Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF-κB activation

FEBS Letters

Volumn 413, Issue 2, 1997, Pages 354-358

  Meyer, Stephanie ^a   Kohler, N Gail ^a   Joly, Alison ^a  

^a CV THERAPEUTICS INC   (United States)

Author keywords

Cyclosporine A; Immunosuppressant; Inflammation; NF B activation; Proteasome proteolysis

Indexed keywords

CHYMOTRYPSIN; CYCLOSPORIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PEPTIDASE; PROTEASOME; RAPAMYCIN; TRYPSIN; TUMOR NECROSIS FACTOR;

ARTICLE; BRAIN; CATTLE; CELL CULTURE; CELL LINE; ENZYME INHIBITION; ENZYME PURIFICATION; IN VITRO STUDY; MACROPHAGE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING;

ANIMALS; BRAIN; CATTLE; CYCLOSPORINE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; LEUPEPTINS; LIPOPOLYSACCHARIDES; MULTIENZYME COMPLEXES; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; POLYENES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PRECURSORS; PROTO-ONCOGENE PROTEINS; SIROLIMUS; TRANSCRIPTION FACTOR RELB; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

BOS TAURUS;

EID: 0030805604     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)00930-7     Document Type: Article

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