Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Parallel synthesis, molecular modelling and structure-activity relationship studies on O-[2-(hetero)arylethyl]-N-phenylthiocarbamates

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 4160-4172

  Cesarini, Sara ^a   Spallarossa, Andrea ^a   Ranise, Angelo ^a   Fossa, Paola ^a   Colla, Paolo La ^b   Sanna, Giuseppina ^b   Collu, Gabriella ^b   Loddo, Roberta ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

HIV 1; Non nucleoside reverse transcriptase inhibitors; Parallel synthesis; Thiocarbamates

Indexed keywords

O [2 (2 PYRIDYL)ETHYL]N (2 CHLOROPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (2 TOLYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (2,4 DICHLOROPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (2,5 DIFLUOROPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (2,6 DIFLUOROPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (3 CHLORO 4 METHYLPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (3 CHLOROPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (3 FLUOROPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (3 NITROPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (3 TOLYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (3,4 DICHLOROPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (3,5 DIFLUOROPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (4 ACETYLPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (4 BROMOPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (4 CHLORO 3 TRIFLUOROMETHYLPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (4 CHLOROPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (4 CYANOPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (4 DIMETHYLAMINOPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (4 ETHYLPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (4 FLUOROPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (4 I PROPYLPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (4 IODOPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (4 METHOXYPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (4 NITROPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (4 TOLYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N (4 TRIFLUOROMETHYLPHENYL)THIOCARBAMATE; O [2 (2 PYRIDYL)ETHYL]N PHENYLTHIOCARBAMATE; RNA DIRECTED DNA POLYMERASE INHIBITOR; THIOCARBAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR MODEL; MUTANT; SIMULATION; STRUCTURE ACTIVITY RELATION; WILD TYPE;

HIV-1; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; NUCLEOSIDES; REVERSE TRANSCRIPTASE INHIBITORS; RNA-DIRECTED DNA POLYMERASE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCARBAMATES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 41649099872     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.12.050     Document Type: Article

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