Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5- bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 11, 1999, Pages 1593-1598

  Mao, Chen ^a   Sudbeck, Elise A ^a   Venkatachalam, T K ^a   Uckun, Fatih M ^a  

^a PARKER HUGHES INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DELAVIRDINE; EMIVIRINE; N [2 (2 FLUOROPHENETHYL)] N' [2 (5 BROMOPYRIDYL)]THIOUREA; N [2 (2,5 DIMETHOXYPHENYLETHYL)] N' [2 (5 BROMOPYRIDYL)]THIOUREA; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE; TROVIRDINE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG TARGETING; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONONUCLEAR CELL; NONHUMAN; VIRUS RESISTANCE; VIRUS STRAIN;

ANTI-HIV AGENTS; DELAVIRDINE; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, MOLECULAR; NEVIRAPINE; PYRIDINES; THIOUREA;

HTLV; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0033532653     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00235-8     Document Type: Article

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