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Volumn 5, Issue 6, 2005, Pages 459-467

Immunotherapy for pancreatic cancer - Science driving clinical progress

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CANCER VACCINE; CETUXIMAB; CYCLOPHOSPHAMIDE; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; GEMCITABINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MONOCLONAL ANTIBODY; VASCULOTROPIN INHIBITOR;

EID: 20344407571     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1630     Document Type: Review
Times cited : (176)

References (108)
  • 2
    • 1642588228 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Li, D. et al. Pancreatic cancer. Lancet 363, 1049-1057 (2004).
    • (2004) Lancet , vol.363 , pp. 1049-1057
    • Li, D.1
  • 3
    • 6044267987 scopus 로고    scopus 로고
    • The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
    • Spratlin, J. et al. The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clin. Cancer Res. 10, 6956-6961 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6956-6961
    • Spratlin, J.1
  • 4
    • 0035409782 scopus 로고    scopus 로고
    • Immunologic approaches to the management of pancreatic cancer
    • Laheru, D., Biedrzycki, B. & Jaffee, E. M. Immunologic approaches to the management of pancreatic cancer. Cancer J. 7, 324-337 (2001).
    • (2001) Cancer J. , vol.7 , pp. 324-337
    • Laheru, D.1    Biedrzycki, B.2    Jaffee, E.M.3
  • 5
    • 4644293572 scopus 로고    scopus 로고
    • Cancer Immunotherapy: Breaking the barriers to harvest the crop
    • Pardoll, D. & Allison, J. Cancer Immunotherapy: breaking the barriers to harvest the crop. Nature Med. 10, 887-892 (2004).
    • (2004) Nature Med. , vol.10 , pp. 887-892
    • Pardoll, D.1    Allison, J.2
  • 6
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • Rosenberg, S. A., Yang, J. C. & Restifo, N. P. Cancer immunotherapy: moving beyond current vaccines. Nature Med. 10, 909-915 (2004).
    • (2004) Nature Med. , vol.10 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 7
    • 0027440470 scopus 로고
    • Molecular mechanisms used by tumors to escape immune recognition: Immunogenetherapy and the cell biology of major histocompatibility complex class I
    • Restifo, N. P. et al. Molecular mechanisms used by tumors to escape immune recognition: immunogenetherapy and the cell biology of major histocompatibility complex class I. J. Immunol. 14, 182-190 (1993).
    • (1993) J. Immunol. , vol.14 , pp. 182-190
    • Restifo, N.P.1
  • 8
    • 0032532318 scopus 로고    scopus 로고
    • Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes
    • Ganss, R. & Hanahan, D. Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes. Cancer Res. 58, 4673-4681 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 4673-4681
    • Ganss, R.1    Hanahan, D.2
  • 9
    • 11144357779 scopus 로고    scopus 로고
    • Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
    • Wang, T. et al. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nature Med. 10, 48-54 (2004).
    • (2004) Nature Med. , vol.10 , pp. 48-54
    • Wang, T.1
  • 10
    • 0031892785 scopus 로고    scopus 로고
    • Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-κB activation in hemopoietic progenitor cells
    • Oyama, T. et al. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-κB activation in hemopoietic progenitor cells. J. Immunol. 160, 1224-1232 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 1224-1232
    • Oyama, T.1
  • 11
    • 0034984740 scopus 로고    scopus 로고
    • VEGF as a mediator of tumor-associated immunodeficiency
    • Ohm, J. E. & Carbone, D. P. VEGF as a mediator of tumor-associated immunodeficiency. Immunol. Res. 23, 263-272 (2001).
    • (2001) Immunol. Res. , vol.23 , pp. 263-272
    • Ohm, J.E.1    Carbone, D.P.2
  • 12
    • 0032770957 scopus 로고    scopus 로고
    • Tumor-associated transforming growth factor β and interieukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patrients
    • Bellone, G. et al. Tumor-associated transforming growth factor β and interieukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patrients. Am. J. Pathol. 155, 537-547 (1999).
    • (1999) Am. J. Pathol. , vol.155 , pp. 537-547
    • Bellone, G.1
  • 13
    • 0141782725 scopus 로고    scopus 로고
    • BTLA: A new inhibitory receptor with a B7-like ligand
    • Carreno, B. M. & Collins, M. BTLA: a new inhibitory receptor with a B7-like ligand. Trends Immunol. 24, 524-527 (2003).
    • (2003) Trends Immunol. , vol.24 , pp. 524-527
    • Carreno, B.M.1    Collins, M.2
  • 14
    • 0038094524 scopus 로고    scopus 로고
    • B7-H4, a molecule of the B7 family, negatively regulates T cell immunity
    • Sica, G. L. et al. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 18, 849-861 (2003).
    • (2003) Immunity , vol.18 , pp. 849-861
    • Sica, G.L.1
  • 15
    • 0035292756 scopus 로고    scopus 로고
    • The expanding B7 superfamily: Increasing complexity in co-stimulatory signals regulating T cell function
    • Coyle, A. J. & Gutierrez-Ramos, J. C. The expanding B7 superfamily: increasing complexity in co-stimulatory signals regulating T cell function. Nature Immunol. 2, 203-209 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 203-209
    • Coyle, A.J.1    Gutierrez-Ramos, J.C.2
  • 17
    • 0035102196 scopus 로고    scopus 로고
    • CTLA-4 regulates induction of anergy in vivo
    • Greenwald, R. J. et al. CTLA-4 regulates induction of anergy in vivo. Immunity 14, 145-155 (2001).
    • (2001) Immunity , vol.14 , pp. 145-155
    • Greenwald, R.J.1
  • 18
    • 2442585121 scopus 로고    scopus 로고
    • Co-inhibitory molecules of the B7-CD28 family in the control of T cell immunity
    • Chen, L. Co-inhibitory molecules of the B7-CD28 family in the control of T cell immunity. Nature Rev. Immun. 4, 336-347 (2004). Summarizes the B7 receptor family on APCs and their role in immune regulation.
    • (2004) Nature Rev. Immun. , vol.4 , pp. 336-347
    • Chen, L.1
  • 20
    • 0029953858 scopus 로고    scopus 로고
    • CTLA-4 ligation blocks CD28-dependent T cell activation
    • Walunas, T. L., Bakker, C. Y. & Bluestone, J. A. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183, 2541-2550 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 2541-2550
    • Walunas, T.L.1    Bakker, C.Y.2    Bluestone, J.A.3
  • 21
    • 0035102196 scopus 로고    scopus 로고
    • CTLA-4 regulates induction of anergy in vivo
    • Greenwald, R. J. et al. CTLA-4 regulates induction of anergy in vivo. Immunity 14, 145-155 (2001).
    • (2001) Immunity , vol.14 , pp. 145-155
    • Greenwald, R.J.1
  • 22
    • 0033062691 scopus 로고    scopus 로고
    • CD28/CTLA-4 and CD80/86 families: Signaling and function
    • Slavik, J. M., Hutchcroft, J. E. & Bierer, B. E. CD28/CTLA-4 and CD80/86 families: signaling and function. Immunol. Res. 19, 1-24 (1999).
    • (1999) Immunol. Res. , vol.19 , pp. 1-24
    • Slavik, J.M.1    Hutchcroft, J.E.2    Bierer, B.E.3
  • 24
    • 0037393460 scopus 로고    scopus 로고
    • T cell costimulatory pathways: Blockade for autoimmunity
    • Najafian, N. & Khoury, S. J. T cell costimulatory pathways: blockade for autoimmunity. Expert Opin. Biol. Ther. 3, 227-236 (2003).
    • (2003) Expert Opin. Biol. Ther. , vol.3 , pp. 227-236
    • Najafian, N.1    Khoury, S.J.2
  • 25
    • 0036214017 scopus 로고    scopus 로고
    • The B7 family of ligands and its receptors: New pathways for co-stimulaton inhibition of immune responses
    • Carreno, B. M. & Collins, M. The B7 family of ligands and its receptors: new pathways for co-stimulaton inhibition of immune responses. Annu. Rev. Immunol. 20, 29-53 (2002)
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 29-53
    • Carreno, B.M.1    Collins, M.2
  • 26
    • 0038796692 scopus 로고    scopus 로고
    • B7-H1 pathway and its role in the evasion of tumor immunity
    • Dong, H. & Chen, L. B7-H1 pathway and its role in the evasion of tumor immunity. J. Mol. Med. 81, 281-287 (2003).
    • (2003) J. Mol. Med. , vol.81 , pp. 281-287
    • Dong, H.1    Chen, L.2
  • 27
    • 0036888554 scopus 로고    scopus 로고
    • New regulatory co-receptors: Inducible co-stimulator and PD-1
    • Okazaki, T., Iwai, Y. & Honjo, T. New regulatory co-receptors: inducible co-stimulator and PD-1. Curr. Opin. Immunol. 14, 779-782 (2002).
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 779-782
    • Okazaki, T.1    Iwai, Y.2    Honjo, T.3
  • 28
    • 0030005099 scopus 로고    scopus 로고
    • Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
    • Agata, Y. et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8, 765-772 (1996).
    • (1996) Int. Immunol. , vol.8 , pp. 765-772
    • Agata, Y.1
  • 29
    • 2442461055 scopus 로고    scopus 로고
    • The roles of the new negative T cell costimulatory pathways in regulating autoimmunity
    • Khoury, S. J. & Sayegh, M. H. The roles of the new negative T cell costimulatory pathways in regulating autoimmunity. Immunity 20, 529-538 (2004). Succinctly describes the complex interaction of T cells and APCs and their relationship in defining immune regulation.
    • (2004) Immunity , vol.20 , pp. 529-538
    • Khoury, S.J.1    Sayegh, M.H.2
  • 30
    • 0242303572 scopus 로고    scopus 로고
    • Regulation of PD-1, PD-L1 ,PD-L2 expression during normal and autoimmune responses
    • Liang, S. C. et al. Regulation of PD-1, PD-L1 ,PD-L2 expression during normal and autoimmune responses. Eur. J. Immunol. 33, 2706-2716 (2003). Describes the relationship and role of the programmed death receptors and immune regulation.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 2706-2716
    • Liang, S.C.1
  • 31
    • 0032794723 scopus 로고    scopus 로고
    • Immunological escape mechanisms in pancreatic carcinoma
    • Ungefroren, H. et al. Immunological escape mechanisms in pancreatic carcinoma. Ann. NY Acad. Sci. 880, 243-251 (1999).
    • (1999) Ann. NY Acad. Sci. , vol.880 , pp. 243-251
    • Ungefroren, H.1
  • 32
    • 0034012799 scopus 로고    scopus 로고
    • Fas and Fas-ligand expression in human pancreatic cancer
    • Kornmann, M., Ishiwata, T., Kleef, J., Beger, H. G. & Korc, M. Fas and Fas-ligand expression in human pancreatic cancer. Ann. Surg. 231, 368-379 (2000).
    • (2000) Ann. Surg. , vol.231 , pp. 368-379
    • Kornmann, M.1    Ishiwata, T.2    Kleef, J.3    Beger, H.G.4    Korc, M.5
  • 33
    • 0035219753 scopus 로고    scopus 로고
    • Human pancreatic cancer cells express non functional Fas receptors and counterattack lymphocytes by expressing Fas ligand; a potential mechanism for immune escape
    • Elnemr, A. et al. Human pancreatic cancer cells express non functional Fas receptors and counterattack lymphocytes by expressing Fas ligand; a potential mechanism for immune escape. Int. J. Oncol. 18, 33-39 (2001). Describes the association between the death receptor FAS ligand and pancreatic cancer.
    • (2001) Int. J. Oncol. , vol.18 , pp. 33-39
    • Elnemr, A.1
  • 34
    • 0032893304 scopus 로고    scopus 로고
    • Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas (APO-1/CD95) receptors and aberrant expression of Fas ligand
    • Von Bernstorff, W. et al. Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas (APO-1/CD95) receptors and aberrant expression of Fas ligand. Surgery 125, 73-84 (1999).
    • (1999) Surgery , vol.125 , pp. 73-84
    • Von Bernstorff, W.1
  • 35
    • 0032522848 scopus 로고    scopus 로고
    • Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas mediated apoptosis
    • Ungefroren, H. et al. Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas mediated apoptosis. Cancer Res. 58, 1741-1749 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 1741-1749
    • Ungefroren, H.1
  • 36
    • 0037606064 scopus 로고    scopus 로고
    • CTLA-4. FasL induces alloantigen-specific hyporesponsiveness
    • Elhalel, M. D. et al. CTLA-4. FasL induces alloantigen-specific hyporesponsiveness. J. Immunol. 170, 5842-5850 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 5842-5850
    • Elhalel, M.D.1
  • 37
    • 3843123323 scopus 로고    scopus 로고
    • Chronic exposure of transforming growth factor β1 confers a more aggressive tumor phenotype through down-regulation of p21 (WAF1/CIP1) in conditionally immortalized pancreatic epithelial cells
    • Ito, D. et al. Chronic exposure of transforming growth factor β1 confers a more aggressive tumor phenotype through down-regulation of p21 (WAF1/CIP1) in conditionally immortalized pancreatic epithelial cells. Surgery 136, 364-374 (2004).
    • (2004) Surgery , vol.136 , pp. 364-374
    • Ito, D.1
  • 38
    • 0041922583 scopus 로고    scopus 로고
    • 1 expression metastatic capability of human pancreatic cancer
    • 1 expression metastatic capability of human pancreatic cancer. Oncology 65, 167-173 (2003).
    • (2003) Oncology , vol.65 , pp. 167-173
    • Sawai, H.1
  • 39
    • 0242490137 scopus 로고    scopus 로고
    • Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells
    • Duda, D. G. et al. Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells. Oncogene 22, 6857-6864 (2003).
    • (2003) Oncogene , vol.22 , pp. 6857-6864
    • Duda, D.G.1
  • 40
    • 0036875671 scopus 로고    scopus 로고
    • Expression of IL-6 receptor in pancreatic cancer: Involvement in VEGF induction
    • Masui, T. et al. Expression of IL-6 receptor in pancreatic cancer: involvement in VEGF induction. Anticancer Res. 22, 4093-4100 (2002).
    • (2002) Anticancer Res. , vol.22 , pp. 4093-4100
    • Masui, T.1
  • 41
    • 0032770957 scopus 로고    scopus 로고
    • Tumor-associated transforming growth factor β and interleukin- 10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients
    • Bellone, G. et al. Tumor-associated transforming growth factor β and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients. Am. J. Pathol. 155, 537-547 (1999).
    • (1999) Am. J. Pathol. , vol.155 , pp. 537-547
    • Bellone, G.1
  • 42
    • 0345865175 scopus 로고    scopus 로고
    • TGF-β how tolerant can it be?
    • Wahl, S. M. & Chen, W. TGF-β: how tolerant can it be? Immunol. Res. 28, 167-179 (2003).
    • (2003) Immunol. Res. , vol.28 , pp. 167-179
    • Wahl, S.M.1    Chen, W.2
  • 43
    • 0025049140 scopus 로고
    • Structure of the T cell antigen receptor: Evidence for two CD3 ε subunits in the T cell receptor-CD3 complex
    • Blumberg, R. S. et al. Structure of the T cell antigen receptor: evidence for two CD3 ε subunits in the T cell receptor-CD3 complex. Proc. Natl Acad. Sci. USA 87, 7220-7224 (1990).
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7220-7224
    • Blumberg, R.S.1
  • 44
    • 0024150991 scopus 로고    scopus 로고
    • The T cell receptor/CD3 complex: A dynamic protein ensemble
    • Clevers, H. The T cell receptor/CD3 complex: a dynamic protein ensemble. Annu. Rev. Immunol. 6, 629-662 (1998).
    • (1998) Annu. Rev. Immunol. , vol.6 , pp. 629-662
    • Clevers, H.1
  • 45
    • 0023443171 scopus 로고
    • Evolutionary relationship between the T3 chain of the T-cell receptor complex and the immunoglobulin supergene family
    • Gold, D. P. et al. Evolutionary relationship between the T3 chain of the T-cell receptor complex and the immunoglobulin supergene family. Proc. Natl Acad. Sci. USA 64, 7649-7653 (1987).
    • (1987) Proc. Natl. Acad. Sci. USA , vol.64 , pp. 7649-7653
    • Gold, D.P.1
  • 46
    • 0026544338 scopus 로고
    • The T cell receptor/CD 3 complex is composed of at least two autonomous transduction modules
    • Wegener, A. M. K. et al. The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell 68, 83-95 (1992).
    • (1992) Cell , vol.68 , pp. 83-95
    • Wegener, A.M.K.1
  • 47
    • 0025971630 scopus 로고
    • T cell antigen receptor activation pathways: The tyrosine kinase connection
    • Klausner, R. D. & Samelson, L. E. T cell antigen receptor activation pathways: the tyrosine kinase connection. Cell 64, 875-878 (1991)
    • (1991) Cell , vol.64 , pp. 875-878
    • Klausner, R.D.1    Samelson, L.E.2
  • 48
    • 0026064305 scopus 로고
    • The cyloplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor associated signal transduction pathways
    • Irving, B. A. & Weiss, A. The cyloplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor associated signal transduction pathways. Cell 64, 891-901 (1991). Describes the regulation of the ζ chain of the T-cell receptor and its important role in immune regulation.
    • (1991) Cell , vol.64 , pp. 891-901
    • Irving, B.A.1    Weiss, A.2
  • 49
    • 0022993986 scopus 로고
    • Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor
    • Samelson, L. E., Patel, M. D., Weissman, A. M., Harford, J. B. & Klausner, R. D. Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell 46, 1083-1090 (1986).
    • (1986) Cell , vol.46 , pp. 1083-1090
    • Samelson, L.E.1    Patel, M.D.2    Weissman, A.M.3    Harford, J.B.4    Klausner, R.D.5
  • 50
    • 0025114471 scopus 로고
    • T cell receptor engagement stimulates c-raf associated kinase activity via a protein kinase C dependent pathway
    • Siegel, J. N., Klausner, R. D., Rapp, U. R. & Samelson, L. E. T cell receptor engagement stimulates c-raf associated kinase activity via a protein kinase C dependent pathway. J. Biol. Chem. 265, 18472-18480 (1990).
    • (1990) J. Biol. Chem. , vol.265 , pp. 18472-18480
    • Siegel, J.N.1    Klausner, R.D.2    Rapp, U.R.3    Samelson, L.E.4
  • 51
    • 0035294392 scopus 로고    scopus 로고
    • Suppressed T-cell receptor ζ chain expression and cytokine production in pancreatic cancer patients
    • Schmielau, J., Nalesnik, M. A. & Finn, O. J. Suppressed T-cell receptor ζ chain expression and cytokine production in pancreatic cancer patients. Clin. Cancer Res. 7, S933-S939 (2001).
    • (2001) Clin. Cancer Res. , vol.7
    • Schmielau, J.1    Nalesnik, M.A.2    Finn, O.J.3
  • 52
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991-1045 (1994).
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 53
    • 0023143676 scopus 로고
    • Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
    • Jenkins, M. K. & Schwartz, R. H. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165, 302-319 (1987).
    • (1987) J. Exp. Med. , vol.165 , pp. 302-319
    • Jenkins, M.K.1    Schwartz, R.H.2
  • 54
    • 12344286127 scopus 로고    scopus 로고
    • Emerging mechanisms of immune regulation-the extended B7 family and regulatory cells
    • Loke, P. & Allison, J. P. Emerging mechanisms of immune regulation-the extended B7 family and regulatory cells. Arthritis Res. Ther. 6, 208-214 (2004).
    • (2004) Arthritis Res. Ther. , vol.6 , pp. 208-214
    • Loke, P.1    Allison, J.P.2
  • 55
    • 2942592429 scopus 로고    scopus 로고
    • Therapeutic targeting of the effector T cell co-stimulatory molecule OX40
    • Sugamura, K., Ishii, N. & Weinberg, A. D. Therapeutic targeting of the effector T cell co-stimulatory molecule OX40. Nature Rev. Immunol. 4, 420-431 (2004).
    • (2004) Nature Rev. Immunol. , vol.4 , pp. 420-431
    • Sugamura, K.1    Ishii, N.2    Weinberg, A.D.3
  • 56
    • 0034677054 scopus 로고    scopus 로고
    • Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th) 1 and Th2 cells
    • Lane, P. Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th)1 and Th2 cells. J. Exp. Med. 191, 201-206 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 201-206
    • Lane, P.1
  • 57
    • 3343015039 scopus 로고    scopus 로고
    • The role of the CD40 pathway in the pathogenesis and treatment of cancer
    • Eliopoulos, A. G. & Young, L. S. The role of the CD40 pathway in the pathogenesis and treatment of cancer. Curr. Opin. Pharmacol. 4, 360-367 (2004).
    • (2004) Curr. Opin. Pharmacol. , vol.4 , pp. 360-367
    • Eliopoulos, A.G.1    Young, L.S.2
  • 58
    • 0037777538 scopus 로고    scopus 로고
    • VEGF inhibits T cell development and may contribute to tumor induced immune suppression
    • Ohm, J. E. et al. VEGF inhibits T cell development and may contribute to tumor induced immune suppression. Blood 101, 4878-4886 (2003). Characterizes the association of VEGF expression and depressed T-cell function in cancer.
    • (2003) Blood , vol.101 , pp. 4878-4886
    • Ohm, J.E.1
  • 59
    • 0037343236 scopus 로고    scopus 로고
    • Tumor cyclooxygenase 2 dependent suppression of dendritic cell function
    • Sharma, S. et al. Tumor cyclooxygenase 2 dependent suppression of dendritic cell function. Clin. Cancer Res. 9, 961-968 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 961-968
    • Sharma, S.1
  • 60
    • 0036569357 scopus 로고    scopus 로고
    • Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation
    • Sombroek, C. C. et al. Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation. J. Immunol. 168, 4333-4343 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 4333-4343
    • Sombroek, C.C.1
  • 61
    • 0348223787 scopus 로고    scopus 로고
    • + regulatory T cells by TGF-β induction of transcription factor Foxp 3
    • + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1
  • 62
    • 1242295282 scopus 로고    scopus 로고
    • + immunoregulatory T cells: Central players in the arena of peripheral tolerance
    • + immunoregulatory T cells: central players in the arena of peripheral tolerance. Sem. Immunol. 16, 81-88 (2004).
    • (2004) Sem. Immunol. , vol.16 , pp. 81-88
    • Piccirillo, C.A.1    Shevach, E.M.2
  • 63
    • 0036721629 scopus 로고    scopus 로고
    • Prevalence of regulatory T cells is increased in peripheral blood tumor microenvironment of patients with pancreas or breast adenocarcinoma
    • Liyanage, U. K. et al. Prevalence of regulatory T cells is increased in peripheral blood tumor microenvironment of patients with pancreas or breast adenocarcinoma. J. Immunol. 169, 2756-2761 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 2756-2761
    • Liyanage, U.K.1
  • 64
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel, T. J. et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nature Med. 10, 942-949 (2004).
    • (2004) Nature Med. , vol.10 , pp. 942-949
    • Curiel, T.J.1
  • 65
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • Mendelsohn, J. & Baselga, J. The EGF receptor family as targets for cancer therapy. Oncogene 19, 6550-6565 (2000).
    • (2000) Oncogene , vol.19 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2
  • 66
    • 12944315074 scopus 로고    scopus 로고
    • SMAD4/DPC4-mediated tumor suppression through suppression of angiogenesis
    • Schwarte-Waldhoff, I., Volpert, O. V. & Bouck, N. P. SMAD4/DPC4-mediated tumor suppression through suppression of angiogenesis. Proc. Natl Acad. Sci. USA 97, 9624-9629 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 9624-9629
    • Schwarte-Waldhoff, I.1    Volpert, O.V.2    Bouck, N.P.3
  • 67
    • 0043245914 scopus 로고    scopus 로고
    • Synergy between tumor immunotherapy and antiangiogenic therapy
    • Nair, S. et al. Synergy between tumor immunotherapy and antiangiogenic therapy. Blood 102, 964-971 (2003).
    • (2003) Blood , vol.102 , pp. 964-971
    • Nair, S.1
  • 68
    • 0032741283 scopus 로고    scopus 로고
    • Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
    • Gabrilovich, D. I. et al. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin. Cancer Res. 5, 2963-2970 (1999)
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2963-2970
    • Gabrilovich, D.I.1
  • 69
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic Cancer: A multicenter phase II trial
    • Xiong, H. Q. et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic Cancer: a multicenter phase II Trial. J. Clin. Oncol. 22, 2610-2616 (2004). The first work reporting the activity of a monoclonal antibody to EGFR and chemotherapy in patients with metastatic pancreatic cancer.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 2610-2616
    • Xiong, H.Q.1
  • 70
    • 8344258509 scopus 로고    scopus 로고
    • Bevacizumab plus gemcitabine in patients with advanced pancreatic cancer: Updated results of a multi-center phase II trial
    • Kindler, H. L. et al. Bevacizumab plus gemcitabine in patients with advanced pancreatic cancer: Updated results of a multi-center phase II trial. Proc. Am. Soc. Clin. Oncol. 23, A4009 (2004)
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23
    • Kindler, H.L.1
  • 71
    • 0043136619 scopus 로고    scopus 로고
    • + T cell effector function and tumor free survival in her-2/neu transgenic mice
    • + T cell effector function and tumor free survival in her-2/neu transgenic mice. J. Immunol. 171, 2161-2169 (2003). Establishes a synergistic effect when combining antigen-specific antibodies and vaccine approaches in preclinical models
    • (2003) J. Immunol. , vol.171 , pp. 2161-2169
    • Walpoe, M.E.1
  • 72
    • 0024376173 scopus 로고
    • ras oncogenes in human cancer: A review
    • Bos, J. L. ras oncogenes in human cancer: a review. Cancer Res. 49, 4682-4689 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 73
    • 0027733796 scopus 로고
    • K-ras oncogene activation in adenocarcinoma of the pancreas
    • Hruban, R. H. et al. K-ras oncogene activation in adenocarcinoma of the pancreas. Am. J. Path. 143, 545-554 (1993).
    • (1993) Am. J. Path. , vol.143 , pp. 545-554
    • Hruban, R.H.1
  • 74
    • 0028856743 scopus 로고
    • Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding ras mutation
    • Gjertsen, M. K. et al. Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding ras mutation. Lancet 346, 1399-1400 (1995).
    • (1995) Lancet , vol.346 , pp. 1399-1400
    • Gjertsen, M.K.1
  • 75
    • 0028989973 scopus 로고
    • MUC-1 epithelial tumor mucin-based immunity and vaccines
    • Finn, O. J. et al. MUC-1 epithelial tumor mucin-based immunity and vaccines. Immunol. Rev. 145, 61-89 (1995).
    • (1995) Immunol. Rev. , vol.145 , pp. 61-89
    • Finn, O.J.1
  • 76
  • 77
    • 0033057177 scopus 로고    scopus 로고
    • The carcinoembryonic antigen (CEA) family: Structures, suggested functions and expression in normal and malignant tissues
    • Hammarstrom, S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin. Cancer Biol. 9, 67-81 (1999).
    • (1999) Semin. Cancer Biol. , vol.9 , pp. 67-81
    • Hammarstrom, S.1
  • 78
    • 20344379581 scopus 로고    scopus 로고
    • Mutant ras vaccine in advanced cancers
    • Achtar, M. et al. Mutant ras vaccine in advanced cancers. Proc. Am. Soc. Clin. Oncol. 22, A677 (2003).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22
    • Achtar, M.1
  • 79
    • 0035152718 scopus 로고    scopus 로고
    • A novel allogeneic GM-CSF secreting tumor vaccine for pancreatic cancer: A phase I trial of safety and immune activation
    • Jaffee, E. M. et al. A novel allogeneic GM-CSF secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation. J. Clin. Oncol. 19, 145-156 (2001). The first work establishing the safety of a GM-CSF-secreting tumour in patients with resected pancreatic cancer.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 145-156
    • Jaffee, E.M.1
  • 80
    • 20344378583 scopus 로고    scopus 로고
    • Phase I study of immunization with dendritic cells modified with recombinant fowlpox encoding carcinoembryonic antigen (CEA) and the triad of costimulatory molecules CD54, CD58 and CD80 (rF-CEA(6D)-TRICOM) in patients with advanced malignancies
    • Morse, M. et al. Phase I study of immunization with dendritic cells modified with recombinant fowlpox encoding carcinoembryonic antigen (CEA) and the triad of costimulatory molecules CD54, CD58 and CD80 (rF-CEA(6D)-TRICOM) in patients with advanced malignancies. Proc. Am. Soc. Clin. Oncol. 23, A2508 (2004).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23
    • Morse, M.1
  • 81
    • 20344366424 scopus 로고    scopus 로고
    • A phase Ib study of a MUC1 pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic or biliary tumors
    • Finn, O. J. et al. A phase Ib study of a MUC1 pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic or biliary tumors. Proc. Am. Soc. Clin. Oncol. 23, A2578 (2004).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23
    • Finn, O.J.1
  • 82
    • 20044364936 scopus 로고    scopus 로고
    • Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas
    • Marshall, J. L. et al. Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas. J. Clin. Oncol. 23, 720-731 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 720-731
    • Marshall, J.L.1
  • 83
    • 18744374426 scopus 로고    scopus 로고
    • Randomised double blind placebo controlled multi-centre group sequential trial of G17DT for patients with advanced pancreatic cancer unsuitable or unwilling to take chemotherapy
    • Gilliam, A. D. et al. Randomised double blind placebo controlled multi-centre group sequential trial of G17DT for patients with advanced pancreatic cancer unsuitable or unwilling to take chemotherapy. Proc. Am. Soc. Clin. Oncol. 23, A2511 (2004).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23
    • Gilliam, A.D.1
  • 84
    • 4143116933 scopus 로고    scopus 로고
    • The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas
    • Harris, J. C. et al. The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas. Cancer Res. 64, 5624-5631 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 5624-5631
    • Harris, J.C.1
  • 85
    • 20344403202 scopus 로고    scopus 로고
    • A feasibility study of a GM-CSF secreting irradiated whole cell allogeneic vaccine (GVAX) alone or in sequence with cytoxan for patients with locally advanced or metastatic pancreatic cancer
    • Laheru, D. A. et al. A feasibility study of a GM-CSF secreting irradiated whole cell allogeneic vaccine (GVAX) alone or in sequence with cytoxan for patients with locally advanced or metastatic pancreatic cancer. Proc. Am. Assoc. Cancer Res. A54 (2004).
    • (2004) Proc. Am. Assoc. Cancer Res.
    • Laheru, D.A.1
  • 86
    • 5644246157 scopus 로고    scopus 로고
    • Anti-tumor effect induced by dendritic cell (DC) based immunotherapy against peritoneal dissemination of the hamster pancreatic cancer
    • Takigawa, Y. et al. Anti-tumor effect induced by dendritic cell (DC) based immunotherapy against peritoneal dissemination of the hamster pancreatic cancer. Cancer Lett. 215, 179-186 (2004).
    • (2004) Cancer Lett. , vol.215 , pp. 179-186
    • Takigawa, Y.1
  • 87
    • 1842430506 scopus 로고    scopus 로고
    • Development of immunotherapy for pancreas cancer
    • Kawakami, Y., Okada, T. & Akada, M. Development of immunotherapy for pancreas cancer. Pancreas 28, 320-325 (2004).
    • (2004) Pancreas , vol.28 , pp. 320-325
    • Kawakami, Y.1    Okada, T.2    Akada, M.3
  • 88
    • 0036202003 scopus 로고    scopus 로고
    • Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method
    • Nakatsura, T. et al. Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method. Eur. J. Immunol 32, 826-836 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 826-836
    • Nakatsura, T.1
  • 89
    • 0035902080 scopus 로고    scopus 로고
    • Progress in human tumour immunology and immunotherapy
    • Rosenberg, S. A. Progress in human tumour immunology and immunotherapy. Nature 411, 380-384 (2001)
    • (2001) Nature , vol.411 , pp. 380-384
    • Rosenberg, S.A.1
  • 90
    • 0028344535 scopus 로고
    • Tumor antigens recognized by T lymphocytes
    • Boon, T., et al. Tumor antigens recognized by T lymphocytes. Annu. Rev. Immunol. 12, 337-365 (1994).
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 337-365
    • Boon, T.1
  • 91
    • 0035360275 scopus 로고    scopus 로고
    • Discovery of new markers of cancer through serial analysis of gene expression (SAGE): Prostate stem cell antigen (PSCA) is overexpressed in pancreatic adenocarcinoma
    • Argani, P. et al. Discovery of new markers of cancer through serial analysis of gene expression (SAGE): prostate stem cell antigen (PSCA) is overexpressed in pancreatic adenocarcinoma. Cancer Res. 61, 4320-4324 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 4320-4324
    • Argani, P.1
  • 92
    • 0034306972 scopus 로고    scopus 로고
    • Prostate stem cell antigen is a promising candidate for immunotherapy of advanced prostate cancer
    • Dannull, J. et al. Prostate stem cell antigen is a promising candidate for immunotherapy of advanced prostate cancer. Cancer Res. 60, 5522-5528 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 5522-5528
    • Dannull, J.1
  • 93
    • 3042621639 scopus 로고    scopus 로고
    • Mesothelin: A new target for immunotherapy. Clin
    • Hassan, R., Bera, T. & Pastan, I. Mesothelin: a new target for immunotherapy. Clin. Cancer Res. 10, 3937-3942 (2004)
    • (2004) Cancer Res. , vol.10 , pp. 3937-3942
    • Hassan, R.1    Bera, T.2    Pastan, I.3
  • 94
    • 12144288836 scopus 로고    scopus 로고
    • Analysis of novel markers in pancreatic and biliary carcinomas using microarrays
    • Swierczynski, S. L. et al. Analysis of novel markers in pancreatic and biliary carcinomas using microarrays. Hum. Path. 35, 357-366 (2004)
    • (2004) Hum. Path. , vol.35 , pp. 357-366
    • Swierczynski, S.L.1
  • 95
    • 0035674996 scopus 로고    scopus 로고
    • Mesothelin is overexpressed in the vast majority of ductal adenocarcinoma of the pancreas: Identification of a new pancreatic cancer marker by serial analysis of gene expression
    • Argani, P. et al. Mesothelin is overexpressed in the vast majority of ductal adenocarcinoma of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression. Clin. Cancer Res. 7, 3862-3868 (2001). Describes the first identification of novel pancreatic cancer antigens identified by SAGE analysis.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3862-3868
    • Argani, P.1
  • 96
    • 3543060047 scopus 로고    scopus 로고
    • - T cell responses provide evidence of in vivo cross priming by antigen presenting cells in vaccinated pancreatic cancer patients
    • + T-cell response to a pancreatic-cancer-specific antigen can be generated through cross presentation by a vaccine approach designed to recruit APCs to the vaccine site.
    • (2004) J. Exp. Med. , vol.200 , pp. 297-306
    • Thomas, A.M.1
  • 97
    • 3042681334 scopus 로고    scopus 로고
    • Vaccinia as a vector for gene delivery
    • Guo, Z. S. & Bartlett, D. L. Vaccinia as a vector for gene delivery. Expert Opin. Biol. Ther. 4, 901-917 (2004).
    • (2004) Expert Opin. Biol. Ther. , vol.4 , pp. 901-917
    • Guo, Z.S.1    Bartlett, D.L.2
  • 98
    • 4043103413 scopus 로고    scopus 로고
    • TRICOM: Enhanced vaccines as anticancer therapy
    • Levy, B., Panicalli, D. & Marshall, J. TRICOM: enhanced vaccines as anticancer therapy. Expert Rev. Vaccines 3, 397-402 (2004).
    • (2004) Expert Rev. Vaccines , vol.3 , pp. 397-402
    • Levy, B.1    Panicalli, D.2    Marshall, J.3
  • 99
    • 0036993763 scopus 로고    scopus 로고
    • Vector based delivery of tumor-associated antigens and T cell co-stimulatory molecules in the induction of immune responses and anti-tumor immunity
    • Hodge, J. W., Grosenbach, D. W. & Schlom, J. Vector based delivery of tumor-associated antigens and T cell co-stimulatory molecules in the induction of immune responses and anti-tumor immunity. Cancer Defect. Prev. 26, 275-291 (2002).
    • (2002) Cancer Defect. Prev. , vol.26 , pp. 275-291
    • Hodge, J.W.1    Grosenbach, D.W.2    Schlom, J.3
  • 100
    • 0038668917 scopus 로고    scopus 로고
    • Advances in the development of bacterial vector technology
    • Kochi, S. K., Killeen, K. P. & Ryan, U. S. Advances in the development of bacterial vector technology. Expert Rev. Vaccines. 2, 31-43 (2003).
    • (2003) Expert Rev. Vaccines , vol.2 , pp. 31-43
    • Kochi, S.K.1    Killeen, K.P.2    Ryan, U.S.3
  • 101
    • 0037299739 scopus 로고    scopus 로고
    • Live attenuated bacteria as vectors to deliver plasmid DNA vaccines
    • Dietrich, G. et al. Live attenuated bacteria as vectors to deliver plasmid DNA vaccines. Curr. Opin. Mol. Ther. 5, 10-19 (2003).
    • (2003) Curr. Opin. Mol. Ther. , vol.5 , pp. 10-19
    • Dietrich, G.1
  • 102
    • 0022597114 scopus 로고
    • Induction of cell-mediated immunity to autologous melanoma cells and regression of metastases after treatment with a melanoma cell vaccine preceded by cyclophosphamide
    • Berd, D., Maguire, H. & Mastrangelo, M. Induction of cell-mediated immunity to autologous melanoma cells and regression of metastases after treatment with a melanoma cell vaccine preceded by cyclophosphamide. Cancer Res. 46, 2572-2577 (1986).
    • (1986) Cancer Res. , vol.46 , pp. 2572-2577
    • Berd, D.1    Maguire, H.2    Mastrangelo, M.3
  • 103
    • 0035116901 scopus 로고    scopus 로고
    • The collaboration of both humoral and cellular HER-2/neu targeted immune responses is required for the complete eradication of HER-2/neu expressing tumors
    • Reilly, R. T. et al. The collaboration of both humoral and cellular HER-2/neu targeted immune responses is required for the complete eradication of HER-2/neu expressing tumors. Cancer Res. 61, 880-883 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 880-883
    • Reilly, R.T.1
  • 104
    • 1642512647 scopus 로고    scopus 로고
    • Mouse models of pancreatic cancer: The fur is finally flying!
    • Leach, S. D. Mouse models of pancreatic cancer: the fur is finally flying! Cancer Cell 5, 7-11 (2004).
    • (2004) Cancer Cell , vol.5 , pp. 7-11
    • Leach, S.D.1
  • 105
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • Hingorani, S. R. et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4, 437-450 (2003). This is a seminal paper that describes for the first time a mouse model that recapitulates progressive early invasive pancreas cancer following activation of activated KRAS.
    • (2003) Cancer Cell , vol.4 , pp. 437-450
    • Hingorani, S.R.1
  • 106
    • 10944236962 scopus 로고    scopus 로고
    • Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
    • Olive, K. P. et al. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 119, 847-860 (2004).
    • (2004) Cell , vol.119 , pp. 847-860
    • Olive, K.P.1


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