Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways

European Respiratory Journal

Volumn 31, Issue 2, 2008, Pages 241-251

  Mroz, R M ^a,b   Schins, R P F ^c   Li, H ^c   Jimenez, L A ^a   Drost, E M ^a   Holownia, A ^b   MacNee, W ^a   Donaldson, K ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

DNA damage; H2A.x histone; Nanoparticles; Particles with a 50 cut off aerodynamic diameter of 10 m; Reactive oxidative species

Indexed keywords

ACETYLCYSTEINE; BENZO[A]PYRENE; BRCA1 PROTEIN; CARBON; CARBON BLACK; HISTONE H2AX; NANOPARTICLE; PEROXIDE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SERINE; SINGLE STRANDED DNA; TERT BUTYL HYPERPEROXIDE; UNCLASSIFIED DRUG; CARCINOGEN; MUTAGENIC AGENT;

ARTICLE; CARCINOGENESIS; CELL CYCLE; CONTROLLED STUDY; CYTOMETRY; DNA DAMAGE; DNA STRAND BREAKAGE; DOUBLE STRANDED DNA BREAK; DUST; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IRRADIATION; LUNG ALVEOLUS EPITHELIUM; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; ANALYSIS OF VARIANCE; CELL TRANSFORMATION; CHEMICALLY INDUCED DISORDER; COMET ASSAY; IN VITRO STUDY; METABOLISM; MULTIVARIATE ANALYSIS; PHOSPHORYLATION; RADIATION EXPOSURE; SENSITIVITY AND SPECIFICITY; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ANALYSIS OF VARIANCE; BLOTTING, WESTERN; CARCINOGENS, ENVIRONMENTAL; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; COMET ASSAY; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; GENES, BRCA1; HUMANS; MULTIVARIATE ANALYSIS; MUTAGENS; NANOPARTICLES; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SENSITIVITY AND SPECIFICITY;

EID: 40649113687     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00006707     Document Type: Article

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