Cutting edge: Blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells

Journal of Immunology

Volumn 163, Issue 5, 1999, Pages 2358-2362

  Newell, Kenneth A ^a   He, Gang ^a   Guo, Zhong ^a   Kim, Oliver ^a   Szot, Gregory L ^a   Rulifson, Ingrid ^a   Zhou, Ping ^a   Hart, John ^a   Thistlethwaite, J Richard ^a   Bluestone, Jeffrey A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GRAFT REJECTION; INTESTINE GRAFT; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD4; ANTIGENS, CD8; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; GRAFT REJECTION; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAPERITONEAL; INTESTINE, SMALL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; TH1 CELLS; TH2 CELLS;

EID: 0033198142     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Schwartz, R. H. 1992. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71: 1065.
2. Chen, C., and N. Nabavi. 1994. In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7-2. Immunity 1:147.
3. Lenschow, D. J., Y. Zeng, K. S. Hathcock, L. A. Zuckerman, G. Freeman, J. R. Thistlethwaite, G. S. Gray, R. J. Hodes, and J. A. Bluestone. 1995. Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies. Transplantation 60:1171.
4. Larsen, C. P., E. T. Elwood, D. Z. Alexander, S. C. Ritchie, R. Hendrix, C. Tucker-Burden, H. R. Cho, A. Aruffo, D. Hollenbaugh, P. S. Linsley, et al. 1996. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 381:434.
5. Akalin, E., A. Chandraker, M. E. Russell, L. A. Turka, W. W. Hancock, and M. H. Sayegh. 1996. CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: inhibition of cell-mediated and humoral immune responses in vivo. Transplantation 62:1942.
6. Tarumi, K., M. Murakanu, A. Yagihashi, I. Nakagawa, K. Hirata, and T. Uede. 1999. CTLA4IgG treatment induces long-term acceptance of rat small bowel allografts. Transplantation 67:520.
7. Yin, D. P., H. N. Sankary, J. Williams, N. Krieger, and C. G. Fathman. 1996. Induction of tolerance to small bowel allografts in high-responder rats by combining anti-CD4 with CTLA4Ig. Transplantation 62:1537.
8. Bishop, D. K., S. Chan, W. Li, R. D. Ensley, S. Xu, and E. J. Eichwald. 1993. CD4-positive helper T lymphocytes mediate mouse cardiac allograft rejection independent of donor alloantigen specific cytotoxic T lymphocytes. Transplantation 56:892.
9. + cells are essential for allorejection. J. Exp. Med. 184:2013.
10. He, G., J. Hart, O. S. Kim, G. L. Szot, C. T. Siegel, J. R. Thistlethwaite, and K. A. Newell. 1999. The role of CD8 and CD4 T cells in intestinal allograft rejection: a comparison of monoclonal antibody-treated and knockout mice. Transplantation 67:131.
11. -/- mice. J. Immunol. 159:4665.
12. + T cells by B7-transfected melanoma cells. Science 259:368.
13. + T cells. J. Immunol. 157:3250.
14. Sigal, L. J., H. Reiser, and K. L. Rock. 1998. The role of B7-1 and B7-2 costimulation for the generation of CTL responses in vivo. J. Immunol. 161:2740.
15. Nickerson, P., J. Steiger, X. X. Zheng, A. W. Steele, W. Steurer, P. Roy-Chaudhury, and T. Strom. 1997. Manipulation of cytokine networks in transplantation. Transplantation 63:489.
16. Piccotti, J. R., S. Y. Chan, A. M. VanBuskirk, E. J. Eichwald, and D. K. Bishop. 1997. Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival? Transplantation 63:619.
17. Sayegh, M. H., E. Akalin, W. W. Hancock, M. E. Russell, C. B. Carpenter, P. S. Linsley, and L. A. Turka. 1995. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J. Exp. Med. 181:1869.