메뉴 건너뛰기




Volumn 13, Issue 2, 2008, Pages 452-474

Application of prodrugs to inflammatory diseases of the gut

Author keywords

5 Aminosalicylic acid; Cysteine and glutathione prodrugs; Digestive tract; Drug delivery; Inflammatory bowel disease; Microbiota; Mycophenolate mofetil

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; IMMUNOLOGIC FACTOR; PRODRUG; REACTIVE OXYGEN METABOLITE;

EID: 40349087243     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules13020452     Document Type: Review
Times cited : (36)

References (126)
  • 1
    • 0037249395 scopus 로고    scopus 로고
    • Assessment of orocaecal transit time in different localization of Crohn's disease and its possible influence on clinical response to therapy
    • Tursi, A.; Brandimarte, G.; Giorgetti, G.M.; Nasi, G. Assessment of orocaecal transit time in different localization of Crohn's disease and its possible influence on clinical response to therapy. Eur. J. Gastroenterol. Hepatol. 2003, 15, 69-74.
    • (2003) Eur. J. Gastroenterol. Hepatol , vol.15 , pp. 69-74
    • Tursi, A.1    Brandimarte, G.2    Giorgetti, G.M.3    Nasi, G.4
  • 2
    • 0034765504 scopus 로고    scopus 로고
    • Pharmacokinetic considerations in the treatment of inflammatory bowel disease
    • Schwab, M.; Klotz, U. Pharmacokinetic considerations in the treatment of inflammatory bowel disease, Clin. Pharmacokinet. 2001, 40, 723-751.
    • (2001) Clin. Pharmacokinet , vol.40 , pp. 723-751
    • Schwab, M.1    Klotz, U.2
  • 4
    • 0001199533 scopus 로고
    • Chemical aspects of selective toxicity
    • Albert, A. Chemical aspects of selective toxicity. Nature 1958, 182, 421-422.
    • (1958) Nature , vol.182 , pp. 421-422
    • Albert, A.1
  • 5
    • 0021800252 scopus 로고    scopus 로고
    • Stella, V.J.; Charman, W.N.A.; Naringrekar, V.H. Prodrugs. Do they have advantages in clinical practice? Drugs 1985, 29, 455-473.
    • Stella, V.J.; Charman, W.N.A.; Naringrekar, V.H. Prodrugs. Do they have advantages in clinical practice? Drugs 1985, 29, 455-473.
  • 6
    • 0001033723 scopus 로고
    • Design and application of prodrugs
    • Krogsgaard-Larsen, P, Bundgaard, H, Eds, Harwood: Reading, UK
    • Bundgaard, H. Design and application of prodrugs. In A Textbook of Drug Design and Development; Krogsgaard-Larsen, P., Bundgaard, H., Eds.; Harwood: Reading, UK, 1991; pp. 113-191.
    • (1991) A Textbook of Drug Design and Development , pp. 113-191
    • Bundgaard, H.1
  • 7
    • 2342481809 scopus 로고    scopus 로고
    • Lessons learned from marketed and investigational prodrugs
    • Ettmayer, P.; Amidon, G.L.; Clement, B.; Testa, B. Lessons learned from marketed and investigational prodrugs. J. Med. Chem. 2004, 47, 2393-2404.
    • (2004) J. Med. Chem , vol.47 , pp. 2393-2404
    • Ettmayer, P.1    Amidon, G.L.2    Clement, B.3    Testa, B.4
  • 8
    • 0042143281 scopus 로고    scopus 로고
    • Targeted prodrug design to optimize drug delivery
    • Han, H.K.; Amidon, G.L. Targeted prodrug design to optimize drug delivery. AAPS Pharm. Sci. 2000, 2, E6.
    • (2000) AAPS Pharm. Sci , vol.2
    • Han, H.K.1    Amidon, G.L.2
  • 9
    • 0028832474 scopus 로고
    • Approaches and opportunities in colon-specific drug delivery
    • Rubinstein, A. Approaches and opportunities in colon-specific drug delivery. Crit. Rev. Ther. Drug Carr. Syst. 1995, 12, 101-149.
    • (1995) Crit. Rev. Ther. Drug Carr. Syst , vol.12 , pp. 101-149
    • Rubinstein, A.1
  • 10
    • 0030469774 scopus 로고    scopus 로고
    • Current applications of polysaccharides in colon targeting
    • Hovgaard, L.; Brondsted, H. Current applications of polysaccharides in colon targeting. Crit. Rev. Ther. Drug Carr. Syst. 1996, 13, 185-223.
    • (1996) Crit. Rev. Ther. Drug Carr. Syst , vol.13 , pp. 185-223
    • Hovgaard, L.1    Brondsted, H.2
  • 12
    • 26044478161 scopus 로고    scopus 로고
    • Synthesis of a novel prodrug of 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid for colon delivery
    • Curini, M.; Epifano, F.; Genovese, S. Synthesis of a novel prodrug of 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid for colon delivery. Bioorg. Med. Chem. Lett. 2005, 15, 5049-5052.
    • (2005) Bioorg. Med. Chem. Lett , vol.15 , pp. 5049-5052
    • Curini, M.1    Epifano, F.2    Genovese, S.3
  • 13
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolskiy, D.K. Inflammatory bowel disease. N. Engl. J. Med. 2002, 347, 417-429.
    • (2002) N. Engl. J. Med , vol.347 , pp. 417-429
    • Podolskiy, D.K.1
  • 14
    • 36549059250 scopus 로고    scopus 로고
    • Mortality by Medication use among patients with inflammatory bowel disease, 1996-2003
    • Hutfless, S.M.; Weng, X.; Liu, L.; Allison, J.; Herrinton, L.J. Mortality by Medication use among patients with inflammatory bowel disease, 1996-2003. Gastroenterology 2007, 133, 1779-1786.
    • (2007) Gastroenterology , vol.133 , pp. 1779-1786
    • Hutfless, S.M.1    Weng, X.2    Liu, L.3    Allison, J.4    Herrinton, L.J.5
  • 15
    • 0034061366 scopus 로고    scopus 로고
    • A meta-analysis and overview of the literature on treatment options for left-sided ulcerative colitis and ulcerative proctitis
    • Cohen, R.D.; Woseth, D.M.; Thistel, R.A.; Hanauer, S.B. A meta-analysis and overview of the literature on treatment options for left-sided ulcerative colitis and ulcerative proctitis. Am. J. Gastroenterol. 2000, 95, 1263-1276.
    • (2000) Am. J. Gastroenterol , vol.95 , pp. 1263-1276
    • Cohen, R.D.1    Woseth, D.M.2    Thistel, R.A.3    Hanauer, S.B.4
  • 16
    • 1542580481 scopus 로고    scopus 로고
    • IL-10 and its related cytokines for treatment of inflammatory bowel disease
    • Li, M.C.; He, S.H. IL-10 and its related cytokines for treatment of inflammatory bowel disease. World J. Gastroenterol. 2004, 10, 620-625.
    • (2004) World J. Gastroenterol , vol.10 , pp. 620-625
    • Li, M.C.1    He, S.H.2
  • 17
    • 0029836444 scopus 로고    scopus 로고
    • Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kB abrogates established experimental colitis in mice
    • Neurath, M.F.; Pettersson, S.; Strober, W. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kB abrogates established experimental colitis in mice. Nature Med. 1996, 2, 998-1004.
    • (1996) Nature Med , vol.2 , pp. 998-1004
    • Neurath, M.F.1    Pettersson, S.2    Strober, W.3
  • 18
    • 33947301294 scopus 로고    scopus 로고
    • Immune dysfunction in inflammatory bowel disease
    • Neuman, M.G. Immune dysfunction in inflammatory bowel disease. Transl. Res. 2007, 149, 173-186.
    • (2007) Transl. Res , vol.149 , pp. 173-186
    • Neuman, M.G.1
  • 19
    • 33751244213 scopus 로고    scopus 로고
    • General principles and pharmacology of biologics in inflammatory bowel disease
    • Kozuch, P.L.; Hanauer, S.B. General principles and pharmacology of biologics in inflammatory bowel disease. Gastroenterol. Clin. North Am. 2006, 35, 757-773.
    • (2006) Gastroenterol. Clin. North Am , vol.35 , pp. 757-773
    • Kozuch, P.L.1    Hanauer, S.B.2
  • 20
    • 40049111515 scopus 로고    scopus 로고
    • Treatment of inflammatory bowel disease: A review of medical therapy
    • Kozuch, P.L.; Hanauer, S.B. Treatment of inflammatory bowel disease: A review of medical therapy. World J. Gastroenterol. 2008, 4, 354-377.
    • (2008) World J. Gastroenterol , vol.4 , pp. 354-377
    • Kozuch, P.L.1    Hanauer, S.B.2
  • 21
    • 0000153298 scopus 로고    scopus 로고
    • Enteric microflora in IBD: Pathogens or commensals?
    • Sartor, R.B. Enteric microflora in IBD: pathogens or commensals? Inflamm. Bowel Dis. 1997, 3, 230- 235.
    • (1997) Inflamm. Bowel Dis , vol.3 , pp. 230-235
    • Sartor, R.B.1
  • 22
    • 0035009786 scopus 로고    scopus 로고
    • Measles virus and Crohn's disease: A critical appraisal of the current literature
    • Robertson, D.J; Sandler, R.S. Measles virus and Crohn's disease: a critical appraisal of the current literature. Inflamm. Bowel Dis. 2001, 7, 51- 57.
    • (2001) Inflamm. Bowel Dis , vol.7 , pp. 51-57
    • Robertson, D.J.1    Sandler, R.S.2
  • 23
    • 0002696589 scopus 로고
    • Microbial factors in the pathogenesis of Crohn's disease, ulcerative colitis, and experimental intestinal inflammation
    • Kirsner, J.B, Shorter, R.G, Eds, Williams and Wilkens: Baltimore
    • Sartor, RB. Microbial factors in the pathogenesis of Crohn's disease, ulcerative colitis, and experimental intestinal inflammation. In Inflammatory Bowel Disease; Kirsner, J.B., Shorter, R.G., Eds.; Williams and Wilkens: Baltimore, 1995; pp. 96-124.
    • (1995) Inflammatory Bowel Disease , pp. 96-124
    • Sartor, R.B.1
  • 24
    • 84947646637 scopus 로고
    • Insights into the pathogenesis of IBD provided by new rodent models of colitis
    • Elson, C.O.; Sartor, R.B. Tennyson, G.S.; Riddell, R.H. Insights into the pathogenesis of IBD provided by new rodent models of colitis. Inflam. Bowel Dis. 1995, 1, 64-75.
    • (1995) Inflam. Bowel Dis , vol.1 , pp. 64-75
    • Elson, C.O.1    Sartor, R.B.2    Tennyson, G.S.3    Riddell, R.H.4
  • 25
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack, B.; Merz, H.; Schorle, H.; Schimpl, A.; Feller, A.C.; Horak, I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993, 75, 255-261.
    • (1993) Cell , vol.75 , pp. 255-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 26
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in IL-10-deficient mice
    • Sellon, R.K.; Tonkonogy, S.; Schultz, M.; Dieleman, L.A.; Grenther, W.; Balish, E.; Rennick, D.M.; Sartor, R.B. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in IL-10-deficient mice. Infect. Immun. 1998, 66, 5224-5231.
    • (1998) Infect. Immun , vol.66 , pp. 5224-5231
    • Sellon, R.K.1    Tonkonogy, S.2    Schultz, M.3    Dieleman, L.A.4    Grenther, W.5    Balish, E.6    Rennick, D.M.7    Sartor, R.B.8
  • 28
    • 0036232151 scopus 로고    scopus 로고
    • Zinc deficiency induced changes in plasma leptin, metabolic rate, and physical activity in rats
    • Gaetke, L.M.; Frederich, R.C.; Oz, H.S.; McClain, C.J. Zinc deficiency induced changes in plasma leptin, metabolic rate, and physical activity in rats. J. Nutr. Biochem. 2002, 13, 237-244.
    • (2002) J. Nutr. Biochem , vol.13 , pp. 237-244
    • Gaetke, L.M.1    Frederich, R.C.2    Oz, H.S.3    McClain, C.J.4
  • 30
    • 26044469410 scopus 로고    scopus 로고
    • Paradox of simultaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease
    • Hatoum, O.A.; Binion, D.G.; Gutterman, D.D. Paradox of simultaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease. Eur. J. Clin. Invest. 2005, 35, 599-609.
    • (2005) Eur. J. Clin. Invest , vol.35 , pp. 599-609
    • Hatoum, O.A.1    Binion, D.G.2    Gutterman, D.D.3
  • 31
    • 0030297089 scopus 로고    scopus 로고
    • The indigenous gastrointestinal microflora
    • Berg, R.D. The indigenous gastrointestinal microflora. Trends Microbiol. 1996, 4, 430-435.
    • (1996) Trends Microbiol , vol.4 , pp. 430-435
    • Berg, R.D.1
  • 32
    • 1942420154 scopus 로고    scopus 로고
    • Probiotics in inflammatory bowel disease - therapeutic rationale and role
    • Rev
    • Shanahan, F. Probiotics in inflammatory bowel disease - therapeutic rationale and role. Drug Deliv. Rev. 2004, 56, 809-818.
    • (2004) Drug Deliv , vol.56 , pp. 809-818
    • Shanahan, F.1
  • 33
    • 0028893265 scopus 로고
    • Role of lipopolysaccharide and tumor necrosis factor-alpha in induction of hepatocyte necrosis
    • Wang, J.H.; Redmond, H.P.; Watson, R.W.; Bouchei-Hayes, D. Role of lipopolysaccharide and tumor necrosis factor-alpha in induction of hepatocyte necrosis. Am. J. Physiol. 1995, 269, G297-G304.
    • (1995) Am. J. Physiol , vol.269
    • Wang, J.H.1    Redmond, H.P.2    Watson, R.W.3    Bouchei-Hayes, D.4
  • 34
    • 0029554196 scopus 로고
    • Lipopolysaccharide signal transduction, regulation of tumor necrosis factor biosynthesis, and signaling by tumor necrosis factor itself
    • Beutler, B.; Kruys, V. Lipopolysaccharide signal transduction, regulation of tumor necrosis factor biosynthesis, and signaling by tumor necrosis factor itself. J. Cardiovasc. Pharmacol. 1995, 25 (suppl. 2), S1-S8.
    • (1995) J. Cardiovasc. Pharmacol , vol.25 , Issue.SUPPL. 2
    • Beutler, B.1    Kruys, V.2
  • 36
    • 0141954186 scopus 로고    scopus 로고
    • Anti-TNF-?́ Antibody Normalizes Serum Leptin in IL-2 Deficient Mice
    • Gaetke, L.; Oz, H.S.; Frederich, R.; McClain, C. Anti-TNF-?́ Antibody Normalizes Serum Leptin in IL-2 Deficient Mice. J. Amer. Coll. Nutri. 2003, 22, 415-420.
    • (2003) J. Amer. Coll. Nutri , vol.22 , pp. 415-420
    • Gaetke, L.1    Oz, H.S.2    Frederich, R.3    McClain, C.4
  • 38
    • 0028879819 scopus 로고
    • Role of transcriptional activation of IΚB-α in mediation of immunosuppression by glucocorticoids
    • Scheinman, R.I.; Cogswell, P.C.; Lofquist, A.K.; Baldwin, A.S. Role of transcriptional activation of IΚB-α in mediation of immunosuppression by glucocorticoids. Science 1995, 270, 283-286,
    • (1995) Science , vol.270 , pp. 283-286
    • Scheinman, R.I.1    Cogswell, P.C.2    Lofquist, A.K.3    Baldwin, A.S.4
  • 39
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NF-ΚB activity through induction of IΚB synthesis
    • Auphan, N.; DiDonato, J.A.; Rosette, C.; Helmberg, A.; Karin, M.; Immunosuppression by glucocorticoids: inhibition of NF-ΚB activity through induction of IΚB synthesis. Science, 1995, 270, 286-290.
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1    DiDonato, J.A.2    Rosette, C.3    Helmberg, A.4    Karin, M.5
  • 40
    • 0032032469 scopus 로고    scopus 로고
    • Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B
    • Wahl, C.; Liptay, S.; Adler, G.; Schmid, R.M. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J. Clin. Invest. 1998, 101, 1163-1174.
    • (1998) J. Clin. Invest , vol.101 , pp. 1163-1174
    • Wahl, C.1    Liptay, S.2    Adler, G.3    Schmid, R.M.4
  • 42
    • 0030805604 scopus 로고    scopus 로고
    • Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF-κB activation
    • Meyer, S.; Kohler, N.G.; Joly, A. Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF-κB activation. FEBS Lett. 1997, 413, 354-358.
    • (1997) FEBS Lett , vol.413 , pp. 354-358
    • Meyer, S.1    Kohler, N.G.2    Joly, A.3
  • 43
    • 0023900998 scopus 로고
    • Neutrophil-mediated mucosal injury. Role of reactive oxygen metabolites
    • Grisham, M.B.; Granger, D.N. Neutrophil-mediated mucosal injury. Role of reactive oxygen metabolites. Dig. Dis. Sci. 1988, 33, 6S-15S.
    • (1988) Dig. Dis. Sci , vol.33
    • Grisham, M.B.1    Granger, D.N.2
  • 44
    • 0030839865 scopus 로고    scopus 로고
    • Oxidative decay of DNA
    • Beckman, K.B.; Ames, B.N. Oxidative decay of DNA. J. Biol. Chem. 1997, 272, 19633-19636.
    • (1997) J. Biol. Chem , vol.272 , pp. 19633-19636
    • Beckman, K.B.1    Ames, B.N.2
  • 45
    • 0026683530 scopus 로고
    • Oxygen radicals in ulcerative colitis
    • Babbs, C.F. Oxygen radicals in ulcerative colitis. Free Radic. Biol. Med. 1992, 13, 169-181.
    • (1992) Free Radic. Biol. Med , vol.13 , pp. 169-181
    • Babbs, C.F.1
  • 46
    • 0023640965 scopus 로고
    • Increased respiratory burst of leukocytes in inflammatory bowel diseases-the analysis of free radical generation by using chemiluminescence probe
    • Suematsu, M.; Suzuki, M.; Kitahora, T.; Miura, S.; Suzuki, K.; Hibi, T.; Watanabe, M.; Nagata, H.; Asakura, H.; Tsuchiya, M. Increased respiratory burst of leukocytes in inflammatory bowel diseases-the analysis of free radical generation by using chemiluminescence probe. J. Clin. Lab. Immunol. 1987, 24, 125-128.
    • (1987) J. Clin. Lab. Immunol , vol.24 , pp. 125-128
    • Suematsu, M.1    Suzuki, M.2    Kitahora, T.3    Miura, S.4    Suzuki, K.5    Hibi, T.6    Watanabe, M.7    Nagata, H.8    Asakura, H.9    Tsuchiya, M.10
  • 49
    • 0033763401 scopus 로고    scopus 로고
    • Comparative tolerability of treatments for inflammatory bowel disease
    • Stein, R.B.; Hanauer, S.B. Comparative tolerability of treatments for inflammatory bowel disease. Drug Saf. 2000, 23, 429-448.
    • (2000) Drug Saf , vol.23 , pp. 429-448
    • Stein, R.B.1    Hanauer, S.B.2
  • 51
    • 0033981670 scopus 로고    scopus 로고
    • Therapy of inflammatory bowel disease
    • Sands, B.E. Therapy of inflammatory bowel disease. Gastroenterology 2000, 118, S68-S82.
    • (2000) Gastroenterology , vol.118
    • Sands, B.E.1
  • 53
    • 0015757745 scopus 로고
    • Metabolism of foreign compounds by gastrointestinal microorganisms
    • Scheline, R. Metabolism of foreign compounds by gastrointestinal microorganisms. Pharmacol. Rev. 1973, 25, 451-523.
    • (1973) Pharmacol. Rev , vol.25 , pp. 451-523
    • Scheline, R.1
  • 54
    • 33748302766 scopus 로고    scopus 로고
    • Review article: High-dose aminosalicylates to induce and maintain remissions in ulcerative colitis
    • Hanauer, S.B. Review article: high-dose aminosalicylates to induce and maintain remissions in ulcerative colitis. Aliment. Pharmacol. Ther. 2006, Suppl 3, 37-40.
    • (2006) Aliment. Pharmacol. Ther , Issue.SUPPL. 3 , pp. 37-40
    • Hanauer, S.B.1
  • 55
    • 0025243656 scopus 로고
    • Disposition of 5-aminosalicylic acid by olsalazine and three mesalazine preparations in patients with ulcerative colitis: Comparison of intraluminal colonic concentrations, serum values, and urinary excretion
    • Staerk Laursen, L.; Stokholm, M.; Bukhave, K.; Rask-Madsen, J.; Lauritsen, K. Disposition of 5-aminosalicylic acid by olsalazine and three mesalazine preparations in patients with ulcerative colitis: comparison of intraluminal colonic concentrations, serum values, and urinary excretion. Gut 1990, 31, 1271-1276.
    • (1990) Gut , vol.31 , pp. 1271-1276
    • Staerk Laursen, L.1    Stokholm, M.2    Bukhave, K.3    Rask-Madsen, J.4    Lauritsen, K.5
  • 56
    • 34249735819 scopus 로고    scopus 로고
    • Colon-specific, mutual azo prodrug of 5-aminosalicylic acid with L-tryptophan: Synthesis, kinetic studies and evaluation of its mitigating effect in trinitrobenzenesulfonic acid- induced colitis in rats
    • Dhaneshwar, S.S.; Gairola, N.; Kandpal, M.; Vadnerkar, G.; Bhatt, L. Colon-specific, mutual azo prodrug of 5-aminosalicylic acid with L-tryptophan: synthesis, kinetic studies and evaluation of its mitigating effect in trinitrobenzenesulfonic acid- induced colitis in rats. Bioorg. Med. Chem. 2007, 15, 4903-4909.
    • (2007) Bioorg. Med. Chem , vol.15 , pp. 4903-4909
    • Dhaneshwar, S.S.1    Gairola, N.2    Kandpal, M.3    Vadnerkar, G.4    Bhatt, L.5
  • 57
    • 34347329215 scopus 로고    scopus 로고
    • Omeprazole for gastroesophageal reflux disease in the first 2 years of life: A dose-finding study with dual-channel pH monitoring
    • Bishop, J.; Furman, M.; Thomson, M. Omeprazole for gastroesophageal reflux disease in the first 2 years of life: a dose-finding study with dual-channel pH monitoring. J. Pediatr. Gastroenterol. Nutr. 2007, 45, 50-55.
    • (2007) J. Pediatr. Gastroenterol. Nutr , vol.45 , pp. 50-55
    • Bishop, J.1    Furman, M.2    Thomson, M.3
  • 58
    • 0024310242 scopus 로고
    • Omeprazole: Pharmacology, pharmacokinetics and interactions
    • Oosterhuis, B.; Jonkman, J.H. Omeprazole: pharmacology, pharmacokinetics and interactions. Digestion, 1989, 44 suppl. 1, 9-17.
    • (1989) Digestion , vol.44 , Issue.SUPPL. 1 , pp. 9-17
    • Oosterhuis, B.1    Jonkman, J.H.2
  • 59
    • 0034959553 scopus 로고    scopus 로고
    • Short chain fatty acids and human colonic function: Roles of resistant starch and non-starch polysaccharides
    • Topping, D.L.; Clifton, P.M. Short chain fatty acids and human colonic function: roles of resistant starch and non-starch polysaccharides. Physiol. Rev. 2001, 81, 1031-1064.
    • (2001) Physiol. Rev , vol.81 , pp. 1031-1064
    • Topping, D.L.1    Clifton, P.M.2
  • 60
    • 0025321505 scopus 로고
    • Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
    • Bergman, E.N. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiol. Rev. 1990, 70, 567-590.
    • (1990) Physiol. Rev , vol.70 , pp. 567-590
    • Bergman, E.N.1
  • 61
    • 0036704365 scopus 로고    scopus 로고
    • Brouns, F.; Kettlitz, B.; Arrigoni, E. Resistant starch and butyrate revolution. Trends Food Sci. Technol. 2002, 13, 251-261.
    • Brouns, F.; Kettlitz, B.; Arrigoni, E. Resistant starch and "butyrate revolution." Trends Food Sci. Technol. 2002, 13, 251-261.
  • 62
    • 0031839010 scopus 로고    scopus 로고
    • Slow-release pellets of sodium butyrate increase apoptosis in the colon of rats treated with azoxymethane, without affecting aberrant crypt foci and colonic proliferation
    • Caderni, G.; Luceri, C.; Lancioni, L.; Tessitore, L.; Dolara, P. Slow-release pellets of sodium butyrate increase apoptosis in the colon of rats treated with azoxymethane, without affecting aberrant crypt foci and colonic proliferation. Nutr. Cancer 1998, 30, 175-181.
    • (1998) Nutr. Cancer , vol.30 , pp. 175-181
    • Caderni, G.1    Luceri, C.2    Lancioni, L.3    Tessitore, L.4    Dolara, P.5
  • 64
    • 0023730222 scopus 로고
    • The hypocholesterolaemic effects of dietary propionate: Studies in whole animals and perfused rat liver
    • Illman, R.J. Topping, D.L.; McIntosh, G.H.; Trimble, R.P.; Storer, G.B.; Taylor, M.N. The hypocholesterolaemic effects of dietary propionate: studies in whole animals and perfused rat liver. Ann. Nutr. Metab. 1988, 32, 97-107.
    • (1988) Ann. Nutr. Metab , vol.32 , pp. 97-107
    • Illman, R.J.1    Topping, D.L.2    McIntosh, G.H.3    Trimble, R.P.4    Storer, G.B.5    Taylor, M.N.6
  • 65
    • 0242409501 scopus 로고    scopus 로고
    • Acetylated propionylated or butyrylated starches raise large bowel short-chain fatty acids preferentially when fed to rats
    • Annison, G.; Illman, R.J. Topping, D.L. Acetylated propionylated or butyrylated starches raise large bowel short-chain fatty acids preferentially when fed to rats. Nutrition 2003, 133, 3523-3528.
    • (2003) Nutrition , vol.133 , pp. 3523-3528
    • Annison, G.1    Illman, R.J.2    Topping, D.L.3
  • 67
    • 0035203147 scopus 로고    scopus 로고
    • Fatty acid transport and mitochondrial oxidation disorders
    • Rinaldo, P. Fatty acid transport and mitochondrial oxidation disorders. Semin. Liver Dis. 2001, 21, 489-500.
    • (2001) Semin. Liver Dis , vol.21 , pp. 489-500
    • Rinaldo, P.1
  • 70
    • 0030590745 scopus 로고    scopus 로고
    • Mycophenolate mofetil
    • Lipsky, J.J. Mycophenolate mofetil. Lancet 1996, 348, 1357-1359.
    • (1996) Lancet , vol.348 , pp. 1357-1359
    • Lipsky, J.J.1
  • 71
    • 0000395398 scopus 로고
    • Riceche bacteriologiche e chimiche sulle alterazioni del mais.
    • Gosio, B. Riceche bacteriologiche e chimiche sulle alterazioni del mais. Riv. Igiene. Sanita Pubblica 1896, 7, 825-868.
    • (1896) Riv. Igiene. Sanita Pubblica , vol.7 , pp. 825-868
    • Gosio, B.1
  • 72
    • 0023028511 scopus 로고
    • IMP dehydrogenase from the intracellular parasitic protozoan Eimeria Tenella and its inhibition by mycophenolic acid
    • Hupe, D.J.; Azzolina, B.A.; Behrens, N.D. IMP dehydrogenase from the intracellular parasitic protozoan Eimeria Tenella and its inhibition by mycophenolic acid. J. Biol. Chem. 1986, 261, 8363-8369.
    • (1986) J. Biol. Chem , vol.261 , pp. 8363-8369
    • Hupe, D.J.1    Azzolina, B.A.2    Behrens, N.D.3
  • 73
    • 0030944969 scopus 로고    scopus 로고
    • Oz, H.S.; Hughes, W. Novel anti-Pneumocystis carinii effects of the immunosuppressant mycophenolate mofetil in contrast to provocative effects of tacrolimus, sirolimus and dexamethasone. J. Infect. Dis. 1997, 175, 901-904.
    • Oz, H.S.; Hughes, W. Novel anti-Pneumocystis carinii effects of the immunosuppressant mycophenolate mofetil in contrast to provocative effects of tacrolimus, sirolimus and dexamethasone. J. Infect. Dis. 1997, 175, 901-904.
  • 74
    • 0035960312 scopus 로고    scopus 로고
    • Provocative effects of immunosuppressants rapamycin, tacrolimus and dexamethasone on P. carinii pneumonitis in contrast to anti-PCP effects of the mycophenolate mofetil
    • Oz, H.S.; Hughes, W.T.; Varilek, G. Provocative effects of immunosuppressants rapamycin, tacrolimus and dexamethasone on P. carinii pneumonitis in contrast to anti-PCP effects of the mycophenolate mofetil. Transplant 2001, 72, 1464-1465.
    • (2001) Transplant , vol.72 , pp. 1464-1465
    • Oz, H.S.1    Hughes, W.T.2    Varilek, G.3
  • 76
    • 0035137115 scopus 로고    scopus 로고
    • Zeeh, J.M. ; Zorlu, Riley, N.E; Hoffmann, P. ; Ruwe, M. ; Goebell, H. ; Gerken, G. ; Dignass, A.U. Mycophenolate mofetil reduces tissue damage and inflammation in an experimental model of colitis in rats. Scand. J. Gastroenterol. 2001, 36, 66-70.
    • Zeeh, J.M. ; Zorlu, Riley, N.E; Hoffmann, P. ; Ruwe, M. ; Goebell, H. ; Gerken, G. ; Dignass, A.U. Mycophenolate mofetil reduces tissue damage and inflammation in an experimental model of colitis in rats. Scand. J. Gastroenterol. 2001, 36, 66-70.
  • 77
    • 0033003888 scopus 로고    scopus 로고
    • Randomised trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohn's disease [comment]
    • Neurath, M.F.; Wanitschke, R.; Peters, M.; Krummenauer, F.; Meyer, zum Buschenfelde, K.H.; Schlaak, J.F. Randomised trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohn's disease [comment]. Gut 1999, 44, 625-628.
    • (1999) Gut , vol.44 , pp. 625-628
    • Neurath, M.F.1    Wanitschke, R.2    Peters, M.3    Krummenauer, F.4    Meyer5    zum Buschenfelde, K.H.6    Schlaak, J.F.7
  • 79
    • 0031829719 scopus 로고    scopus 로고
    • Treatment of steroid refractory inflammatory bowel disease (IBD) with mycophenolate mofetil (MMF)
    • Florin, T.H.; Roberts, R.K.; Watson, M.R.; Radford-Smith, G.L. Treatment of steroid refractory inflammatory bowel disease (IBD) with mycophenolate mofetil (MMF). Aust. N. Z. J. Med. 1998, 28, 344-345.
    • (1998) Aust. N. Z. J. Med , vol.28 , pp. 344-345
    • Florin, T.H.1    Roberts, R.K.2    Watson, M.R.3    Radford-Smith, G.L.4
  • 80
    • 0035075797 scopus 로고    scopus 로고
    • Is mycophenolate mofetil an effective alternative in azathioprine-intolerant patients with chronic active Crohn's disease
    • Miehsler, W.; Reinisch, W.; Moser, G.; Gangl, A.; Vogelsang, H. Is mycophenolate mofetil an effective alternative in azathioprine-intolerant patients with chronic active Crohn's disease. Am. J. Gastroenterol. 2001, 96, 782-787.
    • (2001) Am. J. Gastroenterol , vol.96 , pp. 782-787
    • Miehsler, W.1    Reinisch, W.2    Moser, G.3    Gangl, A.4    Vogelsang, H.5
  • 81
    • 0033056560 scopus 로고    scopus 로고
    • First MR. Mycophenolate mofetil induced colonic ulceration in renal transplant recipients
    • Golconda, M.S.; Valente, J.F.; Bejarano, P.; Gilinsky, N. First MR. Mycophenolate mofetil induced colonic ulceration in renal transplant recipients. Transplant. Proc. 1999, 31, 272-273.
    • (1999) Transplant. Proc , vol.31 , pp. 272-273
    • Golconda, M.S.1    Valente, J.F.2    Bejarano, P.3    Gilinsky, N.4
  • 82
    • 0028862437 scopus 로고
    • Mycophenolic acid: Measurement and relationship to pharmacologic effects
    • Shaw, L.M.; Nowak, I. Mycophenolic acid: measurement and relationship to pharmacologic effects. Ther. Drug Monit. 1995, 17, 685-689.
    • (1995) Ther. Drug Monit , vol.17 , pp. 685-689
    • Shaw, L.M.1    Nowak, I.2
  • 83
    • 2942562539 scopus 로고    scopus 로고
    • Cyclosporine, tacrolimus, and mycophenolate mofetil in the treatment of inflammatory bowel disease
    • Loftus, C.G.; Egan, L.J.; Sandborn, W.J. Cyclosporine, tacrolimus, and mycophenolate mofetil in the treatment of inflammatory bowel disease. Gastroenterol. Clin. N. Am. 2004, 33, 141-169.
    • (2004) Gastroenterol. Clin. N. Am , vol.33 , pp. 141-169
    • Loftus, C.G.1    Egan, L.J.2    Sandborn, W.J.3
  • 84
    • 22144482338 scopus 로고    scopus 로고
    • Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation
    • Breen, D.P.; Marinaki, A.M.; Arenas, M.; Hayes, P.C. Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation. Liver Transpl. 2005, 11, 826-833.
    • (2005) Liver Transpl , vol.11 , pp. 826-833
    • Breen, D.P.1    Marinaki, A.M.2    Arenas, M.3    Hayes, P.C.4
  • 86
    • 0020633994 scopus 로고
    • Role of oxygen-derived free radicals in digestive tract diseases
    • Parks, D.A.; Bulkley, G.B.; Granger, D.N. Role of oxygen-derived free radicals in digestive tract diseases. Surgery 1983, 94, 415-422.
    • (1983) Surgery , vol.94 , pp. 415-422
    • Parks, D.A.1    Bulkley, G.B.2    Granger, D.N.3
  • 88
    • 0025741144 scopus 로고
    • Enterocyte injury by O2-dependent processes
    • Baker, S.S.; Campbell, C.L. Enterocyte injury by O2-dependent processes. Gastroenterology 1991, 101, 716-720.
    • (1991) Gastroenterology , vol.101 , pp. 716-720
    • Baker, S.S.1    Campbell, C.L.2
  • 89
    • 0025256045 scopus 로고
    • Glutathione is required for intestinal function
    • Mrtensson, J.; Jain, A.; Meister, A. Glutathione is required for intestinal function. Proc. Nat. Acad. Sci. 1990, 87, 1715-1719.
    • (1990) Proc. Nat. Acad. Sc , vol.1 , Issue.87 , pp. 1715-1719
    • Mrtensson, J.1    Jain, A.2    Meister, A.3
  • 90
    • 0026744569 scopus 로고
    • The physiological consequences of glutathione variations
    • Uhlig, S.; Wendel, A. The physiological consequences of glutathione variations. Life. Sci. 1992, 51, 1083-1094.
    • (1992) Life. Sci , vol.51 , pp. 1083-1094
    • Uhlig, S.1    Wendel, A.2
  • 91
    • 0036302954 scopus 로고    scopus 로고
    • Chronic Inflammation Alters Protein Metabolism in Several Organs of Adult Rats
    • Mercier, S.; Breuille, D.; Mosoni, L.; Obled, C.; Patureau Mirand, P. Chronic Inflammation Alters Protein Metabolism in Several Organs of Adult Rats. J. Nutr. 2002, 132, 1921-1928.
    • (2002) J. Nutr , vol.132 , pp. 1921-1928
    • Mercier, S.1    Breuille, D.2    Mosoni, L.3    Obled, C.4    Patureau Mirand, P.5
  • 92
    • 22144447861 scopus 로고    scopus 로고
    • Antioxidants a novel therapy in a murine model of colitis
    • Oz, H.S.; Chen, T.; McClain, C.J.; deVilliers, W. Antioxidants a novel therapy in a murine model of colitis. J. Nutri. Biochem. 2005, 16, 297-304.
    • (2005) J. Nutri. Biochem , vol.16 , pp. 297-304
    • Oz, H.S.1    Chen, T.2    McClain, C.J.3    deVilliers, W.4
  • 93
    • 0031736096 scopus 로고    scopus 로고
    • Chronic experimental colitis induced by dextran sulfate sodium (DSS) is characterized by Th1 and Th2 cytokines
    • Dieleman, L.A.; Palmen, M. J.; Akol, H.; Bloemena, E.; Pena, A.S. Meuwissen, S.G.; et al. Chronic experimental colitis induced by dextran sulfate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin. Exp. Immunol. 1998, 114, 385-391.
    • (1998) Clin. Exp. Immunol , vol.114 , pp. 385-391
    • Dieleman, L.A.1    Palmen, M.J.2    Akol, H.3    Bloemena, E.4    Pena, A.S.5    Meuwissen, S.G.6
  • 94
    • 15944383761 scopus 로고    scopus 로고
    • Metallothionein overexpression does not protect against inflammatory bowel disease in a DSS murine colitis model
    • Oz, H.S.; Chen, T.; de Villiers, W.; McClain, C. Metallothionein overexpression does not protect against inflammatory bowel disease in a DSS murine colitis model. Med. Sci. Monit. 2005, 11, BR69-73.
    • (2005) Med. Sci. Monit , vol.11
    • Oz, H.S.1    Chen, T.2    de Villiers, W.3    McClain, C.4
  • 95
    • 0031903014 scopus 로고    scopus 로고
    • Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease
    • Sido, B. ; Hack, V. ; Hochlehnert, A. ; Lipps, H. ; Herfarth, C. ; Dröge, W. Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. Gut 1998, 42, 485-492.
    • (1998) Gut , vol.42 , pp. 485-492
    • Sido, B.1    Hack, V.2    Hochlehnert, A.3    Lipps, H.4    Herfarth, C.5    Dröge, W.6
  • 96
    • 0025681755 scopus 로고    scopus 로고
    • Chen, T.S., Richie, J.P. Jr; Lang, C.A. Life span profiles of glutathione and acetaminophen detoxification. Drug Metab. Disp. 1990, 18, 882-887.
    • Chen, T.S., Richie, J.P. Jr; Lang, C.A. Life span profiles of glutathione and acetaminophen detoxification. Drug Metab. Disp. 1990, 18, 882-887.
  • 97
    • 12844283855 scopus 로고    scopus 로고
    • Diverse Antioxidants protect Against Acetaminophen Hepatotoxicity
    • Oz, H.S.; McClain, C.; Nagasawa, H.; Ray, M.; Chen. T. Diverse Antioxidants protect Against Acetaminophen Hepatotoxicity. J. Biochem. Mol. Tox. 2004, 18, 361-368.
    • (2004) J. Biochem. Mol. Tox , vol.18 , pp. 361-368
    • Oz, H.S.1    McClain, C.2    Nagasawa, H.3    Ray, M.4    Chen, T.5
  • 98
    • 0026781166 scopus 로고
    • Glutathione deficiency increases organ dysfunction after hemorrhagic shock
    • Robinson, M.K.; Rounds, J.D; Hong, R.W.; Jacobs, D.O.; Wilmore, D.W. Glutathione deficiency increases organ dysfunction after hemorrhagic shock. Surgery 1992, 112,140-7, 148-149.
    • (1992) Surgery , vol.112 , Issue.140-147 , pp. 148-149
    • Robinson, M.K.1    Rounds, J.D.2    Hong, R.W.3    Jacobs, D.O.4    Wilmore, D.W.5
  • 99
    • 0034534498 scopus 로고    scopus 로고
    • Induction of enlarged intestinal lymphoid aggregates during acute glutathione depletion in a murine model
    • Koch, T.R.; Yuan, L.X.; Fink, J.G.; Petro, A.; Opara, E.C. Induction of enlarged intestinal lymphoid aggregates during acute glutathione depletion in a murine model. Dig. Dis. Sci. 2000, 45, 2115-2121.
    • (2000) Dig. Dis. Sci , vol.45 , pp. 2115-2121
    • Koch, T.R.1    Yuan, L.X.2    Fink, J.G.3    Petro, A.4    Opara, E.C.5
  • 101
    • 0000616228 scopus 로고
    • Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)-thiazolidine-4(R) -carboxylic acids
    • Roberts, J.C.; Nagasawa, H.T.; Zera, R.T.; Fricke, R.F.; Goon, D.J. Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)-thiazolidine-4(R) -carboxylic acids. J. Med. Chem. 1987, 30, 1891-1896.
    • (1987) J. Med. Chem , vol.30 , pp. 1891-1896
    • Roberts, J.C.1    Nagasawa, H.T.2    Zera, R.T.3    Fricke, R.F.4    Goon, D.J.5
  • 102
    • 0034011876 scopus 로고    scopus 로고
    • Status of glutathione and other thiols and disulfides in human plasma
    • Kleinman W.A.; Richie Jr, J.P. Status of glutathione and other thiols and disulfides in human plasma. Biochem. Pharmacol. 2000, 60, 19-29.
    • (2000) Biochem. Pharmacol , vol.60 , pp. 19-29
    • Kleinman, W.A.1    Richie Jr, J.P.2
  • 103
    • 0023256535 scopus 로고
    • Pharmacologic role of cysteine in ameliorating or exacerbating mineral toxicities
    • Baker, D.H.; Czarnecki-Maulden, G.L. Pharmacologic role of cysteine in ameliorating or exacerbating mineral toxicities. J. Nutr. 1987, 117, 1003-1010.
    • (1987) J. Nutr , vol.117 , pp. 1003-1010
    • Baker, D.H.1    Czarnecki-Maulden, G.L.2
  • 104
    • 0034074793 scopus 로고    scopus 로고
    • Replenishment of glutathione levels improves mucosal function in experimental acute colitis
    • Ardite, E. ; Sans, M. ; Panes, J. ; Romero, F. ; Pique, J.M. ; Fernandez-Checa, J. Replenishment of glutathione levels improves mucosal function in experimental acute colitis. Lab. Invest. 2000, 80, 735-744.
    • (2000) Lab. Invest , vol.80 , pp. 735-744
    • Ardite, E.1    Sans, M.2    Panes, J.3    Romero, F.4    Pique, J.M.5    Fernandez-Checa, J.6
  • 105
    • 0026631007 scopus 로고
    • Experimental colitis in animal model
    • Kim, H.S.; Berstad, A. Experimental colitis in animal model. Scand. J. Gastroentrol. 1992, 27, 529-537.
    • (1992) Scand. J. Gastroentrol , vol.27 , pp. 529-537
    • Kim, H.S.1    Berstad, A.2
  • 106
    • 0031669038 scopus 로고    scopus 로고
    • Changes in colonic inflammation induced by dextran sulfate sodium (DSS) during short- and long-term administration of rebamipide
    • Iwai, A.; Iwashita, E. Changes in colonic inflammation induced by dextran sulfate sodium (DSS) during short- and long-term administration of rebamipide. Dig. Dis. Sci. 1998, 43, 143S-147S.
    • (1998) Dig. Dis. Sci , vol.43
    • Iwai, A.1    Iwashita, E.2
  • 107
    • 0021319807 scopus 로고
    • 2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine, protection of mice against acetaminophen hepatotoxicity
    • Nagasawa, H.T.; Goon, D.J.; Muldoon, W.P. Zera, R.T. 2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine, protection of mice against acetaminophen hepatotoxicity. J. Med. Chem. 1984, 27, 591-596.
    • (1984) J. Med. Chem , vol.27 , pp. 591-596
    • Nagasawa, H.T.1    Goon, D.J.2    Muldoon, W.P.3    Zera, R.T.4
  • 108
    • 0029892222 scopus 로고    scopus 로고
    • Prevention of naphthalene-induced cataract and hepatic glutathione loss by the L-cysteine prodrugs, MTCA and PTCA
    • Rathbun, W.B.; Nagasawa, H.T.; Killen; C.E. Prevention of naphthalene-induced cataract and hepatic glutathione loss by the L-cysteine prodrugs, MTCA and PTCA. Exp. Eye Res. 1996, 62, 433-441.
    • (1996) Exp. Eye Res , vol.62 , pp. 433-441
    • Rathbun, W.B.1    Nagasawa, H.T.2    Killen, C.E.3
  • 109
    • 0020464964 scopus 로고
    • Accumulation of cystine from glutathione-cysteine mixed disulfide in cystinotic fibroblasts; blockade by an inhibitor of γ-glutamyl transpeptidase
    • Butler, J.D.B.; Spielberg, S.P. Accumulation of cystine from glutathione-cysteine mixed disulfide in cystinotic fibroblasts; blockade by an inhibitor of γ-glutamyl transpeptidase. Life Sci. 1982, 31, 2563-2570.
    • (1982) Life Sci , vol.31 , pp. 2563-2570
    • Butler, J.D.B.1    Spielberg, S.P.2
  • 110
    • 0038324477 scopus 로고    scopus 로고
    • Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione
    • Berkeley, L.I.; Cohen, J.F.; Crankshaw, D.L.; Shirota, F.; Nagasawa, H.T. Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione. J. Biochem. Mol. Toxicol. 2003, 17, 95-97.
    • (2003) J. Biochem. Mol. Toxicol , vol.17 , pp. 95-97
    • Berkeley, L.I.1    Cohen, J.F.2    Crankshaw, D.L.3    Shirota, F.4    Nagasawa, H.T.5
  • 111
    • 0009844209 scopus 로고
    • The reduction of the L-cysteine-glutathione mixed disulfide in rat liver. Involvement of an enzyme catalyzing thiol-disulfide interchange
    • Eriksson, S.A., Mannervik, B. The reduction of the L-cysteine-glutathione mixed disulfide in rat liver. Involvement of an enzyme catalyzing thiol-disulfide interchange. FEBS Lett. 1970, 7, 26-28.
    • (1970) FEBS Lett , vol.7 , pp. 26-28
    • Eriksson, S.A.1    Mannervik, B.2
  • 112
    • 2942520946 scopus 로고    scopus 로고
    • Efficacy of a TGF-β2 Containing Nutritional Support Formula in a Murine Model of IBD
    • Oz, H.S.; Ray, M.; Chen, T.S.; McClain, C.J. Efficacy of a TGF-β2 Containing Nutritional Support Formula in a Murine Model of IBD. J. Amer. Coll. Nutri. 2004, 23, 220-226.
    • (2004) J. Amer. Coll. Nutri , vol.23 , pp. 220-226
    • Oz, H.S.1    Ray, M.2    Chen, T.S.3    McClain, C.J.4
  • 113
  • 114
    • 34447504685 scopus 로고    scopus 로고
    • Comparative Efficacies of Two Cysteine Prodrugs and a Glutathione Delivery Agent in a Colitis Model
    • Oz, H.S.; Chen, T.; Nagasawa, H. Comparative Efficacies of Two Cysteine Prodrugs and a Glutathione Delivery Agent in a Colitis Model. Translat. Res. 2007, 150, 122-129.
    • (2007) Translat. Res , vol.150 , pp. 122-129
    • Oz, H.S.1    Chen, T.2    Nagasawa, H.3
  • 115
    • 0035863174 scopus 로고    scopus 로고
    • Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4(R)- carboxylic acid in mice
    • Srinivasan, C.; Williams, W.M.; Ray, M.B.; Chen, T.S. Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4(R)- carboxylic acid in mice. Biochem. Pharmacol. 2001, 61, 245-252.
    • (2001) Biochem. Pharmacol , vol.61 , pp. 245-252
    • Srinivasan, C.1    Williams, W.M.2    Ray, M.B.3    Chen, T.S.4
  • 116
    • 0035313679 scopus 로고    scopus 로고
    • Effects of 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid on extrahepatic sulfhydryl levels in mice treated with acetaminophen
    • Srinivasan, C.; Williams, W.M.; Nagasawa, H.T.; Chen, T.S. Effects of 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid on extrahepatic sulfhydryl levels in mice treated with acetaminophen. Biochem. Pharmacol. 2001, 61, 925-931.
    • (2001) Biochem. Pharmacol , vol.61 , pp. 925-931
    • Srinivasan, C.1    Williams, W.M.2    Nagasawa, H.T.3    Chen, T.S.4
  • 118
    • 0029933002 scopus 로고    scopus 로고
    • An HPLC radiotracer method for assessing the ability of L-Cysteine prodrugs to maintain glutathione levels in the cultured rat lens
    • Holleschau, A.M.; Rathbun, W.B.; Nagasawa, H.T. An HPLC radiotracer method for assessing the ability of L-Cysteine prodrugs to maintain glutathione levels in the cultured rat lens. Curr. Eye Res. 1996, 15, 510.
    • (1996) Curr. Eye Res , vol.15 , pp. 510
    • Holleschau, A.M.1    Rathbun, W.B.2    Nagasawa, H.T.3
  • 119
    • 0030920140 scopus 로고    scopus 로고
    • S-adenosylmethionine synthesis: Molecular mechanisms and clinical implications
    • Mato, J.M.; Alvarez, L.; Ortiz, P.; Pajares, M.A. S-adenosylmethionine synthesis: molecular mechanisms and clinical implications. Pharmacol. Ther. 1997, 73, 265-280.
    • (1997) Pharmacol. Ther , vol.73 , pp. 265-280
    • Mato, J.M.1    Alvarez, L.2    Ortiz, P.3    Pajares, M.A.4
  • 120
  • 121
    • 0021347806 scopus 로고
    • Transmethylation, transsulfuration, and aminopropylation reactions of S-adenosyl-L-methionine in vivo
    • Giulidori, P.; Galli-Kienle, M.; Catto, E.; Stramentinoli, E. Transmethylation, transsulfuration, and aminopropylation reactions of S-adenosyl-L-methionine in vivo. J. Biol. Chem. 1984, 259, 4205-4211.
    • (1984) J. Biol. Chem , vol.259 , pp. 4205-4211
    • Giulidori, P.1    Galli-Kienle, M.2    Catto, E.3    Stramentinoli, E.4
  • 122
    • 0029927157 scopus 로고    scopus 로고
    • Methionine derivatives diminish sulphide damage to colonocytes - implications for ulcerative colitis
    • Roediger, W.E.; Babidge, W.; Millard, S. Methionine derivatives diminish sulphide damage to colonocytes - implications for ulcerative colitis. Gut 1996, 39, 77-81.
    • (1996) Gut , vol.39 , pp. 77-81
    • Roediger, W.E.1    Babidge, W.2    Millard, S.3
  • 123
    • 0033915156 scopus 로고    scopus 로고
    • Thiol methyltransferase activity in inflammatory bowel disease
    • Roediger, W.E.; Babidge, W.J. Thiol methyltransferase activity in inflammatory bowel disease. Gut 2000, 47, 206-210.
    • (2000) Gut , vol.47 , pp. 206-210
    • Roediger, W.E.1    Babidge, W.J.2
  • 124
    • 0030780249 scopus 로고    scopus 로고
    • Thiolmethyltransferase activity in the human colonic mucosa: Implications for ulcerative colitis
    • Moore, J.W.; Babidge, W.J.; Millard, S.H.; Roediger, W.E. Thiolmethyltransferase activity in the human colonic mucosa: implications for ulcerative colitis. J. Gastroenterol. Hepatol. 1997, 12, 678-684.
    • (1997) J. Gastroenterol. Hepatol , vol.12 , pp. 678-684
    • Moore, J.W.1    Babidge, W.J.2    Millard, S.H.3    Roediger, W.E.4
  • 126
    • 39849106893 scopus 로고    scopus 로고
    • Methionine deficiency and liver injury in a dietary NASH model
    • DOI: 10.1007/s10620-007-9900-7
    • Oz, H.S.; Chen, T.; Neuman, M. Methionine deficiency and liver injury in a dietary NASH model. Dig. Dis. Sci. 2007, DOI: 10.1007/s10620-007-9900-7.
    • (2007) Dig. Dis. Sci
    • Oz, H.S.1    Chen, T.2    Neuman, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.