Protein Kinase Cα Negatively Regulates Systolic and Diastolic Function in Pathological Hypertrophy

Circulation Research

Volumn 93, Issue 11, 2003, Pages 1111-1119

  Hahn, Harvey S ^a   Marreez, Yehia ^a   Odley, Amy ^a   Sterbling, Amber ^a   Yussman, Martin G ^a   Hilty, K Chad ^a   Bodi, Ilona ^a   Liggett, Stephen B ^a   Schwartz, Arnold ^a   Dorn II, Gerald W ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

Interstitial fibrosis; Protein kinase C; Restrictive cardiomyopathy; Systolic and diastolic heart failure

Indexed keywords

BETA ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPROTEIN; PROTEIN KINASE C ALPHA; PROTEIN SUBUNIT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; ENZYME INHIBITOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PEPTIDE; PRKCA PROTEIN, MOUSE; PROTEIN KINASE C;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIASTOLE; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TRANSLOCATION; HEART FAILURE; HEART VENTRICLE FUNCTION; HEART VENTRICLE HYPERTROPHY; HUMAN VERSUS ANIMAL COMPARISON; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR SENSITIVITY; SYSTOLE; TRANSGENIC MOUSE; UPREGULATION; ANIMAL; CARDIOMEGALY; CARDIOMYOPATHY; CELL SEPARATION; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; HEART MUSCLE CELL; METABOLISM; PATCH CLAMP; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ADRENERGIC BETA-AGONISTS; ANIMALS; CARDIOMEGALY; CARDIOMYOPATHIES; CELL SEPARATION; DIASTOLE; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; ENZYME INHIBITORS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; MICE; MICE, TRANSGENIC; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PEPTIDES; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN TRANSPORT; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION; SYSTOLE; VENTRICULAR DYSFUNCTION;

EID: 0344011683     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000105087.79373.17     Document Type: Article

References (40)

1. Akhter SA, Luttrell LM, Rockman HA, Iaccarino G, Lefkowitz RJ, Koch WJ. Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science. 1998;280:574-577.
2. Wettschureck N, Rutten H, Zywietz A, Gehring D, Wilkie TM, Chen J, Chien KR, Offermanns S. Absence of pressure overload induced myocardial hypertrophy after conditional inctivation of Gαq/Gα11 in cardiomyocytes. Nat Med. 2001;7:1236-1240.
3. Simpson P. Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an α1 adrenergic response. J Clin Invest. 1983;72:732-738.
4. Knowlton KU, Michel MC, Itani M, Shubeita HE, Ishihara K, Brown JH, Chien KR. The α1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem. 1993;268:15374-15380.
5. Sadoshima J, Izumo S. Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts: critical role of the AT1 receptor subtype. Circ Res. 1993;73:413-423.
6. Shubeita HE, McDonough PM, Harris AN, Knowlton KU, Glembotski CC, Brown JH, Chien KR. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes: a paracrine mechanism for myocardial cell hypertrophy. J Biol Chem. 1990;265:20555-20562.
7. D'Angelo DD, Sakata Y, Lorenz JN, Boivin GP, Walsh RA, Liggett SB, Dorn GW. Transgenic Gαq overexpression induces cardiac contractile failure in mice. Proc Natl Acad Sci U S A. 1997;94:8121-8126.
8. Sakata Y, Hoit BD, Liggett SB, Walsh RA, Dorn GW. Decompensation of pressure-overload hypertrophy in Gαq-overexpressing mice. Circulation. 1998;97:1488-1495.
9. Minamino T, Yujiri T, Terada N, Taffet GE, Michael LH, Johnson GL, Schneider MD. MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq. Proc Natl Acad Sci USA. 2002;99:3866-3871.
10. 2+-sensitive isoforms in the failing human heart. Circulation. 1999;99:384-391.
11. Nishizuka Y. Studies and perspectives of protein kinase C. Science. 1986;233:305-312.
12. Newton AC. Protein kinase C: structure, function, and regulation. J Biol Chem. 1995;270:28495-28498.
13. Hodge CW, Mehmert KK, Kelley SP, McMahon T, Haywood A, Olive MF, Wang D, Sanchez-Perez AM, Messing RO. Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCε. Nat Neurosci. 1999;2:997-1002.
14. Leitges M, Mayr M, Braun U, Mayr U, Li C, Pfister G, Ghaffari-Tabrizi N, Baier G, Hu Y, Xu Q. Exacerbated vein graft arteriosclerosis in protein kinase Cδ-null mice. J Clin Invest. 2001;108:1505-1512.
15. Leitges M, Schmedt C, Guinamard R, Davoust J, Schaal S, Stabel S, Tarakhovsky A. Immunodeficiency in protein kinase Cβ-deficient mice. Science. 1996;273:788-791.
16. Malmberg AB, Chen C, Tonegawa S, Basbaum AI. Preserved acute pain and reduced neuropathic pain in mice lacking PKCγ. Science. 1997;278:279-283.
17. Wakasaki H, Koya D, Schoen FJ, Jirousek MR, Ways DK, Hoit BD, Walsh RA, King GL. Targeted overexpression of protein kinase Cβ2 isoform in myocardium causes cardiomyopathy. Proc Natl Acad Sci USA. 1997;94:9320-9325.
18. Bowman JC, Steinberg SF, Jiang T, Geenen DL, Fishman GI, Buttrick PM. Expression of protein kinase Cβ in the heart causes hypertrophy in adult mice and sudden death in neonates. J Clin Invest. 1997;100:2189-2195.
19. Takeishi Y, Ping P, Bolli R, Kirkpatrick DL, Hoit BD, Walsh RA. Transgenic overexpression of constitutively active protein kinase CE causes concentric cardiac hypertrophy. Circ Res. 2000;86:1218-1223.
20. Mochly-Rosen D, Wu G, Hahn H, Osinska H, Liron T, Lorenz JN, Yatani A, Robbins J, Dorn GW. Cardiotrophic effects of protein kinase Cε: analysis by in vivo modulation of PKCε translocation. Circ Res. 2000;86:1173-1179.
21. Chen L, Hahn H, Wu G, Chen CH, Liron T, Schechtman D, Cavallaro G, Banci L, Guo Y, Bolli R, Dorn GW, Mochly-Rosen D. Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and εPKC. Proc Natl Acad Sci USA. 2001;98:11114-11119.
22. Braz JC, Bueno OF, De Windt LJ, Molkentin JD. PKCα regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2). J Cell Biol. 2002;156:905-919.
23. q-mediated cardiac hypertrophy and ventricular dysfunction. Mol Pharmacol. 2000;57:278-287.
24. Stebbins EG, Mochly-Rosen D. Binding specificity for RACK1 resides in the V5 region of βII protein kinase C. J Biol Chem. 2001;276:29644-29650.
25. Wu G, Toyokawa T, Hahn H, Dorn GW. ε Protein kinase C in pathological myocardial hypertrophy: analysis by combined transgenic expression of translocation modifiers and Gαq. J Biol Chem. 2000;275:29927-29930.
26. Hahn HS, Yussman MG, Toyokawa T, Marreez Y, Barrett TJ, Hilty KC, Osinska H, Robbins J, Dorn GW. Ischemic protection and myofibrillar cardiomyopathy: dose-dependent effects of in vivo δPKC inhibition. Circ Res. 2002;91:741-748.
27. Dorn GW, Souroujon MC, Liron T, Chen CH, Gray MO, Zhou HZ, Csukai M, Wu G, Lorenz JN, Mochly-Rosen D. Sustained in vivo cardiac protection by a rationally designed peptide that causes ε protein kinase C translocation. Proc Natl Acad Sci USA. 1999;96:12798-12803.
28. Rybin V, Steinberg SF. Do adult rat ventricular myocytes express protein kinase C-α? Am J Physiol. 1997;272:H2485-H2491.
29. Dorn GW II, Robbins J, Sugden PH. Phenotyping hypertrophy: eschew obfuscation. Circ Res. 2003;92:1171-1175.
30. Rohrer D, Chruscinski A, Schauble E, Bernstein D, Kobilka B. Cardiovascular and metabolic alterations in mice lacking both β-1 and β-2-adrenergic receptors. J Biol Chem. 1999;274:16701-16708.
31. Bouvier M, Guilbault N, Bonin H. Phorbol-ester-induced phosphorylation of the β2-adrenergic receptor decreases its coupling to Gs. FEBS Lett. 1991;279:243-248.
32. Bouvier M, Leeb-Lundberg LM, Benovic JL, Caron MG, Lefkowitz RJ. Regulation of adrenergic receptor function by phosphorylation, II: effects of agonist occupancy on phosphorylation ofα1- and β2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase. J Biol Chem. 1987;262:3106-3113.
33. 2-adrenergic receptor overexpression in mouse hearts: critical role for expression level. Circulation. 2000;101:1707-1714.
34. Yussman MG, Toyokawa T, Odley A, Lynch RA, Wu G, Colbert MC, Aronow BJ, Lorenz JN, Dorn GW. Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nat Med. 2002;8:725-730.
35. Kadokami T, McTieman CF, Kubota T, Frye CS, Feldman AM. Sex-related survival differences in murine cardiomyopathy are associated with differences in TNF-receptor expression. J Clin Invest. 2000;106:589-597.
36. Weber KT, Brilla CG. Pathological hypertrophy and cardiac interstitium: fibrosis and renin-angiotensin-aldosterone system. Circulation. 1991;83:1849-1865.
37. Weber KT. Cardiac interstitium. In: Poole-Wilson P, Colucci W, Massie B, Chaterjee K, Coats A, eds. Heart Failure. New York, NY: Churchill Livingstone; 1997:13-31.
38. Zou Y, Komuro I, Yamazaki T, Aikawa R, Kudoh S, Shiojima I, Hiroi Y, Mizuno T, Yazaki Y. Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes. J Biol Chem. 1996;271:33592-33597.
39. Ichihara S, Senbonmatsu T, Price E Jr, Ichiki T, Gaffney FA, Inagami T. Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Circulation. 2001;104:346-351.
40. Matsusaka T, Katori H, Inagami T, Fogo A, Ichikawa I. Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice. J Clin Invest. 1999;103:1451-1458.