The role of neutral lipases in human adipose tissue lipolysis

Current Opinion in Lipidology

Volumn 18, Issue 3, 2007, Pages 246-250

  Arner, Peter ^a   Langin, Dominique ^b,c,d,e  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b INSERM   (France)

^c UNIVERSITÉ DE TOULOUSE   (France)

^d TOULOUSE UNIVERSITY HOSPITAL   (France)

^e Inserm   (Czech Republic)

Author keywords

Fat cells; Lipases; Lipolysis; Obesity

Indexed keywords

HORMONE SENSITIVE LIPASE; LIPID BINDING PROTEIN; TRIACYLGLYCEROL LIPASE;

ADIPOCYTE; ADIPOSE TISSUE; CYTOLYSIS; DNA POLYMORPHISM; ENZYME ACTIVITY; GENE MUTATION; GENE OVEREXPRESSION; HORMONAL REGULATION; HUMAN; LIPID HYDROLYSIS; LIPOLYSIS; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; CHOLESTEROL ESTERASE; HUMANS; LIPASE; LIPOLYSIS; MODELS, BIOLOGICAL; OBESITY; POLYMORPHISM, GENETIC; SIGNAL TRANSDUCTION;

RODENTIA;

EID: 34248340524     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e32811e16fb     Document Type: Review

References (33)

1. Arner P. The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones. Trends Endocrinol Metab 2003; 14:137-145.
2. Langin D. Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacol Res 2006; 53:482-491.
3. Lafontan M, Moro C, Sengenes C, et al. An unsuspected metabolic role for atrial natriuretic peptides: the control of lipolysis, lipid mobilization, and systemic nonesterified fatty acids levels in humans. Arterioscler Thromb Vasc Biol 2005; 25:2032-2042.
4. Zechner R, Strauss JG, Haemmerle G, et al. Lipolysis: pathway under construction. Curr Opin Lipidol 2005; 16:333-340.
5. Langin D, Lucas S, Lafontan M. Millennium fat-cell lipolysis reveals unsuspected novel tracks. Horm Metab Res 2000; 32:443-452.
6. Moore HP, Silver RB, Mottillo EP, et al. Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase. J Biol Chem 2005; 280:43109-43120.
7. Miyoshi H, Souza SC, Zhang HH, et al. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation- dependent and -independent mechanisms. J Biol Chem 2006; 281:15837-15844. This article sheds new light on the role of perilipin as a regulator of HSL and disputes the original idea that perilipin merely functions as a barrier protein for HSL.
8. Marcinkiewicz A, Gauthier D, Garcia A, Brasaemle DL. The phosphorylation of serine 492 of perilipin A directs lipid droplet fragmentation and dispersion. J Biol Chem 2006; 281:11901-11909.
9. Miyoshi H, Perfield JW 2nd, Souza SC, et al. Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes. J Biol Chem 2007; 282:996-1002.
10. Smith AJ, Sanders MA, Thompson BR, et al. Physical association between the adipocyte fatty acid-binding protein and hormone-sensitive lipase: a fluorescence resonance energy transfer analysis. J Biol Chem 2004; 279:52399-52405.
11. Baar RA, Dingfelder CS, Smith LA, et al. Investigation of in vivo fatty acid metabolism in AFABP/aP2(-/-) mice. Am J Physiol Endocrinol Metab 2005; 288:E187-E193.
12. Langin D, Arner P. Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis. Trends Endocrinol Metab 2006; 17:314-320. This is a comprehensive review on the recent developments in the study of human fat cell lipolysis.
13. Zimmermann R, Strauss JG, Haemmerle G, et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 2004; 306:1383-1386.
14. Jenkins CM, Mancuso DJ, Yan W, et al. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 2004; 279:48968-48975.
15. Villena JA, Roy S, Sarkadi-Nagy E, et al. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem 2004; 279:47066-47075.
16. Lake AC, Sun Y, Li JL, et al. Expression, regulation, and triglyceride hydrolase activity of adiponutrin family members. J Lipid Res 2005; 46:2477-2487.
17. Kershaw EE, Hamm JK, Verhagen LA, et al. Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin. Diabetes 2006; 55:148-157.
18. Haemmerle G, Lass A, Zimmermann R, et al. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 2006; 312:734-737. This study describes the phenotype of ATGL-deficient mice, including the impact on lipolysis.
19. Schweiger M, Schreiber R, Haemmerle G, et al. Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J Biol Chem 2006; 281:40236-40241.
20. Lass A, Zimmermann R, Haemmerle G, et al. Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman syndrome. Cell Metab 2006; 3:309-319.
21. Subramanian V, Rothenberg A, Gomez C, et al. Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. J Biol Chem 2004; 279:42062-42071.
22. Yamaguchi T, Omatsu N, Matsushita S, Osumi T. CGI-58 interacts with perilipin and is localized to lipid droplets: possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. J Biol Chem 2004; 279:30490-30497.
23. Granneman JG, Moore HP, Granneman RL, et al. Analysis of lipolytic protein trafficking and interactions in adipocytes. J Biol Chem 2007; 282:5726-5735.
24. Mairal A, Langin D, Arner P, Hoffstedt J. Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity. Diabetologia 2006; 49:1629-1636. This report shows that ATGL and HSL expression are differently regulated in human adipose tissue.
25. Langin D, Dicker A, Tavernier G, et al. Adipocyte lipases and defect of lipolysis in human obesity. Diabetes 2005; 54:3190-3197.
26. Soni KG, Lehner R, Metalnikov P, et al. Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase. J Biol Chem 2004; 279:40683-40689.
27. Okazaki H, Igarashi M, Nishi M, et al. Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis. Diabetes 2006; 55:2091-2097.
28. Schoenborn V, Heid IM, Vollmert C, et al. The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes. Diabetes 2006; 55:1270-1275. This study suggests a role of ATGL genetic variation in lipid metabolism.
29. Arner P. Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Pract Res Clin Endocrinol Metab 2005; 19:471-482.
30. Fischer J, Lefevre C, Morava E, et al. The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy. Nat Genet 2007; 39:28-30. The data in this study suggest that deficiency in ATGL activity in humans, unlike in rodents, is not associated with obesity.
31. Karpe F, Frayn KN. The nicotinic acid receptor: a new mechanism for an old drug. Lancet 2004; 363:1892-1894.
32. Wang M, Fotsch C. Small-molecule compounds that modulate lipolysis in adipose tissue: targeting strategies and molecular classes. Chem Biol 2006; 13:1019-1027.
33. Claus TH, Lowe DB, Liang Y, et al. Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose. J Pharmacol Exp Ther 2005; 315:1396-1402.