Inhibition of Cardiac Myocyte Apoptosis Improves Cardiac Function and Abolishes Mortality in the Peripartum Cardiomyopathy of Gαq Transgenic Mice

Circulation

Volumn 108, Issue 24, 2003, Pages 3036-3041

  Hayakawa, Yukihiro ^a   Chandra, Madhulika ^a   Miao, Wenfeng ^a   Shirani, Jamshid ^a   Brown, Joan Heller ^b   Dorn II, Gerald W ^c   Armstrong, Robert C ^d   Kitsis, Richard N ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d PFIZER INC   (United States)

Author keywords

Apoptosis; Cardiomyopathy; Caspases

Indexed keywords

CASPASE 3; CASPASE INHIBITOR; GQ PROTEIN ALPHA; GUANINE NUCLEOTIDE BINDING PROTEIN; IDN 1965; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENZYME INHIBITION; FEMALE; GENE OVEREXPRESSION; HEART CONTRACTION; HEART FAILURE; HEART LEFT VENTRICLE DP-DT; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE SIZE; HEART MUSCLE CELL; HEMODYNAMICS; LETHALITY; MORTALITY; MOUSE; NONHUMAN; PATHOGENESIS; PERIPARTUM CARDIOMYOPATHY; PRIORITY JOURNAL; PUERPERAL DISORDER; SURVIVAL; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CARDIOMYOPATHY, DILATED; CASPASE 3; CASPASES; CYSTEINE PROTEINASE INHIBITORS; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEART VENTRICLES; INDOLES; MICE; MICE, TRANSGENIC; MYOCYTES, CARDIAC; OLIGOPEPTIDES; POSTPARTUM PERIOD; PREGNANCY; SURVIVAL ANALYSIS; VENTRICULAR FUNCTION, LEFT;

EID: 0347539774     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000101920.72665.58     Document Type: Article

References (44)

1. Taegtmeyer H. Switching metabolic genes to build a better heart. Circulation. 2002;106:2043-2045.
2. Luo W, Grupp IL, Harrer J, et al. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of β-agonist stimulation. Circ Res. 1994:75:401-409.
3. Marks AR. Ryanodine receptors, FKBP12, and heart failure. Front Biosci. 2002;7:d970-d977.
4. Chien KR. Stress pathways and heart failure. Cell. 1999;98:555-558.
5. Lefkowitz RJ, Rockman HA, Koch WJ. Catecholamines, cardiac β-adrenergic receptor, and heart failure. Circulation. 2000;101:1634-1637.
6. Liu Y, Cigola E, Cheng W, et al. Myocyte nuclear mitotic division and programmed myocyte cell death characterize the cardiac myopathy induced by rapid ventricular pacing in dogs. Lab Invest. 1995;73:771-787.
7. Sharov VG, Sabbah HN, Shimoyama H, et al. Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure. Am J Pathol. 1996;148:141-149.
8. Li Z, Bing OH, Long X, et al. Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat. Am J Physiol. 1997;272:H2313-H2319.
9. Adams JW, Sakata Y, Davis MG, et al. Enhanced Gαq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proc Natl Acad Sci USA. 1998;95:10140-10145.
10. Hirota H, Chen J, Betz UA, et al. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell. 1999;97:189-198.
11. Condorelli G, Morisco C, Stassi G, et al. Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat. Circulation. 1999;99:3071-3078.
12. Geng YJ, Ishikawa Y, Vatner DE, et al. Apoptosis of cardiac myocytes in Gsα transgenic mice. Circ Res. 1999;84:34-42.
13. Zhang D, Gaussin V, Taffet GE, et al. TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice. Nat Med. 2000;6:556-563.
14. Xing H, Zhang S, Weinheimer C, et al. 14-3-3 proteins block apoptosis and differentially regulate MAPK cascades. EMBO J. 2000;19:349-358.
15. Bisognano JD, Weinberger HD, Bohlmeyer TJ, et al. Myocardial-directed overexpression of the human beta(1)-adrenergic receptor in transgenic mice. J Mol Cell Cardiol. 2000;32:817-830.
16. Sam F, Sawyer DB, Chang DL, et al. Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart. Am J Physiol. 2000;279:H422-H428.
17. Palojoki E, Saraste A, Eriksson A, et al. Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats. Am J Physiol. 2001;280:H2726-H2731.
18. Narula J, Haider N, Virmani R, et al. Apoptosis in myocytes in end-stage heart failure. N Engl J Med. 1996;335:1182-1189.
19. Olivetti G, Abbi R, Quaini F, et al. Apoptosis in the failing human heart. N Engl J Med. 1997;336:1131-1141.
20. Saraste A, Pulkki K, Kallajoki M, et al. Cardiomyocyte apoptosis and progression of heart failure to transplantation. Eur J Clin Invest. 1999;29:380-386.
21. Guerra S, Leri A, Wang X, et al. Myocyte death in the failing human heart is gender dependent. Circ Res. 1999;85:856-866.
22. Dorn GW II, Brown JH. Gq signaling in cardiac adaptation and maladaptation. Trends Cardiovasc Med. 1999;9:26-34.
23. D'Angelo DD, Sakata Y, Lorenz JN, et al. Transgenic Gaq overexpression induces cardiac contractile failure in mice. Proc Natl Acad Sci USA. 1997;94:8121-8126.
24. Sakata Y, Hoit BD, Liggett SB, et al. Decompensation of pressure-overload hypertrophy in Gαq-overexpressing mice. Circulation. 1998;97:1488-1495.
25. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science. 1998;281:1312-1316.
26. Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science. 1998;281:1305-1308.
27. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309-1312.
28. Jeremias I, Kupatt C, Martin-Villalba A, et al. Involvement of CD95/Apo1/Fas in cell death after myocardial ischemia. Circulation. 2000;102:915-920.
29. Lee P, Sata M, Lefer DJ, et al. Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo. Am J Physiol. 2003;284:H456-H463.
30. Bialik S, Cryns VL, Drincic A, et al. The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes. Circ Res. 1999;85:403-414.
31. Malhotra R, Brosius FC III. Glucose uptake and glycolysis reduce hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes. J Biol Chem. 1999;274:12567-12575.
32. von Harsdorf R, Li PF, Dietz R. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation. 1999;99:2934-2941.
33. de Moissac D, Gurevich RM, Zheng H, et al. Caspase activation and mitochondrial cytochrome c release during hypoxia-mediated apoptosis of adult ventricular myocytes. J Mol Cell Cardiol. 2000;32:53-63.
34. Kang PM, Haunstetter A, Aoki H, et al. Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation. Circ Res. 2000;87:118-125.
35. Adams JW, Pagel AL, Means CK, et al. Cardiomyocyte apoptosis induced by Gaq signaling is mediated by permeability transition pore formation and activation of the mitochondrial death pathway. Circ Res. 2000;87:1180-1187.
36. Yussman MG, Toyokawa T, Odley A, et al. Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nat Med. 2002;8:725-730.
37. Wencker D, Chandra M, Nguyen K, et al. A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest. 2003;111:1497-1504.
38. Adrain C, Creagh EM, Martin SJ. Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. EMBO J. 2001;20:6627-6636.
39. Du C, Fang M, Li Y, et al. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 2000;102:33-42.
40. Verhagen AM, Ekert PG, Pakusch M, et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell. 2000;102:43-53.
41. Srinivasula SM, Hegde R, Saleh A, et al. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature. 2001;410:112-116.
42. Laugwitz KL, Moretti A, Weig HJ, et al. Blocking caspase-activated apoptosis improves contractility in failing myocardium. Hum Gene Ther. 2001;12:2051-2063.
43. Moretti A, Weig HJ, Ott T, et al. Essential myosin light chain as a target for caspase-3 in failing myocardium. Proc Natl Acad Sci U S A. 2002;99:11860-11865.
44. Communal C, Sumandea M, de Tombe P, et al. Functional consequences of caspase activation in cardiac myocytes. Proc Natl Acad Sci USA. 2002;99:6252-6256.