High-affinity hnRNP A1 binding sites and duplex-forming inverted repeats have similar effects on 5′ splice site selection in support of a common looping out and repression mechanism

RNA

Volumn 8, Issue 8, 2002, Pages 1078-1089

  Nasim, Faiz Ul Hassan ^a   Hutchison, Stephen ^a   Cordeau, Mélanie ^a   Chabot, Benoit ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

Alternative splicing; hnRNP A1; Pre mRNA; RNA duplex

Indexed keywords

ARTICLE; BINDING SITE; COMPLEX FORMATION; DNA FLANKING REGION; ENHANCER REGION; EXON; GENE REPRESSION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; RECEPTOR AFFINITY; RECEPTOR BINDING;

BASE SEQUENCE; BINDING SITES; HELA CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP A-B; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; MODELS, BIOLOGICAL; MUTATION; PROTEIN BINDING; REPETITIVE SEQUENCES, NUCLEIC ACID; RIBONUCLEOPROTEINS; RNA PRECURSORS; RNA SPLICING;

MAMMALIA;

EID: 0036674179     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838202024056     Document Type: Article

References (40)

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2. Control of 3′ splice site choice in vivo by ASF/SF2 and hnRNP A1
3. RNA splicing at human immunodeficiency virus type 1 3′ splice site A2 is regulated by binding of hnRNP A/B proteins to an exonic splicing silencer element
4. Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization
5. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors
6. hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing
7. hnRNP A1 selectively interacts through its Gly-rich domain with different RNA-binding proteins
8. Synthesis and purification of RNA substrates
9. An intron element modulating 5′ splice site selection in the hnRNP A1 pre-mRNA interacts with hnRNP A1
10. Intramolecular structure in yeast introns aids the early steps of in vitro spliceosome assembly
11. Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing
12. The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5′ splice site
13. hnRNP A1 recruited to an exon in vivo can function as an exon splicing silencer
14. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
15. Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA
16. Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ASF
17. Selection of alternative 5′ splice sites: Role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1
18. The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing
19. Mutation of an RSV intronic element abolishes both U11/U12 snRNP binding and negative regulation of splicing
20. Sorting out the complexity of SR protein functions
21. Intron self-complementarity enforces exon inclusion in a yeast pre-mRNA
22. Alternative splicing of hnRNP A1: Complex control of a simple splicing event
23. Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA
24. Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes
25. A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding
26. TIA-1 and TIAR activate splicing of alternative exons with weak 5′ splice sites followed by a U-rich stretch on their own pre-mRNAs
27. RNA structural patterns and splicing: Molecular basis for an RNA-based enhancer
28. Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF
29. Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2
30. Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins
31. Heterogeneous nuclear ribonucleoprotein A1 catalyzes RNA.RNA annealing
32. Specific accessory sequences in Saccharomyces cerevisiae introns control assembly of pre-mRNAs into spliceosomes
33. Renaturation of complementary DNA strands mediated by purified mammalian heterogeneous nuclear ribonucleoprotein A1 protein: Implications for a mechanism for rapid molecular assembly
34. Control of hnRNP A1 alternative splicing: An intron element represses use of the common 3′ splice site
35. Amount of RNA secondary structure required to induce an alternative splice
36. Functions of SR and Tra2 proteins in pre-mRNA splicing regulation
37. The hnRNP A1 protein regulates HIV-1 tat splicing via a novel intron silencer element
38. Post-transcriptional regulation: The dawn of PTB
39. B proteins of heterogeneous nuclear ribonucleoparticles modulate 5′ splice site selection in vivo
40. Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins