-
1
-
-
34247606685
-
-
American Cancer Society:, Atlanta, American Cancer Society
-
American Cancer Society: Cancer Facts & Figures 2007. Atlanta, American Cancer Society, 2007
-
(2007)
Cancer Facts & Figures 2007
-
-
-
2
-
-
14544270277
-
Does anyone survive pancreatic ductal adenocarcinoma? A nationwide study re-evaluating the data of the Finnish Cancer Registry
-
Carpelan-Holmstrom M, Nordling S, Pukkala E, Sankila R, Luttges J, Kloppel G, Haglund C: Does anyone survive pancreatic ductal adenocarcinoma? A nationwide study re-evaluating the data of the Finnish Cancer Registry. Gut 2005, 54:385-387
-
(2005)
Gut
, vol.54
, pp. 385-387
-
-
Carpelan-Holmstrom, M.1
Nordling, S.2
Pukkala, E.3
Sankila, R.4
Luttges, J.5
Kloppel, G.6
Haglund, C.7
-
3
-
-
33645526144
-
Cancer statistics, 2006
-
Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, Thun MJ: Cancer statistics, 2006. CA Cancer J Clin 2006, 56:106-130
-
(2006)
CA Cancer J Clin
, vol.56
, pp. 106-130
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Murray, T.4
Xu, J.5
Smigal, C.6
Thun, M.J.7
-
4
-
-
0035254966
-
Nonrandom chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping
-
Sirivatanauksorn V, Sirivatanauksorn Y, Gorman PA, Davidson JM, Sheer D, Moore PS, Scarpa A, Edwards PA, Lemoine NR: Nonrandom chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping. Int J Cancer 2001, 91:350-358
-
(2001)
Int J Cancer
, vol.91
, pp. 350-358
-
-
Sirivatanauksorn, V.1
Sirivatanauksorn, Y.2
Gorman, P.A.3
Davidson, J.M.4
Sheer, D.5
Moore, P.S.6
Scarpa, A.7
Edwards, P.A.8
Lemoine, N.R.9
-
5
-
-
0029001472
-
Consistent chromosome abnormalities in adenocarcinoma of the pancreas
-
Griffin CA, Hruban RH, Morsberger LA, Ellingham T, Long PP, Jaffee EM, Hauda KM, Bohlander SK, Yeo CJ: Consistent chromosome abnormalities in adenocarcinoma of the pancreas. Cancer Res 1995, 55:2394-2399
-
(1995)
Cancer Res
, vol.55
, pp. 2394-2399
-
-
Griffin, C.A.1
Hruban, R.H.2
Morsberger, L.A.3
Ellingham, T.4
Long, P.P.5
Jaffee, E.M.6
Hauda, K.M.7
Bohlander, S.K.8
Yeo, C.J.9
-
6
-
-
10744229498
-
Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss
-
Iacobuzio-Donahue CA, van der Heijden MS, Baumgartner MR, Troup WJ, Romm JM, Doheny K, Pugh E, Yeo CJ, Goggins MG, Hruban RH, Kern SE: Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss. Cancer Res 2004, 64:871-875
-
(2004)
Cancer Res
, vol.64
, pp. 871-875
-
-
Iacobuzio-Donahue, C.A.1
van der Heijden, M.S.2
Baumgartner, M.R.3
Troup, W.J.4
Romm, J.M.5
Doheny, K.6
Pugh, E.7
Yeo, C.J.8
Goggins, M.G.9
Hruban, R.H.10
Kern, S.E.11
-
7
-
-
19944429290
-
MAP2K4/MKK4 expression in pancreatic cancer: Genetic validation of immunohistochemistry and relationship to disease course
-
Xin W, Yun KJ, Ricci F, Zahurak M, Qiu W, Su GH, Yeo CJ, Hruban RH, Kern SE, Iacobuzio-Donahue CA: MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course. Clin Cancer Res 2004, 10:8516-8520
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8516-8520
-
-
Xin, W.1
Yun, K.J.2
Ricci, F.3
Zahurak, M.4
Qiu, W.5
Su, G.H.6
Yeo, C.J.7
Hruban, R.H.8
Kern, S.E.9
Iacobuzio-Donahue, C.A.10
-
8
-
-
0032404111
-
Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas
-
Goggins M, Shekher M, Turnacioglu K, Yeo CJ, Hruban RH, Kern SE: Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res 1998, 58:5329-5332
-
(1998)
Cancer Res
, vol.58
, pp. 5329-5332
-
-
Goggins, M.1
Shekher, M.2
Turnacioglu, K.3
Yeo, C.J.4
Hruban, R.H.5
Kern, S.E.6
-
9
-
-
0035853078
-
ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma
-
Su GH, Bansal R, Murphy KM, Montgomery E, Yeo CJ, Hruban RH, Kern SE: ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma. Proc Natl Acad Sci USA 2001, 98:3254-3257
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3254-3257
-
-
Su, G.H.1
Bansal, R.2
Murphy, K.M.3
Montgomery, E.4
Yeo, C.J.5
Hruban, R.H.6
Kern, S.E.7
-
10
-
-
0035004797
-
Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis
-
Luttges J, Galehdari H, Brocker V, Schwarte-Waldhoff I, Henne-Bruns D, Kloppel G, Schmiegel W, Hahn SA: Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis. Am J Pathol 2001, 158:1677-1683
-
(2001)
Am J Pathol
, vol.158
, pp. 1677-1683
-
-
Luttges, J.1
Galehdari, H.2
Brocker, V.3
Schwarte-Waldhoff, I.4
Henne-Bruns, D.5
Kloppel, G.6
Schmiegel, W.7
Hahn, S.A.8
-
11
-
-
0033888296
-
Genetic progression and divergence in pancreatic carcinoma
-
Yamano M, Fujii H, Takagaki T, Kadowaki N, Watanabe H, Shirai T: Genetic progression and divergence in pancreatic carcinoma. Am J Pathol 2000, 156:2123-2133
-
(2000)
Am J Pathol
, vol.156
, pp. 2123-2133
-
-
Yamano, M.1
Fujii, H.2
Takagaki, T.3
Kadowaki, N.4
Watanabe, H.5
Shirai, T.6
-
12
-
-
0343811679
-
Comparative genomic hybridization reveals frequent gains of 20q, 8q, 11q, 12p, and 17q, and losses of 18q, 9p, and 15q in pancreatic cancer
-
Mahlamaki EH, Hoglund M, Gorunova L, Karhu R, Dawiskiba S, Andren-Sandberg A, Kallioniemi OP, Johansson B: Comparative genomic hybridization reveals frequent gains of 20q, 8q, 11q, 12p, and 17q, and losses of 18q, 9p, and 15q in pancreatic cancer. Genes Chromosomes Cancer 1997, 20:383-391
-
(1997)
Genes Chromosomes Cancer
, vol.20
, pp. 383-391
-
-
Mahlamaki, E.H.1
Hoglund, M.2
Gorunova, L.3
Karhu, R.4
Dawiskiba, S.5
Andren-Sandberg, A.6
Kallioniemi, O.P.7
Johansson, B.8
-
13
-
-
17344371740
-
High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays
-
Pinkel D, Segraves R, Sudar D, Clark S, Poole I, Kowbel D, Collins C, Kuo WL, Chen C, Zhai Y, Dairkee SH, Ljung BM, Gray JW, Albertson DG: High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat Genet 1998, 20:207-211
-
(1998)
Nat Genet
, vol.20
, pp. 207-211
-
-
Pinkel, D.1
Segraves, R.2
Sudar, D.3
Clark, S.4
Poole, I.5
Kowbel, D.6
Collins, C.7
Kuo, W.L.8
Chen, C.9
Zhai, Y.10
Dairkee, S.H.11
Ljung, B.M.12
Gray, J.W.13
Albertson, D.G.14
-
14
-
-
0032823523
-
Genome-wide analysis of DNA copy-number changes using cDNA microarrays
-
Pollack JR, Perou CM, Alizadeh AA, Eisen MB, Pergamenschikov A, Williams CF, Jeffrey SS, Botstein D, Brown PO: Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat Genet 1999, 23:41-46
-
(1999)
Nat Genet
, vol.23
, pp. 41-46
-
-
Pollack, J.R.1
Perou, C.M.2
Alizadeh, A.A.3
Eisen, M.B.4
Pergamenschikov, A.5
Williams, C.F.6
Jeffrey, S.S.7
Botstein, D.8
Brown, P.O.9
-
15
-
-
10744231187
-
Representational oligonucleotide microarray analysis: A high-resolution method to detect genome copy number variation
-
Lucito R, Healy J, Alexander J, Reiner A, Esposito D, Chi M, Rodgers L, Brady A, Sebat J, Troge J, West JA, Rostan S, Nguyen KC, Powers S, Ye KQ, Olshen A, Venkatraman E, Norton L, Wigler M: Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation. Genome Res 2003, 13:2291-2305
-
(2003)
Genome Res
, vol.13
, pp. 2291-2305
-
-
Lucito, R.1
Healy, J.2
Alexander, J.3
Reiner, A.4
Esposito, D.5
Chi, M.6
Rodgers, L.7
Brady, A.8
Sebat, J.9
Troge, J.10
West, J.A.11
Rostan, S.12
Nguyen, K.C.13
Powers, S.14
Ye, K.Q.15
Olshen, A.16
Venkatraman, E.17
Norton, L.18
Wigler, M.19
-
16
-
-
3042743983
-
Genomic DNA-chip hybridization reveals a higher incidence of genomic amplifications in pancreatic cancer than conventional comparative genomic hybridization and leads to the identification of novel candidate genes
-
Holzmann K, Kohlhammer H, Schwaenen C, Wessendorf S, Kestler HA, Schwoerer A, Rau B, Radlwimmer B, Dohner H, Lichter P, Gress T, Bentz M: Genomic DNA-chip hybridization reveals a higher incidence of genomic amplifications in pancreatic cancer than conventional comparative genomic hybridization and leads to the identification of novel candidate genes. Cancer Res 2004, 64:4428-4433
-
(2004)
Cancer Res
, vol.64
, pp. 4428-4433
-
-
Holzmann, K.1
Kohlhammer, H.2
Schwaenen, C.3
Wessendorf, S.4
Kestler, H.A.5
Schwoerer, A.6
Rau, B.7
Radlwimmer, B.8
Dohner, H.9
Lichter, P.10
Gress, T.11
Bentz, M.12
-
17
-
-
2942643922
-
High-resolution characterization of the pancreatic adenocarcinoma genome
-
Aguirre AJ, Brennan C, Bailey G, Sinha R, Feng B, Leo C, Zhang Y, Zhang J, Gans JD, Bardeesy N, Cauwels C, Cordon-Cardo C, Redston MS, DePinho RA, Chin L: High-resolution characterization of the pancreatic adenocarcinoma genome. Proc Natl Acad Sci USA 2004, 101:9067-9072
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 9067-9072
-
-
Aguirre, A.J.1
Brennan, C.2
Bailey, G.3
Sinha, R.4
Feng, B.5
Leo, C.6
Zhang, Y.7
Zhang, J.8
Gans, J.D.9
Bardeesy, N.10
Cauwels, C.11
Cordon-Cardo, C.12
Redston, M.S.13
DePinho, R.A.14
Chin, L.15
-
18
-
-
33750317308
-
Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: A model for patient classification to aid fluoropyrimidine therapy
-
Brody JR, Hucl T, Gallmeier E, Winter JM, Kern SE, Murphy KM: Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapy. Cancer Res 2006, 66:9369-9373
-
(2006)
Cancer Res
, vol.66
, pp. 9369-9373
-
-
Brody, J.R.1
Hucl, T.2
Gallmeier, E.3
Winter, J.M.4
Kern, S.E.5
Murphy, K.M.6
-
19
-
-
0028059330
-
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
-
Caldas C, Hahn SA, da Costa LT, Redston MS, Schutte M, Seymour AB, Weinstein CL, Hruban RH, Yeo CJ, Kern SE: Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 1994, 8:27-32
-
(1994)
Nat Genet
, vol.8
, pp. 27-32
-
-
Caldas, C.1
Hahn, S.A.2
da Costa, L.T.3
Redston, M.S.4
Schutte, M.5
Seymour, A.B.6
Weinstein, C.L.7
Hruban, R.H.8
Yeo, C.J.9
Kern, S.E.10
-
20
-
-
76249091957
-
Emerging molecular biology of pancreatic cancer
-
in press
-
Hruban RH, Maitra A, Schulick R, Laheru D, Herman J, Kern SE, Goggins M: Emerging molecular biology of pancreatic cancer. Gastrointestinal Cancer Res 2007 (in press)
-
(2007)
Gastrointestinal Cancer Res
-
-
Hruban, R.H.1
Maitra, A.2
Schulick, R.3
Laheru, D.4
Herman, J.5
Kern, S.E.6
Goggins, M.7
-
21
-
-
0030988302
-
p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
-
Moskaluk CA, Hruban RH, Kern SE: p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res 1997, 57:2140-2143
-
(1997)
Cancer Res
, vol.57
, pp. 2140-2143
-
-
Moskaluk, C.A.1
Hruban, R.H.2
Kern, S.E.3
-
22
-
-
0033872039
-
Genetic progression in the pancreatic ducts
-
Hruban RH, Wilentz RE, Kern SE: Genetic progression in the pancreatic ducts. Am J Pathol 2000, 156:1821-1825
-
(2000)
Am J Pathol
, vol.156
, pp. 1821-1825
-
-
Hruban, R.H.1
Wilentz, R.E.2
Kern, S.E.3
-
23
-
-
0141425732
-
BRAF and FBXW7 (CDC4. FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: Potential therapeutic targets
-
Calhoun ES, Jones JB, Ashfaq R, Adsay V, Baker SJ, Valentine V, Hempen PM, Hilgers W, Yeo CJ, Hruban RH, Kern SE: BRAF and FBXW7 (CDC4. FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. Am J Pathol 2003, 163:1255-1260
-
(2003)
Am J Pathol
, vol.163
, pp. 1255-1260
-
-
Calhoun, E.S.1
Jones, J.B.2
Ashfaq, R.3
Adsay, V.4
Baker, S.J.5
Valentine, V.6
Hempen, P.M.7
Hilgers, W.8
Yeo, C.J.9
Hruban, R.H.10
Kern, S.E.11
-
24
-
-
0037093087
-
Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray
-
Han H, Bearss DJ, Browne LW, Calaluce R, Nagle RB, Von Hoff DD: Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray. Cancer Res 2002, 62:2890-2896
-
(2002)
Cancer Res
, vol.62
, pp. 2890-2896
-
-
Han, H.1
Bearss, D.J.2
Browne, L.W.3
Calaluce, R.4
Nagle, R.B.5
Von Hoff, D.D.6
-
25
-
-
0037133575
-
Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts
-
Berg T, Cohen SB, Deshamais J, Sonderegger C, Maslyar DJ, Goldberg J, Boger DL, Vogt PK: Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts. Proc Natl Acad Sci USA 2002, 99:3830-3835
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 3830-3835
-
-
Berg, T.1
Cohen, S.B.2
Deshamais, J.3
Sonderegger, C.4
Maslyar, D.J.5
Goldberg, J.6
Boger, D.L.7
Vogt, P.K.8
-
26
-
-
0031936947
-
Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas
-
Ruggeri BA, Huang L, Wood M, Cheng JQ, Testa JR: Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas. Mol Carcinog 1998, 21:81-86
-
(1998)
Mol Carcinog
, vol.21
, pp. 81-86
-
-
Ruggeri, B.A.1
Huang, L.2
Wood, M.3
Cheng, J.Q.4
Testa, J.R.5
-
27
-
-
1242286948
-
Frequent activation of AKT2 kinase in human pancreatic carcinomas
-
Altomare DA, Tanno S, De Rienzo A, Klein-Szanto AJ, Tanno S, Skele KL, Hoffman JP, Testa JR: Frequent activation of AKT2 kinase in human pancreatic carcinomas. J Cell Biochem 2003, 88:470-476
-
(2003)
J Cell Biochem
, vol.88
, pp. 470-476
-
-
Altomare, D.A.1
Tanno, S.2
De Rienzo, A.3
Klein-Szanto, A.J.4
Tanno, S.5
Skele, K.L.6
Hoffman, J.P.7
Testa, J.R.8
-
28
-
-
13844273087
-
PI3K-Akt pathway: Its functions and alterations in human cancer
-
Osaki M, Oshimura M, Ito H: PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 2004, 9:667-676
-
(2004)
Apoptosis
, vol.9
, pp. 667-676
-
-
Osaki, M.1
Oshimura, M.2
Ito, H.3
-
29
-
-
21644469223
-
Gefitinib ("Iressa". ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits pancreatic cancer cell growth, invasion, and colony formation
-
Li J, Kleeff J, Giese N, Buchler MW, Korc M, Friess H: Gefitinib ("Iressa". ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits pancreatic cancer cell growth, invasion, and colony formation. Int J Oncol 2004, 25:203-210
-
(2004)
Int J Oncol
, vol.25
, pp. 203-210
-
-
Li, J.1
Kleeff, J.2
Giese, N.3
Buchler, M.W.4
Korc, M.5
Friess, H.6
-
30
-
-
16944367477
-
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
-
Schutte M, Hruban RH, Geradts J, Maynard R, Hilgers W, Rabindran SK, Moskaluk CA, Hahn SA, Schwarte-Waldhoff I, Schmiegel W, Baylin SB, Kern SE, Herman JG: Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res 1997, 57:3126-3130
-
(1997)
Cancer Res
, vol.57
, pp. 3126-3130
-
-
Schutte, M.1
Hruban, R.H.2
Geradts, J.3
Maynard, R.4
Hilgers, W.5
Rabindran, S.K.6
Moskaluk, C.A.7
Hahn, S.A.8
Schwarte-Waldhoff, I.9
Schmiegel, W.10
Baylin, S.B.11
Kern, S.E.12
Herman, J.G.13
-
31
-
-
0032532379
-
Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: Loss of intranuclear expression
-
Wilentz RE, Geradts J, Maynard R, Offerhaus GJ, Kang M, Goggins M, Yeo CJ, Kern SE, Hruban RH: Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. Cancer Res 1998, 58:4740-4744
-
(1998)
Cancer Res
, vol.58
, pp. 4740-4744
-
-
Wilentz, R.E.1
Geradts, J.2
Maynard, R.3
Offerhaus, G.J.4
Kang, M.5
Goggins, M.6
Yeo, C.J.7
Kern, S.E.8
Hruban, R.H.9
-
32
-
-
0030023025
-
Gene deletion chemoselectivity: Codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the alpha- and beta-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy
-
Chen ZH, Zhang H, Savarese TM: Gene deletion chemoselectivity: codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the alpha- and beta-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy. Cancer Res 1996, 56:1083-1090
-
(1996)
Cancer Res
, vol.56
, pp. 1083-1090
-
-
Chen, Z.H.1
Zhang, H.2
Savarese, T.M.3
-
33
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996, 271:350-353
-
(1996)
Science
, vol.271
, pp. 350-353
-
-
Hahn, S.A.1
Schutte, M.2
Hoque, A.T.3
Moskaluk, C.A.4
da Costa, L.T.5
Rozenblum, E.6
Weinstein, C.L.7
Fischer, A.8
Yeo, C.J.9
Hruban, R.H.10
Kern, S.E.11
-
34
-
-
9344223357
-
DPC4 gene in various tumor types
-
Schutte M, Hruban RH, Hedrick L, Cho KR, Nadasdy GM, Weinstein CL, Bova GS, Isaacs WB, Cairns P, Nawroz H, Sidransky D, Casero RA Jr, Meltzer PS, Hahn SA, Kern SE: DPC4 gene in various tumor types. Cancer Res 1996, 56:2527-2530
-
(1996)
Cancer Res
, vol.56
, pp. 2527-2530
-
-
Schutte, M.1
Hruban, R.H.2
Hedrick, L.3
Cho, K.R.4
Nadasdy, G.M.5
Weinstein, C.L.6
Bova, G.S.7
Isaacs, W.B.8
Cairns, P.9
Nawroz, H.10
Sidransky, D.11
Casero Jr, R.A.12
Meltzer, P.S.13
Hahn, S.A.14
Kern, S.E.15
-
35
-
-
0141742113
-
Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
-
Maitra A, Adsay NV, Argani P, Iacobuzio-Donahue C, De Marzo A, Cameron JL, Yeo CJ, Hruban RH: Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod Pathol 2003, 16:902-912
-
(2003)
Mod Pathol
, vol.16
, pp. 902-912
-
-
Maitra, A.1
Adsay, N.V.2
Argani, P.3
Iacobuzio-Donahue, C.4
De Marzo, A.5
Cameron, J.L.6
Yeo, C.J.7
Hruban, R.H.8
-
36
-
-
0038107613
-
Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms
-
Sahin F, Maitra A, Argani P, Sato N, Maehara N, Montgomery E, Goggins M, Hruban RH, Su GH: Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms. Mod Pathol 2003, 16:686-691
-
(2003)
Mod Pathol
, vol.16
, pp. 686-691
-
-
Sahin, F.1
Maitra, A.2
Argani, P.3
Sato, N.4
Maehara, N.5
Montgomery, E.6
Goggins, M.7
Hruban, R.H.8
Su, G.H.9
-
37
-
-
0032100617
-
Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene
-
Su GH, Hilgers W, Shekher MC, Tang DJ, Yeo CJ, Hruban RH, Kern SE: Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. Cancer Res 1998, 58:2339-2342
-
(1998)
Cancer Res
, vol.58
, pp. 2339-2342
-
-
Su, G.H.1
Hilgers, W.2
Shekher, M.C.3
Tang, D.J.4
Yeo, C.J.5
Hruban, R.H.6
Kern, S.E.7
-
38
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B, Kinzler KW: Cancer genes and the pathways they control. Nat Med 2004, 10:789-799
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
39
-
-
85015066476
-
DNA damage and repair
-
Friedberg EC: DNA damage and repair. Nature 2003, 421:436-440
-
(2003)
Nature
, vol.421
, pp. 436-440
-
-
Friedberg, E.C.1
-
40
-
-
0032898651
-
Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumours
-
Ghimenti C, Tannergard P, Wahlberg S, Liu T, Giulianotti PG, Mosca F, Fornaciari G, Bevilacqua G, Lindblom A, Caligo MA: Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumours. Br J Cancer 1999, 80:11-16
-
(1999)
Br J Cancer
, vol.80
, pp. 11-16
-
-
Ghimenti, C.1
Tannergard, P.2
Wahlberg, S.3
Liu, T.4
Giulianotti, P.G.5
Mosca, F.6
Fornaciari, G.7
Bevilacqua, G.8
Lindblom, A.9
Caligo, M.A.10
-
41
-
-
0033847858
-
Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: A newly described and characterized entity
-
Wilentz RE, Goggins M, Redston M, Marcus VA, Adsay NV, Sohn TA, Kadkol SS, Yeo CJ, Choti M, Zahurak M, Johnson K, Tascilar M, Offerhaus GJ, Hruban RH, Kern SE: Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: a newly described and characterized entity. Am J Pathol 2000, 156:1641-1651
-
(2000)
Am J Pathol
, vol.156
, pp. 1641-1651
-
-
Wilentz, R.E.1
Goggins, M.2
Redston, M.3
Marcus, V.A.4
Adsay, N.V.5
Sohn, T.A.6
Kadkol, S.S.7
Yeo, C.J.8
Choti, M.9
Zahurak, M.10
Johnson, K.11
Tascilar, M.12
Offerhaus, G.J.13
Hruban, R.H.14
Kern, S.E.15
-
42
-
-
17644430199
-
Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wildtype K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+
-
Goggins M, Offerhaus GJ, Hilgers W, Griffin CA, Shekher M, Tang D, Sohn TA, Yeo CJ, Kern SE, Hruban RH: Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wildtype K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+. Am J Pathol 1998, 152:1501-1507
-
(1998)
Am J Pathol
, vol.152
, pp. 1501-1507
-
-
Goggins, M.1
Offerhaus, G.J.2
Hilgers, W.3
Griffin, C.A.4
Shekher, M.5
Tang, D.6
Sohn, T.A.7
Yeo, C.J.8
Kern, S.E.9
Hruban, R.H.10
-
43
-
-
0036644884
-
Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: Deleterious BRCA2 mutations in 17%
-
Murphy KM, Brune KA, Griffin C, Sollenberger JE, Petersen GM, Bansal R, Hruban RH, Kern SE: Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%. Cancer Res 2002, 62:3789-3793
-
(2002)
Cancer Res
, vol.62
, pp. 3789-3793
-
-
Murphy, K.M.1
Brune, K.A.2
Griffin, C.3
Sollenberger, J.E.4
Petersen, G.M.5
Bansal, R.6
Hruban, R.H.7
Kern, S.E.8
-
44
-
-
0037505830
-
Fanconi anemia gene mutations in young-onset pancreatic cancer
-
van der Heijden MS, Yeo CJ, Hruban RH, Kern SE: Fanconi anemia gene mutations in young-onset pancreatic cancer. Cancer Res 2003, 63:2585-2588
-
(2003)
Cancer Res
, vol.63
, pp. 2585-2588
-
-
van der Heijden, M.S.1
Yeo, C.J.2
Hruban, R.H.3
Kern, S.E.4
-
45
-
-
33747376928
-
DNA repair pathways in clinical practice: Lessons from pediatric cancer susceptibility syndromes
-
Kennedy RD, D'Andrea AD: DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes. J Clin Oncol 2006, 24:3799-3808
-
(2006)
J Clin Oncol
, vol.24
, pp. 3799-3808
-
-
Kennedy, R.D.1
D'Andrea, A.D.2
-
46
-
-
33744481750
-
Molecular pathogenesis of Fanconi anemia: Recent progress
-
Taniguchi T, D'Andrea AD: Molecular pathogenesis of Fanconi anemia: recent progress. Blood 2006, 107:4223-4233
-
(2006)
Blood
, vol.107
, pp. 4223-4233
-
-
Taniguchi, T.1
D'Andrea, A.D.2
-
47
-
-
0039250954
-
Facile detection of mitochondrial DNA mutations in tumors and bodily fluids
-
Riss MS, Usadel H, Caballero OL, Wu L, Buta MR, Eleff SM, Jen J, Sidransky D: Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science 2000, 287:2017-2019
-
(2000)
Science
, vol.287
, pp. 2017-2019
-
-
Riss, M.S.1
Usadel, H.2
Caballero, O.L.3
Wu, L.4
Buta, M.R.5
Eleff, S.M.6
Jen, J.7
Sidransky, D.8
-
48
-
-
0035866352
-
Detection of mitochondrial DNA mutations in pancreatic cancer offers a "mass"-ive advantage over detection of nuclear DNA mutations
-
Jones JB, Song JJ, Hempen PM, Parmigiani G, Hruban RH, Kern SE: Detection of mitochondrial DNA mutations in pancreatic cancer offers a "mass"-ive advantage over detection of nuclear DNA mutations. Cancer Res 2001, 61:1299-1304
-
(2001)
Cancer Res
, vol.61
, pp. 1299-1304
-
-
Jones, J.B.1
Song, J.J.2
Hempen, P.M.3
Parmigiani, G.4
Hruban, R.H.5
Kern, S.E.6
-
49
-
-
2442720182
-
The Human MitoChip: A high-throughput sequencing microarray for mitochondrial mutation detection
-
Maitra A, Cohen Y, Gillespie SE, Mambo E, Fukushima N, Hoque MO, Shah N, Goggins M, Califano J, Sidransky D, Chakravarti A: The Human MitoChip: a high-throughput sequencing microarray for mitochondrial mutation detection. Genome Res 2004, 14:812-819
-
(2004)
Genome Res
, vol.14
, pp. 812-819
-
-
Maitra, A.1
Cohen, Y.2
Gillespie, S.E.3
Mambo, E.4
Fukushima, N.5
Hoque, M.O.6
Shah, N.7
Goggins, M.8
Califano, J.9
Sidransky, D.10
Chakravarti, A.11
-
50
-
-
0037288474
-
Chromosome instability in cancer: How, when, and why?
-
Gisselsson D: Chromosome instability in cancer: how, when, and why? Adv Cancer Res 2003, 87:1-29
-
(2003)
Adv Cancer Res
, vol.87
, pp. 1-29
-
-
Gisselsson, D.1
-
51
-
-
0036841802
-
Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia
-
van Heek NT, Meeker AK, Kern SE, Yeo CJ, Lillemoe KD, Cameron JL, Offerhaus GJ, Hicks JL, Wilentz RE, Goggins MG, De Marzo AM, Hruban RH, Maitra A: Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am J Pathol 2002, 161:1541-1547
-
(2002)
Am J Pathol
, vol.161
, pp. 1541-1547
-
-
van Heek, N.T.1
Meeker, A.K.2
Kern, S.E.3
Yeo, C.J.4
Lillemoe, K.D.5
Cameron, J.L.6
Offerhaus, G.J.7
Hicks, J.L.8
Wilentz, R.E.9
Goggins, M.G.10
De Marzo, A.M.11
Hruban, R.H.12
Maitra, A.13
-
52
-
-
33644777482
-
Telomeres and telomerase in prostatic intraepithelial neoplasia and prostate cancer biology
-
Meeker AK: Telomeres and telomerase in prostatic intraepithelial neoplasia and prostate cancer biology. Urol Oncol 2006, 24:122-130
-
(2006)
Urol Oncol
, vol.24
, pp. 122-130
-
-
Meeker, A.K.1
-
53
-
-
0037148282
-
Balancing instability: Dual roles for telomerase and telomere dysfunction in tumorigenesis
-
Hackett JA, Greider CW: Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis. Oncogene 2002, 21:619-626
-
(2002)
Oncogene
, vol.21
, pp. 619-626
-
-
Hackett, J.A.1
Greider, C.W.2
-
54
-
-
0034176798
-
DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
-
Baylin SB, Herman JG: DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 2000, 16:168-174
-
(2000)
Trends Genet
, vol.16
, pp. 168-174
-
-
Baylin, S.B.1
Herman, J.G.2
-
55
-
-
0034075153
-
Hypermethylation of multiple genes in pancreatic adenocarcinoma
-
Ueki T, Toyota M, Sohn T, Yeo CJ, Issa JP, Hruban RH, Goggins M: Hypermethylation of multiple genes in pancreatic adenocarcinoma. Cancer Res 2000, 60:1835-1839
-
(2000)
Cancer Res
, vol.60
, pp. 1835-1839
-
-
Ueki, T.1
Toyota, M.2
Sohn, T.3
Yeo, C.J.4
Issa, J.P.5
Hruban, R.H.6
Goggins, M.7
-
56
-
-
0037742210
-
Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays
-
Sato N, Fukushima N, Maitra A, Matsubayashi H, Yeo CJ, Cameron JL, Hruban RH, Goggins M: Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays. Cancer Res 2003, 63:3735-3742
-
(2003)
Cancer Res
, vol.63
, pp. 3735-3742
-
-
Sato, N.1
Fukushima, N.2
Maitra, A.3
Matsubayashi, H.4
Yeo, C.J.5
Cameron, J.L.6
Hruban, R.H.7
Goggins, M.8
-
57
-
-
25144461600
-
Aberrant methylation of the human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms
-
Martin ST, Sato N, Dhara S, Chang R, Hustinx SR, Abe T, Maitra A, Goggins M: Aberrant methylation of the human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms. Cancer Biol Ther 2005, 4:728-733
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 728-733
-
-
Martin, S.T.1
Sato, N.2
Dhara, S.3
Chang, R.4
Hustinx, S.R.5
Abe, T.6
Maitra, A.7
Goggins, M.8
-
58
-
-
0036097181
-
Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma
-
Fukushima N, Sato N, Ueki T, Rosty C, Walter KM, Wilentz RE, Yeo CJ, Hruban RH, Goggins M: Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma. Am J Pathol 2002, 160:1573-1581
-
(2002)
Am J Pathol
, vol.160
, pp. 1573-1581
-
-
Fukushima, N.1
Sato, N.2
Ueki, T.3
Rosty, C.4
Walter, K.M.5
Wilentz, R.E.6
Yeo, C.J.7
Hruban, R.H.8
Goggins, M.9
-
59
-
-
0037484547
-
Diagnosing pancreatic cancer using methylation specific PCR analysis of pancreatic juice
-
Fukushima N, Walter KM, Uek T, Sato N, Matsubayashi H, Cameron JL, Hruban RH, Canto M, Yeo CJ, Goggins M: Diagnosing pancreatic cancer using methylation specific PCR analysis of pancreatic juice. Cancer Biol Ther 2003, 2:78-83
-
(2003)
Cancer Biol Ther
, vol.2
, pp. 78-83
-
-
Fukushima, N.1
Walter, K.M.2
Uek, T.3
Sato, N.4
Matsubayashi, H.5
Cameron, J.L.6
Hruban, R.H.7
Canto, M.8
Yeo, C.J.9
Goggins, M.10
-
60
-
-
0042674172
-
Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma
-
Sato N, Maitra A, Fukushima N, van Heek NT, Matsubayashi H, Iacobuzio-Donahue CA, Rosty C, Goggins M: Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res 2003, 63:4158-4166
-
(2003)
Cancer Res
, vol.63
, pp. 4158-4166
-
-
Sato, N.1
Maitra, A.2
Fukushima, N.3
van Heek, N.T.4
Matsubayashi, H.5
Iacobuzio-Donahue, C.A.6
Rosty, C.7
Goggins, M.8
-
61
-
-
0035360275
-
Discovery of new markers of cancer through serial analysis of gene expression: Prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma
-
Argani P, Rosty C, Reiter RE, Wilentz RE, Murugesan SR, Leach SD, Ryu B, Skinner HG, Goggins M, Jaffee EM, Yeo CJ, Cameron JL, Kern SE, Hruban RH: Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma. Cancer Res 2001, 61:4320-4324
-
(2001)
Cancer Res
, vol.61
, pp. 4320-4324
-
-
Argani, P.1
Rosty, C.2
Reiter, R.E.3
Wilentz, R.E.4
Murugesan, S.R.5
Leach, S.D.6
Ryu, B.7
Skinner, H.G.8
Goggins, M.9
Jaffee, E.M.10
Yeo, C.J.11
Cameron, J.L.12
Kern, S.E.13
Hruban, R.H.14
-
62
-
-
9144241047
-
Highly expressed genes in pancreatic ductal adenocarcinomas: A comprehensive characterization and comparison of the transcription profiles obtained from three major technologies
-
Iacobuzio-Donahue CA, Ashfaq R, Maitra A, Adsay NV, Shen-Ong GL, Berg K, Hollingsworth MA, Cameron JL, Yeo CJ, Kern SE, Goggins M, Hruban RH: Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res 2003, 63:8614-8622
-
(2003)
Cancer Res
, vol.63
, pp. 8614-8622
-
-
Iacobuzio-Donahue, C.A.1
Ashfaq, R.2
Maitra, A.3
Adsay, N.V.4
Shen-Ong, G.L.5
Berg, K.6
Hollingsworth, M.A.7
Cameron, J.L.8
Yeo, C.J.9
Kern, S.E.10
Goggins, M.11
Hruban, R.H.12
-
63
-
-
0037379406
-
Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays
-
Iacobuzio-Donahue CA, Maitra A, Olsen M, Lowe AW, van Heek NT, Rosty C, Walter K, Sato N, Parker A, Ashfaq R, Jaffee E, Ryu B, Jones J, Eshleman JR, Yeo CJ, Cameron JL, Kern SE, Hruban RH, Brown PO, Goggins M: Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. Am J Pathol 2003, 162:1151-1162
-
(2003)
Am J Pathol
, vol.162
, pp. 1151-1162
-
-
Iacobuzio-Donahue, C.A.1
Maitra, A.2
Olsen, M.3
Lowe, A.W.4
van Heek, N.T.5
Rosty, C.6
Walter, K.7
Sato, N.8
Parker, A.9
Ashfaq, R.10
Jaffee, E.11
Ryu, B.12
Jones, J.13
Eshleman, J.R.14
Yeo, C.J.15
Cameron, J.L.16
Kern, S.E.17
Hruban, R.H.18
Brown, P.O.19
Goggins, M.20
more..
-
64
-
-
0036107889
-
Discovery of novel tumor markers of pancreatic cancer using global gene expression technology
-
Iacobuzio-Donahue CA, Maitra A, Shen-Ong GL, van Heek T, Ashfaq R, Meyer R, Walter K, Berg K, Hollingsworth MA, Cameron JL, Yeo CJ, Kern SE, Goggins M, Hruban RH: Discovery of novel tumor markers of pancreatic cancer using global gene expression technology. Am J Pathol 2002, 160:1239-1249
-
(2002)
Am J Pathol
, vol.160
, pp. 1239-1249
-
-
Iacobuzio-Donahue, C.A.1
Maitra, A.2
Shen-Ong, G.L.3
van Heek, T.4
Ashfaq, R.5
Meyer, R.6
Walter, K.7
Berg, K.8
Hollingsworth, M.A.9
Cameron, J.L.10
Yeo, C.J.11
Kern, S.E.12
Goggins, M.13
Hruban, R.H.14
-
65
-
-
0036468914
-
Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression
-
Ryu B, Jones J, Blades NJ, Parmigiani G, Hollingsworth MA, Hruban RH, Kern SE: Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression. Cancer Res 2002, 62:819-826
-
(2002)
Cancer Res
, vol.62
, pp. 819-826
-
-
Ryu, B.1
Jones, J.2
Blades, N.J.3
Parmigiani, G.4
Hollingsworth, M.A.5
Hruban, R.H.6
Kern, S.E.7
-
66
-
-
0035266179
-
Invasion-specific genes in malignancy: Serial analysis of gene expression comparisons of primary and passaged cancers
-
Ryu B, Jones J, Hollingsworth MA, Hruban RH, Kern SE: Invasion-specific genes in malignancy: serial analysis of gene expression comparisons of primary and passaged cancers. Cancer Res 2001, 61:1833-1838
-
(2001)
Cancer Res
, vol.61
, pp. 1833-1838
-
-
Ryu, B.1
Jones, J.2
Hollingsworth, M.A.3
Hruban, R.H.4
Kern, S.E.5
-
67
-
-
0031670371
-
Isolation of differentially expressed genes by combining representational difference analysis (RDA) and cDNA library arrays
-
Geng M, Wallrapp C, Muller-Pillasch F, Frohme M, Hoheisel JD, Gress TM: Isolation of differentially expressed genes by combining representational difference analysis (RDA) and cDNA library arrays. Biotechniques 1998, 25:434-438
-
(1998)
Biotechniques
, vol.25
, pp. 434-438
-
-
Geng, M.1
Wallrapp, C.2
Muller-Pillasch, F.3
Frohme, M.4
Hoheisel, J.D.5
Gress, T.M.6
-
68
-
-
0035504739
-
Gene expression profiles of pancreatic cancer and stromal desmoplasia
-
Crnogorac-Jurcevic T, Efthimiou E, Capelli P, Blaveri E, Baron A, Terris B, Jones M, Tyson K, Bassi C, Scarpa A, Lemoine NR: Gene expression profiles of pancreatic cancer and stromal desmoplasia. Oncogene 2001, 20:7437-7446
-
(2001)
Oncogene
, vol.20
, pp. 7437-7446
-
-
Crnogorac-Jurcevic, T.1
Efthimiou, E.2
Capelli, P.3
Blaveri, E.4
Baron, A.5
Terris, B.6
Jones, M.7
Tyson, K.8
Bassi, C.9
Scarpa, A.10
Lemoine, N.R.11
-
69
-
-
0942266005
-
Claudin 4 protein expression in primary and metastatic pancreatic cancer: Support for use as a therapeutic target
-
Nichols LS, Ashfaq R, Iacobuzio-Donahue CA: Claudin 4 protein expression in primary and metastatic pancreatic cancer: support for use as a therapeutic target. Am J Clin Pathol 2004, 121:226-230
-
(2004)
Am J Clin Pathol
, vol.121
, pp. 226-230
-
-
Nichols, L.S.1
Ashfaq, R.2
Iacobuzio-Donahue, C.A.3
-
70
-
-
0034837388
-
Claudin-4: A new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin
-
Michl P, Buchholz M, Rolke M, Kunsch S, Lohr M, McClane B, Tsukita S, Leder G, Adler G, Gress TM: Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin. Gastroenterology 2001, 121:678-684
-
(2001)
Gastroenterology
, vol.121
, pp. 678-684
-
-
Michl, P.1
Buchholz, M.2
Rolke, M.3
Kunsch, S.4
Lohr, M.5
McClane, B.6
Tsukita, S.7
Leder, G.8
Adler, G.9
Gress, T.M.10
-
71
-
-
34250780578
-
Radiolabeled anti-claudin 4 and antiprostate stem cell antigen: Initial imaging in experimental models of pancreatic cancer
-
Foss CA, Fox J, Feldmann G, Maitra A, Iacobuzio-Donahue C, Kern SE, Hruban RH, Pomper MG: Radiolabeled anti-claudin 4 and antiprostate stem cell antigen: initial imaging in experimental models of pancreatic cancer. Molecular Imaging 2007, 6
-
(2007)
Molecular Imaging
, pp. 6
-
-
Foss, C.A.1
Fox, J.2
Feldmann, G.3
Maitra, A.4
Iacobuzio-Donahue, C.5
Kern, S.E.6
Hruban, R.H.7
Pomper, M.G.8
-
72
-
-
0035674996
-
Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: Identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE)
-
Argani P, Iacobuzio-Donahue C, Ryu B, Rosty C, Goggins M, Wilentz RE, Murugesan SR, Leach SD, Jaffee E, Yeo CJ, Cameron JL, Kern SE, Hruban RH: Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE). Clin Cancer Res 2001, 7:3862-3868
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3862-3868
-
-
Argani, P.1
Iacobuzio-Donahue, C.2
Ryu, B.3
Rosty, C.4
Goggins, M.5
Wilentz, R.E.6
Murugesan, S.R.7
Leach, S.D.8
Jaffee, E.9
Yeo, C.J.10
Cameron, J.L.11
Kern, S.E.12
Hruban, R.H.13
-
73
-
-
3543060047
-
Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients
-
Thomas AM, Santarsiero LM, Lutz ER, Armstrong TD, Chen YC, Huang LQ, Laheru DA, Goggins M, Hruban RH, Jaffee EM: Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. J Exp Med 2004, 200:297-306
-
(2004)
J Exp Med
, vol.200
, pp. 297-306
-
-
Thomas, A.M.1
Santarsiero, L.M.2
Lutz, E.R.3
Armstrong, T.D.4
Chen, Y.C.5
Huang, L.Q.6
Laheru, D.A.7
Goggins, M.8
Hruban, R.H.9
Jaffee, E.M.10
-
74
-
-
23044451727
-
Prostate stem cell antigen is a putative target for immunotherapy in pancreatic cancer
-
Wente MN, Jain A, Kono E, Berberat PO, Giese T, Reber HA, Friess H, Buchler MW, Reiter RE, Hines OJ: Prostate stem cell antigen is a putative target for immunotherapy in pancreatic cancer. Pancreas 2005, 31:119-125
-
(2005)
Pancreas
, vol.31
, pp. 119-125
-
-
Wente, M.N.1
Jain, A.2
Kono, E.3
Berberat, P.O.4
Giese, T.5
Reber, H.A.6
Friess, H.7
Buchler, M.W.8
Reiter, R.E.9
Hines, O.J.10
-
75
-
-
34548636132
-
Elucidation of a universal size-control mechanism in Drosophila and mammals
-
Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford SA, Gayyed MF, Anders RA, Maitra A, Pan D: Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 2007, 130:1120-1133
-
(2007)
Cell
, vol.130
, pp. 1120-1133
-
-
Dong, J.1
Feldmann, G.2
Huang, J.3
Wu, S.4
Zhang, N.5
Comerford, S.A.6
Gayyed, M.F.7
Anders, R.A.8
Maitra, A.9
Pan, D.10
-
76
-
-
33750595408
-
Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma
-
Guo J, Kleeff J, Zhao Y, Li J, Giese T, Esposito I, Buchler MW, Korc M, Friess H: Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma. Int J Mol Med 2006, 17:761-767
-
(2006)
Int J Mol Med
, vol.17
, pp. 761-767
-
-
Guo, J.1
Kleeff, J.2
Zhao, Y.3
Li, J.4
Giese, T.5
Esposito, I.6
Buchler, M.W.7
Korc, M.8
Friess, H.9
-
77
-
-
33745877926
-
Survivin expression in pancreatic intraepithelial neoplasia (PanlN): Steady increase along the developmental stages of pancreatic ductal adenocarcinoma
-
Bhanot U, Heydrich R, Moller P, Hasel C: Survivin expression in pancreatic intraepithelial neoplasia (PanlN): steady increase along the developmental stages of pancreatic ductal adenocarcinoma. Am J Surg Pathol 2006, 30:754-759
-
(2006)
Am J Surg Pathol
, vol.30
, pp. 754-759
-
-
Bhanot, U.1
Heydrich, R.2
Moller, P.3
Hasel, C.4
-
78
-
-
0035878930
-
Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors
-
Satoh K, Kaneko K, Hirota M, Masamune A, Satoh A, Shimosegawa T: Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors. Cancer 2001, 92:271-278
-
(2001)
Cancer
, vol.92
, pp. 271-278
-
-
Satoh, K.1
Kaneko, K.2
Hirota, M.3
Masamune, A.4
Satoh, A.5
Shimosegawa, T.6
-
79
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernandez-del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw AL, Hebrok M: Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003, 425:851-856
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
di Magliano, M.P.2
Heiser, P.W.3
Nielsen, C.M.4
Roberts, D.J.5
Lauwers, G.Y.6
Qi, Y.P.7
Gysin, S.8
Fernandez-del Castillo, C.9
Yajnik, V.10
Antoniu, B.11
McMahon, M.12
Warshaw, A.L.13
Hebrok, M.14
-
80
-
-
0242268525
-
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
-
Berman DM, Karhadkar SS, Maitra A, Montes De Oca R, Gerstenblith MR, Briggs K, Parker AR, Shimada Y, Eshleman JR, Watkins DN, Beachy PA: Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003, 425:846-851
-
(2003)
Nature
, vol.425
, pp. 846-851
-
-
Berman, D.M.1
Karhadkar, S.S.2
Maitra, A.3
Montes De Oca, R.4
Gerstenblith, M.R.5
Briggs, K.6
Parker, A.R.7
Shimada, Y.8
Eshleman, J.R.9
Watkins, D.N.10
Beachy, P.A.11
-
81
-
-
10744223624
-
Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis
-
Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA, Sriuranpong V, Iso T, Meszoely IM, Wolfe MS, Hruban RH, Ball DW, Schmid RM, Leach SD: Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 2003, 3:565-576
-
(2003)
Cancer Cell
, vol.3
, pp. 565-576
-
-
Miyamoto, Y.1
Maitra, A.2
Ghosh, B.3
Zechner, U.4
Argani, P.5
Iacobuzio-Donahue, C.A.6
Sriuranpong, V.7
Iso, T.8
Meszoely, I.M.9
Wolfe, M.S.10
Hruban, R.H.11
Ball, D.W.12
Schmid, R.M.13
Leach, S.D.14
-
82
-
-
33845611029
-
Activation of Notch signaling in tumorigenesis of experimental pancreatic cancer induced by dimethylbenzanthracene in mice
-
Kimura K, Satoh K, Kanno A, Hamada S, Hirota M, Endoh M, Masamune A, Shimosegawa T: Activation of Notch signaling in tumorigenesis of experimental pancreatic cancer induced by dimethylbenzanthracene in mice. Cancer Sci 2007, 98:155-162
-
(2007)
Cancer Sci
, vol.98
, pp. 155-162
-
-
Kimura, K.1
Satoh, K.2
Kanno, A.3
Hamada, S.4
Hirota, M.5
Endoh, M.6
Masamune, A.7
Shimosegawa, T.8
-
83
-
-
33646877856
-
Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells
-
Wang Z, Zhang Y, Banerjee S, Li Y, Sarkar FH: Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer 2006, 106:2503-2513
-
(2006)
Cancer
, vol.106
, pp. 2503-2513
-
-
Wang, Z.1
Zhang, Y.2
Banerjee, S.3
Li, Y.4
Sarkar, F.H.5
-
84
-
-
33645473185
-
Downregulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
-
Wang Z, Zhang Y, Li Y, Banerjee S, Liao J, Sarkar FH: Downregulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 2006, 5:483-493
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 483-493
-
-
Wang, Z.1
Zhang, Y.2
Li, Y.3
Banerjee, S.4
Liao, J.5
Sarkar, F.H.6
-
85
-
-
28244469644
-
The Notch signaling pathway is related to neurovascular progression of pancreatic cancer
-
discussion 800-791
-
Buchler P, Gazdhar A, Schubert M, Giese N, Reber HA, Hines OJ, Giese T, Ceyhan GO, Muller M, Buchler MW, Friess H: The Notch signaling pathway is related to neurovascular progression of pancreatic cancer. Ann Surg 2005, 242:791-800, discussion 800-791
-
(2005)
Ann Surg
, vol.242
, pp. 791-800
-
-
Buchler, P.1
Gazdhar, A.2
Schubert, M.3
Giese, N.4
Reber, H.A.5
Hines, O.J.6
Giese, T.7
Ceyhan, G.O.8
Muller, M.9
Buchler, M.W.10
Friess, H.11
-
86
-
-
33748469128
-
Cyclopamine increases the cytotoxic effects of paclitaxel and radiation but not cisplatin and gemcitabine in Hedgehog expressing pancreatic cancer cells
-
Shafaee Z, Schmidt H, Du W, Posner M, Weichselbaum R: Cyclopamine increases the cytotoxic effects of paclitaxel and radiation but not cisplatin and gemcitabine in Hedgehog expressing pancreatic cancer cells. Cancer Chemother Pharmacol 2006, 58:765-770
-
(2006)
Cancer Chemother Pharmacol
, vol.58
, pp. 765-770
-
-
Shafaee, Z.1
Schmidt, H.2
Du, W.3
Posner, M.4
Weichselbaum, R.5
-
87
-
-
33947254016
-
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
-
Feldmann G, Dhara S, Fendrich V, Bedja D, Beaty R, Mullendore M, Karikari C, Alvarez H, Iacobuzio-Donahue C, Jimeno A, Gabrielson KL, Matsui W, Maitra A: Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res 2007, 67:2187-2196
-
(2007)
Cancer Res
, vol.67
, pp. 2187-2196
-
-
Feldmann, G.1
Dhara, S.2
Fendrich, V.3
Bedja, D.4
Beaty, R.5
Mullendore, M.6
Karikari, C.7
Alvarez, H.8
Iacobuzio-Donahue, C.9
Jimeno, A.10
Gabrielson, K.L.11
Matsui, W.12
Maitra, A.13
-
88
-
-
33847052127
-
Identification of pancreatic cancer stem cells
-
Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V, Wicha M, Clarke MF, Simeone DM: Identification of pancreatic cancer stem cells. Cancer Res 2007, 67:1030-1037
-
(2007)
Cancer Res
, vol.67
, pp. 1030-1037
-
-
Li, C.1
Heidt, D.G.2
Dalerba, P.3
Burant, C.F.4
Zhang, L.5
Adsay, V.6
Wicha, M.7
Clarke, M.F.8
Simeone, D.M.9
-
89
-
-
34249898611
-
Molecular genetics of pancreatic intraepithelial neoplasia
-
Feldmann G, Beaty R, Hruban RH, Maitra A: Molecular genetics of pancreatic intraepithelial neoplasia. J Hepatobiliary Pancreat Surg 2007, 14:224-232
-
(2007)
J Hepatobiliary Pancreat Surg
, vol.14
, pp. 224-232
-
-
Feldmann, G.1
Beaty, R.2
Hruban, R.H.3
Maitra, A.4
-
90
-
-
34248204213
-
Precursor lesions of pancreatic cancer: Molecular pathology and clinical implications
-
Singh M, Maitra A: Precursor lesions of pancreatic cancer: molecular pathology and clinical implications. Pancreatology 2007, 7:9-19
-
(2007)
Pancreatology
, vol.7
, pp. 9-19
-
-
Singh, M.1
Maitra, A.2
-
91
-
-
0037086181
-
Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology
-
Rosty C, Christa L, Kuzdzal S, Baldwin WM, Zahurak ML, Carnot F, Chan DW, Canto M, Lillemoe KD, Cameron JL, Yeo CJ, Hruban RH, Goggins M: Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology. Cancer Res 2002, 62:1868-1875
-
(2002)
Cancer Res
, vol.62
, pp. 1868-1875
-
-
Rosty, C.1
Christa, L.2
Kuzdzal, S.3
Baldwin, W.M.4
Zahurak, M.L.5
Carnot, F.6
Chan, D.W.7
Canto, M.8
Lillemoe, K.D.9
Cameron, J.L.10
Yeo, C.J.11
Hruban, R.H.12
Goggins, M.13
-
92
-
-
10744223905
-
Serum diagnosis of pancreatic adenocarcinoma using surface-enhanced laser desorption and ionization mass spectrometry
-
Koopmann J, Zhang Z, White N, Rosenzweig J, Fedarko N, Jagannath S, Canto Ml, Yeo CJ, Chan DW, Goggins M: Serum diagnosis of pancreatic adenocarcinoma using surface-enhanced laser desorption and ionization mass spectrometry. Clin Cancer Res 2004, 10:860-868
-
(2004)
Clin Cancer Res
, vol.10
, pp. 860-868
-
-
Koopmann, J.1
Zhang, Z.2
White, N.3
Rosenzweig, J.4
Fedarko, N.5
Jagannath, S.6
Canto, M.7
Yeo, C.J.8
Chan, D.W.9
Goggins, M.10
-
93
-
-
7044237450
-
Comprehensive proteomic analysis of human pancreatic juice
-
Gronborg M, Bunkenborg J, Kristiansen TZ, Jensen ON, Yeo CJ, Hruban RH, Maitra A, Goggins MG, Pandey A: Comprehensive proteomic analysis of human pancreatic juice. J Proteome Res 2004, 3:1042-1055
-
(2004)
J Proteome Res
, vol.3
, pp. 1042-1055
-
-
Gronborg, M.1
Bunkenborg, J.2
Kristiansen, T.Z.3
Jensen, O.N.4
Yeo, C.J.5
Hruban, R.H.6
Maitra, A.7
Goggins, M.G.8
Pandey, A.9
-
94
-
-
33748088524
-
An in vivo platform for translational drug development in pancreatic cancer
-
Rubio-Viqueira B, Jimeno A, Cusatis G, Zhang X, Iacobuzio-Donahue C, Karikari C, Shi C, Danenberg K, Danenberg PV, Kuramochi H, Tanaka K, Singh S, Salimi-Moosavi H, Bouraoud N, Amador ML, Altiok S, Kulesza P, Yeo C, Messersmith W, Eshleman J, Hruban RH, Maitra A, Hidalgo M: An in vivo platform for translational drug development in pancreatic cancer. Clin Cancer Res 2006, 12:4652-4661
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4652-4661
-
-
Rubio-Viqueira, B.1
Jimeno, A.2
Cusatis, G.3
Zhang, X.4
Iacobuzio-Donahue, C.5
Karikari, C.6
Shi, C.7
Danenberg, K.8
Danenberg, P.V.9
Kuramochi, H.10
Tanaka, K.11
Singh, S.12
Salimi-Moosavi, H.13
Bouraoud, N.14
Amador, M.L.15
Altiok, S.16
Kulesza, P.17
Yeo, C.18
Messersmith, W.19
Eshleman, J.20
Hruban, R.H.21
Maitra, A.22
Hidalgo, M.23
more..
-
95
-
-
1942422743
-
Of mice and men: Values and liabilities of the athymic nude mouse model in anticancer drug development
-
Kelland LR: Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development. Eur J Cancer 2004, 40:827-836
-
(2004)
Eur J Cancer
, vol.40
, pp. 827-836
-
-
Kelland, L.R.1
-
96
-
-
1542436704
-
Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: Better than commonly perceived - but they can be improved
-
Kerbel RS: Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: better than commonly perceived - but they can be improved. Cancer Biol Ther 2003, 2:S134-139
-
(2003)
Cancer Biol Ther
, vol.2
-
-
Kerbel, R.S.1
-
97
-
-
4644266467
-
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity
-
Loukopoulos P, Kanetaka K, Takamura M, Shibata T, Sakamoto M, Hirohashi S: Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. Pancreas 2004, 29:193-203
-
(2004)
Pancreas
, vol.29
, pp. 193-203
-
-
Loukopoulos, P.1
Kanetaka, K.2
Takamura, M.3
Shibata, T.4
Sakamoto, M.5
Hirohashi, S.6
-
98
-
-
0023247255
-
Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice
-
Ornitz DM, Hammer RE, Messing A, Palmiter RD, Brinster RL: Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice. Science 1987, 238:188-193
-
(1987)
Science
, vol.238
, pp. 188-193
-
-
Ornitz, D.M.1
Hammer, R.E.2
Messing, A.3
Palmiter, R.D.4
Brinster, R.L.5
-
99
-
-
0025297086
-
Overexpression of TGF alpha in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast
-
Sandgren EP, Luetteke NC, Palmiter RD, Brinster RL, Lee DC: Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell 1990, 61:1121-1135
-
(1990)
Cell
, vol.61
, pp. 1121-1135
-
-
Sandgren, E.P.1
Luetteke, N.C.2
Palmiter, R.D.3
Brinster, R.L.4
Lee, D.C.5
-
100
-
-
9144266295
-
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
-
Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, Jacks T, Wright CV, Hruban RH, Lowy AM, Tuveson DA: Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 2003, 4:437-450
-
(2003)
Cancer Cell
, vol.4
, pp. 437-450
-
-
Hingorani, S.R.1
Petricoin, E.F.2
Maitra, A.3
Rajapakse, V.4
King, C.5
Jacobetz, M.A.6
Ross, S.7
Conrads, T.P.8
Veenstra, T.D.9
Hitt, B.A.10
Kawaguchi, Y.11
Johann, D.12
Liotta, L.A.13
Crawford, H.C.14
Putt, M.E.15
Jacks, T.16
Wright, C.V.17
Hruban, R.H.18
Lowy, A.M.19
Tuveson, D.A.20
more..
-
101
-
-
0028149890
-
Insulin-promoter-factor 1 is required for pancreas development in mice
-
Jonsson J, Carlsson L, Edlund T, Edlund H: Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 1994, 371:606-609
-
(1994)
Nature
, vol.371
, pp. 606-609
-
-
Jonsson, J.1
Carlsson, L.2
Edlund, T.3
Edlund, H.4
-
102
-
-
0032417268
-
The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial Organization of the endocrine pancreas
-
Krapp A, Knofler M, Ledermann B, Burki K, Berney C, Zoerkler N, Hagenbuchle O, Wellauer PK: The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial Organization of the endocrine pancreas. Genes Dev 1998, 12:3752-3763
-
(1998)
Genes Dev
, vol.12
, pp. 3752-3763
-
-
Krapp, A.1
Knofler, M.2
Ledermann, B.3
Burki, K.4
Berney, C.5
Zoerkler, N.6
Hagenbuchle, O.7
Wellauer, P.K.8
-
103
-
-
33845194691
-
RAS unplugged: Negative feedback and oncogene-induced senescence
-
Bardeesy N, Sharpless NE: RAS unplugged: negative feedback and oncogene-induced senescence. Cancer Cell 2006, 10:451-453
-
(2006)
Cancer Cell
, vol.10
, pp. 451-453
-
-
Bardeesy, N.1
Sharpless, N.E.2
-
104
-
-
0038405066
-
Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice
-
Grippo PJ, Nowlin PS, Demeure MJ, Longnecker DS, Sandgren EP: Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice. Cancer Res 2003, 63:2016-2019
-
(2003)
Cancer Res
, vol.63
, pp. 2016-2019
-
-
Grippo, P.J.1
Nowlin, P.S.2
Demeure, M.J.3
Longnecker, D.S.4
Sandgren, E.P.5
-
105
-
-
0346455774
-
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
-
Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS, DePinho RA: Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev 2003, 17:3112-3126
-
(2003)
Genes Dev
, vol.17
, pp. 3112-3126
-
-
Aguirre, A.J.1
Bardeesy, N.2
Sinha, M.3
Lopez, L.4
Tuveson, D.A.5
Horner, J.6
Redston, M.S.7
DePinho, R.A.8
-
106
-
-
33645824724
-
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
-
Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA: Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci USA 2006, 103:5947-5952
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 5947-5952
-
-
Bardeesy, N.1
Aguirre, A.J.2
Chu, G.C.3
Cheng, K.H.4
Lopez, L.V.5
Hezel, A.F.6
Feng, B.7
Brennan, C.8
Weissleder, R.9
Mahmood, U.10
Hanahan, D.11
Redston, M.S.12
Chin, L.13
Depinho, R.A.14
-
107
-
-
19344362405
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, Rustgi AK, Chang S, Tuveson DA: Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 2005, 7:469-483
-
(2005)
Cancer Cell
, vol.7
, pp. 469-483
-
-
Hingorani, S.R.1
Wang, L.2
Multani, A.S.3
Combs, C.4
Deramaudt, T.B.5
Hruban, R.H.6
Rustgi, A.K.7
Chang, S.8
Tuveson, D.A.9
-
108
-
-
0035252589
-
A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease
-
Wagner M, Greten FR, Weber CK, Koschnick S, Mattfeldt T, Deppert W, Kern H, Adler G, Schmid RM: A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. Genes Dev 2001, 15:286-293
-
(2001)
Genes Dev
, vol.15
, pp. 286-293
-
-
Wagner, M.1
Greten, F.R.2
Weber, C.K.3
Koschnick, S.4
Mattfeldt, T.5
Deppert, W.6
Kern, H.7
Adler, G.8
Schmid, R.M.9
-
109
-
-
31544457405
-
Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses
-
Garbe AI, Vermeer B, Gamrekelashvili J, von Wasielewski R, Greten FR, Westendorf AM, Buer J, Schmid RM, Manns MP, Korangy F, Greten TF: Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses. Cancer Res 2006, 66:508-516
-
(2006)
Cancer Res
, vol.66
, pp. 508-516
-
-
Garbe, A.I.1
Vermeer, B.2
Gamrekelashvili, J.3
von Wasielewski, R.4
Greten, F.R.5
Westendorf, A.M.6
Buer, J.7
Schmid, R.M.8
Manns, M.P.9
Korangy, F.10
Greten, T.F.11
-
110
-
-
0034665508
-
Mice with spontaneous pancreatic cancer naturally develop MUC-1-specific CTLs that eradicate tumors when adoptively transferred
-
Mukherjee P, Ginardi AR, Madsen CS, Sterner CJ, Adriance MC, Tevethia MJ, Gendler SJ: Mice with spontaneous pancreatic cancer naturally develop MUC-1-specific CTLs that eradicate tumors when adoptively transferred. J Immunol 2000, 165:3451-3460
-
(2000)
J Immunol
, vol.165
, pp. 3451-3460
-
-
Mukherjee, P.1
Ginardi, A.R.2
Madsen, C.S.3
Sterner, C.J.4
Adriance, M.C.5
Tevethia, M.J.6
Gendler, S.J.7
-
111
-
-
0036435924
-
Dendritic cell-tumor cell fusion and staphylococcal enterotoxin B treatment in a pancreatic tumor model
-
McConnell EJ, Pathangey LB, Madsen CS, Gendler SJ, Mukherjee P: Dendritic cell-tumor cell fusion and staphylococcal enterotoxin B treatment in a pancreatic tumor model. J Surg Res 2002, 107:196-202
-
(2002)
J Surg Res
, vol.107
, pp. 196-202
-
-
McConnell, E.J.1
Pathangey, L.B.2
Madsen, C.S.3
Gendler, S.J.4
Mukherjee, P.5
-
112
-
-
0030843485
-
A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice
-
Tevethia MJ, Bonneau RH, Griffith JW, Mylin L: A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice. J Virol 1997, 71:8157-8166
-
(1997)
J Virol
, vol.71
, pp. 8157-8166
-
-
Tevethia, M.J.1
Bonneau, R.H.2
Griffith, J.W.3
Mylin, L.4
-
113
-
-
33751251034
-
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
-
Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA: Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev 2006, 20:3130-3146
-
(2006)
Genes Dev
, vol.20
, pp. 3130-3146
-
-
Bardeesy, N.1
Cheng, K.H.2
Berger, J.H.3
Chu, G.C.4
Pahler, J.5
Olson, P.6
Hezel, A.F.7
Horner, J.8
Lauwers, G.Y.9
Hanahan, D.10
DePinho, R.A.11
-
114
-
-
33847387472
-
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas
-
Izeradjene K, Combs C, Best M, Gopinathan A, Wagner A, Grady WM, Deng CX, Hruban RH, Adsay NV, Tuveson DA, Hingorani SR: Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell 2007, 11:229-243
-
(2007)
Cancer Cell
, vol.11
, pp. 229-243
-
-
Izeradjene, K.1
Combs, C.2
Best, M.3
Gopinathan, A.4
Wagner, A.5
Grady, W.M.6
Deng, C.X.7
Hruban, R.H.8
Adsay, N.V.9
Tuveson, D.A.10
Hingorani, S.R.11
-
115
-
-
33751247898
-
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression
-
Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, Fujitani S, Wright CV, Moses HL: Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev 2006, 20:3147-3160
-
(2006)
Genes Dev
, vol.20
, pp. 3147-3160
-
-
Ijichi, H.1
Chytil, A.2
Gorska, A.E.3
Aakre, M.E.4
Fujitani, Y.5
Fujitani, S.6
Wright, C.V.7
Moses, H.L.8
-
116
-
-
24644487312
-
TGF-beta and epithelial-to-mesenchymal transitions
-
Zavadil J, Bottinger EP: TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005, 24:5764-5774
-
(2005)
Oncogene
, vol.24
, pp. 5764-5774
-
-
Zavadil, J.1
Bottinger, E.P.2
-
117
-
-
33751209187
-
Hedgehog/Ras interactions regulate early stages of pancreatic cancer
-
Pasca di Magliano M, Sekine S, Ermilov A, Ferris J, Dlugosz AA, Hebrok M: Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev 2006, 20:3161-3173
-
(2006)
Genes Dev
, vol.20
, pp. 3161-3173
-
-
Pasca di Magliano, M.1
Sekine, S.2
Ermilov, A.3
Ferris, J.4
Dlugosz, A.A.5
Hebrok, M.6
-
118
-
-
33744524388
-
Preinvasive duct-derived neoplasms in pancreas of keratin 5-promoter cyclooxygenase-2 transgenic mice
-
Muller-Decker K, Furstenberger G, Annan N, Kucher D, Pohl-Arnold A, Steinbauer B, Esposito I, Chiblak S, Friess H, Schirmacher P, Berger I: Preinvasive duct-derived neoplasms in pancreas of keratin 5-promoter cyclooxygenase-2 transgenic mice. Gastroenterology 2006, 130:2165-2178
-
(2006)
Gastroenterology
, vol.130
, pp. 2165-2178
-
-
Muller-Decker, K.1
Furstenberger, G.2
Annan, N.3
Kucher, D.4
Pohl-Arnold, A.5
Steinbauer, B.6
Esposito, I.7
Chiblak, S.8
Friess, H.9
Schirmacher, P.10
Berger, I.11
-
119
-
-
0036161385
-
Expression of CCK2 receptors in the murine pancreas: Proliferation, transdifferentiation of acinar cells, and neoplasia
-
Clerc P, Leung-Theung-Long S, Wang TC, Dockray GJ, Bouisson M, Delisle MB, Vaysse N, Pradayrol L, Fourmy D, Dufresne M: Expression of CCK2 receptors in the murine pancreas: proliferation, transdifferentiation of acinar cells, and neoplasia. Gastroenterology 2002, 122:428-437
-
(2002)
Gastroenterology
, vol.122
, pp. 428-437
-
-
Clerc, P.1
Leung-Theung-Long, S.2
Wang, T.C.3
Dockray, G.J.4
Bouisson, M.5
Delisle, M.B.6
Vaysse, N.7
Pradayrol, L.8
Fourmy, D.9
Dufresne, M.10
-
120
-
-
33645049305
-
Downregulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells
-
Wang Z, Banerjee S, Li Y, Rahman KM, Zhang Y, Sarkar FH: Downregulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res 2006, 66:2778-2784
-
(2006)
Cancer Res
, vol.66
, pp. 2778-2784
-
-
Wang, Z.1
Banerjee, S.2
Li, Y.3
Rahman, K.M.4
Zhang, Y.5
Sarkar, F.H.6
-
121
-
-
55349119506
-
Extracellular sulfatases, elements of the wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells
-
Nawroth R, van Zante A, Cervantes S, McManus M, Hebrok M, Rosen SD: Extracellular sulfatases, elements of the wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS ONE 2007, 2:e392
-
(2007)
PLoS ONE
, vol.2
-
-
Nawroth, R.1
van Zante, A.2
Cervantes, S.3
McManus, M.4
Hebrok, M.5
Rosen, S.D.6
-
122
-
-
33646425568
-
Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma
-
Zeng G, Germinaro M, Micsenyi A, Monga NK, Bell A, Sood A, Malhotra V, Sood N, Midda V, Monga DK, Kokkinakis DM, Monga SP: Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma. Neoplasia 2006, 8:279-289
-
(2006)
Neoplasia
, vol.8
, pp. 279-289
-
-
Zeng, G.1
Germinaro, M.2
Micsenyi, A.3
Monga, N.K.4
Bell, A.5
Sood, A.6
Malhotra, V.7
Sood, N.8
Midda, V.9
Monga, D.K.10
Kokkinakis, D.M.11
Monga, S.P.12
-
123
-
-
20344407571
-
Immunotherapy for pancreatic cancer: Science driving clinical progress
-
Laheru D, Jaffee EM: Immunotherapy for pancreatic cancer: science driving clinical progress. Nat Rev Cancer 2005, 5:459-467
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 459-467
-
-
Laheru, D.1
Jaffee, E.M.2
-
124
-
-
0035152718
-
Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: A phase I trial of safety and immune activation
-
Jaffee EM, Hruban RH, Biedrzycki B, Laheru D, Schepers K, Sauter PR, Goemann M, Coleman J, Grochow L, Donehower RC, Lillemoe KD, O'Reilly S, Abrams RA, Pardoll DM, Cameron JL, Yeo CJ: Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation. J Clin Oncol 2001, 19:145-156
-
(2001)
J Clin Oncol
, vol.19
, pp. 145-156
-
-
Jaffee, E.M.1
Hruban, R.H.2
Biedrzycki, B.3
Laheru, D.4
Schepers, K.5
Sauter, P.R.6
Goemann, M.7
Coleman, J.8
Grochow, L.9
Donehower, R.C.10
Lillemoe, K.D.11
O'Reilly, S.12
Abrams, R.A.13
Pardoll, D.M.14
Cameron, J.L.15
Yeo, C.J.16
-
125
-
-
27144532118
-
In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor
-
van der Heijden MS, Brody JR, Dezentje DA, Gallmeier E, Cunningham SC, Swartz MJ, DeMarzo AM, Offerhaus GJ, Isacoff WH, Hruban RH, Kern SE: In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor. Clin Cancer Res 2005, 11:7508-7515
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7508-7515
-
-
van der Heijden, M.S.1
Brody, J.R.2
Dezentje, D.A.3
Gallmeier, E.4
Cunningham, S.C.5
Swartz, M.J.6
DeMarzo, A.M.7
Offerhaus, G.J.8
Isacoff, W.H.9
Hruban, R.H.10
Kern, S.E.11
-
126
-
-
26844527356
-
CXCR4 expression increases liver and lung metastasis in a mouse model of pancreatic cancer
-
Saur D, Seidler B, Schneider G, Algul H, Beck R, Senekowitsch-Schmidtke R, Schwaiger M, Schmid RM: CXCR4 expression increases liver and lung metastasis in a mouse model of pancreatic cancer. Gastroenterology 2005, 129:1237-1250
-
(2005)
Gastroenterology
, vol.129
, pp. 1237-1250
-
-
Saur, D.1
Seidler, B.2
Schneider, G.3
Algul, H.4
Beck, R.5
Senekowitsch-Schmidtke, R.6
Schwaiger, M.7
Schmid, R.M.8
-
127
-
-
21344441462
-
Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner
-
Guleng B, Tateishi K, Ohta M, Kanai F, Jazag A, Ijichi H, Tanaka Y, Washida M, Morikane K, Fukushima Y, Yamori T, Tsuruo T, Kawabe T, Miyagishi M, Taira K, Sata M, Omata M: Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res 2005, 65:5864-5871
-
(2005)
Cancer Res
, vol.65
, pp. 5864-5871
-
-
Guleng, B.1
Tateishi, K.2
Ohta, M.3
Kanai, F.4
Jazag, A.5
Ijichi, H.6
Tanaka, Y.7
Washida, M.8
Morikane, K.9
Fukushima, Y.10
Yamori, T.11
Tsuruo, T.12
Kawabe, T.13
Miyagishi, M.14
Taira, K.15
Sata, M.16
Omata, M.17
-
128
-
-
33947368690
-
TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window
-
Koschny R, Ganten TM, Sykora J, Haas TL, Sprick MR, Kolb A, Stremmel W, Walczak H: TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. Hepatology 2007, 45:649-658
-
(2007)
Hepatology
, vol.45
, pp. 649-658
-
-
Koschny, R.1
Ganten, T.M.2
Sykora, J.3
Haas, T.L.4
Sprick, M.R.5
Kolb, A.6
Stremmel, W.7
Walczak, H.8
-
129
-
-
34147144169
-
Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein
-
Karikari CA, Roy I, Tryggestad E, Feldmann G, Pinilla C, Welsh K, Reed JC, Armour EP, Wong J, Herman J, Rakheja D, Maitra A: Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein. Mol Cancer Ther 2007, 6:957-966
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 957-966
-
-
Karikari, C.A.1
Roy, I.2
Tryggestad, E.3
Feldmann, G.4
Pinilla, C.5
Welsh, K.6
Reed, J.C.7
Armour, E.P.8
Wong, J.9
Herman, J.10
Rakheja, D.11
Maitra, A.12
-
130
-
-
34247620285
-
Bacterially Derived 400 nm Particles for Encapsulation and Cancer Cell Targeting of Chemotherapeutics
-
Macdiarmid JA, Mugridge NB, Weiss JC, Phillips L, Burn AL, Paulin RP, Haasdyk JE, Dickson KA, Brahmbhatt VN, Pattison ST, James AC, Al Bakri G, Straw RC, Stillman B, Graham RM, Brahmbhatt H: Bacterially Derived 400 nm Particles for Encapsulation and Cancer Cell Targeting of Chemotherapeutics. Cancer Cell 2007, 11:431-445
-
(2007)
Cancer Cell
, vol.11
, pp. 431-445
-
-
Macdiarmid, J.A.1
Mugridge, N.B.2
Weiss, J.C.3
Phillips, L.4
Burn, A.L.5
Paulin, R.P.6
Haasdyk, J.E.7
Dickson, K.A.8
Brahmbhatt, V.N.9
Pattison, S.T.10
James, A.C.11
Al Bakri, G.12
Straw, R.C.13
Stillman, B.14
Graham, R.M.15
Brahmbhatt, H.16
-
131
-
-
34248573808
-
Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products
-
Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB: Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res 2007, 67:3853-3861
-
(2007)
Cancer Res
, vol.67
, pp. 3853-3861
-
-
Kunnumakkara, A.B.1
Guha, S.2
Krishnan, S.3
Diagaradjane, P.4
Gelovani, J.5
Aggarwal, B.B.6
-
132
-
-
33746353391
-
Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis
-
Cruz-Correa M, Shoskes DA, Sanchez P, Zhao R, Hylind LM, Wexner SD, Giardiello FM: Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol 2006, 4:1035-1038
-
(2006)
Clin Gastroenterol Hepatol
, vol.4
, pp. 1035-1038
-
-
Cruz-Correa, M.1
Shoskes, D.A.2
Sanchez, P.3
Zhao, R.4
Hylind, L.M.5
Wexner, S.D.6
Giardiello, F.M.7
-
133
-
-
0035174504
-
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions
-
Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC, Hsieh CY: Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 2001, 21:2895-2900
-
(2001)
Anticancer Res
, vol.21
, pp. 2895-2900
-
-
Cheng, A.L.1
Hsu, C.H.2
Lin, J.K.3
Hsu, M.M.4
Ho, Y.F.5
Shen, T.S.6
Ko, J.Y.7
Lin, J.T.8
Lin, B.R.9
Ming-Shiang, W.10
Yu, H.S.11
Jee, S.H.12
Chen, G.S.13
Chen, T.M.14
Chen, C.A.15
Lai, M.K.16
Pu, Y.S.17
Pan, M.H.18
Wang, Y.J.19
Tsai, C.C.20
Hsieh, C.Y.21
more..
-
134
-
-
33645648062
-
Dose escalation of a curcuminoid formulation
-
Lao CD, Ruffin MT, Normolle D, Heath DD, Murray SI, Bailey JM, Boggs ME, Crowell J, Rock CL, Brenner DE: Dose escalation of a curcuminoid formulation. BMC Complement Altern Med 2006, 6:10
-
(2006)
BMC Complement Altern Med
, vol.6
, pp. 10
-
-
Lao, C.D.1
Ruffin, M.T.2
Normolle, D.3
Heath, D.D.4
Murray, S.I.5
Bailey, J.M.6
Boggs, M.E.7
Crowell, J.8
Rock, C.L.9
Brenner, D.E.10
-
135
-
-
34248205135
-
Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): A novel strategy for human cancer therapy
-
Bisht S, Feldmann G, Soni S, Ravi R, Karikar C, Maitra A, Maitra A: Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy. J Nanobiotechnol 2007, 5:3
-
(2007)
J Nanobiotechnol
, vol.5
, pp. 3
-
-
Bisht, S.1
Feldmann, G.2
Soni, S.3
Ravi, R.4
Karikar, C.5
Maitra, A.6
Maitra, A.7
-
136
-
-
24644508916
-
-
Li L, Braiteh FS, Kurzrock R: Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer 2005, 104:1322-1331
-
Li L, Braiteh FS, Kurzrock R: Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer 2005, 104:1322-1331
-
-
-
|