Deregulated expression of c-Myc depletes epidermal stem cells

Nature Genetics

Volumn 28, Issue 2, 2001, Pages 165-168

  Waikel, Rebekah L ^a   Kawachi, Yasuhiro ^a   Waikel, Patricia A ^a   Wang, Xiao Jing ^a   Roop, Dennis R ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; COMPLEMENTARY DNA; RNA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; EPIDERMIS CELL; EPIDERMIS HYPERPLASIA; GENE EXPRESSION; KERATINOCYTE; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; WOUND HEALING;

ANIMALS; ANTIGENS, CD29; BROMODEOXYURIDINE; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HYPERPLASIA; KERATIN-14; KERATINOCYTES; KERATINS; MICE; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-MYC; SKIN; STEM CELLS; WOUND HEALING;

ANIMALIA; EUKARYOTA;

EID: 0034978920     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/88889     Document Type: Article

References (25)

1. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
2. Identification of c-MYC as a target of the APC pathway
3. c-Myc promotes differentiation of human epidermal stem cells
4. Separation of human epidermal stem cells from transient amplifying cells on the basis of differences in integrin function and expression
5. Myc-Max-Mad: A transcription factor network controlling cell cycle progression, differentiation and death
6. Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis
7. Focal activation of a mutant allele defines the role of stem cells in mosaic skin disorders
8. Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound re-epithelialization
9. Mechanism of human keratinocyte migration on fibronectin: Unique roles of RGD site and integrins
10. Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice
11. Activation of human keratinocyte migration on type I collagen and fibronectin
12. Enrichment for murine keratinocyte stem cells based on cell surface phenotype
13. Association of the decreased expression of α3β1 integrin with the altered cell: Environmental interactions and enhanced soft agar cloning ability of c-Myc-overexpressing small cell lung cancer cells
14. Concomitant down-regulation of expression of integrin subunits by N-Myc in human neuroblastoma cells: Differential regulation of α2, α3 and β1
15. Out of Eden: Stem cells and their niches
16. Label-retaining keratinocytes and Langerhans cells in mouse epithelia
17. Evidence for discrete cell kinetic subpopulations in mouse epidermis based on mathematical analysis
18. Selection and extended growth of murine epidermal stem cells in culture
19. Epidermal stem cells: Markers, patterning and the control of stem cell fate
20. Inhibitory effects of antisense oligodeoxynucleotides targeting c-Myc mRNA on smooth muscle cell proliferation and migration
21. c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny
22. Characterization of an inducible, epidermal-specific knockout system: Differential expression of lacz in different Cre reporter mouse strains
23. TGFα and v-fos cooperation in transgenic mouse epidermis induces aberrant keratinocyte differentiation and stable, autonomous papillomas
24. Impaired energy homeostasis in C/EBP alpha knockout mice
25. Specific epidermal protein markers are modulated during calcium-induced terminal differentiation