Development of donor-specific immunoregulatory T-cells after local CTLA4Ig gene transfer to pancreatic allograft

Transplantation

Volumn 78, Issue 1, 2004, Pages 59-64

  Miao, Gang ^a   Ito, Toshinori ^a   Uchikoshi, Fumihiro ^a   Akamaru, Yusuke ^a   Kiyomoto, Tetsuma ^a   Komodo, Hiroshi ^a   Song, Jinghai ^a   Nozawa, Masumi ^a   Matsuda, Hikaru ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

CTLA4Ig; Gene transfer; Pancreas transplantation; T suppressor cell

Indexed keywords

ADENOVIRUS VECTOR; CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2 RECEPTOR; TACROLIMUS;

ADOPTIVE TRANSFER; ALLOIMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; CYTOTOXICITY; DONOR; GENE EXPRESSION; GENE TRANSFER; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNE DEFICIENCY; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PANCREAS ALLOGRAFT; PANCREAS TRANSPLANTATION; PANCREATICODUODENAL TRANSPLANTATION; PRIORITY JOURNAL; RECIPIENT; SPLEEN CELL; STREPTOZOCIN DIABETES; T LYMPHOCYTE; TRANSPLANTATION TOLERANCE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD4; DUODENUM; GENE TRANSFER TECHNIQUES; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; MALE; PANCREAS TRANSPLANTATION; RATS; RATS, INBRED BN; RATS, INBRED LEW; RATS, INBRED WF; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES; TACROLIMUS; TRANSPLANTATION, HOMOLOGOUS;

EID: 3142733494     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000128330.64007.85     Document Type: Article

References (28)

1. Olthoff KM, Chen XD, Gelman A, et al. Adenovirus-mediated gene transfer of CTLA4Ig to liver allografts results in prolonged survival and local T-cell energy. Transplant Proc 1997; 29: 1030.
2. Yang Z, Rostami S, Koeberlein B, et al. Cardiac allograft tolerance induced by intra-arterial infusion of recombinant adnoviral CTLA4Ig. Transplantation 1999; 67: 1517.
3. Tomasoni S, Azzollini N, Casiraghi F, et al. CTLA4Ig gene transfer prolongs survival and induces donor-specific tolerance in a rat renal allograft. J Am Soc Nephol 2000; 11: 747.
4. Uchikoshi F, Yang ZD, Rostami S, et al. Prevention of autoimmune recurrence and rejection by adenovirus-mediated CTLA4Ig gene transfer to the pancreatic graft in BB rat. Diabetes 1999; 48: 652.
5. Guillot C, Mathieu P, Coathalem H, et al. Tolerance to cardiac allografts via local and systemic mechanisms after adenovirus-mediated CTLA4Ig expression. J Immunol 2000; 164: 5258.
6. Liu C, Deng S, Yang Z, et al. Local production of CTLA4Ig by adenoviral-mediated gene transfer to the pancreas induces permanent allograft survival and donor-specific tolerance. Transplant Proc 1999; 31: 625.
7. Akamaru Y, Ito T, Uchikoshi F, et al. Ex vivo and systemic transfer of adnovirus-mediated CTLA4Ig gene combined with a short course of FK506 therapy prolongs islet graft survival. Transpl Immunol 2003; 11: 91.
8. Uchikoshi F, Ito T, Kamiike W, et al. Restoration of immune abnormalities in diabetic BB rats after pancreas transplantation. Transplantation 1996; 61: 1629.
9. Ito T, Stepkowski SM, Kahan BD. Soluble antigen and cyclosporine-induce specific unresponsiveness in rats. Frequency of alloantigen-specific T cytotoxic cells in normal, sensitized, and unresponsive rats. Transplantation 1990; 49: 422.
10. Lenschow DJ, Zeng Y, Thistlethwaite JR, et al. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig. Science 1992; 257: 789.
11. Grohmann U, Orabona C, Fallarino F, et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat. Immunol 2002; 3: 1097.
12. Mellor AL, Baban B, Chandler P, et al. Cutting Edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immuol 2003; 171: 1652.
13. Tran HM, Nickerson PW, Restifo AC, et al. Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment. J Immunol 1997; 159: 2232.
14. Scully R, Qin S, Cobbold S, et al. Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. Eur J Immunol 1994; 24: 2383.
15. Lehmann M, Graser E, Risch K, et al. Anti-CD4 monoclonal antibody-induced allograft tolerance in rats despite persistence of donor-reactive T cell. Transplantation 1997; 64: 1181.
16. Perloff LJ, Naji A, Silvers WK, et al. Vascularized pancreas versus isolated islet allograft: an immunological comparison. Surgery 1980; 88: 222.
17. + T cells after successful pancreas transplantation in diabetic BB rats. Transplant Proc 1995; 27: 599.
18. Rosengard BR, Kortz EO, Guzzetta PC, et al. Transplantation in miniature swine: analysis of graft-infiltrating lymphocytes provides evidence for local suppression. Hun Immunol 1990; 28: 153.
19. Bushell A, Morris PJ, Wood KJ. Transplantation tolerance induced by antigen pretreatment and depleting anti-CD4 antibody depends on CD4+ T cell regulation during the induction phase of the response. Eur J Immunol 1995; 25: 2643.
20. Onodera K, Lehmann M, Akalin E, et al. Induction of " infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients. J Immunol 1996; 157: 1944.
21. Cerwenka A, Carter LL, Reome JB, et al. In vivo persistence of CD8 polarized T subsets producing type 1 or type 2 cytokines. J Immunol 1998; 161: 97.
22. Palathumpat V, Dejbakhsh-Jones S, Holm B, et al. Studies of CD4- CD8- alpha beta bone marrow T cells with suppressor activity. J Immunol 1992; 148: 373.
23. Qin S, Cobbold S, Pope H, et al. "Infectious" transplantation tolerance. Science 1993; 259: 974.
24. Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoiumune diseases. J Immunol 1995; 155: 1151.
25. + immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med 2001; 193: 1311.
26. Sanchez-Fueyo A, Weber M, Domenig C, et al. Tracking the immunoregulatory mechanisms active during allograft tolerance. J Immunol 2002; 168: 2274.
27. + regulatory T cells prevent graft rejection: CTLA4- and IL10-dependent immunoregulation of alloresponses. J Immunol 2002; 16: 1080.
28. + T cells induced by donor dendritic cells in allograft tolerance by LF15-0195 treatment. J Immunol 2002; 168: 5058.