-
6
-
-
0029951587
-
Non-nucleoside anti-HIV-1 reverse transcriptase inhibitors (NNRTts): A chemical survey from lead compounds to selected drugs for clinical trials
-
(1996)
Farmaco
, vol.51
, pp. 305-331
-
-
Artico, M.1
-
8
-
-
0029011730
-
Toward improved anti-HIV chemotherapy: Therapeutic strategies for intervention with HIV infections
-
(1995)
J Med Chem
, vol.38
, pp. 2491-2517
-
-
De Clercq, E.1
-
10
-
-
0032437454
-
The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection
-
(1998)
Antivir Res
, vol.38
, pp. 153-179
-
-
De Clercq, E.1
-
16
-
-
0029096567
-
Synthesis and antiviral activity of 6-benzyl analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents
-
(1995)
J Med Chem
, vol.38
, pp. 2860-2865
-
-
Tanaka, H.1
Takashima, H.2
Ubasawa, M.3
-
23
-
-
84885332268
-
-
note
-
-
-
-
25
-
-
0025770237
-
Specific anti-HIV-1 "acyclonucleosides" which cannot be phosphorylated: Synthesis of some deoxy analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine
-
(1991)
J Med Chem
, vol.34
, pp. 1508-1511
-
-
Tanaka, H.1
Baba, M.2
Saito, S.3
-
26
-
-
0026543676
-
Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylyhio)thymine analogues: Effect of substitutions at the C-6 phenyl ring and at the C-5 position on the anti-HIV-1 activity
-
(1992)
J Med Chem
, vol.35
, pp. 337-345
-
-
Tanaka, H.1
Takashima, H.2
Ubasawa, M.3
-
27
-
-
0027094782
-
Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)-methyl]-6-(phenylthio) thymine (HEPT) as potent and selective anti-HIV-1 agents
-
(1992)
J Med Chem
, vol.35
, pp. 4713-4719
-
-
Tanaka, H.1
Takashima, H.2
Ubasawa, M.3
-
33
-
-
0029976422
-
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside/inhibitors
-
(1996)
J Med Chem
, vol.39
, pp. 1589-1600
-
-
Hopkins, A.L.1
Ren, J.2
Esnouf, R.M.3
-
34
-
-
15444340492
-
Dihydro(alkylthio)(naphthylmethyl)oxo pyrimidines: Novel non-nucleoside reverse transcriptase inhibitors of the S-DABO series
-
(1997)
J Med Chem
, vol.40
, pp. 1447-1454
-
-
Mai, A.1
Artico, M.2
Sbardella, G.3
-
37
-
-
0033602141
-
5-Alkyl-2-alkylthio-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: Novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives
-
(1999)
J Med Chem
, vol.42
, pp. 619-627
-
-
Mai, A.1
Artico, M.2
Sbardella, G.3
-
38
-
-
0034640387
-
Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding
-
(2000)
J Biol Chem
, vol.275
, pp. 14316-14320
-
-
Ren, J.1
Nichols, C.2
Bird, L.E.3
-
44
-
-
0035797356
-
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5- alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase
-
(2001)
J Med Chem
, vol.44
, pp. 2544-2554
-
-
Mai, A.1
Sbardella, G.2
Artico, M.3
-
45
-
-
0035146092
-
Chiral resolution and molecular modeling investigation of rac-2-cyclopentylthio-6-[1-(2,6-difluorophenyl)ethyl]- 3,4-dihydro-5-methylpyrimidin-4(3H)-one (MC-1047), a potent anti-HIV-1 reverse transcriptase agent of the DABO class
-
(2001)
Chirality
, vol.13
, pp. 75-80
-
-
Quaglia, M.G.1
Mai, A.2
Sbardella, G.3
-
49
-
-
0034687250
-
Synthesis and antiviral activity of 4-benzylpyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors
-
(2000)
J Med Chem
, vol.43
, pp. 3949-3962
-
-
Dollé, V.1
Nguyen, C.H.2
Legraverend, M.3
-
51
-
-
84885332181
-
-
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-
-
-
-
52
-
-
84885332260
-
-
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-
-
-
-
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-
-
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-
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