Antioxidant function of phenethyl-5-bromo-pyridyl thiourea compounds with potent anti-HIV activity

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 1, 2000, Pages 87-90

  Dong, Yanhong ^a   Venkatachalam, T K ^a   Narla, Rama Krishna ^a   Trieu, Vuong N ^a   Sudbeck, Elise A ^a   Uckun, Fatih M ^a  

^a PARKER HUGHES INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N [2 (2 CHLOROPHENYLETHYL)] N' [2 (5 BROMOPYRIDYL)]THIOUREA; N [2 (2 METHOXYPHENYLETHYL)] N' [2 (5 BROMOPYRIDYL)]THIOUREA; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; OXIDATIVE STRESS; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; ANTIOXIDANTS; B-LYMPHOCYTES; CRYSTALLOGRAPHY, X-RAY; FLOW CYTOMETRY; FLUORESCENCE; FREE RADICAL SCAVENGERS; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; HYDROGEN PEROXIDE; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; THIOUREA;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0034598350     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00581-8     Document Type: Article

References (29)

1. Halliwell B., Cross C.E. Environ. Health Perspect. 102:1994;5-12.
2. Martinez-Cayuela M. Biochimie. 77:1995;147-262.
3. Lee R., Beauparlant P., Elford H., Ponka P., Hiscott J. Virology. 234:1997;277-290.
4. Chanarat N., Chanarat P., Suttajit M., Chiewsilp D. J. Med. Assoc. Thai. 80:1997;S116-S119.
5. Packer L., Cadenas E. Handbook of Synthetic Antioxidants. 1996;Marcel Decker, New York.
6. Pace G.W., Leaf C.D. Free Rad. Biol. Med. 19:1995;523-528.
7. Israel N., Gougerot-Pocidalo M.A. Cell Mol. Life Sci. 53:1997;864-870.
8. Allard J.P., Aghdassi E., Chau J., Salit I., Walmsley S. Am. J. Clin. Nutr. 67:1998;143-147.
9. Malorni W., Rivabene R., Lucia B.M., Ferrara R., Mazzone A.M., Cauda R., Paganelli R. AIDS Res. Hum. Retroviruses. 14:1998;1589-1596.
10. Dobmeyer T.S., Findhammer S., Dobmeyer J.M., Klein S.A., Raffel B., Hoelzer D., Helm E.B., Kabelitz D., Rossol R. Free Rad. Bio. Med. 22:1997;775-785.
11. Raju P.A., Herzenberg L.A., Herzenberg L.A., Roederer M. AIDS Res. Hum. Retroviruses. 10:1994;961-967.
12. Aillet F., Gougerot-Pocidalo M.A., Virelizier J.L., Israel N. AIDS Res. Hum. Retroviruses. 10:1994;405-411.
13. Staal F.J., Roederer M., Raju P.A., Anderson M.T., Ela S.W., Herzenberg L.A., Herzenberg L.A. AIDS Res. Hum. Retroviruses. 9:1993;299-306.
14. Allard J.P., Aghdassi E., Chau J., Tam C., Kovacs C.M., Salit I.E., Walmsley S.L. AIDS. 12:1998;1653-1659.
15. Miller N.J., Rice-Evans C., Davies M.J., Gopinathan V., Milner A. Clinical Science. 84:1993;407-412.
16. Yuan L., Inoue S., Saito Y., Nakajima O. Exp. Cell Res. 209:1993;375-381.
17. Casado J.A., Merino J., Cid J., Subira M.L., Sanchez-Ibarrola A. J. Immunol. Methods. 159:1993;173-176.
18. Model M.A., Kuruga M.A.J. Immunol. Methods. 202:1997;105-111.
19. Kalinich J.F., Ramakrishnan N., McClain D.E. Free Rad. Res. 26:1997;37-47.
20. Wasil M., Halliwell B., Grootveld M., Moorhouse C.P., Hutchison D.C.S., Baum H. Biochem. J. 243:1987;867-870.
21. Fox R.B. J. Clin. Invest. 74:1984;1456-1464.
22. Curtis W.E., Muldrow M.E., Parker N.B., Barkley R., Linas S.L., Repine J.E. Proc. Natl. Acad. Sci. USA. 85:1988;3422-3425.
23. Beehler C.J., Simchuk M.L., McCord J.M., Repine J.E. J. Lab. Clin. Med. 119:1992;508-513.
24. Kelner M.J., Bagnell R., Welch K.J. J. Biol. Chem. 265:1990;1306-1311.
25. Lai Y.-L., Wu H.-D., Chen C.-F. J. Cardiovascular Pharmacology. 32:1998;714-720.
26. Vig R., Mao C., Venkatachalam T.K., Tuel-Ahlgren L., Sudbeck E.A., Uckun F.M. Bioorg. Med. Chem. 6:1998;1789-1797.
27. Mao C., Vig R., Venkatachalam T.K., Sudbeck E.A., Uckun F.M. Bioorg. Med. Chem. Lett. 8:1998;2213-2218.
28. 3S): 385.4; found: 385.9.
29. Hicks M., Wong L.S., Day R.O. Biochem. Pharmacol. 43:1992;439-444.