Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: Toxicity is not dependent upon particle size but on surface characteristics

Toxicological Sciences

Volumn 95, Issue 1, 2007, Pages 270-280

  Warheit, David B ^a   Webb, Thomas R ^a   Colvin, Vicki L ^b   Reed, Kenneth L ^a   Sayes, Christie M ^a  

^a DUPONT COMPANY   (United States)

^b RICE UNIVERSITY   (United States)

Author keywords

Quartz particles; Nanoscale quartz particles; Particle characterization; Particle size; Pulmonary toxicity; Surface activity

Indexed keywords

CARBONYL IRON; PHOSPHATE BUFFERED SALINE; SILICON DIOXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; EXPOSURE; HEMOLYSIS; HISTOPATHOLOGY; LUNG FIBROSIS; LUNG LAVAGE; LUNG PARENCHYMA; LUNG TOXICITY; MACROPHAGE; MALE; NONHUMAN; PARTICLE SIZE; RAT; RESPIRATORY TRACT INFLAMMATION;

ANIMALS; BIOLOGICAL ASSAY; BRONCHOALVEOLAR LAVAGE FLUID; CELL PROLIFERATION; CRYSTALLOGRAPHY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON SPIN RESONANCE SPECTROSCOPY; ERYTHROCYTES; HEMOLYSIS; HUMANS; LUNG; MALE; NANOPARTICLES; ORGAN SIZE; PARTICLE SIZE; PARTICULATE MATTER; QUARTZ; RATS; SURFACE PROPERTIES; TIME FACTORS;

EID: 33845613217     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl128     Document Type: Article

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