Genes involved in stem cell fate decisions and commitment to differentiation play a role in skin disease

Journal of Investigative Dermatology Symposium Proceedings

Volumn 9, Issue 3, 2004, Pages 261-268

  Honeycutt, Kimberly A ^a   Koster, Maranke I ^a   Roop, Dennis R ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

c Myc; Epidermal differentiation; p63; Stem cells

Indexed keywords

MYC PROTEIN; PROTEIN P53; TRANSFORMING GROWTH FACTOR BETA;

CARBOXY TERMINAL SEQUENCE; CELL; CELL DIFFERENTIATION; CELL FATE; CELL MATURATION; CELL RENEWAL; CONFERENCE PAPER; EPIDERMIS CELL; HAIR FOLLICLE; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SKIN DISEASE; SQUAMOUS CELL; STEM CELL;

EID: 4243165543     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1087-0024.2004.09312.x     Document Type: Conference Paper

References (104)

1. Andl T, Reddy ST, Gaddapara T, Millar SE: WNT signals are required for the initiation of hair follicle development. Dev Cell 2:643-653, 2002
2. Arnold I, Watt FM: c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr Biol 11:558-568, 2001
3. Aviv T, Lin Z, Lau S, Rendl LM, Sicheri F, Smibert CA: The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators. Nat Struct Biol 10:614-621, 2003
4. Bakkers J, Hild M, Kramer C, Furutani-Seiki M, Hammerschmidt M: Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm. Dev Cell 2:617-627, 2002
5. Barrera FN, Poveda JA, Gonzalez-Ros JM, Neira JL: Binding of the C-terminal SAM domain of human p73 to lipid membranes. J Biol Chem 278:46878-46885, 2003
6. Baudino TA, McKay C, Pendeville-Samain H, et al: c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev 16:2530-2543, 2002
7. Bian J, Sun Y: p53CP, a putative p53 competing protein that specifically binds to the consensus p53 DNA binding sites: A third member of the p53 family? Proc Natl Acad Sci USA 94:14753-14758, 1997
8. Bishop JM: Molecular themes in oncogenesis. Cell 64:235-248, 1991
9. Bouchard C, Thieke K, Maier A, et al: Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27. EMBO J 18:5321-5333, 1999
10. Brunner HG, Hamel BC, Bokhoven HH: P63 gene mutations and human developmental syndromes. Am J Med Genet 112:284-290, 2002
11. Celli J, Duijf P, Hamel BC, et al: Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome. Cell 99:143-153, 1999
12. Chi SW, Ayed A, Arrowsmith CH: Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain. EMBO J 18:4438-4445, 1999
13. Chin L, Schreiber-Agus N, Pellicer I, et al: Contrasting roles for Myc and Mad proteins in cellular growth and differentiation. Proc Natl Acad Sci USA 92:8488-8492, 1995
14. Choi HR, Batsakis JG, Zhan F, Sturgis E, Luna MA, El Naggar AK: Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis. Hum Pathol 33:158-164, 2002
15. Coller HA, Grandori C, Tamayo P, Colbert T, Lander ES, Eisenman RN, Golub TR: Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci USA 97:3260-3265, 2000
16. Cotter FE: Molecular pathology of lymphomas. Cancer Surv 16:157-174, 1993
17. Crook T, Nicholls JM, Brooks L, O'Nions J, Allday MJ: High level expression of deltaN-p63: A mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)? Oncogene 19:3439-3444, 2000
18. Delehedde M, Cho SH, Sarkiss M, Brisbay S, Davies M, El Naggar AK, McDonnell TJ: Altered expression of bcl-2 family member proteins in nonmelanoma skin cancer. Cancer 85:1514-1522, 1999
19. Dellambra E, Golisano O, Bondanza S, et al: Downregulation of 14-3-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes. J Cell Biol 149:1117-1130, 2000
20. Di Como CJ, Urist MJ, Babayan I, et al: p63 expression profiles in human normal and tumor tissues. Clin Cancer Res 8:494-501, 2002
21. Dietz S, Rother K, Bamberger C, Schmale H, Mossner J, Engeland K: Differential regulation of transcription and induction of programmed cell death by human p53-family members p63 and p73. FEBS Lett 525:93-99, 2002
22. Dohn M, Jiang J, Chen X: Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis. Oncogene 20:6503-6515, 2001a
23. Dohn M, Zhang S, Chen X: p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes. Oncogene 20:3193-3205, 2001b
24. Dunnwald M, Tomanek-Chalkley A, Alexandrunas D, Fishbaugh J, Bickenbach JR: Isolating a pure population of epidermal stem cells for use in tissue engineering. Exp Dermatol 10:45-54, 2001
25. Fernandez PC, Frank SR, Wang L, et al: Genomic targets of the human c-Myc protein. Genes Dev 17:1115-1129, 2003
26. Flores ER, Tsai KY, Crowley D, Sengupta S, Yang A, McKeon F, Jacks T: p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 416:560-564, 2002
27. Fomenkov A, Huang YP, Topaloglu O, et al: P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome. J Biol Chem 278:23906-23914, 2003
28. Fontemaggi G, Kela I, Amariglio N, et al: Identification of direct p73 target genes cpmbining DNA microarray and chromatin immunoprecipitation analyses. J Biol Chem 277:43359-43368, 2002
29. Frye M, Gardner C, Li ER, Arnold I, Watt FM: Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment. Development 130:2793-2808, 2003
30. Gandarillas A, Watt FM: c-Myc promotes differentiation of human epidermal stem cells. Genes Dev 11:2869-2882, 1997
31. Gat U, DasGupta R, Degenstein L, Fuchs E: De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 95:605-614, 1998
32. Gazdar AF: The molecular and cellular basis of human lung cancer. Anticancer Res 14:261-267, 1994
33. Gebhart E, Liehr T: Patterns of genomic imbalances in human solid tumors (review). Int J Oncol 16:383-399, 2000
34. Green JB, Gardner CD, Wharton RP, Aggarwal AK: RNA recognition via the SAM domain of Smaug. Mol Cell 11:1537-1548, 2003
35. Hatton KS, Mahon K, Chin L, et al: Expression and activity of L-Myc in normal mouse development. Mol Cell Biol 16:1794-1804, 1996
36. Hermeking H, Rago C, Schuhmacher M, et al: Identification of CDK4 as a target of c-MYC. Proc Natl Acad Sci USA 97:2229-2234, 2000
37. Hibi K, Trink B, Patturajan M, et al: AIS is an oncogene amplified in squamous cell carcinoma. Proc Natl Acad Sci USA 97:5462-5467, 2000
38. Hirning U, Schmid P, Schulz WA, Rettenberger G, Hameister H: A comparative analysis of N-myc and c-myc expression and cellular proliferation in mouse organogenesis. Mech Dev 33:119-125, 1991
39. Honeycutt KA, Roop DR: c-Myc and epidermal stem cell fate determination. J Dermatol, 2003 (in press)
40. Hurlin PJ, Foley KP, Ayer DE, Eisenman RN, Hanahan D, Arbeit JM: Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis. Oncogene 11:2487-2501, 1995
41. Ikawa S, Nakagawara A, Ikawa Y: p53 family genes: Structural comparison, expression and mutation. Cell Death Differ 6:1154-1161, 1999
42. Jain M, Arvanitis C, Chu K, et al: Sustained loss of a neoplastic phenotype by brief inactivation of MYC. Science 297:102-104, 2002
43. Jones PH, Watt FM: Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 73:713-724, 1993
44. Jost CA, Marin MC, Kaelin WG Jr: p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Nature 389:191-194, 1997
45. King KE, Ponnamperuma RM, Yamashita T, Tokino T, Lee LA, Young MF, Weinberg WC: deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes. Oncogene 22:3635-3644, 2003
46. Kopnin B: Genetic events responsible for colorectal tumorigenesis: Achievements and challenges. Tumori 79:235-243, 1993
47. Koster MI, Huntzinger KA, Roop DR: Epidermal differentiation: Transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation. J Investig Dermatol Symp Proc 7:41-45, 2002
48. Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR: p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev, 18:126-131, 2004
49. Koster MI, Roop DR: The role of p63 in development and differentiation of the epidermis. J Dermatol Sci, 34:3-9, 2004
50. Kurita T, Cunha GR: Roles of p63 in differentiation of Mullerian duct epithelial cells. Ann N Y Acad Sci 948:9-12, 2001
51. Lajtha LG: Stem cell concepts. Differentiation 14:23-34, 1979
52. Lee H, Kimelman D: A dominant-negative form of p63 is required for epidermal proliferation in zebrafish. Dev Cell 2:607-616, 2002
53. Li A, Simmons PJ, Kaur P: Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype. Proc Natl Acad Sci USA 95:3902-3907, 1998
54. Liefer KM, Koster MI, Wang XJ, Yang A, McKeon F, Roop DR: Down-regulation of p63 is required for epidermal UV-B-induced apoptosis. Cancer Res 60:4016-4020, 2000
55. Massion PP, Taflan PM, Jamshedur Rahman SM, et al: Significance of p63 amplification and overexpression in lung cancer development and prognosis. Cancer Res 63:7113-7121, 2003
56. McGrath JA, Duijf PH, Doetsch V, et al: Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63. Hum Mol Genet 10:221-229, 2001
57. Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A: p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398:708-713, 1999
58. Missero C, Calautti E, Eckner R, Chin J, Tsai LH, Livingston DM, Dotto GP: Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. Proc Natl Acad Sci USA 92:5451-5455, 1995
59. Mugrauer G, Alt FW, Ekblom P: N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization. J Cell Biol 107:1325-1335, 1988
60. Nass SJ, Dickson RB: Defining a role for c-Myc in breast tumorigenesis. Breast Cancer Res Treat 44:1-22, 1997
61. Nass SJ, Li M, Amundadottir LT, Furth PA, Dickson RB: Role for Bcl-xL in the regulation of apoptosis by EGF and TGF beta 1 in c-myc overexpressing mammary epithelial cells. Biochem Biophys Res Commun 227:248-256, 1996
62. Nesbit CE, Tersak JM, Prochownik EV: MYC oncogenes and human neoplastic disease. Oncogene 18:3004-3016, 1999
63. Nishi H, Isaka K, Sagawa Y, et al: Mutation and transcription analyses of the p63 gene in cervical carcinoma. Int J Oncol 15:1149-1153, 1999
64. Nishi H, Senoo M, Nishi KH, et al: p53 homologue p63 represses epidermal growth factor receptor expression. J Biol Chem 276:41717-41724, 2001
65. Nylander K, Coates PJ, Hall PA: Characterization of the expression pattern of p63 alpha and delta Np63 alpha in benign and malignant oral epithelial lesions. Int J Cancer 87:368-372, 2000
66. Nylander K, Vojtesek B, Nenutil R, et al: Differential expression of p63 isoforms in normal tissues and neoplastic cells. J Pathol 198:417-427, 2002
67. Okada Y, Osada M, Kurata S, et al: p53 gene family p51(p63)-encoded, secondary transactivator p51B(TAp63alpha) occurs without forming an immunoprecipitable complex with MDM2, but responds to genotoxic stress by accumulation. Exp Cell Res 276:194-200, 2002
68. Osada M, Ohba M, Kawahara C, et al: Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat Med 4:839-843, 1998
69. Oshima H, Rochat A, Kedzia C, Kobayashi K, Barrandon Y: Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell 104:233-245, 2001
70. Owens DM, Watt FM: Contribution of stem cells and differentiated cells to epidermal tumours. Nat Rev Cancer 3:444-451, 2003
71. Park BJ, Lee SJ, Kim JI, et al: Frequent alteration of p63 expression in human primary bladder carcinomas. Cancer Res 60:3370-3374, 2000
72. Parsa R, Yang A, McKeon F, Green H: Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol 113:1099-1105, 1999
73. Pelengaris S, Khan M: The many faces of c-MYC. Arch Biochem Biophys 416:129-136, 2003
74. Pelengaris S, Khan M, Evan GI: Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 109:321-334, 2002
75. Pelengaris S, Littlewood T, Khan M, Elia G, Evan G: Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol Cell 3:565-577, 1999
76. Pellegrini G, Dellambra E, Golisano O, et al: p63 identifies keratinocyte stem cells. Proc Natl Acad Sci USA 98:3156-3161, 2001
77. Perez-Losada J, Balmain A: Stem-cell hierarchy in skin cancer. Nat Rev Cancer 3:434-443, 2003
78. Petiot A, Conti FJ, Grose R, Revest JM, Hodivala-Dilke KM, Dickson C: A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Development 130:5493-5501, 2003
79. Redon R, Muller D, Caulee K, Wanherdrick K, Abecassis J, Du MS: A simple specific pattern of chromosomal aberrations at early stages of head and neck squamous cell carcinomas: PIK3CA but not p63 gene as a likely target of 3q26-qter gains. Cancer Res 61:4122-4129, 2001
80. Reis-Filho JS, Simpson PT, Martins A, Preto A, Gartner F, Schmitt FC: Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray. Virchows Arch, 443:122-132, 2003
81. Reis-Filho JS, Torio B, Albergaria A, Schmitt FC: p63 expression in normal skin and usual cutaneous carcinomas. J Cutan Pathol 29:517-523, 2002
82. Saccone C, Barome PO, D'Erchia AM, D'Errico I, Pesole G, Sbisa E, Tullo A: Molecular strategies in Metazoan genomic evolution. Gene 300:195-201, 2002
83. Sasaki Y, Ishida S, Morimoto I, et al: The p53 family member genes are involved in the Notch signal pathway. J Biol Chem 277:719-724, 2001
84. Schultz J, Ponting CP, Hofmann K, Bork P: SAM as a protein interaction domain involved in developmental regulation. Protein Sci 6:249-253, 1997
85. Staller P, Peukert K, Kiermaier A, et al: Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol 3:392-399, 2001
86. Steinman RA, Hoffman B, Iro A, Guillouf C, Liebermann DA, el Houseini ME: Induction of p21 (WAF-1/CIP1) during differentiation. Oncogene 9:3389-3396, 1994
87. Sunahara M, Shishikura T, Takahashi M, et al: Mutational analysis of p51A/ TAp63gamma, a p53 homolog, in non-small cell lung cancer and breast cancer. Oncogene 18:3761-3765, 1999
88. Tani H, Morris RJ, Kaur P: Enrichment for murine keratinocyte stem cells based on cell surface phenotype. Proc Natl Acad Sci USA 97:10960-10965, 2000
89. Taylor G, Lehrer MS, Jensen PJ, Sun TT, Lavker RM: Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell 102:451-461, 2000
90. Trempus CS, Morris RJ, Bortner CD, Cotsarelis G, Faircloth RS, Reece JM, Tennant RW: Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol 120:501-511, 2003
91. van Genderen C, Okamura RM, Farinas I, Quo RG, Parslow TG, Bruhn L, Grosschedl R: Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev 8:2691-2703, 1994
92. Waikel RL, Kawachi Y, Waikel PA, Wang XJ, Roop DR: Deregulated expression of c-Myc depletes epidermal stem cells. Nat Genet 28:165-168, 2001
93. Waikel RL, Wang XJ, Roop DR: Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis. Oncogene 18:4870-4878, 1999
94. Weber A, Bellmann U, Bootz F, Wittekind C, Tannapfel A: Expression of p53 and its homologues in primary and recurrent squamous cell carcinomas of the head and neck. Int J Cancer 99:22-28, 2002
95. Westfall MD, Mays DJ, Sniezek JC, Pietenpol JA: The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Mol Cell Biol 23:2264-2276, 2003
96. Wu G, Nomoto S, Hoque MO, et al: DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development. Cancer Res 63:2351-2357, 2003
97. Yamaguchi K, Wu L, Caballero OL, et al: Frequent gain of the p40/p51/p63 gene locus in primary head and neck squamous cell carcinoma. Int J Cancer 86:684-689, 2000
98. Yang A, Kaghad M, Caput D, McKeon F: On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet 18:90-95, 2002
99. Yang A, Kaghad M, Wang Y, et al: p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 2:305-316, 1998
100. Yang A, Schweitzer R, Sun D, et al: p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398:714-718, 1999
101. Yang A, Walker N, Bronson R, et al: p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404:99-103, 2000
102. Zeng X, Levine AJ, Lu H: Non-p53 p53RE binding protein, a human transcription factor functionally analogous to P53. Proc Natl Acad Sci USA 95:6681-6686, 1998
103. Zhou P, Byrne C, Jacobs J, Fuchs E: Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. Genes Dev 9:700-713, 1995
104. Zimmerman KA, Yancopoulos GD, Collum RG, et al: Differential expression of myc family genes during murine development. Nature 319:780-783, 1986