Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis

Diabetologia

Volumn 46, Issue 6, 2003, Pages 789-797

  Mottagui Tabar, S ^a   Ryden M ^a   Lofgren P ^a   Faulds, G ^a   Hoffstedt, J ^a   Brookes, A J ^a   Andersson, I ^a   Arner, P ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Catecholamines; Fat cells; Obesity; Single nucleotide polymorphism; Women

Indexed keywords

FATTY ACID; GLYCEROL; NORADRENALIN; PERILIPIN; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ADIPOCYTE; ADULT; ARTICLE; BODY MASS; CELL VOLUME; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENETIC ANALYSIS; HETEROZYGOTE; HUMAN; HUMAN CELL; INTRON; LIPID ANALYSIS; LIPID METABOLISM; LIPOLYSIS; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN FUNCTION; REGULATORY MECHANISM; SINGLE NUCLEOTIDE POLYMORPHISM; SUBCUTANEOUS FAT;

ADIPOCYTES; ADULT; AMINO ACID SEQUENCE; BASE SEQUENCE; BLOOD GLUCOSE; BODY MASS INDEX; CELL SIZE; CHOLESTEROL; DNA PRIMERS; GENOTYPE; HUMANS; INSULIN; LIPOLYSIS; OBESITY; PHOSPHOPROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; REFERENCE VALUES; TRIGLYCERIDES;

EID: 0038235846     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1112-x     Document Type: Article

References (33)

1. Bergman RN, Van Citters GW, Mittelman SD et al. (2001) Central role of the adipocyte in the metabolic syndrome. J Investig Med 49:119-126
2. Schmitz-Peiffer C (2000) Signaling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply. Cell Signal 12:583-594
3. Bergman RN, Ader M (2000) Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol Metab 11:351-356
4. Arner P (2001) Free fatty acids - do they play a central role in type 2 diabetes? Diabetes Obes Metab 1:11-19
5. Kraegen EW, Cooney GJ, Ye JM, Thompson AL, Furler SM (2001) The role of lipids in the pathogenesis of muscle insulin resistance and beta cell failure in type II diabetes and obesity. Exp Clin Endocrinol Diabetes 2:189-201
6. Coppack SW, Jensen MD, Miles JM (1994) In vivo regulation of lipolysis in humans. JLipid Res 35:177-193
7. Ramsay TG (1996) Fat cells. Endocrinol Metab Clin North Am 25:847-870
8. Large V, Arner P (1998) Regulation of lipolysis in humans. Pathophysiclogical modulation in obesity, diabetes and hyperlipidemia. Diabetes Metab 24:409-418
9. Coppack SW, Patel JN, Lawrence VJ (2001) Nutritional regulation of lipid metabolism in human adipose tissue. Exp Clin Endocrinol Diabetes 109:202-214
10. Arner P (1988) Control of lipolysis and its relevance to development of obesity in man. Diabetes Metab Rev 4:507-515
11. Londos C, Brasaemle DL, Schultz CJ et al. (1999) On the control of lipolysis in adipocytes. Ann NY Acad Sci 892:155-168
12. Souza SC, Vargas LM de, Yamamoto MT et al. (1998) Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes. J Biol Chem 1 8:24665-24669
13. Souza SC, Muliro K, Liscum L et al. (2002) Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system. JBiol Chem 277:8267-8272
14. Martinez-Botas J, Anderson JB, Tessier D et al. (2000) Absence or perilipin results in leanness and reverses obesity in Lepr(db/db)mice. Nat Genet 26:474-479
15. Tansey JT, Sztalryd C, Gruia-Gray J et al. (2001) Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci USA 98:6494-6499
16. Brasaemle DL, Barber T, Kimmel AR, Londos C (1997) Post-translational regulation of perilipin expression. Stabilization by stored intracellular neutral lipids. J Biol Chem 272:9378-9387
17. Nishiu J, Tanaka T, Nakamura Y (1998) Isolation and chromosomal mapping of the human homolog of perilipin (PLIN), a rat adipose tissue-specific gene, by differential display methods. Genomics 48:254-257
18. 2-adrenoceptors. Diabetologia 38:126-128
19. Large V, Reynisdottir S, Eleborg L, Harmelen V van, Strömmer L, Arner P (1997) Lipolysis in human fat cells obtained under local and general anesthesia. Int J Obes RelatMetab Disord 21:78-82
20. Kather H, Bieger W, Michel G, Aktories K, Jakobs (1985) Human fat cell lipolysis is primarily regulated by inhibitory modulators acting through distinct mechanisms. J Clin Invest 76:1559-1565
21. Kenakin T (1990) Drugs and receptors. An overview of the current state of knowledge. Drugs 40:666-687
22. Ek I, Amer P, Rydén M et al. (2002) A unique defect in the regulation of visceral fat cell lipolysis in the polycystic ovary syndrome as an early link to insulin resistance. Diabetes 51:484-492
23. 2-adrenoceptor function. J Clin Invest 100:3005-3013
24. Howell WM, Jobs M, Gyllensten U, Brookes AJ (1999) Dynamic allele-specific hybridization. A new method for scoring single nucleotide polymorphism. Nat Biotechnol 17:87-88
25. Prince JA, Feuk L, Howell WM et al. (2001) Robust and accurate single nucleotide polymorphism genotyping by dynamic allele-specific hybridization (DASH): design criteria and assay validation. Genome Res 11:152-162
26. SantaLucia J Jr (1998) A unified view of polymer, dumbbell and oligonucleotide DNA nearest-neighbor thermodynamics. Proc Natl Acad Sci USA 95:1460-1465
27. Wingender E, Chen X, Hehl R et al. (2000) TRANSFAC: an integrated system for gene expression regulation. Nucleic Acids Res 28:316-319
28. Mauriege P, Imbeault P, Prud'homme D et al. (2000) Subcutaneous adipose tissue metabolism at menopause: importance of body fatness and regional fat distribution. J ClinEndocrinol Metab 85:2446-2454
29. Greenberg AS, Egan JJ, Wek SA, Moos MC Jr, Londos C, Kimmel AR (1993) Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Proc Natl Acad Sci 90:12035-12039
30. Thornborrow EC, Patel S, Mastropietro AE, Schwartzfarb EM, Manfredi JJ (2002) A conserved intronic response element mediate direct p53-depedent transcriptional activation of both the human and murine bax genes. Oncogen 21:990-999
31. Van Haasterena G, Lib S, Rysera S, Schlegela W (2000) Essential contribution of intron sequences to Ca2+dependent activation of c-fos transcription in pituitary cells. Neuroendocrinology 72:368-378
32. Large V, Reynisdottir S, Langin D et al. (1999) Decreased expression and function of adipocyte hormone-sensitive lipase in subcutaneous fat cells of obese subjects. J Lipid Res 40:2059-2066
33. Large V, Arner P, Reynisdottir S et al. (1998) Hormone-sensitive lipase expression and activity in relation to lipolysis in human fat cells. J Lipid Res 39:1688-1695