Tumor environment: A potent driving force in colorectal cancer?

Trends in Molecular Medicine

Volumn 7, Issue 12, 2001, Pages 535-537

  Barker, Nick ^a   Clevers, Hans ^b  

^a Semaia Pharmaceuticals   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN;

CANCER INVASION; CARCINOGENESIS; CELL ADHESION; COLORECTAL CANCER; DNA REPAIR; GENE MUTATION; HUMAN; METASTASIS; ONCOGENE; PROTEIN LOCALIZATION; REVIEW; TUMOR GROWTH; TUMOR MODEL; TUMOR SUPPRESSOR GENE;

ADENOMATOUS POLYPOSIS COLI PROTEIN; BETA CATENIN; CADHERINS; CELL ADHESION; COLORECTAL NEOPLASMS; CYTOSKELETAL PROTEINS; DISEASE PROGRESSION; HUMANS; ONCOGENES; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 0035194206     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(01)02215-8     Document Type: Review

References (17)

1. The hallmarks of cancer
2. Linking colorectal cancer to Wnt signalling
3. Lessons from hereditary colorectal cancer
4. Expression of nuclear β-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas
5. Patterning and nuclear β-catenin expression in the colonic adenoma-carcinoma sequence
6. Variable β-catenin progression in colorectal cancers indicates tumor progression driven by the tumor environment
7. Down-regulation of β-catenin Tcf signalling is linked to colonic epithelial cell differentiation
8. Restoration of epithelial cell polarity in a colorectal cancer cell line by suppression of β-catenin/T-cell factor 4-mediated gene transactivation
9. β-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
10. The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors
11. Expression of CD44 in Apc and Tcf mutant mice implies regulation by the Wnt pathway
12. The Wnt/Wg signal transducer β-catenin controls fibronectin expression
13. Target genes of β-catenin-T cell-factor/lymphoid-enhancer factor signalling in human colorectal carcinomas
14. Suppression of β-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells
15. -/- human colon carcinoma cells
16. Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells
17. Methylation patterns of the E-cadherin 5′CpG island are unstable and reflect the dynamic, heterogenous loss of E-cadherin expression during metastatic progression