The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation

Cancer Research

Volumn 65, Issue 24, 2005, Pages 11605-11612

  Conacci Sorrell, Maralice ^a   Kaplan, Anna ^a   Raveh, Shani ^a   Gavert, Nancy ^b   Sakurai, Takeshi ^a   Ben Ze'ev, Avri ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CELL ADHESION MOLECULE; EXTRACELLULAR MATRIX RECEPTOR; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; NR CAM; NR CAM FC FUSION PROTEIN; PROTEIN KINASE B; RECEPTOR; RETROVIRUS VECTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CARCINOGENICITY; CELL ADHESION; CELL MOTILITY; CELL PROLIFERATION; CELL PROTECTION; CELL STRAIN 3T3; CELL TRANSFORMATION; COLON CARCINOMA; CONTROLLED STUDY; CULTURE MEDIUM; ECTODOMAIN; EXTRACELLULAR MATRIX; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MELANOMA; MELANOMA B16; MOUSE; NERVE CELL GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, NORTHERN; CELL ADHESION; CELL ADHESION MOLECULES; CELL MOVEMENT; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHO CELLS; CRICETINAE; CULTURE MEDIA, CONDITIONED; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; HUMANS; INTEGRIN ALPHA4BETA1; KIDNEY; MELANOMA, EXPERIMENTAL; METALLOPROTEASES; MICE; NIH 3T3 CELLS; PROTO-ONCOGENE PROTEINS C-AKT; RETROVIRIDAE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 29244479537     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-2647     Document Type: Article

References (38)

1. Polakis P. Wnt signaling and cancer. Genes Dev 2000;14:1837-51.
2. Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell 2000;103:311-20.
3. Conacci-Sorrell ME, Ben-Yedidia T, Shtutman M, Feinstein E, Einat P, Ben-Ze'ev A. Nr-CAM is a target gene of the β-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Genes Dev 2002;16:2058-72.
4. Conacci-Sorrell M, Zhurinsky J, Ben-Ze'ev A. The cadherin-catenin adhesion system in signaling and cancer. J Clin Invest 2002;109:987-91.
5. Chen D, Xu W, Bales E, Colmenares C, et al. SKI activates Wnt/β-catenin signaling in human melanoma. Cancer Res 2003;63:6626-34.
6. Grumet M. Nr-CAM: a cell adhesion molecule with ligand and receptor functions. Cell Tissue Res 1997;290: 423-8.
7. Grumet M, Mauro V, Burgoon MP, Edelman GM, Cunningham BA. Structure of a new nervous system glycoprotein, Nr-CAM, and its relationship to subgroups of neural cell adhesion molecules. J Cell Biol 1991;113: 1399-412.
8. Stoeckli ET, Landmesser LT. Axonin-1, Nr-CAM, and Ng-CAM play different roles in the in vivo guidance of chick commissural neurons. Neuron 1995;14:1165-79.
9. Perrin F, Rathjen F, Stoeckli E. Distinct subpopulations of sensory afferents require F11 or axonin-1 for growth to their target layers within the spinal cord of the chick. Neuron 2001;30:707-23.
10. Morales G, Hubert M, Brummendorf T, et al. Induction of axonal growth by heterophilic interactions between the cell surface recognition proteins F11 and Nr-CAM/Bravo. Neuron 1993;11:1113-22.
11. Sakurai T, Lustig M, Babiarz J, et al. Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development. J Cell Biol 2001;154:1259-73.
12. Volkmer H, Leuschner R, Zacharias U, Rathjen F. Neurofascin induces neuntes by heterophilic interactions with axonal NrCAM while NrCAM requires F11 on the axonal surface to extend neuntes. J Cell Biol 1996;135:1059-69.
13. Sakurai T, Lustig M, Nativ M, et al. Induction of neunte outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase β. J Cell Biol 1997;136:907-18.
14. Zacharias UA, Norenberg U, Rathjen FG. Functional interactions of the immunoglobulin superfamily member F11 are differentially regulated by the extracellular matrix proteins tensacin-R and tenascin-C. J Biol Chem 1999;274:24357-65.
15. Dhodapkar K, Friedlander D, Scholes J, Grumet M. Differential expression of the cell-adhesion molecule Nr-CAM in hyperplastic and neoplastic human pancreatic tissue. Hum Pathol 2001;32:396-400.
16. Sakurai T, Roonprapunt C, Grumet M. Purification of Ig-fusion proteins from medium containing Ig. Biotechniques 1998;25:382-5.
17. Damalas A, Kahan S, Shtutman M, Ben-Ze'ev A, Oren M. Deregulated β-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBO J 2001;20:4912-22.
18. Zhurinsky J, Shtutman M, Ben-Ze'ev A. Differential mechanisms of LEF/TCF family-dependent transcriptional activation by β-catenin and plakoglobin. Mol Cell Biol 2000;20:4238-52.
19. Mechtersheimer S, Gutwein P, Agmon-Levin N, et al. Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins. J Cell Biol 2001;155:661-73.
20. Kayyem JF, Roman JM, de la Rosa EJ, Schwarz U, Dreyer WJ. Bravo/Nr-CAM is closely related to the cell adhesion molecules L1 and Ng-CAM and has a similar heterodimer structure. J Cell Biol 1992;118: 1259-70.
21. Voura E, Ramjeesingh R, Montgomery A, Siu C. Involvement of integrin α(v)β(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells. Mol Biol Cell 2001;12:2699-710.
22. Silletti S, Yebra M, Perez B, Cirulli V, McMahon M, Montgomery AM. Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. J Biol Chem 2004;279:28880-8.
23. Gavert N, Conacci-Sorrell M, Gast D, et al. L1, a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J Cell Biol 2005;168:633-42.
24. Schaefer AW, Kamiguchi H, Wong EV, Beach CM, Landreth G, Lemmon V. Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization. J Biol Chem 1999;274: 37965-73.
25. Schmid RS, Pruitt WM, Maness PF. A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis. J Neurosci 2000;20:4177-88.
26. Maretzky T, Reiss K, Ludwig A, et al. ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and β-catenin translocation. Proc Natl Acad Sci U S A 2005;102:9182-7.
27. Reiss K, Maretzky T, Ludwig A, et al. ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and β-catenin nuclear signalling. EMBO J 2005;24:742-52.
28. Beer S, Oleszewski M, Gutwein P, Geiger C, Altevogt P. Metalloproteinase-mediated release of the ectodomain of L1 adhesion molecule. J Cell Sci 1999;112:2667-75.
29. Gutwein P, Oleszewski M, Mechtersheimer S, Agmon-Levin N, Krauss K, Altevogt P. Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells. J Biol Chem 2000;275:15490-7.
30. Crawford H, Fingleton B, Rudolph-Owen L, et al. The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors. Oncogene 1999;18: 2883-91.
31. Brabletz T, Jung A, Dag S, Hlubek F, Kirchner T. β-Catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol 1999;155:1033-8.
32. Takahashi M, Tsunoda T, Seiki M, Nakamura Y, Furukawa Y. Identification of membrane-type matrix metalloproteinase-1 as a target of the β-catenin/Tcf4 complex in human colorectal cancers. Oncogene 2002;21:5861-7.
33. Hlubek F, Spaderna S, Jung A, Kirchner T, Brabletz T. β-Catenin activates a coordinated expression of the proinvasive factors laminin-5 γ2 chain and MT1-MMP in colorectal carcinomas. Int J Cancer 2004;108:321-6.
34. Oleszewski M, Beer S, Katich S, et al. Integrin and neurocan binding to L1 involves distinct Ig domains. J Biol Chem 1999;274:24602-10.
35. Liu ZJ, Herlyn M. Slit-Robo: neuronal guides signal in tumor angiogenesis. Cancer Cell 2003;4:1-2.
36. Chedotal A, Kerjan G, Moreau-Fauvarque C. The brain within the tumor: new roles for axon guidance molecules in cancers. Cell Death Differ 2005;12:1044-56.
37. Glienke J, Schmitt A, Pilarsky C, et al. Differential gene expression by endothelial cells in distinct angiogenic states. Eur J Biochem 2000;267:2820-30.
38. Aitkenhead M, Wang SJ, Nakatsu MN, Mestas J, Heard C, Hughes CC. Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (β)ig-h3, and NrCAM. Microvasc Res 2002;63:159-71.