Characterization of the expression pattern of p63α and ΔNp63α in benign and malignant oral epithelial lesions

International Journal of Cancer

Volumn 87, Issue 3, 2000, Pages 368-372

  Nylander, Karin ^a   Coates, Philip J ^b   Hall, Peter A ^b  

^a UMEÅ UNIVERSITY   (Sweden)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; ISOPROTEIN; PROTEIN P53;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE OVEREXPRESSION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; LICHEN PLANUS; MOUTH CARCINOMA; MOUTH LESION; MOUTH MUCOSA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; ANTIGENS, NEOPLASM; CARCINOMA, SQUAMOUS CELL; DNA-BINDING PROTEINS; EPITOPES; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; HYPERPLASIA; LICHEN PLANUS, ORAL; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MOUTH DISEASES; MOUTH MUCOSA; MOUTH NEOPLASMS; NEOPLASM PROTEINS; PHOSPHOPROTEINS; PROTEIN ISOFORMS; RABBITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0034255855     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20000801)87:3<368::AID-IJC9>3.0.CO;2-J     Document Type: Article

References (18)

1. BJORKQVIST, A.M., HUSGAFVEL-PURSIAINEN, K., ANTTILA, S., KARJALAINEN, A., TAMMILEHTO, L., MATTSON, K., VAINIO, H. and KNUUTILA, S., DNA gains in 3q occur frequently in squamous-cell carcinoma of the lung, but not in adenocarcinoma. Genes Chromosomes Cancer, 22, 79-82 (1998).
2. BOCKMÜHL, U., SCHWENDEL, A., DIETEL, M. and PETERSEN, I., Distinct patterns of chromosomal alterations in high- and low-grade head-and-neck squamous-cell carcinomas. Cancer Res., 56, 5325-5329 (1996).
3. BRAY, S.E., SCHORL, C., and HALL, P.A., The challenge of p53: linking biochemistry, biology and patient management. Stem Cells, 16, 248-260 (1998).
4. DE LAURENZI, V., CONSTANZO, A., BARCAROLI, D., TERRINONI, A., FALCO, M., ANNICCHIARICO-PETRUZELLI, M., LEVRERO, M. and MELINO, G., Two new p73 splice variants, gamma and delta, with different transcriptional activity. J. exp. Med., 188, 1763-1768 (1998).
5. HALL, P.A., CAMPBELL, S.J., O'NEILL, M., ROYSTON, D.J., NYLANDER, K., CAREY, F.A. and KERNOHAN, N.M., The expression of the p53 homologue, p63a and ΔNp63α in normal and neoplastic cells. Carcinogenesis (2000). (In press).
6. HAN, S., and 13 OTHERS, Infrequent somatic mutations of the p73 gene in various human cancers. Eur. J. Surg. Oncol., 25, 194-198 (1999).
7. HARLOW, E. and LANE, D.P., Antibodies: a laboratory manual. Cold Spring Harbor Laboratory Press, New York (1998).
8. JOST, C.A., MARIN, M.C. and KAELIN, W.O., JR. p73 is a human p53-related protein that can induce apoptosis. Nature (Lond.), 389, 191-194 (1997).
9. KAGHAD, M. and 12 OTHERS. Mono-allelically expressed gene. Cell, 90, 809-819 (1997).
10. MILLS, A.A., ZHENG, B., WANG, X.J., VOGEL, H., ROOP, D.R. and BRADLEY, A., p63 is a p53 homologue required for limb anb epidermal morphogenesis. Nature (Lond.), 398, 708-713 (1999).
11. NYLANDER, K., BOURDON, J.C., BRAY, S.E., GIBBS, N.K., KAY, R., HART, I. and HALL, P.A., Transcriptional activation of tyrosinase and TRP-1 by p53 links UV irradiation to the protective tanning response. J. Pathol. 190, 39-46, 2000.
12. OSADA, M., OHBA, M., KAWAHARA, C., ISHIOKA, C., KANAMARU, R., KATOH, I., IKAWA, Y., NIMURA, Y., NAKAGAWARA, A., OBINATA, M. and IKAWA, S., Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nature Med., 4, 839-843 (1998).
13. PRIVES, C. and HALL, P.A., The p53 pathway. J. Pathol., 187, 112-126 (1999).
14. SCHMALE, H. and BAMBERGER, C., A novel protein with strong homology to the tumor suppressor p53. Oncogene, 15, 1363-1367 (1997).
15. VAN BOKHOVEN, H. and 13 OTHERS, Limb mammary syndrome: a new genetic disorder with mammary hypoplasia, ectrodactyly and other hand/ foot anomalies maps to human chromosome 3q27. Amer. J. hum. Genet., 64, 538-546 (1999).
16. YANG, A., KAGDAH, M., WANG, Y., GILLETT, E., FLEMING, M.D., DÖTSCH, V., ANDREWS, N.C., CAPUT, D. and MCKEON, F., p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell. 2, 305-316 (1998).
17. YANG, A., SCHWEITZER, R., SUN, D., KAGHAD, M., WALKER, N., BRONSON, R.T., TABIN, C., SHARPE, A., CAPUT, D., CRUM, C. and MCKEON, F., p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature (Lond.), 398, 714-718 (1999).
18. ZHU, J., JIANG, J., ZHOU, W. and CHEN, X., The potential tumor-suppressor p73 differentially regulates cellular p53 target genes. Cancer Res., 58, 5061-5065 (1998).