-
1
-
-
0003998061
-
-
(ed. DeVita, V. T.) (J. B. Lippincott, Philadelphia)
-
Evans, D. B., Abbruzzese, J. L. & Willett, C. G. in Principles and Practice of Oncology 6th edn (ed. DeVita, V. T.) 1126-1161 (J. B. Lippincott, Philadelphia, 2001).
-
(2001)
Principles and Practice of Oncology 6th Edn.
, pp. 1126-1161
-
-
Evans, D.B.1
Abbruzzese, J.L.2
Willett, C.G.3
-
2
-
-
1642588228
-
Pancreatic cancer
-
Li, D. et al. Pancreatic cancer. Lancet 363, 1049-1057 (2004).
-
(2004)
Lancet
, vol.363
, pp. 1049-1057
-
-
Li, D.1
-
3
-
-
6044267987
-
The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
-
Spratlin, J. et al. The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clin. Cancer Res. 10, 6956-6961 (2004).
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 6956-6961
-
-
Spratlin, J.1
-
4
-
-
0035409782
-
Immunologic approaches to the management of pancreatic cancer
-
Laheru, D., Biedrzycki, B. & Jaffee, E. M. Immunologic approaches to the management of pancreatic cancer. Cancer J. 7, 324-337 (2001).
-
(2001)
Cancer J.
, vol.7
, pp. 324-337
-
-
Laheru, D.1
Biedrzycki, B.2
Jaffee, E.M.3
-
5
-
-
4644293572
-
Cancer Immunotherapy: Breaking the barriers to harvest the crop
-
Pardoll, D. & Allison, J. Cancer Immunotherapy: breaking the barriers to harvest the crop. Nature Med. 10, 887-892 (2004).
-
(2004)
Nature Med.
, vol.10
, pp. 887-892
-
-
Pardoll, D.1
Allison, J.2
-
6
-
-
4644324025
-
Cancer immunotherapy: Moving beyond current vaccines
-
Rosenberg, S. A., Yang, J. C. & Restifo, N. P. Cancer immunotherapy: moving beyond current vaccines. Nature Med. 10, 909-915 (2004).
-
(2004)
Nature Med.
, vol.10
, pp. 909-915
-
-
Rosenberg, S.A.1
Yang, J.C.2
Restifo, N.P.3
-
7
-
-
0027440470
-
Molecular mechanisms used by tumors to escape immune recognition: Immunogenetherapy and the cell biology of major histocompatibility complex class I
-
Restifo, N. P. et al. Molecular mechanisms used by tumors to escape immune recognition: immunogenetherapy and the cell biology of major histocompatibility complex class I. J. Immunol. 14, 182-190 (1993).
-
(1993)
J. Immunol.
, vol.14
, pp. 182-190
-
-
Restifo, N.P.1
-
8
-
-
0032532318
-
Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes
-
Ganss, R. & Hanahan, D. Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes. Cancer Res. 58, 4673-4681 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 4673-4681
-
-
Ganss, R.1
Hanahan, D.2
-
9
-
-
11144357779
-
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
-
Wang, T. et al. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nature Med. 10, 48-54 (2004).
-
(2004)
Nature Med.
, vol.10
, pp. 48-54
-
-
Wang, T.1
-
10
-
-
0031892785
-
Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-κB activation in hemopoietic progenitor cells
-
Oyama, T. et al. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-κB activation in hemopoietic progenitor cells. J. Immunol. 160, 1224-1232 (1998).
-
(1998)
J. Immunol.
, vol.160
, pp. 1224-1232
-
-
Oyama, T.1
-
11
-
-
0034984740
-
VEGF as a mediator of tumor-associated immunodeficiency
-
Ohm, J. E. & Carbone, D. P. VEGF as a mediator of tumor-associated immunodeficiency. Immunol. Res. 23, 263-272 (2001).
-
(2001)
Immunol. Res.
, vol.23
, pp. 263-272
-
-
Ohm, J.E.1
Carbone, D.P.2
-
12
-
-
0032770957
-
Tumor-associated transforming growth factor β and interieukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patrients
-
Bellone, G. et al. Tumor-associated transforming growth factor β and interieukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patrients. Am. J. Pathol. 155, 537-547 (1999).
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 537-547
-
-
Bellone, G.1
-
13
-
-
0141782725
-
BTLA: A new inhibitory receptor with a B7-like ligand
-
Carreno, B. M. & Collins, M. BTLA: a new inhibitory receptor with a B7-like ligand. Trends Immunol. 24, 524-527 (2003).
-
(2003)
Trends Immunol.
, vol.24
, pp. 524-527
-
-
Carreno, B.M.1
Collins, M.2
-
14
-
-
0038094524
-
B7-H4, a molecule of the B7 family, negatively regulates T cell immunity
-
Sica, G. L. et al. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 18, 849-861 (2003).
-
(2003)
Immunity
, vol.18
, pp. 849-861
-
-
Sica, G.L.1
-
15
-
-
0035292756
-
The expanding B7 superfamily: Increasing complexity in co-stimulatory signals regulating T cell function
-
Coyle, A. J. & Gutierrez-Ramos, J. C. The expanding B7 superfamily: increasing complexity in co-stimulatory signals regulating T cell function. Nature Immunol. 2, 203-209 (2001).
-
(2001)
Nature Immunol.
, vol.2
, pp. 203-209
-
-
Coyle, A.J.1
Gutierrez-Ramos, J.C.2
-
17
-
-
0035102196
-
CTLA-4 regulates induction of anergy in vivo
-
Greenwald, R. J. et al. CTLA-4 regulates induction of anergy in vivo. Immunity 14, 145-155 (2001).
-
(2001)
Immunity
, vol.14
, pp. 145-155
-
-
Greenwald, R.J.1
-
18
-
-
2442585121
-
Co-inhibitory molecules of the B7-CD28 family in the control of T cell immunity
-
Chen, L. Co-inhibitory molecules of the B7-CD28 family in the control of T cell immunity. Nature Rev. Immun. 4, 336-347 (2004). Summarizes the B7 receptor family on APCs and their role in immune regulation.
-
(2004)
Nature Rev. Immun.
, vol.4
, pp. 336-347
-
-
Chen, L.1
-
20
-
-
0029953858
-
CTLA-4 ligation blocks CD28-dependent T cell activation
-
Walunas, T. L., Bakker, C. Y. & Bluestone, J. A. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183, 2541-2550 (1996).
-
(1996)
J. Exp. Med.
, vol.183
, pp. 2541-2550
-
-
Walunas, T.L.1
Bakker, C.Y.2
Bluestone, J.A.3
-
21
-
-
0035102196
-
CTLA-4 regulates induction of anergy in vivo
-
Greenwald, R. J. et al. CTLA-4 regulates induction of anergy in vivo. Immunity 14, 145-155 (2001).
-
(2001)
Immunity
, vol.14
, pp. 145-155
-
-
Greenwald, R.J.1
-
22
-
-
0033062691
-
CD28/CTLA-4 and CD80/86 families: Signaling and function
-
Slavik, J. M., Hutchcroft, J. E. & Bierer, B. E. CD28/CTLA-4 and CD80/86 families: signaling and function. Immunol. Res. 19, 1-24 (1999).
-
(1999)
Immunol. Res.
, vol.19
, pp. 1-24
-
-
Slavik, J.M.1
Hutchcroft, J.E.2
Bierer, B.E.3
-
23
-
-
0031671268
-
CD28/B7 co-stimulation: A review
-
Greenfeld, E. A., Nguyen, K. A. & Kuchroo, V. K. CD28/B7 co-stimulation: a review. Crit. Rev. Immunol. 18, 389-418 (1998).
-
(1998)
Crit. Rev. Immunol.
, vol.18
, pp. 389-418
-
-
Greenfeld, E.A.1
Nguyen, K.A.2
Kuchroo, V.K.3
-
24
-
-
0037393460
-
T cell costimulatory pathways: Blockade for autoimmunity
-
Najafian, N. & Khoury, S. J. T cell costimulatory pathways: blockade for autoimmunity. Expert Opin. Biol. Ther. 3, 227-236 (2003).
-
(2003)
Expert Opin. Biol. Ther.
, vol.3
, pp. 227-236
-
-
Najafian, N.1
Khoury, S.J.2
-
25
-
-
0036214017
-
The B7 family of ligands and its receptors: New pathways for co-stimulaton inhibition of immune responses
-
Carreno, B. M. & Collins, M. The B7 family of ligands and its receptors: new pathways for co-stimulaton inhibition of immune responses. Annu. Rev. Immunol. 20, 29-53 (2002)
-
(2002)
Annu. Rev. Immunol.
, vol.20
, pp. 29-53
-
-
Carreno, B.M.1
Collins, M.2
-
26
-
-
0038796692
-
B7-H1 pathway and its role in the evasion of tumor immunity
-
Dong, H. & Chen, L. B7-H1 pathway and its role in the evasion of tumor immunity. J. Mol. Med. 81, 281-287 (2003).
-
(2003)
J. Mol. Med.
, vol.81
, pp. 281-287
-
-
Dong, H.1
Chen, L.2
-
27
-
-
0036888554
-
New regulatory co-receptors: Inducible co-stimulator and PD-1
-
Okazaki, T., Iwai, Y. & Honjo, T. New regulatory co-receptors: inducible co-stimulator and PD-1. Curr. Opin. Immunol. 14, 779-782 (2002).
-
(2002)
Curr. Opin. Immunol.
, vol.14
, pp. 779-782
-
-
Okazaki, T.1
Iwai, Y.2
Honjo, T.3
-
28
-
-
0030005099
-
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
-
Agata, Y. et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8, 765-772 (1996).
-
(1996)
Int. Immunol.
, vol.8
, pp. 765-772
-
-
Agata, Y.1
-
29
-
-
2442461055
-
The roles of the new negative T cell costimulatory pathways in regulating autoimmunity
-
Khoury, S. J. & Sayegh, M. H. The roles of the new negative T cell costimulatory pathways in regulating autoimmunity. Immunity 20, 529-538 (2004). Succinctly describes the complex interaction of T cells and APCs and their relationship in defining immune regulation.
-
(2004)
Immunity
, vol.20
, pp. 529-538
-
-
Khoury, S.J.1
Sayegh, M.H.2
-
30
-
-
0242303572
-
Regulation of PD-1, PD-L1 ,PD-L2 expression during normal and autoimmune responses
-
Liang, S. C. et al. Regulation of PD-1, PD-L1 ,PD-L2 expression during normal and autoimmune responses. Eur. J. Immunol. 33, 2706-2716 (2003). Describes the relationship and role of the programmed death receptors and immune regulation.
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 2706-2716
-
-
Liang, S.C.1
-
31
-
-
0032794723
-
Immunological escape mechanisms in pancreatic carcinoma
-
Ungefroren, H. et al. Immunological escape mechanisms in pancreatic carcinoma. Ann. NY Acad. Sci. 880, 243-251 (1999).
-
(1999)
Ann. NY Acad. Sci.
, vol.880
, pp. 243-251
-
-
Ungefroren, H.1
-
32
-
-
0034012799
-
Fas and Fas-ligand expression in human pancreatic cancer
-
Kornmann, M., Ishiwata, T., Kleef, J., Beger, H. G. & Korc, M. Fas and Fas-ligand expression in human pancreatic cancer. Ann. Surg. 231, 368-379 (2000).
-
(2000)
Ann. Surg.
, vol.231
, pp. 368-379
-
-
Kornmann, M.1
Ishiwata, T.2
Kleef, J.3
Beger, H.G.4
Korc, M.5
-
33
-
-
0035219753
-
Human pancreatic cancer cells express non functional Fas receptors and counterattack lymphocytes by expressing Fas ligand; a potential mechanism for immune escape
-
Elnemr, A. et al. Human pancreatic cancer cells express non functional Fas receptors and counterattack lymphocytes by expressing Fas ligand; a potential mechanism for immune escape. Int. J. Oncol. 18, 33-39 (2001). Describes the association between the death receptor FAS ligand and pancreatic cancer.
-
(2001)
Int. J. Oncol.
, vol.18
, pp. 33-39
-
-
Elnemr, A.1
-
34
-
-
0032893304
-
Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas (APO-1/CD95) receptors and aberrant expression of Fas ligand
-
Von Bernstorff, W. et al. Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas (APO-1/CD95) receptors and aberrant expression of Fas ligand. Surgery 125, 73-84 (1999).
-
(1999)
Surgery
, vol.125
, pp. 73-84
-
-
Von Bernstorff, W.1
-
35
-
-
0032522848
-
Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas mediated apoptosis
-
Ungefroren, H. et al. Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas mediated apoptosis. Cancer Res. 58, 1741-1749 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 1741-1749
-
-
Ungefroren, H.1
-
36
-
-
0037606064
-
CTLA-4. FasL induces alloantigen-specific hyporesponsiveness
-
Elhalel, M. D. et al. CTLA-4. FasL induces alloantigen-specific hyporesponsiveness. J. Immunol. 170, 5842-5850 (2003).
-
(2003)
J. Immunol.
, vol.170
, pp. 5842-5850
-
-
Elhalel, M.D.1
-
37
-
-
3843123323
-
Chronic exposure of transforming growth factor β1 confers a more aggressive tumor phenotype through down-regulation of p21 (WAF1/CIP1) in conditionally immortalized pancreatic epithelial cells
-
Ito, D. et al. Chronic exposure of transforming growth factor β1 confers a more aggressive tumor phenotype through down-regulation of p21 (WAF1/CIP1) in conditionally immortalized pancreatic epithelial cells. Surgery 136, 364-374 (2004).
-
(2004)
Surgery
, vol.136
, pp. 364-374
-
-
Ito, D.1
-
38
-
-
0041922583
-
1 expression metastatic capability of human pancreatic cancer
-
1 expression metastatic capability of human pancreatic cancer. Oncology 65, 167-173 (2003).
-
(2003)
Oncology
, vol.65
, pp. 167-173
-
-
Sawai, H.1
-
39
-
-
0242490137
-
Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells
-
Duda, D. G. et al. Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells. Oncogene 22, 6857-6864 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 6857-6864
-
-
Duda, D.G.1
-
40
-
-
0036875671
-
Expression of IL-6 receptor in pancreatic cancer: Involvement in VEGF induction
-
Masui, T. et al. Expression of IL-6 receptor in pancreatic cancer: involvement in VEGF induction. Anticancer Res. 22, 4093-4100 (2002).
-
(2002)
Anticancer Res.
, vol.22
, pp. 4093-4100
-
-
Masui, T.1
-
41
-
-
0032770957
-
Tumor-associated transforming growth factor β and interleukin- 10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients
-
Bellone, G. et al. Tumor-associated transforming growth factor β and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients. Am. J. Pathol. 155, 537-547 (1999).
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 537-547
-
-
Bellone, G.1
-
42
-
-
0345865175
-
TGF-β how tolerant can it be?
-
Wahl, S. M. & Chen, W. TGF-β: how tolerant can it be? Immunol. Res. 28, 167-179 (2003).
-
(2003)
Immunol. Res.
, vol.28
, pp. 167-179
-
-
Wahl, S.M.1
Chen, W.2
-
43
-
-
0025049140
-
Structure of the T cell antigen receptor: Evidence for two CD3 ε subunits in the T cell receptor-CD3 complex
-
Blumberg, R. S. et al. Structure of the T cell antigen receptor: evidence for two CD3 ε subunits in the T cell receptor-CD3 complex. Proc. Natl Acad. Sci. USA 87, 7220-7224 (1990).
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 7220-7224
-
-
Blumberg, R.S.1
-
44
-
-
0024150991
-
The T cell receptor/CD3 complex: A dynamic protein ensemble
-
Clevers, H. The T cell receptor/CD3 complex: a dynamic protein ensemble. Annu. Rev. Immunol. 6, 629-662 (1998).
-
(1998)
Annu. Rev. Immunol.
, vol.6
, pp. 629-662
-
-
Clevers, H.1
-
45
-
-
0023443171
-
Evolutionary relationship between the T3 chain of the T-cell receptor complex and the immunoglobulin supergene family
-
Gold, D. P. et al. Evolutionary relationship between the T3 chain of the T-cell receptor complex and the immunoglobulin supergene family. Proc. Natl Acad. Sci. USA 64, 7649-7653 (1987).
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.64
, pp. 7649-7653
-
-
Gold, D.P.1
-
46
-
-
0026544338
-
The T cell receptor/CD 3 complex is composed of at least two autonomous transduction modules
-
Wegener, A. M. K. et al. The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell 68, 83-95 (1992).
-
(1992)
Cell
, vol.68
, pp. 83-95
-
-
Wegener, A.M.K.1
-
47
-
-
0025971630
-
T cell antigen receptor activation pathways: The tyrosine kinase connection
-
Klausner, R. D. & Samelson, L. E. T cell antigen receptor activation pathways: the tyrosine kinase connection. Cell 64, 875-878 (1991)
-
(1991)
Cell
, vol.64
, pp. 875-878
-
-
Klausner, R.D.1
Samelson, L.E.2
-
48
-
-
0026064305
-
The cyloplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor associated signal transduction pathways
-
Irving, B. A. & Weiss, A. The cyloplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor associated signal transduction pathways. Cell 64, 891-901 (1991). Describes the regulation of the ζ chain of the T-cell receptor and its important role in immune regulation.
-
(1991)
Cell
, vol.64
, pp. 891-901
-
-
Irving, B.A.1
Weiss, A.2
-
49
-
-
0022993986
-
Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor
-
Samelson, L. E., Patel, M. D., Weissman, A. M., Harford, J. B. & Klausner, R. D. Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell 46, 1083-1090 (1986).
-
(1986)
Cell
, vol.46
, pp. 1083-1090
-
-
Samelson, L.E.1
Patel, M.D.2
Weissman, A.M.3
Harford, J.B.4
Klausner, R.D.5
-
50
-
-
0025114471
-
T cell receptor engagement stimulates c-raf associated kinase activity via a protein kinase C dependent pathway
-
Siegel, J. N., Klausner, R. D., Rapp, U. R. & Samelson, L. E. T cell receptor engagement stimulates c-raf associated kinase activity via a protein kinase C dependent pathway. J. Biol. Chem. 265, 18472-18480 (1990).
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 18472-18480
-
-
Siegel, J.N.1
Klausner, R.D.2
Rapp, U.R.3
Samelson, L.E.4
-
51
-
-
0035294392
-
Suppressed T-cell receptor ζ chain expression and cytokine production in pancreatic cancer patients
-
Schmielau, J., Nalesnik, M. A. & Finn, O. J. Suppressed T-cell receptor ζ chain expression and cytokine production in pancreatic cancer patients. Clin. Cancer Res. 7, S933-S939 (2001).
-
(2001)
Clin. Cancer Res.
, vol.7
-
-
Schmielau, J.1
Nalesnik, M.A.2
Finn, O.J.3
-
52
-
-
0028201732
-
Tolerance, danger, and the extended family
-
Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991-1045 (1994).
-
(1994)
Annu. Rev. Immunol.
, vol.12
, pp. 991-1045
-
-
Matzinger, P.1
-
53
-
-
0023143676
-
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
-
Jenkins, M. K. & Schwartz, R. H. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165, 302-319 (1987).
-
(1987)
J. Exp. Med.
, vol.165
, pp. 302-319
-
-
Jenkins, M.K.1
Schwartz, R.H.2
-
54
-
-
12344286127
-
Emerging mechanisms of immune regulation-the extended B7 family and regulatory cells
-
Loke, P. & Allison, J. P. Emerging mechanisms of immune regulation-the extended B7 family and regulatory cells. Arthritis Res. Ther. 6, 208-214 (2004).
-
(2004)
Arthritis Res. Ther.
, vol.6
, pp. 208-214
-
-
Loke, P.1
Allison, J.P.2
-
55
-
-
2942592429
-
Therapeutic targeting of the effector T cell co-stimulatory molecule OX40
-
Sugamura, K., Ishii, N. & Weinberg, A. D. Therapeutic targeting of the effector T cell co-stimulatory molecule OX40. Nature Rev. Immunol. 4, 420-431 (2004).
-
(2004)
Nature Rev. Immunol.
, vol.4
, pp. 420-431
-
-
Sugamura, K.1
Ishii, N.2
Weinberg, A.D.3
-
56
-
-
0034677054
-
Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th) 1 and Th2 cells
-
Lane, P. Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th)1 and Th2 cells. J. Exp. Med. 191, 201-206 (2000).
-
(2000)
J. Exp. Med.
, vol.191
, pp. 201-206
-
-
Lane, P.1
-
57
-
-
3343015039
-
The role of the CD40 pathway in the pathogenesis and treatment of cancer
-
Eliopoulos, A. G. & Young, L. S. The role of the CD40 pathway in the pathogenesis and treatment of cancer. Curr. Opin. Pharmacol. 4, 360-367 (2004).
-
(2004)
Curr. Opin. Pharmacol.
, vol.4
, pp. 360-367
-
-
Eliopoulos, A.G.1
Young, L.S.2
-
58
-
-
0037777538
-
VEGF inhibits T cell development and may contribute to tumor induced immune suppression
-
Ohm, J. E. et al. VEGF inhibits T cell development and may contribute to tumor induced immune suppression. Blood 101, 4878-4886 (2003). Characterizes the association of VEGF expression and depressed T-cell function in cancer.
-
(2003)
Blood
, vol.101
, pp. 4878-4886
-
-
Ohm, J.E.1
-
59
-
-
0037343236
-
Tumor cyclooxygenase 2 dependent suppression of dendritic cell function
-
Sharma, S. et al. Tumor cyclooxygenase 2 dependent suppression of dendritic cell function. Clin. Cancer Res. 9, 961-968 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 961-968
-
-
Sharma, S.1
-
60
-
-
0036569357
-
Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation
-
Sombroek, C. C. et al. Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation. J. Immunol. 168, 4333-4343 (2002).
-
(2002)
J. Immunol.
, vol.168
, pp. 4333-4343
-
-
Sombroek, C.C.1
-
61
-
-
0348223787
-
+ regulatory T cells by TGF-β induction of transcription factor Foxp 3
-
+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
-
62
-
-
1242295282
-
+ immunoregulatory T cells: Central players in the arena of peripheral tolerance
-
+ immunoregulatory T cells: central players in the arena of peripheral tolerance. Sem. Immunol. 16, 81-88 (2004).
-
(2004)
Sem. Immunol.
, vol.16
, pp. 81-88
-
-
Piccirillo, C.A.1
Shevach, E.M.2
-
63
-
-
0036721629
-
Prevalence of regulatory T cells is increased in peripheral blood tumor microenvironment of patients with pancreas or breast adenocarcinoma
-
Liyanage, U. K. et al. Prevalence of regulatory T cells is increased in peripheral blood tumor microenvironment of patients with pancreas or breast adenocarcinoma. J. Immunol. 169, 2756-2761 (2002).
-
(2002)
J. Immunol.
, vol.169
, pp. 2756-2761
-
-
Liyanage, U.K.1
-
64
-
-
4644237613
-
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
-
Curiel, T. J. et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nature Med. 10, 942-949 (2004).
-
(2004)
Nature Med.
, vol.10
, pp. 942-949
-
-
Curiel, T.J.1
-
65
-
-
0034722889
-
The EGF receptor family as targets for cancer therapy
-
Mendelsohn, J. & Baselga, J. The EGF receptor family as targets for cancer therapy. Oncogene 19, 6550-6565 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 6550-6565
-
-
Mendelsohn, J.1
Baselga, J.2
-
66
-
-
12944315074
-
SMAD4/DPC4-mediated tumor suppression through suppression of angiogenesis
-
Schwarte-Waldhoff, I., Volpert, O. V. & Bouck, N. P. SMAD4/DPC4-mediated tumor suppression through suppression of angiogenesis. Proc. Natl Acad. Sci. USA 97, 9624-9629 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9624-9629
-
-
Schwarte-Waldhoff, I.1
Volpert, O.V.2
Bouck, N.P.3
-
67
-
-
0043245914
-
Synergy between tumor immunotherapy and antiangiogenic therapy
-
Nair, S. et al. Synergy between tumor immunotherapy and antiangiogenic therapy. Blood 102, 964-971 (2003).
-
(2003)
Blood
, vol.102
, pp. 964-971
-
-
Nair, S.1
-
68
-
-
0032741283
-
Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
-
Gabrilovich, D. I. et al. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin. Cancer Res. 5, 2963-2970 (1999)
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 2963-2970
-
-
Gabrilovich, D.I.1
-
69
-
-
4344590997
-
Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic Cancer: A multicenter phase II trial
-
Xiong, H. Q. et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic Cancer: a multicenter phase II Trial. J. Clin. Oncol. 22, 2610-2616 (2004). The first work reporting the activity of a monoclonal antibody to EGFR and chemotherapy in patients with metastatic pancreatic cancer.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 2610-2616
-
-
Xiong, H.Q.1
-
70
-
-
8344258509
-
Bevacizumab plus gemcitabine in patients with advanced pancreatic cancer: Updated results of a multi-center phase II trial
-
Kindler, H. L. et al. Bevacizumab plus gemcitabine in patients with advanced pancreatic cancer: Updated results of a multi-center phase II trial. Proc. Am. Soc. Clin. Oncol. 23, A4009 (2004)
-
(2004)
Proc. Am. Soc. Clin. Oncol.
, vol.23
-
-
Kindler, H.L.1
-
71
-
-
0043136619
-
+ T cell effector function and tumor free survival in her-2/neu transgenic mice
-
+ T cell effector function and tumor free survival in her-2/neu transgenic mice. J. Immunol. 171, 2161-2169 (2003). Establishes a synergistic effect when combining antigen-specific antibodies and vaccine approaches in preclinical models
-
(2003)
J. Immunol.
, vol.171
, pp. 2161-2169
-
-
Walpoe, M.E.1
-
72
-
-
0024376173
-
ras oncogenes in human cancer: A review
-
Bos, J. L. ras oncogenes in human cancer: a review. Cancer Res. 49, 4682-4689 (1989).
-
(1989)
Cancer Res.
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
73
-
-
0027733796
-
K-ras oncogene activation in adenocarcinoma of the pancreas
-
Hruban, R. H. et al. K-ras oncogene activation in adenocarcinoma of the pancreas. Am. J. Path. 143, 545-554 (1993).
-
(1993)
Am. J. Path.
, vol.143
, pp. 545-554
-
-
Hruban, R.H.1
-
74
-
-
0028856743
-
Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding ras mutation
-
Gjertsen, M. K. et al. Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding ras mutation. Lancet 346, 1399-1400 (1995).
-
(1995)
Lancet
, vol.346
, pp. 1399-1400
-
-
Gjertsen, M.K.1
-
75
-
-
0028989973
-
MUC-1 epithelial tumor mucin-based immunity and vaccines
-
Finn, O. J. et al. MUC-1 epithelial tumor mucin-based immunity and vaccines. Immunol. Rev. 145, 61-89 (1995).
-
(1995)
Immunol. Rev.
, vol.145
, pp. 61-89
-
-
Finn, O.J.1
-
77
-
-
0033057177
-
The carcinoembryonic antigen (CEA) family: Structures, suggested functions and expression in normal and malignant tissues
-
Hammarstrom, S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin. Cancer Biol. 9, 67-81 (1999).
-
(1999)
Semin. Cancer Biol.
, vol.9
, pp. 67-81
-
-
Hammarstrom, S.1
-
78
-
-
20344379581
-
Mutant ras vaccine in advanced cancers
-
Achtar, M. et al. Mutant ras vaccine in advanced cancers. Proc. Am. Soc. Clin. Oncol. 22, A677 (2003).
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.22
-
-
Achtar, M.1
-
79
-
-
0035152718
-
A novel allogeneic GM-CSF secreting tumor vaccine for pancreatic cancer: A phase I trial of safety and immune activation
-
Jaffee, E. M. et al. A novel allogeneic GM-CSF secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation. J. Clin. Oncol. 19, 145-156 (2001). The first work establishing the safety of a GM-CSF-secreting tumour in patients with resected pancreatic cancer.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 145-156
-
-
Jaffee, E.M.1
-
80
-
-
20344378583
-
Phase I study of immunization with dendritic cells modified with recombinant fowlpox encoding carcinoembryonic antigen (CEA) and the triad of costimulatory molecules CD54, CD58 and CD80 (rF-CEA(6D)-TRICOM) in patients with advanced malignancies
-
Morse, M. et al. Phase I study of immunization with dendritic cells modified with recombinant fowlpox encoding carcinoembryonic antigen (CEA) and the triad of costimulatory molecules CD54, CD58 and CD80 (rF-CEA(6D)-TRICOM) in patients with advanced malignancies. Proc. Am. Soc. Clin. Oncol. 23, A2508 (2004).
-
(2004)
Proc. Am. Soc. Clin. Oncol.
, vol.23
-
-
Morse, M.1
-
81
-
-
20344366424
-
A phase Ib study of a MUC1 pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic or biliary tumors
-
Finn, O. J. et al. A phase Ib study of a MUC1 pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic or biliary tumors. Proc. Am. Soc. Clin. Oncol. 23, A2578 (2004).
-
(2004)
Proc. Am. Soc. Clin. Oncol.
, vol.23
-
-
Finn, O.J.1
-
82
-
-
20044364936
-
Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas
-
Marshall, J. L. et al. Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas. J. Clin. Oncol. 23, 720-731 (2005).
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 720-731
-
-
Marshall, J.L.1
-
83
-
-
18744374426
-
Randomised double blind placebo controlled multi-centre group sequential trial of G17DT for patients with advanced pancreatic cancer unsuitable or unwilling to take chemotherapy
-
Gilliam, A. D. et al. Randomised double blind placebo controlled multi-centre group sequential trial of G17DT for patients with advanced pancreatic cancer unsuitable or unwilling to take chemotherapy. Proc. Am. Soc. Clin. Oncol. 23, A2511 (2004).
-
(2004)
Proc. Am. Soc. Clin. Oncol.
, vol.23
-
-
Gilliam, A.D.1
-
84
-
-
4143116933
-
The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas
-
Harris, J. C. et al. The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas. Cancer Res. 64, 5624-5631 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 5624-5631
-
-
Harris, J.C.1
-
85
-
-
20344403202
-
A feasibility study of a GM-CSF secreting irradiated whole cell allogeneic vaccine (GVAX) alone or in sequence with cytoxan for patients with locally advanced or metastatic pancreatic cancer
-
Laheru, D. A. et al. A feasibility study of a GM-CSF secreting irradiated whole cell allogeneic vaccine (GVAX) alone or in sequence with cytoxan for patients with locally advanced or metastatic pancreatic cancer. Proc. Am. Assoc. Cancer Res. A54 (2004).
-
(2004)
Proc. Am. Assoc. Cancer Res.
-
-
Laheru, D.A.1
-
86
-
-
5644246157
-
Anti-tumor effect induced by dendritic cell (DC) based immunotherapy against peritoneal dissemination of the hamster pancreatic cancer
-
Takigawa, Y. et al. Anti-tumor effect induced by dendritic cell (DC) based immunotherapy against peritoneal dissemination of the hamster pancreatic cancer. Cancer Lett. 215, 179-186 (2004).
-
(2004)
Cancer Lett.
, vol.215
, pp. 179-186
-
-
Takigawa, Y.1
-
87
-
-
1842430506
-
Development of immunotherapy for pancreas cancer
-
Kawakami, Y., Okada, T. & Akada, M. Development of immunotherapy for pancreas cancer. Pancreas 28, 320-325 (2004).
-
(2004)
Pancreas
, vol.28
, pp. 320-325
-
-
Kawakami, Y.1
Okada, T.2
Akada, M.3
-
88
-
-
0036202003
-
Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method
-
Nakatsura, T. et al. Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method. Eur. J. Immunol 32, 826-836 (2002).
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 826-836
-
-
Nakatsura, T.1
-
89
-
-
0035902080
-
Progress in human tumour immunology and immunotherapy
-
Rosenberg, S. A. Progress in human tumour immunology and immunotherapy. Nature 411, 380-384 (2001)
-
(2001)
Nature
, vol.411
, pp. 380-384
-
-
Rosenberg, S.A.1
-
90
-
-
0028344535
-
Tumor antigens recognized by T lymphocytes
-
Boon, T., et al. Tumor antigens recognized by T lymphocytes. Annu. Rev. Immunol. 12, 337-365 (1994).
-
(1994)
Annu. Rev. Immunol.
, vol.12
, pp. 337-365
-
-
Boon, T.1
-
91
-
-
0035360275
-
Discovery of new markers of cancer through serial analysis of gene expression (SAGE): Prostate stem cell antigen (PSCA) is overexpressed in pancreatic adenocarcinoma
-
Argani, P. et al. Discovery of new markers of cancer through serial analysis of gene expression (SAGE): prostate stem cell antigen (PSCA) is overexpressed in pancreatic adenocarcinoma. Cancer Res. 61, 4320-4324 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 4320-4324
-
-
Argani, P.1
-
92
-
-
0034306972
-
Prostate stem cell antigen is a promising candidate for immunotherapy of advanced prostate cancer
-
Dannull, J. et al. Prostate stem cell antigen is a promising candidate for immunotherapy of advanced prostate cancer. Cancer Res. 60, 5522-5528 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 5522-5528
-
-
Dannull, J.1
-
93
-
-
3042621639
-
Mesothelin: A new target for immunotherapy. Clin
-
Hassan, R., Bera, T. & Pastan, I. Mesothelin: a new target for immunotherapy. Clin. Cancer Res. 10, 3937-3942 (2004)
-
(2004)
Cancer Res.
, vol.10
, pp. 3937-3942
-
-
Hassan, R.1
Bera, T.2
Pastan, I.3
-
94
-
-
12144288836
-
Analysis of novel markers in pancreatic and biliary carcinomas using microarrays
-
Swierczynski, S. L. et al. Analysis of novel markers in pancreatic and biliary carcinomas using microarrays. Hum. Path. 35, 357-366 (2004)
-
(2004)
Hum. Path.
, vol.35
, pp. 357-366
-
-
Swierczynski, S.L.1
-
95
-
-
0035674996
-
Mesothelin is overexpressed in the vast majority of ductal adenocarcinoma of the pancreas: Identification of a new pancreatic cancer marker by serial analysis of gene expression
-
Argani, P. et al. Mesothelin is overexpressed in the vast majority of ductal adenocarcinoma of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression. Clin. Cancer Res. 7, 3862-3868 (2001). Describes the first identification of novel pancreatic cancer antigens identified by SAGE analysis.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 3862-3868
-
-
Argani, P.1
-
96
-
-
3543060047
-
- T cell responses provide evidence of in vivo cross priming by antigen presenting cells in vaccinated pancreatic cancer patients
-
+ T-cell response to a pancreatic-cancer-specific antigen can be generated through cross presentation by a vaccine approach designed to recruit APCs to the vaccine site.
-
(2004)
J. Exp. Med.
, vol.200
, pp. 297-306
-
-
Thomas, A.M.1
-
98
-
-
4043103413
-
TRICOM: Enhanced vaccines as anticancer therapy
-
Levy, B., Panicalli, D. & Marshall, J. TRICOM: enhanced vaccines as anticancer therapy. Expert Rev. Vaccines 3, 397-402 (2004).
-
(2004)
Expert Rev. Vaccines
, vol.3
, pp. 397-402
-
-
Levy, B.1
Panicalli, D.2
Marshall, J.3
-
99
-
-
0036993763
-
Vector based delivery of tumor-associated antigens and T cell co-stimulatory molecules in the induction of immune responses and anti-tumor immunity
-
Hodge, J. W., Grosenbach, D. W. & Schlom, J. Vector based delivery of tumor-associated antigens and T cell co-stimulatory molecules in the induction of immune responses and anti-tumor immunity. Cancer Defect. Prev. 26, 275-291 (2002).
-
(2002)
Cancer Defect. Prev.
, vol.26
, pp. 275-291
-
-
Hodge, J.W.1
Grosenbach, D.W.2
Schlom, J.3
-
100
-
-
0038668917
-
Advances in the development of bacterial vector technology
-
Kochi, S. K., Killeen, K. P. & Ryan, U. S. Advances in the development of bacterial vector technology. Expert Rev. Vaccines. 2, 31-43 (2003).
-
(2003)
Expert Rev. Vaccines
, vol.2
, pp. 31-43
-
-
Kochi, S.K.1
Killeen, K.P.2
Ryan, U.S.3
-
101
-
-
0037299739
-
Live attenuated bacteria as vectors to deliver plasmid DNA vaccines
-
Dietrich, G. et al. Live attenuated bacteria as vectors to deliver plasmid DNA vaccines. Curr. Opin. Mol. Ther. 5, 10-19 (2003).
-
(2003)
Curr. Opin. Mol. Ther.
, vol.5
, pp. 10-19
-
-
Dietrich, G.1
-
102
-
-
0022597114
-
Induction of cell-mediated immunity to autologous melanoma cells and regression of metastases after treatment with a melanoma cell vaccine preceded by cyclophosphamide
-
Berd, D., Maguire, H. & Mastrangelo, M. Induction of cell-mediated immunity to autologous melanoma cells and regression of metastases after treatment with a melanoma cell vaccine preceded by cyclophosphamide. Cancer Res. 46, 2572-2577 (1986).
-
(1986)
Cancer Res.
, vol.46
, pp. 2572-2577
-
-
Berd, D.1
Maguire, H.2
Mastrangelo, M.3
-
103
-
-
0035116901
-
The collaboration of both humoral and cellular HER-2/neu targeted immune responses is required for the complete eradication of HER-2/neu expressing tumors
-
Reilly, R. T. et al. The collaboration of both humoral and cellular HER-2/neu targeted immune responses is required for the complete eradication of HER-2/neu expressing tumors. Cancer Res. 61, 880-883 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 880-883
-
-
Reilly, R.T.1
-
104
-
-
1642512647
-
Mouse models of pancreatic cancer: The fur is finally flying!
-
Leach, S. D. Mouse models of pancreatic cancer: the fur is finally flying! Cancer Cell 5, 7-11 (2004).
-
(2004)
Cancer Cell
, vol.5
, pp. 7-11
-
-
Leach, S.D.1
-
105
-
-
9144266295
-
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
-
Hingorani, S. R. et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4, 437-450 (2003). This is a seminal paper that describes for the first time a mouse model that recapitulates progressive early invasive pancreas cancer following activation of activated KRAS.
-
(2003)
Cancer Cell
, vol.4
, pp. 437-450
-
-
Hingorani, S.R.1
-
106
-
-
10944236962
-
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
-
Olive, K. P. et al. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 119, 847-860 (2004).
-
(2004)
Cell
, vol.119
, pp. 847-860
-
-
Olive, K.P.1
-
107
-
-
0034236449
-
Computational tools for protein modeling
-
Xu, D., Xu, Y. & Uberbacher, E. C. Computational tools for protein modeling. Curr. Protein Pept. Sci. 1, 1-21 (2000).
-
(2000)
Curr. Protein Pept. Sci.
, vol.1
, pp. 1-21
-
-
Xu, D.1
Xu, Y.2
Uberbacher, E.C.3
-
108
-
-
0033388725
-
SYFPEITHI: Database for MHC ligands and peptide motifs
-
Rammensee, H., Bachmann, J., Emmerich, N. P., Bachor, O. A. & Stevanovic, S. SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics 50, 213-219 (1999).
-
(1999)
Immunogenetics
, vol.50
, pp. 213-219
-
-
Rammensee, H.1
Bachmann, J.2
Emmerich, N.P.3
Bachor, O.A.4
Stevanovic, S.5
|