The effect of dibenzo[a,l]pyrene and benzo[a]pyrene on human diploid lung fibroblasts: The induction of DNA adducts, expression of p53 and p21(WAF1) proteins and cell cycle distribution

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 471, Issue 1-2, 2000, Pages 57-70

  Binková, Blanka ^a   Giguère, Yves ^a   Rössner Jr , Pavel ^a   Dostál, Miroslav ^a   Šrám, Radim J ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

Author keywords

DNA adducts; Flow cytometry; Human lung fibroblasts; p53 and p21(WAF1) proteins; PAHs; Western blotting

Indexed keywords

BENZO[A]PYRENE; DIBENZO[A,1]PYRENE; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG; BENZO[A]PYRENE DERIVATIVE; CARCINOGEN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; DIAGNOSTIC AGENT; DIBENZO(A,L)PYRENE; DNA; PHOSPHORUS;

ARTICLE; CARCINOGENESIS; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; DNA BINDING; FLOW CYTOMETRY; GENE INDUCTION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; MITOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; AFFINITY CHROMATOGRAPHY; AUTORADIOGRAPHY; BIOSYNTHESIS; CELL LINE; CYTOLOGY; DIPLOIDY; DNA ADDUCT; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECT; FIBROBLAST; ISOLATION AND PURIFICATION; LUNG; METABOLISM; PRENATAL DEVELOPMENT; TIME;

AUTORADIOGRAPHY; BENZO(A)PYRENE; BENZOPYRENES; CARCINOGENS; CELL CYCLE; CELL LINE; CHROMATOGRAPHY, AFFINITY; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DIPLOIDY; DNA; DNA ADDUCTS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; FLOW CYTOMETRY; HUMANS; LUNG; PHOSPHORUS RADIOISOTOPES; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034694124     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(00)00111-X     Document Type: Article

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