) J. Cell Biol. , vol.163 , pp. 847-857
    • Conacci-Sorrell, M.1
  • 33
    • 0035964349 scopus 로고    scopus 로고
    • Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
    • Brabletz T., et al. Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 10356-10361
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 10356-10361
    • Brabletz, T.1
  • 34
    • 0035149139 scopus 로고    scopus 로고
    • The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear β-catenin, cyclin D1, and p16INK4A and is a region of low proliferation
    • Jung A., et al. The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear β-catenin, cyclin D1, and p16INK4A and is a region of low proliferation. Am. J. Pathol. 159 (2001) 1613-1617
    • (2001) Am. J. Pathol. , vol.159 , pp. 1613-1617
    • Jung, A.1
  • 35
    • 0035194206 scopus 로고    scopus 로고
    • Tumor environment: a potent driving force in colorectal cancer?
    • Barker N., and Clevers H. Tumor environment: a potent driving force in colorectal cancer?. Trends Mol. Med. 7 (2001) 535-537
    • (2001) Trends Mol. Med. , vol.7 , pp. 535-537
    • Barker, N.1    Clevers, H.2
  • 36
    • 35648949978 scopus 로고    scopus 로고
    • β-catenin signaling in biological control and cancer
    • Gavert N., and Ben-Ze'ev A. β-catenin signaling in biological control and cancer. J. Cell. Biochem. 102 (2007) 820-828
    • (2007) J. Cell. Biochem. , vol.102 , pp. 820-828
    • Gavert, N.1    Ben-Ze'ev, A.2
  • 37
    • 0030578460 scopus 로고    scopus 로고
    • Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cell-cell adhesion
    • Takahashi K., and Suzuki K. Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cell-cell adhesion. Exp. Cell Res. 226 (1996) 214-222
    • (1996) Exp. Cell Res. , vol.226 , pp. 214-222
    • Takahashi, K.1    Suzuki, K.2
  • 38
    • 0031005659 scopus 로고    scopus 로고
    • The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition
    • Savagner P., et al. The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J. Cell Biol. 137 (1997) 1403-1419
    • (1997) J. Cell Biol. , vol.137 , pp. 1403-1419
    • Savagner, P.1
  • 39
    • 33751514601 scopus 로고    scopus 로고
    • A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells
    • Yook J.I., et al. A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells. Nat. Cell Biol. 8 (2006) 1398-1416
    • (2006) Nat. Cell Biol. , vol.8 , pp. 1398-1416
    • Yook, J.I.1
  • 40
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad M., and Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer 2 (2002) 161-174
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 41
    • 0347417018 scopus 로고    scopus 로고
    • MMP-2 plays an essential role in producing epithelial-mesencymal transformation in the avian embryo
    • Duong T.D., and Erickson C.A. MMP-2 plays an essential role in producing epithelial-mesencymal transformation in the avian embryo. Dev. Dyn. 229 (2004) 42-53
    • (2004) Dev. Dyn. , vol.229 , pp. 42-53
    • Duong, T.D.1    Erickson, C.A.2
  • 42
    • 0041343293 scopus 로고    scopus 로고
    • E-Cadherin mediates MMP down-regulation in highly invasive bronchial tumor cells
    • Nawrocki-Raby B., et al. E-Cadherin mediates MMP down-regulation in highly invasive bronchial tumor cells. Am. J. Pathol. 163 (2003) 653-661
    • (2003) Am. J. Pathol. , vol.163 , pp. 653-661
    • Nawrocki-Raby, B.1
  • 43
    • 0037780977 scopus 로고    scopus 로고
    • Upregulation of MMPs by soluble E-cadherin in human lung tumor cells
    • Nawrocki-Raby B., et al. Upregulation of MMPs by soluble E-cadherin in human lung tumor cells. Int. J. Cancer 105 (2003) 790-795
    • (2003) Int. J. Cancer , vol.105 , pp. 790-795
    • Nawrocki-Raby, B.1
  • 44
    • 0345736990 scopus 로고    scopus 로고
    • Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion
    • Lu Z., et al. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion. Cancer Cell 4 (2003) 499-515
    • (2003) Cancer Cell , vol.4 , pp. 499-515
    • Lu, Z.1
  • 45
    • 0033822935 scopus 로고    scopus 로고
    • IgCAMs: bidirectional signals underlying neurite growth
    • Kamiguchi H., and Lemmon V. IgCAMs: bidirectional signals underlying neurite growth. Curr. Opin. Cell Biol. 12 (2000) 598-605
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 598-605
    • Kamiguchi, H.1    Lemmon, V.2
  • 46
    • 29244479537 scopus 로고    scopus 로고
    • The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation
    • Conacci-Sorrell M., et al. The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation. Cancer Res. 65 (2005) 11605-11612
    • (2005) Cancer Res. , vol.65 , pp. 11605-11612
    • Conacci-Sorrell, M.1
  • 47
    • 0037102578 scopus 로고    scopus 로고
    • Nr-CAM is a target gene of the β-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis
    • Conacci-Sorrell M.E., et al. Nr-CAM is a target gene of the β-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Genes Dev. 16 (2002) 2058-2072
    • (2002) Genes Dev. , vol.16 , pp. 2058-2072
    • Conacci-Sorrell, M.E.1
  • 48
    • 34548015630 scopus 로고    scopus 로고
    • Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis
    • Gavert N., et al. Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. Cancer Res. 67 (2007) 7703-7712
    • (2007) Cancer Res. , vol.67 , pp. 7703-7712
    • Gavert, N.1
  • 49
    • 0028029162 scopus 로고
    • Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin
    • Williams E.J., et al. Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin. Neuron 13 (1994) 583-594
    • (1994) Neuron , vol.13 , pp. 583-594
    • Williams, E.J.1
  • 50
    • 0034945537 scopus 로고    scopus 로고
    • N-CAM modulates tumor-cell adhesion to matrix by inducing FGF-receptor signaling
    • Cavallaro U., et al. N-CAM modulates tumor-cell adhesion to matrix by inducing FGF-receptor signaling. Nat. Cell Biol. 3 (2001) 650-657
    • (2001) Nat. Cell Biol. , vol.3 , pp. 650-657
    • Cavallaro, U.1
  • 51
    • 33745297408 scopus 로고    scopus 로고
    • New signals from the invasive front
    • Christofori G. New signals from the invasive front. Nature 441 (2006) 444-450
    • (2006) Nature , vol.441 , pp. 444-450
    • Christofori, G.1
  • 52
    • 0037204990 scopus 로고    scopus 로고
    • Signal transduction by the TGF-β superfamily
    • Attisano L., and Wrana J. Signal transduction by the TGF-β superfamily. Science 296 (2002) 1646-1647
    • (2002) Science , vol.296 , pp. 1646-1647
    • Attisano, L.1    Wrana, J.2
  • 53
    • 22144461325 scopus 로고    scopus 로고
    • Transforming growth factor-β signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis
    • Nawshad A., et al. Transforming growth factor-β signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis. Cells Tissues Organs 179 (2005) 11-23
    • (2005) Cells Tissues Organs , vol.179 , pp. 11-23
    • Nawshad, A.1
  • 54
    • 24644487312 scopus 로고    scopus 로고
    • TGF-β and epithelial-to-mesenchymal transitions
    • Zavadil J., and Böttinger E.P. TGF-β and epithelial-to-mesenchymal transitions. Oncogene 24 (2005) 5764-5774
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Böttinger, E.P.2
  • 55
    • 34250738303 scopus 로고    scopus 로고
    • Complexity in interpretation of embryonic epithelial-mesenchymal transition in response to transforming growth factor-β signaling
    • Ahmed S., and Nawshad A. Complexity in interpretation of embryonic epithelial-mesenchymal transition in response to transforming growth factor-β signaling. Cells Tissues Organs 185 (2007) 131-145
    • (2007) Cells Tissues Organs , vol.185 , pp. 131-145
    • Ahmed, S.1    Nawshad, A.2
  • 56
    • 3543095147 scopus 로고    scopus 로고
    • β-Catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse
    • Liebner S., et al. β-Catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J. Cell Biol. 166 (2004) 359-367
    • (2004) J. Cell Biol. , vol.166 , pp. 359-367
    • Liebner, S.1
  • 57
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor β in human disease
    • Blobe G.C., et al. Role of transforming growth factor β in human disease. N. Engl. J. Med. 342 (2000) 1350-1358
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1350-1358
    • Blobe, G.C.1
  • 58
    • 15744372725 scopus 로고    scopus 로고
    • Role of transforming growth factor β in human cancer
    • Blobe G.C., and Elliott R. Role of transforming growth factor β in human cancer. J. Clin. Oncol. 23 (2005) 2078-2093
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2078-2093
    • Blobe, G.C.1    Elliott, R.2
  • 59
    • 33845979811 scopus 로고    scopus 로고
    • The type III TGF-β receptor suppresses breast cancer progression
    • Dong M., et al. The type III TGF-β receptor suppresses breast cancer progression. J. Clin. Invest. 117 (2007) 206-217
    • (2007) J. Clin. Invest. , vol.117 , pp. 206-217
    • Dong, M.1
  • 60
    • 27744527762 scopus 로고    scopus 로고
    • Laminin-5 with transforming growth factor-β1 induces epithelial to mesenchymal transition in hepatocellular carcinoma
    • Giannelli G., et al. Laminin-5 with transforming growth factor-β1 induces epithelial to mesenchymal transition in hepatocellular carcinoma. Gastroenterology 129 (2005) 1375-1383
    • (2005) Gastroenterology , vol.129 , pp. 1375-1383
    • Giannelli, G.1
  • 61
    • 34648813274 scopus 로고    scopus 로고
    • Heterogeneous expression of Wnt/β-catenin target genes within colorectal cancer
    • Hlubek F. Heterogeneous expression of Wnt/β-catenin target genes within colorectal cancer. Int. J. Cancer 121 (2007) 1941-1948
    • (2007) Int. J. Cancer , vol.121 , pp. 1941-1948
    • Hlubek, F.1
  • 62
    • 0036317838 scopus 로고    scopus 로고
    • Transforming growth factor-β1 triggers hepatocellular carcinoma invasiveness via α3β1 integrin
    • Giannelli G., et al. Transforming growth factor-β1 triggers hepatocellular carcinoma invasiveness via α3β1 integrin. Am. J. Pathol. 161 (2002) 183-193
    • (2002) Am. J. Pathol. , vol.161 , pp. 183-193
    • Giannelli, G.1
  • 63
    • 0023661693 scopus 로고
    • Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
    • Stoker M., et al. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 327 (1987) 239-242
    • (1987) Nature , vol.327 , pp. 239-242
    • Stoker, M.1
  • 64
    • 0345601083 scopus 로고    scopus 로고
    • Met, metastasis, motility and more
    • Birchmeier C., et al. Met, metastasis, motility and more. Nat. Rev. Mol. Cell Biol. 4 (2003) 915-925
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 915-925
    • Birchmeier, C.1
  • 65
    • 4444276194 scopus 로고    scopus 로고
    • Essential role of BCL9-2 in the switch between β-catenin's adhesive and transcriptional functions
    • Brembeck F.H., et al. Essential role of BCL9-2 in the switch between β-catenin's adhesive and transcriptional functions. Genes Dev. 18 (2004) 2225-2230
    • (2004) Genes Dev. , vol.18 , pp. 2225-2230
    • Brembeck, F.H.1
  • 66
    • 30644458570 scopus 로고    scopus 로고
    • Balancing cell adhesion and Wnt signaling, the key role of β-catenin
    • Brembeck F.H., et al. Balancing cell adhesion and Wnt signaling, the key role of β-catenin. Curr. Opin. Genet. Dev. 16 (2006) 51-59
    • (2006) Curr. Opin. Genet. Dev. , vol.16 , pp. 51-59
    • Brembeck, F.H.1
  • 67
    • 33645302628 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition: new insights in signaling, development, and disease
    • Lee J.M., et al. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J. Cell Biol. 172 (2006) 973-981
    • (2006) J. Cell Biol. , vol.172 , pp. 973-981
    • Lee, J.M.1
  • 68
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-κB in cancer development and progression
    • Karin M. Nuclear factor-κB in cancer development and progression. Nature 441 (2006) 431-436
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 69
    • 33750432183 scopus 로고    scopus 로고
    • Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression
    • Basseres D.S., and Baldwin A.S. Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression. Oncogene 25 (2006) 6817-6830
    • (2006) Oncogene , vol.25 , pp. 6817-6830
    • Basseres, D.S.1    Baldwin, A.S.2
  • 70
    • 4344612243 scopus 로고    scopus 로고
    • NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
    • Huber M.A., et al. NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J. Clin. Invest. 114 (2004) 569-581
    • (2004) J. Clin. Invest. , vol.114 , pp. 569-581
    • Huber, M.A.1
  • 71
    • 33947196379 scopus 로고    scopus 로고
    • Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma
    • Horikawa T., et al. Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma. Cancer Res. 67 (2007) 1970-1978
    • (2007) Cancer Res. , vol.67 , pp. 1970-1978
    • Horikawa, T.1
  • 72
    • 36349011403 scopus 로고    scopus 로고
    • Activation of NF-κB by Akt upregulates Snail expression and induces epithelium mesenchyme transition
    • Julien S., et al. Activation of NF-κB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene 26 (2007) 7445-7456
    • (2007) Oncogene , vol.26 , pp. 7445-7456
    • Julien, S.1
  • 73
    • 1542315627 scopus 로고    scopus 로고
    • NF-κB binds to a polymorphic repressor element in the MMP-3 promoter
    • Borghaei R.C., et al. NF-κB binds to a polymorphic repressor element in the MMP-3 promoter. Biochem. Biophys. Res. Commun. 316 (2004) 182-188
    • (2004) Biochem. Biophys. Res. Commun. , vol.316 , pp. 182-188
    • Borghaei, R.C.1
  • 74
    • 2442640603 scopus 로고    scopus 로고
    • A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NF-κB motif drives the transition from a repressed to an activated state of gene expression
    • Yan C., et al. A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NF-κB motif drives the transition from a repressed to an activated state of gene expression. FASEB J. 18 (2004) 540-541
    • (2004) FASEB J. , vol.18 , pp. 540-541
    • Yan, C.1
  • 75
    • 33750446341 scopus 로고    scopus 로고
    • Inhibitors of NF-κB signaling: 785 and counting
    • Gilmore T.D., and Hershkovitz M. Inhibitors of NF-κB signaling: 785 and counting. Oncogene 25 (2006) 6887-6899
    • (2006) Oncogene , vol.25 , pp. 6887-6899
    • Gilmore, T.D.1    Hershkovitz, M.2
  • 76
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
    • Cobleigh M.A., et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J. Clin. Oncol. 17 (1999) 2639-2648
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2639-2648
    • Cobleigh, M.A.1
  • 77
    • 24644441368 scopus 로고    scopus 로고
    • The comings and goings of actin: coupling protrusion and retraction in cell motility
    • Small J.V., and Resch G.P. The comings and goings of actin: coupling protrusion and retraction in cell motility. Curr. Opin. Cell Biol. 17 (2005) 517-523
    • (2005) Curr. Opin. Cell Biol. , vol.17 , pp. 517-523
    • Small, J.V.1    Resch, G.P.2
  • 78
    • 0345059766 scopus 로고    scopus 로고
    • Intravital imaging of cell movement in tumors
    • Condeelis J., and Segall J. Intravital imaging of cell movement in tumors. Nat. Rev. Cancer 3 (2003) 921-930
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 921-930
    • Condeelis, J.1    Segall, J.2
  • 79
    • 33748535444 scopus 로고    scopus 로고
    • Role of fascin in filopodial protrusion
    • Vignjevic D., et al. Role of fascin in filopodial protrusion. J. Cell Biol. 174 (2006) 863-875
    • (2006) J. Cell Biol. , vol.174 , pp. 863-875
    • Vignjevic, D.1
  • 80
    • 21844439742 scopus 로고    scopus 로고
    • Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker?
    • Hashimoto Y., et al. Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker?. Int. J. Biochem. Cell Biol. 37 (2005) 1787-1804
    • (2005) Int. J. Biochem. Cell Biol. , vol.37 , pp. 1787-1804
    • Hashimoto, Y.1
  • 81
    • 23144461051 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to lung
    • Minn A.J., et al. Genes that mediate breast cancer metastasis to lung. Nature 436 (2005) 518-524
    • (2005) Nature , vol.436 , pp. 518-524
    • Minn, A.J.1
  • 82
    • 34547101481 scopus 로고    scopus 로고
    • Fascin, a novel target of β-catenin-TCF signaling, is expressed at the invasive front of human colon cancer
    • Vignjevic D., et al. Fascin, a novel target of β-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. Cancer Res. 67 (2007) 6844-6853
    • (2007) Cancer Res. , vol.67 , pp. 6844-6853
    • Vignjevic, D.1
  • 83
    • 1642282882 scopus 로고    scopus 로고
    • Prespecification and plasticity: shifting mechanisms of cell migration
    • Friedl P. Prespecification and plasticity: shifting mechanisms of cell migration. Curr. Opin. Cell Biol. 16 (2004) 14-23
    • (2004) Curr. Opin. Cell Biol. , vol.16 , pp. 14-23
    • Friedl, P.1
  • 84
    • 33645758275 scopus 로고    scopus 로고
    • Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton
    • Wicki A., et al. Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell 9 (2006) 261-272
    • (2006) Cancer Cell , vol.9 , pp. 261-272
    • Wicki, A.1
  • 85
    • 33846188563 scopus 로고    scopus 로고
    • The potential role of podoplanin in tumor invasion
    • Wicki A., and Christofori G. The potential role of podoplanin in tumor invasion. Br. J. Cancer 96 (2007) 1-5
    • (2007) Br. J. Cancer , vol.96 , pp. 1-5
    • Wicki, A.1    Christofori, G.2
  • 86
    • 22244432840 scopus 로고    scopus 로고
    • The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program
    • De Craene B., et al. The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program. Cancer Res. 65 (2005) 6237-6244
    • (2005) Cancer Res. , vol.65 , pp. 6237-6244
    • De Craene, B.1
  • 87
    • 16344378397 scopus 로고    scopus 로고
    • TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
    • Valcourt U., et al. TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol. Biol. Cell 16 (2005) 1987-2002
    • (2005) Mol. Biol. Cell , vol.16 , pp. 1987-2002
    • Valcourt, U.1
  • 88
    • 0035810944 scopus 로고    scopus 로고
    • Genetic programs of epithelial cell plasticity directed by transforming growth factor-β
    • Zavadil J., et al. Genetic programs of epithelial cell plasticity directed by transforming growth factor-β. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 6686-6691
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 6686-6691
    • Zavadil, J.1
  • 89
    • 33748168727 scopus 로고    scopus 로고
    • ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells
    • Waerner T., et al. ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. Cancer Cell 10 (2006) 227-239
    • (2006) Cancer Cell , vol.10 , pp. 227-239
    • Waerner, T.1
  • 90
    • 33846892054 scopus 로고    scopus 로고
    • Copper-67 radioimmunotherapy and growth inhibition by anti-L1-cell adhesion molecule monoclonal antibodies in a therapy model of ovarian cancer metastasis
    • Knogler K., et al. Copper-67 radioimmunotherapy and growth inhibition by anti-L1-cell adhesion molecule monoclonal antibodies in a therapy model of ovarian cancer metastasis. Clin. Cancer Res. 13 (2007) 603-611
    • (2007) Clin. Cancer Res. , vol.13 , pp. 603-611
    • Knogler, K.1
  • 91
    • 0141518671 scopus 로고    scopus 로고
    • L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas
    • Fogel M., et al. L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas. Lancet 362 (2003) 869-875
    • (2003) Lancet , vol.362 , pp. 869-875
    • Fogel, M.1
  • 92
    • 39449095723 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition in breast cancer relates to the basal-like phenotype
    • Sarrio D., et al. Epithelial mesenchymal transition in breast cancer relates to the basal-like phenotype. Cancer Res. 68 (2008) 989-997
    • (2008) Cancer Res. , vol.68 , pp. 989-997
    • Sarrio, D.1
  • 93
    • 34047107247 scopus 로고    scopus 로고
    • The transcription factor ZEB1 (δEF1) represses plakophilin 3 during human cancer progression
    • Aigner K., et al. The transcription factor ZEB1 (δEF1) represses plakophilin 3 during human cancer progression. FEBS Lett. 581 (2007) 1617-1624
    • (2007) FEBS Lett. , vol.581 , pp. 1617-1624
    • Aigner, K.1
  • 94
    • 33748116186 scopus 로고    scopus 로고
    • A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer
    • Spaderna S., et al. A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. Gastroenterology 131 (2006) 830-840
    • (2006) Gastroenterology , vol.131 , pp. 830-840
    • Spaderna, S.1
  • 95
    • 39049160267 scopus 로고    scopus 로고
    • The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer
    • Spaderna S., et al. The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res. 68 (2008) 537-544
    • (2008) Cancer Res. , vol.68 , pp. 537-544
    • Spaderna, S.1
  • 96
    • 38349023012 scopus 로고    scopus 로고
    • Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
    • Vesuna F., et al. Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer. Biochem. Biophys. Res. Commun. 367 (2008) 235-241
    • (2008) Biochem. Biophys. Res. Commun. , vol.367 , pp. 235-241
    • Vesuna, F.1
  • 97
    • 40149110961 scopus 로고    scopus 로고
    • Overexpression of Slug is associated with malignant progression of esophageal adenocarcinoma
    • Jethwa P., et al. Overexpression of Slug is associated with malignant progression of esophageal adenocarcinoma. World J. Gastroenterol. 14 (2008) 1044-1052
    • (2008) World J. Gastroenterol. , vol.14 , pp. 1044-1052
    • Jethwa, P.1
  • 98
    • 40249113328 scopus 로고    scopus 로고
    • Direct regulation of TWIST by HIF-1a promotes metastasis
    • 10.1038/ncb1691 http://www.nature.com/ncb/index.html
    • Yang M.-H., et al. Direct regulation of TWIST by HIF-1a promotes metastasis. Nat. Cell Biol (2008). http://www.nature.com/ncb/index.html 10.1038/ncb1691 http://www.nature.com/ncb/index.html
    • (2008) Nat. Cell Biol
    • Yang, M.-H.1
  • 99
    • 47549086944 scopus 로고    scopus 로고
    • Precise measurement of the E-cadherin repressor Snail in formalin-fixed endometrial carcinoma using protein lysate microarrays
    • 10.1007/s10585-008-9149-3 http://www.springerlink.com/content/100126/
    • Hipps S., et al. Precise measurement of the E-cadherin repressor Snail in formalin-fixed endometrial carcinoma using protein lysate microarrays. Clin. Exp. Metast. (2008). http://www.springerlink.com/content/100126/ 10.1007/s10585-008-9149-3 http://www.springerlink.com/content/100126/
    • (2008) Clin. Exp. Metast.
    • Hipps, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.