N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea and N'-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-chloropyridyl)]-thiourea as potent inhibitors of multidrug-resistant human immunodeficiency virus-1

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 18, 1999, Pages 2721-2726

  Uckun, Fatih M ^a   Mao, Chen ^a   Pendergrass, Sharon ^a   Maher, Danielle ^a   Zhu, Dan ^a   Tuel Ahlgren, Lisa ^a   Venkatachalam, T K ^a  

^a PARKER HUGHES INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; N [2 (1 CYCLOHEXENYL)ETHYL] N' [2 (5 BROMOPYRIDYL)]THIOUREA; N [2 (1 CYCLOHEXENYL)ETHYL] N' [2 (5 CHLOROPYRIDYL)]THIOUREA; RNA DIRECTED DNA POLYMERASE; THIOUREA DERIVATIVE; TROVIRDINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MONONUCLEAR CELL; NONHUMAN; STRUCTURE ANALYSIS; VIRUS MUTANT;

AMINOPYRIDINES; ANTI-HIV AGENTS; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MODELS, MOLECULAR; REVERSE TRANSCRIPTASE INHIBITORS; THIOUREA;

HTLV; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0033588963     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00460-6     Document Type: Article

References (11)

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11. 3) δ 178.5, 151.6, 143.9, 138.4, 134.4, 125.0, 124.0, 113.2, 44.0, 36.8, 27.7, 25.4, 22.8, 22.3.