CLIP Identifies Nova-Regulated RNA Networks in the Brain

Science

Volumn 302, Issue 5648, 2003, Pages 1212-1215

  Ule, Jernej ^a   Jensen, Kirk B ^a   Ruggiu, Matteo ^a   Mele, Aldo ^a   Ule, Aljaž ^b   Darnell, Robert B ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CROSSLINKING; IMMUNOLOGY; ORGANIC ACIDS; PRECIPITATION (CHEMICAL); PROTEINS;

NEURONAL INHIBITION;

RNA;

4 AMINOBUTYRIC ACID RECEPTOR; BRAIN PROTEIN; GEPHYRIN; GLYCINE RECEPTOR; MESSENGER RNA PRECURSOR; MITOGEN ACTIVATED PROTEIN KINASE P38; NEOGENIN; PHOSPHORUS 32; PROTEIN NOVA; RNA; RNA BINDING PROTEIN; SMALL NUCLEAR RIBONUCLEOPROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; COVALENT BOND; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PARANEOPLASTIC OPSOCLONUS MYOCLONUS ATAXIA; PARANEOPLASTIC SYNDROME; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN RNA BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; RNA SPLICING; SYNAPSE; ULTRAVIOLET RADIATION; WESTERN BLOTTING;

3' UNTRANSLATED REGIONS; ALTERNATIVE SPLICING; ANIMALS; ANTIGENS, NEOPLASM; BRAIN; CARRIER PROTEINS; EXONS; INTRONS; MEMBRANE PROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 9; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE TISSUE PROTEINS; NEURAL INHIBITION; NEURONS; PRECIPITIN TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA PRECURSORS; RNA, MESSENGER; RNA-BINDING PROTEINS; ULTRAVIOLET RAYS;

ANIMALIA;

EID: 0242497663     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1090095     Document Type: Article

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35. K.B.J. developed the CLIP methodology. We thank N. Heintz, L. Jan, and H. Zoghbi for helpful comments on the manuscript and members of the lab, especially J. C. Darnell, B. K. Dredge, and G. Stefani, for their help and insight throughout this work. Supported by the NIN (K01 MH64753 to K.B.J. and R01 NS34389 and NS40955 to R.B.D.), the Howard Hughes Medical Institute, a Human Frontiers Science Program fellowship (M.R.), and the tumor immunology program of Cancer Research Institute (J.U.). R.B.D. is an Investigator of the Howard Hughes Medical Institute.